A framework for the various potential causes of insomnia

The overlooked physical causes of insomnia

Persistent lack of sleep is dangerous for anyone, but women are especially unlikely to have their symptoms taken seriously. This article highlights the physical causes of insomnia—a condition often written off as solely psychological—and the importance of early diagnosis. The writer, Courtney Maum, was diagnosed with an anterior nasal valve collapse as the source of her insomnia.

A quick technical overview of insomnia

Insomnia is one of the world's most common sleep disorders. Characterized by difficulties falling and staying asleep, long-term struggles with insomnia can prelude or contribute to health difficulties. Treatments range from sleep hygiene management and relaxation therapy, and medication, including antidepressants and melatonin.

Genetics play a role in the reliability of the body's biological clocks

Growing evidence suggests genetics influence when, how long, and how well one sleeps, meaning insomnia may have a genetic component. While exact insomnia biomarkers have yet to be determined, some genes, including those related to psychiatric disorders, have been implicated.

About 10%-15% of people experience chronic insomnia

How often would you say you struggle to stay or fall asleep? If it's more than three times per week (and has been going on for at least one month), then you might have one of the most common sleep disorders: insomnia.

What it's like to live with insomnia

The biological process Shakespeare referred to as the chief nourisher of life's feast is necessary for the body and mind to rest and repair from the activities of daily life. As sleep evades the exhausted, sufferers also lose emotional stability, mental clarity, social connections, and more while simultaneously gaining waves of interrupted biological processes that can lead to disease and death.

Stress and anxiety may lead to similar symptoms, but stress is a response to external triggers, while anxiety is persistent, and its symptoms won't disappear once an immediate stressor is gone.

Clinical insomnia is defined as trouble sleeping for three nights per week for at least one month

The term "insomnia" is often used in popular culture to refer to general difficulty sleeping or staying asleep. In the US, insomnia transitions to a clinical disorder when symptoms—dissatisfying, nonrestful, and life-disrupting sleep—occur at least three nights per week for at least one month and cause "clinically significant" distress in important areas of life.

Temperature and certain medications can also affect your circadian rhythms

Although light and dark have the largest influence on circadian rhythms, temperature, stress, and certain medications are among the factors that also play a role. Persistent trouble sleeping or staying asleep may signal it’s time to see your doctor to get a better sleep-wake schedule.

Chronic stress affects nearly all parts of the body

Stress is our body’s internal mechanism to deal with changes in our internal balance. As such, the stress response affects nearly every organ system through a cascade of both fast and slow hormonal changes. While short-term stress can be adaptive, long-term stress may cause serious health issues.

Our ancient fight-or-flight response may contribute to modern ailments

Many common modern diseases humans struggle with may in fact have their origins in our ancient fight-or-flight stress response. Long-term effects of the stress hormones cortisol and adrenaline—in this case, triggered by things like workplace stressors—can wreak havoc on the delicate internal balance of our organ systems.

How stress affects every organ in the body

If you are a visual learner, this resource is for you. Not only does this article from the World Economic Forum outline the causes of modern stress along with helpful strategies, but they have created an approachable infographic to show exactly how stress manifests throughout our different bodily systems. Pair this visual guide with our other resources to gain a deep knowledge of stress and the human body.

External factors, not aging itself, lead to sleep loss in older adults

Though it is often believed that people need less sleep as they age, the recommended sleep guidelines for all adult age groups are almost identical. However, factors such as medication use, lack of physical activity, and loneliness can lead to sleep problems, and thereby lead older people to believe that they actually need less sleep than they do.

Circadian rhythm disruption can influence various mental health disorders

This 2020 research overview surveys the relationship between disrupted circadian clocks and disorders including schizophrenia, anxiety, and bipolar disorder. It incorporates findings and therapeutic approaches drawing from human night shift studies and jet lag studies alongside animal research.

How do anxiety and stress differ?

This article explains that though “stress” and “anxiety” are often used interchangeably, there are distinct differences between the two. Stress is defined as the body's response to an external trigger and can be classified as acute or chronic. Anxiety, however, tends to be triggered internally by excessive thoughts and judgement. Whereas stress disappears when the trigger is gone, anxiety tends to stick around. If left unchecked, both can escalate into more severe mental health conditions.

Narcolepsy occurs when the brain loses its ability to control its sleep-wake cycle.

The biology of stress in your body

Stress is a normal human response that has evolved over millions of years to handle changes or threats in our environment. This article is a helpful overview of the biological basics of this response. While it is not harmful to our physiology in the acute setting, chronic stress can lead to damaging changes in the human body over many years.

A closer look at why people snore

Snoring is simply noise caused by improper airflow during sleep—and while it’s something that most people will do at some point in their lives, it can also be indicative of larger health problems. Generally speaking, snoring occurs when soft...

Poor sleep increases the risk of developing Alzheimer's, and a main reason appears to be that the brain disposes of toxic protein buildup during high-quality sleep.

How burnout alters your brain

Stress is a normal part of everyday life, and it’s not necessarily all bad. But chronic stress—the kind that leads to burnout—can change the size and functioning of parts of your brain. It can alter the ability to make new brain cells and memories and even potentially modify your DNA.

Inflammation appears to cause specific symptoms of depression

A large analysis of existing studies published in 2021 found that systemic inflammation is associated with fatigue, appetite changes, and sleep disruption, rather than some of depression's broader symptoms including hopelessness about the future, or feeling fearful. This may suggest that inflammation influences specific symptoms of the condition, rather than the disease as a whole.

Easy resets for stress reduction

Individual solutions for burnout, often called “self-care,” can be helpful for managing stress. Harvard researcher Aditi Nerurkar’s 2024 book The Five Resets details a road map for burnout recovery. In this interview she suggests, among other tactics, gaining focus on what matters the most in one’s life, taking breaks from both work and the internet, and making time for practices that strengthen the mind-body connection.

Anxiety is one of the world's most common mental health disorders, causing persistent excessive fear and worry that interferes with daily activities.

Prolonged stress impairs the prefrontal cortex

Burnout isn't just a feeling—it physically affects the brain. Prolonged stress impairs regions of the brain responsible for decision-making, emotional control, memory, and more. It can also lead to chemical imbalances, like reduced dopamine and norepinephrine levels, that worsen these effects.

Sleep disorders can exacerbate neurological and other health conditions

Brain regions that control sleep sit adjacent to those that regulate the autonomic nervous system, which controls involuntary bodily functions like heart and breathing rates. These neighbors influence each other, meaning poor sleep can impair or negatively impact the ANS, further disturbing sleep.

Stress and the brain

While an acute stress response is a normal bodily function, the effects of chronic stress can be extremely damaging to the human body. This is particularly true with regard to the brain. This article explores the effects of stress on the human brain, including how chronic stress may lead to psychological conditions such as depression and memory loss.

Key symptoms of burnout can be both mental and physical

Burnout can be accompanied by several symptoms, including low energy and chronic fatigue, trouble concentrating, difficulty sleeping, and depression. It may even manifest physically as musculoskeletal pain, headaches, stomach and intestinal pain, and more. More intense cases have been linked to cardiovascular and mental health disorders.

Five patterns may define how we sleep—not just night owl or early bird.

Nightmares are unpredictable, but are linked to stress, anxiety, trauma, and more.

The deadly genetic disease that steals shut-eye

Few are haunted by fatal familial insomnia. This neurodegenerative disease is typically carried through bloodlines via genetic mutation of the prion protein gene, forcing the body to create abnormal and pathological protein variations that can corrupt normal versions. This article follows a musician as they attempt to come to terms with the FFI plaguing their family (and, possibly, their future).

How we frame stress—as good or bad—seems to alter how it affects us

This podcast discusses research that indicates stress perception may drastically affect how we respond to it. In research exploring if our stress is presented as diminishing our health versus if we're told it enhances our performance, it will lead to differences in how successful participants are at performing tasks—with the enhancers doing better.

The body's sleep-wake cycle is one of its many circadian rhythms

The body's sleep-wake cycle is one of its many circadian rhythms, which are behaviors or biological processes that exhibit 24-hour patterns. These rhythms are deeply impacted by light exposure, food availability, and much more, meaning where you live impacts your sleep.

Clinical burnout: prolonged exhaustion, mental distance, and persistent negative feelings

Burnout isn’t just stress—it’s a pervasive feeling of exhaustion that can start in the workplace and seep into everyday life. It causes feelings of dread and cynicism about work tasks. On top of emotional distress, there can be physical symptoms and a tendency towards addictive behavior.

One-third of early- and mid-career workers have considered quitting due to stress

In 2024, around half of all full-time employees polled by the National Alliance on Mental Illness reported experiencing burnout at their jobs. Around a third of all employees ages 18 to 49 had considered quitting their jobs due to workplace stress.

Anxiety can arise at any stage of life and make someone feel unsafe in their mind and body.

Sleep is often viewed individually, when its impact and meaning may be more communal

At any given point, roughly 2 billion people may be asleep on Earth. The typical scientific description of sleep focuses on its individual impact, but the phenomenon shapes whole cultures and eons. This essay prompts a fresh rethinking of the importance of sleep for humanity.

Links between long-term caregiving and chronic stress

This Cleveland Clinic overview suggests that around 60% of people caring for family or loved ones with health conditions will experience burnout. Caregivers prepare meals, help with transportation, administer medications, and perform daily tasks for others, all while managing their own lives. This guide may help readers overcome the guilt or frustration of long-term caregiving to seek alternative options.

The US loses roughly $400B a year in productivity due to sleep deprivation

For an article about a woman who built a business empire telling bedtime stories, the Hustle created this graphic showing the estimated GDP loss associated with chronic insomnia. The United States had a much more significant loss than other countries.

Studies suggest when you sleep is as important as how much you get.

Autoimmune disease prevalence and incidence are on the rise—but no one knows why

Researchers theorize that environmental factors, including shifts to less healthy diets, air pollution, infections, stress, climate change, and exposures to xenobiotics—substances like pesticides, plastics, and toxins that incite immune responses—may all be fueling epigenetic changes to our bodies that make people's immune responses go awry.

Stress can be contagious—and scientists want to learn more about it

Researchers have shown that being around someone who is stressed can trigger a stress response in your body, such as elevated cortisol levels and elevated heart rate. One way this was recently studied was by having people watch stressful activities, like a recorded job interview or solving challenging math problems, and then sampling hormones in observers' spit.

A sleep expert discusses the broad benefits of quality rest

In this three-part series, renowned sleep expert Matthew Walker and doctor Peter Attia explore the role of sleep in memory consolidation and mental health, and the detrimental effects of chronic lack of sleep. The latter has been linked to increased risk of dementia, hypertension, and more.

The positives of feeling stressed

Worrying about past events and upcoming challenges is not a pleasant experience, but a reasonable amount of stress can bring a lot of good into our lives. In this episode of "The Happiness Lab" with Dr. Laurie Santos, two psychology experts offer tips for resetting one's relationship with stress. Listen and learn how to make stress a positive tool rather than a debilitating emotion.

Based on its varied symptoms, scientists think that long COVID is not a single disease, but rather a group of different conditions triggered by COVID-19 infection.

Sleep apnea explained

While sleep apnea is directly tied to an increased risk of cardiovascular and metabolic health problems, many affected people are unaware of their problem. Sleep apnea occurs when upper airway muscles relax during sleep and pinch off the airway, which can cause breathing to pause for 10 seconds or more at a time. Sleep partners (rather than those inflicted) are often the first to notice breathing pauses or loud snoring in their bedmates.

Too little stress can also harm our health because mild or moderate stress—followed by recovery—helps make us resilient.

Light pollution is giving oysters insomnia

Oysters, bivalve mollusks that have light-detecting cells along their skin, can't sleep with all this artificial light. According to a 2022 study, oysters' sleep cycles are disturbed by light dimmer than that provided by the full moon. As with humans, it's possible that these bouts of insomnia could have adverse health effects and contribute to the development of disease over time.

Stress affects different animals in different, but useful, ways

Animals feel stress when they experience actual dangers—such as a zebra chased by a lion. Humans often feel stress from worries, memories, or even thoughts about problems that may occur in the future. For this reason, animals tend to experience stress in short, intense bursts. Conversely, people can feel stressed for long periods, which can eventually be harmful to their health.

Obsessing over sleep metrics leads to worse sleep quality

Over one-third of Americans have used wearable technology to track their sleep, and the anxiety over having perfect sleep data, or orthosomnia, has made getting a good night's sleep more difficult. Experts agree that most devices cannot correctly assess sleep details, making the data unreliable.

Understanding the stages of sleep

Do you have trouble keeping the different stages of sleep straight and organized in your mind? Us too. Sometimes it helps to have a straightforward listing of what each stage is and why it’s important. Look no further than this resource from Lumen. It is a basic outline of the four stages of the sleep cycle, along with the brainwaves and attributes that characterize each. If you’re brave enough, test yourself on the built-in quiz!

The WHO defines burnout as an occupational phenomenon

While it’s not a medical condition, the World Health Organization defines burnout as an occupational phenomenon in the International Classification of Diseases (ICD-11), and considers it separate from general stress.