Chronobiologists study the effect of time on biological cycles

Studies suggest when you sleep is as important as how much you get.

Parasites have circadian rhythms, too

Researchers are working to unravel how circadian rhythms of parasites and their hosts affect one another. They’re investigating how to potentially target and disrupt those clocks for disease treatments.

Circadian rhythm disruption can influence various mental health disorders

This 2020 research overview surveys the relationship between disrupted circadian clocks and disorders including schizophrenia, anxiety, and bipolar disorder. It incorporates findings and therapeutic approaches drawing from human night shift studies and jet lag studies alongside animal research.

Single-cell organisms have circadian clocks that direct daily biochemical routines

Cyanobacteria, a type of light-sensitive bacteria, use this clock to signal when to alternate between making organic compounds through photosynthesis and when to convert atmospheric nitrogen into usable ammonia. Upregulating photosynthetic machinery before dawn helps ensure efficient photosynthesis.

The body's sleep-wake cycle is one of its many circadian rhythms

The body's sleep-wake cycle is one of its many circadian rhythms, which are behaviors or biological processes that exhibit 24-hour patterns. These rhythms are deeply impacted by light exposure, food availability, and much more, meaning where you live impacts your sleep.

In 2017, researchers won a Nobel Prize for their work controlling fruit fly circadian rhythms

This detailed circadian rhythm infographic breaks down a day in the biological life of a fly, providing a peek at some of the groundbreaking work that elicited a Nobel Prize in Physiology or Medicine.

'Zeitgebers' like light are external cues for the circadian clock

German for "time giver" or "time cues," common external zeitgebers include sunlight, food, and physical activity. The timing of these external influences can shift circadian clocks or lead to irregularities: A 2018 study, for example, found that later light exposure and meals were linked to later timing of peak activity and bedtimes.

Circadian rhythms shift as we age—making older adults want to go to bed earlier

Throughout our lives our internal biological clocks shift. Early-to-rise toddlers become hard-to-wake teens and eventually early-to-sleep seniors. Circadian rhythm fluctuations throughout our life cycle explain some of these changes.

A 2,000-year history of alarm clocks

Clocks have revolutionized the way we live, structuring our days into abstract, regular units and providing quantification for those who are chronically late. The alarm clock was the next obvious step: clocks which not only tell you the time but...

Genetics play a role in the reliability of the body's biological clocks

Growing evidence suggests genetics influence when, how long, and how well one sleeps, meaning insomnia may have a genetic component. While exact insomnia biomarkers have yet to be determined, some genes, including those related to psychiatric disorders, have been implicated.

Emulating Earth’s light-dark cycle is important for astronaut health and safety

Astronauts aboard the International Space Station experience 16 daily sunrises, but scientists have learned to try to promote circadian rhythms by phasing through several light settings aboard the ISS to improve astronauts’ sleep and productivity.

Artificial lighting and modern practices like working late are linked with sleep shifts

An analysis of five adults participating in a German reality program that tasked them with living in a Stone-Age-like settlement for 2.5 months, provided some insights into how modern conditions may have shifted our circadian rhythms. The participants slept about 90 minutes more under these conditions, and went to bed earlier and rose earlier, raising questions about how circadian rhythms, sleep, and sleep quality are affected by modern lifestyles.

Temperature and certain medications can also affect your circadian rhythms

Although light and dark have the largest influence on circadian rhythms, temperature, stress, and certain medications are among the factors that also play a role. Persistent trouble sleeping or staying asleep may signal it’s time to see your doctor to get a better sleep-wake schedule.

Most things you would get tested for at the doctor’s office are influenced by circadian rhythm

In this video, a Salk Institute Researcher offers daily habit tips focused on aligning with your circadian rhythms. She notes heart rate and blood pressure are highest in the afternoon, for example, and there’s a triglyceride peak in the morning. Generally, she says, it’s a good idea to schedule your doctor’s checkups at the same time of day each year so there’s consistency across your data.

Studying the circadian clock of a tiny swimming polar creature may help forecast polar ecosystem health

A 2025 study found that Antarctic krill, a food chain staple in the Southern Ocean, have an internal biological clock that helps regulate its swimming patterns and helps the tiny shrimp-like animals adapt to daily and seasonal environmental changes. Better understanding of how the clock and light cues interact may help scientists understand how well the species will respond to pronounced climate change in the polar region.

The lost medieval habit of 'two sleeps'

While most people accept a single seven-to-nine-hour nightly slumber is ideal, the approach is a relatively modern idea. For centuries, interrupted sleep was the norm, with historians uncovering descriptions of two periods of sleep during the normal 24-hour cycle.

Before alarm clocks, people relied more heavily on their circadian rhythms, humans hired to wake them, and on tools such as candle clocks that dropped pins in metal trays at roughly set intervals.

Babies don't develop a circadian rhythm right away

Newborns don't develop circadian rhythm until they are a few months old, which helps to explain their erratic sleep schedules. When they're around three months old they begin to release melatonin, which influences sleep, and around the same time they develop more regular sleeping routines.

Chronological versus biological age

Science has come to understand different types of aging. What we call age is simply the number of years since birth, or chronological age. At the cellular level, biological aging happens at different rates for different people, and explains why some seem to age more quickly (or slowly).

There is a best way to wake up—but not a best time

Sleep and circadian rhythm researchers say that waking up at a consistent time each day—even on weekends—and viewing morning sunlight are the best ways to keep body functions running at their peak. (Some users may encounter a paywall.)

The design of a psychiatric ward in Norway aims to integrate more circadian rhythm-friendly lights as part of its treatment protocols for conditions including psychosis, severe depression, and more.

The hour originated from an ancient Egyptian astronomical system

The movements of astronomical objects, measured in a day and a year, form the foundation of our sense of time. The Egyptians divided each day and night into 12 time eras, using arbitrarily selected stars as references rather than movements of specific celestial objects.

Early timekeeping tools included sundials, water clocks, and astrolabes

Astrolabes also provided a person's latitude based on the height of the stars in the sky, thus aiding in navigation. Incense and candle clocks relied on the constant burning rate of fire to track the passage of time based on premarked locations with equal-interval spacing.

Biological aging tests assess the breakdown of physiological systems

Known as aging clocks, these tests compare various metrics, like DNA methylation patterns and protein profiles, to healthy baselines. However, the non-uniformity of these baselines across individuals limits testing accuracy and prevents their clinical use.

The body's master clock has 20,000 neurons

The suprachiasmatic nucleus, the master clock in mammals, has 20,000 neurons that help maintain the light-dark cycle in the body. Among its jobs: It receives light input information from the retina and then signals peripheral body clocks to act on this information, driving everything from body temperature to hunger.

Read Norman Rosenthal’s original 1984 paper describing SAD

The study helped formalize research and diagnosis of seasonal affective disorder, catalyzing the development of therapies (like bright light) and leading to broader adoption of effective treatments. It also helped connect the influence of light and seasons on biological mechanisms in the human body, spurring exploration of circadian rhythms.

Why atoms are used to keep track of time and define the meaning of a second

Small variations in the production of human-made devices, such as mechanical watches and pendulums, make them unreliable for the ultraprecise timekeeping required by modern technology, including financial transaction timestamping and GPS. Because atoms obey fundamental laws of nature and never wear out, their light emissions when energized provide a consistent timekeeping signal.

Astronauts follow strict schedules to mimic Earth days and stay healthy in space

Experiencing 15 sunrises and sunsets a day while aboard the International Space Station, visitors preserve their circadian rhythms and mental health with fixed timetables. Astronauts have described sleep as living in a vacuum cleaner due to ongoing air filtration.

World records are often broken later in the day—and scientists wonder if muscle clocks explain the difference.

Can humans delay or reverse old age?

We're not sure yet. Researchers at the University of California San Francisco are studying why some conditions and behaviors, such as low-oxygen environments and exercise, benefit the aging process, hoping to reveal potential health applications. Some of this research focuses on klotho, a naturally occurring age-regulating hormone named after the Greek Fate Clotho. Animal studies on klotho brain injections found subjects had improved memory recall and age-related degeneration resistance.

Rather than measuring the rising and falling of the sun or pendulum swings, optical clocks track the passage of time using the extremely consistent vibrations of atoms.

The frequency of visible light is significantly greater than that of microwaves used in cesium atomic clocks. This makes optical clocks about 100 times more accurate, losing at most one second across the entire age of the universe.

The study of dreams, formally called oneirology, has evolved over the centuries, from anecdotal interpretations to advanced brain imaging.

Time crystals are systems of atoms organized into periodic patterns of motion

Unlike traditional crystals—whose atomic structures cause them to look identical no matter how you look at them in space—time crystals exhibit this behavior through time, where the motion of atoms will bring them to the same positions relative to one another regularly.

SAD disrupts melatonin secretion, producing it longer in the morning

The hormone is secreted from the pineal gland in the brain and is key to the timing of sleep. However, the substance does not generate sleep itself. With seasonal affective disorder, the body misperceives the photoperiod—the time with light—and the cycle of sleeping and waking gets off-phase, leading to issues with circadian rhythms.

Ending daylight saving time may prevent as many as 300,000 strokes annually

Changing clocks twice a year disrupts circadian rhythms, which last an average of 24 hours and 12 minutes. Studies have shown that permanent daylight saving time provides fewer health benefits than standard time.

The first appearance of bioluminescence was at least 540 million years ago

After analyzing fossils, genetic data, and statistical methods, scientists believe octocorals were the first organisms to evolve light-producing abilities. As a result of independent evolution across at least 94 species, this phenomenon is connected to a diverse range of behaviors.

What happens when we sleep

Sleep is a highly specialized and complex process that begins via signals from a region of the brain called the hypothalamus. As explained in this overview video from The Economist, the hypothalamus maintains our circadian rhythm by using light cues from our environment to regulate sleep via a compound known as melatonin. Once asleep, the brain begins the "sleep cycle" and progresses through the four stages of sleep over and over again each night.

How atomic clocks have been used to measure the universe's fundamental constants

Atoms behave according to a set of parameters that scientists have determined give reality its properties. For example, the fine-structure constant, α, quantifies the strength of interactions between charged particles. Since the light emitted by atoms as they move between energy levels is affected by α, analyzing these emissions—the basis of atomic clocks—using different atoms helps calculate α.

An engineer tracked his moods for decades and helped researchers identify SAD

Civil engineer Herb Kern had bipolar and would record his moods dating back to 1967. He noticed the seasons were a major factor in the increase and severity of his episodes. By reaching out to researchers at the National Institute of Mental Health, Kern became the first human to confirm increased melatonin levels during winter and to receive bright light therapy.

Five patterns may define how we sleep—not just night owl or early bird.

Why you should work 4 hours a day, according to science

Some of history's luminaries worked just four hours a day, including literary great Charles Dickens and biologist Charles Darwin. Observers suggest such a short period forces intense focus sustained by extended rest. In contemporary work, the high premium placed on the number of hours worked can overlook the importance of rest.

Light pollution is giving oysters insomnia

Oysters, bivalve mollusks that have light-detecting cells along their skin, can't sleep with all this artificial light. According to a 2022 study, oysters' sleep cycles are disturbed by light dimmer than that provided by the full moon. As with humans, it's possible that these bouts of insomnia could have adverse health effects and contribute to the development of disease over time.

Philosophers have debated the nature of time since at least the 6th century B.C.E.

Greek philosopher Parmenides of Elea was skeptical of time and reasoned that if it were real, then the present would emerge from nothing because the future did not yet exist. Just as the color red is our perception of a specific wavelength of light, others have suggested time is a psychological projection based on how we interpret the world.

Cell theory originated from microscopic observations of cork and dental plaque

In the mid-1600s, Robert Hooke identified compartment-like structures—which he called cells—in cork, and Anton van Leeuwenhoek discovered bacteria in samples of his dental scrapings. Almost 200 years later, Matthias Schleiden and Theodor Schwann showed that plants and animals, respectively, are composed of cells, proving that cells are the foundation of all living things.

The extreme precision of atomic clocks highlights gravitational time dilation

Scientists at the National Institute of Standards and Technology have constructed clocks made out of stacked strontium atoms, which show differences in the passage of time across just a millimeter of height consistent with predictions from general relativity, where atoms closer to Earth's center tick off time more slowly.

Sleep deprivation leads to the buildup of dangerous molecules in the gut.

Railroads and long-distance communication led to the development of time zones, with Greenwich established as the prime meridian—the longitude of 0 degrees—due to British advancements in star mapping and navigation.

The origins of our fascination with time travel

Humans have been captivated by the prospect of leaping forward and backward in time for thousands of years. Georgia Institute of Technology Science Fiction Studies Professor Lisa Yaszek recounts how the concept has been utilized by storytellers from 400 BCE to modern-day to explore our relationship with the supernatural, technology, and the past. In a way, this historical recounting is a journey through time.

There is a template for how to live a better, healthier day, and it includes a digital sunset

Science suggests that early-morning exercise, later-morning peak work or social time, consistent exercise, and a "digital sunset"—starting to turn down the lights in the evening and avoid screens—are important for circadian health.

Social jetlag—differing weekend and weekday schedules—is physiologically similar to jet lag

Recovering from schedules that drastically differ between weekends and weekdays, something that was first described in academic work in 2006, is a growing concern in public health as more research shows that consistent daily routines are important for human health.