More than 4,000 people died from cholera in 2023

1 in 4 people around the world don't have access to clean water

Poor water sanitation puts people at risk of acquiring this diarrheal infection. Cholera infections are on the rise due to extreme weather events and conflict. In recent years there have been cholera outbreaks in locations that hadn't seen the disease in many years, including Haiti.

We're in the middle of a decadeslong cholera pandemic

In 1961, the world's seventh recorded cholera pandemic started in South Asia, and it has continued through the decades. India and Bangladesh are at particular risk. This pandemic is driven partly by conflict, population displacement, extreme weather, and poor water infrastructure.

About 20% of people infected with cholera have severe symptoms

That's according to studies from outbreaks in Bangladesh. Most people who contract the disease have mild or moderate symptoms, or none at all. Yet anyone infected with the disease-causing bacteria can shed the pathogens in their feces for a few days, or even up to around 10, seeding the environment with bacteria.

Extreme weather conditions heighten cholera risks in settings like refugee camps

Runoff from sewage—exacerbated by situations like flooding or extreme rains—heightens this threat. Increasing temperatures also create the ideal conditions for the bacteria to reproduce, increasing transmission risks.

See how cholera spreads in a community

This animated video offers a comprehensive look at how cholera spreads. It makes clear why it's so difficult to stamp out this disease in communities around the world. It also details what steps can help control cholera.

There may be 500,000 additional malaria deaths by 2050 according to peer-reviewed research published in 2026.

Cholera went global thanks to global trade

The first cholera pandemic grew from an outbreak in India, in 1817. Scientists suggest it spread from there throughout the continent and onward to Africa, Russia and Europe through the poop of traders.

Climate shifts are projected to cause more cases of food poisoning

Research published in 2024 suggests that with more severe heatwaves and natural disasters, scientists expect there to be a rise in foodborne disease, especially in Africa and Asia. Already, there are an estimated 600 million food poisoning cases and 420,000 deaths annually. Diarrhea is the most common cause of those deaths.

Cholera vaccines can protect people from disease for months—or even years

There are three recommended cholera vaccines on the market. The number of required shots and the period of protection they provide vary, but each of them can be life-saving.

Heat-related deaths may have climbed by more than 50% over 20 years

Between 2000 and 2009 one study suggests annual heat deaths averaged around 2,670, but between 2010 and 2020 that figure was likely more than 4,000. Researchers studied 54 million death records from the contiguous US and created mathematical models to arrive at these figures, noting that a combination of aging populations and climate change drove that increase.

Severe cases of food poisoning have doubled even as food recalls dropped

Food recalls were down in 2024 by 5% as compared to 2023. But some researchers suspect that’s just because there were fewer inspections or fewer people reporting illnesses: Hospitalizations from food poisoning more than doubled during that same period, from 230 to 487, and deaths rose from 8 to 19.

Learn how cholera bacteria sicken humans

Once a person has ingested large amounts of the bacteria, typically through contaminated water, cholera bacteria begin producing and releasing a toxin inside their host. It attacks the mucosal lining of the intestine, making it hard to absorb liquids. This process leads to cholera's characteristic symptoms, like voluminous, watery diarrhea.

Historically, cholera has repeatedly disrupted the Hajj for Muslims

Outbreaks of the disease throughout the 19th century and the beginning of the 20th, killed thousands of religious pilgrims as they sought to complete this obligatory pilgrimage.

Cholera was called the 'Blue Death'

In the mid-1800s—when John Snow identified cholera in London—the disease was known simply as the "Blue Death." That's because blood would thicken in patients' veins when they were struggling with extreme dehydration. As a result, their skin would turn a blueish hue as their blood was starved of oxygen.

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

More than 39 million people are expected to die from antimicrobial resistance by 2050

In 2024, researchers published an incredibly detailed study aimed at predicting the real-world impact of antimicrobial resistance over the next 25 years. The key findings were clear: the superbug crisis is poised to get much worse and needs to be addressed. This article offers a clear, concise overview of the study, which was published in The Lancet.

A timeline of major pandemics from 1899–2025

Modern pandemics have been defined by the race between globalization (which increases risk) and the development of new medicines. The Great Influenza epidemic claimed some 50 million lives, and the COVID-19 pandemic killed more than 7 million. In between, diseases like Ebola, cholera, AIDS, and more have devastated communities.

America's top causes of death are heart disease, cancer, accidents, and stroke

Heart disease killed more than 680,000 people in 2023 and cancer killed around 613,000 people that year. Both causes of death are far above the next leading cause of death—accidents, which numbered around 223,000. Provisional data for 2024 indicates the leading causes of death remained the same.

Hurricanes may kill 300 times more people than officially reported

A recent study suggests that, since 1930, more than 3.5 million people have died due to hurricanes. This incorporates the long-term effects of storms on people's health and economic well-being, contributing to thousands of premature deaths each year.

There were 23 reported cruise ship outbreaks of gastrointestinal illness in 2025—something that happens often enough that there's a whole program at the US CDC devoted to tracking them.

The measles vaccine has saved an estimated 94 million lives since its introduction.

Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

University of Maryland Hospital researchers intentionally infected volunteers with the cholera bacterium in the late 1970s to further their understanding of the disease. They proceeded with this work following the recommendation of a US government panel. (Some users may encounter a paywall.)

Superbugs could claim 1.9 million lives per year by 2050

The increased use of antibiotics combined with an aging population, is projected to result in an almost 50% increase in global deaths from antimicrobial resistance each year. At the same time, antibiotic use for livestock is expected to increase by 30% over the same time frame.

West Nile was reported in 47 states in 2025, with more than 1,400 people severely affected

Tracking numbers from the CDC indicate that the virus spread widely that year, with more than 2,000 reported human cases and many states seeing more than 25 sickened people. More than 1,400 people had neuroinvasive cases of the disease—meaning the virus had entered the nervous system, which can cause severe, potentially life-threatening illness.

One in six Americans contracts food poisoning each year.

Vector-borne diseases kill more than 700,000 people globally each year—and are growing

The diseases with the greatest potential to spread widely aren't the ones that quickly kill human hosts. Instead, the best hosts or reservoirs for vector-borne diseases would be chronically ill over the long term, increasing the likelihood that the pathogen could be transmitted to others.

Influenza infects up to a billion people worldwide each year

The World Health Organization estimates that seasonal influenza causes about 1B cases annually, including 3 to 5M severe illnesses and between 290,000 to 650,000 deaths.

Antimicrobial resistance is responsible for 1.3 million deaths each year

Antimicrobial resistance is a global health threat, driven by the misuse and overuse of antimicrobials in humans, animals, and more. Estimates suggest superbugs could lead to $1T in healthcare costs by 2050, and the world faces a shortage of new drug development to meet the challenge.

See the polio cases that occur worldwide each year by region

Worldwide, the number of cases of polio reported each year from 1980 to 2024 has declined. This graphic depicts regional trends and declines by year.

Drug-resistant infections worldwide have increased by about 65% since 2000

Since 1990, antibiotic resistance has claimed at least one million lives annually and is projected to account for 39 million deaths between now and 2050 if current trends continue. The expanded use of antibiotics, particularly in agriculture, combined with a slowing pipeline of new drugs has led to the crisis.

Antibiotic resistance is a growing global health problem

Over decades, bacteria have grown increasingly resistant to antibiotics. This resistance now causes an estimated 1.27 million deaths each year and is associated with nearly 5 million deaths worldwide, according to the World Health Organization.

In 2012, a virus that causes HFMD may have killed dozens of kids in Asia

More than 50 young children in Cambodia died in spring 2012 for unknown reasons, but laboratory testing of samples available from a limited number of those children came back positive for Enterovirus 71. That virus, which can cause HFMD, is known to cause severe complications among some people who contract the disease. But health officials concluded that poor baseline health and then incorrect treatment using steroids helped exacerbate their condition, helping lead to the deaths.

Climate change is influencing the spread of disease

Rising temperatures and water levels are forcing animals and pathogens beyond their typical boundaries. This article and its data visualizations explore the proliferation of climate-driven diseases.

Discover the latest information on US measles cases from official outbreak tracking figures.

Heatstroke deaths may be massively undercounted—perhaps by a factor of 10

One often-cited average estimate of annual American heat deaths—roughly 1,200 per year—is based on death certificate data, but it may be a significant undercount because heat kills through cardiovascular, kidney, and respiratory causes that are more likely to be cited on those documents. (Separate analysis that looked at data from 1999 to 2023 found that the highest number, in 2023, was 2325.)

Cholera can persist in the environment, unlike smallpox, which needs a human host

Vibrio cholerae is the pathogen that causes cholera. It can reproduce in the environment without a human host, which means it's formally called a facultative pathogen. Obligate pathogens need a host to reproduce. Examples of obligate-based diseases include leprosy and smallpox.

Restaurants are where most of us contract food poisoning in the US.

Foodborne illnesses cost our country an estimated $74.7 billion in 2023

A US government estimate puts the cost of all foodborne illness in 2023 at almost $75 billion dollars. In a report published by the US Department of Agriculture’s Economic Research Service, government analysts detailed how the burden of foodborne illness includes medical costs, but also more hidden costs like lost wages. The analysis also breaks down estimated costs by pathogen.

From 2023 to 2025, coral reefs experienced their fourth global bleaching event and the largest such event through 2025.

11 people died from firework injuries in the US in 2024, with most of those deaths involving misuse of the explosives and device malfunctions or misfires.

The cholera bacteria was first isolated in 1854—but the discovery was largely ignored

The pathogen was isolated by the Italian physician Filippo Pacini in Florence, Italy, though his discovery was largely ignored in favor of the popular miasma—bad air—theory of disease at the time. The pathogen was separately isolated about three decades later by German microbiologist Robert Koch.

Unprecedented imaging of the Vibrio bacteria, published in 2026, may highlight new treatment targets

Researchers have produced the most detailed image ever of a key part of the Vibrio bacteria—the cause of cholera—known as the sheathed flagellum, which helps it move.

Neglected tropical diseases affect more people than the population of Europe

This group of conditions, which includes hookworm, sickens roughly one in seven people on the planet—a tally which dwarfs Europe's population of roughly 450 million. International cooperation and donations are helping to control some of these illnesses, which can be caused by parasites, viruses, and bacteria. They're all treatable or preventable, but primarily occur among poor, isolated communities that may not receive adequate care.

See the geographic spread and incidence of malaria

This graphic shows the estimated global burden of malaria in 2025 as new cases per 1000 people at risk.

Diphtheria was once a leading childhood killer before antibiotics and vaccines

In 18th- and 19th-century outbreaks, some New England families lost as many as eight children to diphtheria, and fatality rates in hospitals often topped 60%. The invention of antitoxins, penicillin, and vaccines dramatically reduced deaths.

Mosquitoes top the ranking of the world's deadliest animals.

More than 1 in 7 people worldwide have had Lyme disease

Research published in 2022 suggests that 14.5% of the world's population has contracted Lyme disease. Researchers arrived at that estimate by analyzing the presence of Lyme disease antibodies (indicating prior infection) across 89 studies conducted between January 1984 and December 2021. The works collectively included blood samples from more than 150,000 people. (Some user may encounter a paywall.)

Roughly 10% of the world's population is older than 65 (2023 data)

With recent advances in medicine, sanitation, and nutrition, expected lifespans have rapidly risen around the globe—resulting in a rapidly aging global population. The worldwide distribution has seen a nearly 600% jump in the population of people aged 65 and older.

10 locally acquired malaria cases were reported in the US in 2023—a surprise

The cases, reported in Florida, Texas, Maryland, and Arkansas, broke a 20-year streak since there had been no reported locally acquired mosquito-transmitted malaria in the country since 2003, when there was a case in Florida.

The COVID-19 pandemic led to a decrease in immunizations in the US and worldwide

Public health funds and resources that were diverted to COVID-19 response reduced efforts to combat polio and vaccinations for polio and other diseases declined during the pandemic, putting more people at risk for polio.