Age, stress, and neurological disorders can prevent memory formation and recall

Synaptic plasticity allows neurons to communicate effectively and form memories

First proposed in 1949, synaptic plasticity allows the brain to adjust communication strength between neurons. This ability to change synaptic strength—either briefly or over long periods—is essential for learning and memory, with long-term synaptic plasticity forming the basis of how memories are stored.

Neurons send signals through electrical impulses and chemical messengers

By converting electrical signals into chemical messages at synapses, neurons allow information to travel throughout the nervous system. With repeated use, synapses grow stronger, enhancing the associations between neurons.

How aging degrades neural functioning in the brain over time

Aging affects the brain perhaps more than any other organ in the body. Throughout life, the brain experiences radical shifts in the number of neurons, synaptic connections between neurons, and hormone levels that regulate our mood and processing.

Memories are formed through attention, repetition, and emotional significance

Our brains create memories by taking in sensory input, filtering it through short-term memory, and storing it in long-term memory. Emotional events are more likely to become vivid, lasting memories because they activate stronger neural connections.

Consistency and emotional engagement can improve the formation of memories

While sleep lets the brain re-trigger neurons associated with our experiences to cement them in long-term memory, repeating actions, like storing one's keys in the same location, can mimic these benefits. Emotionally charged memories are often ruminated upon, improving their future recall.

Memory disorders disrupt the brain's ability to make, store, or recall memories

These disorders stem from reversible issues like vitamin deficiencies or irreversible causes such as stroke or dementia. Only one type of dementia—familial Alzheimer’s disease—is directly inherited and accounts for about 20% of Alzheimer’s cases.

Exercise releases chemicals that enhance cognitive function

Neurotransmitters like dopamine, serotonin, and norepinephrine, along with increased brain-derived neurotrophic factor levels, enhance a wide range of brain functions. New research demonstrates a direct link between movement and numerous cognitive benefits, including memory, learning, and stress resilience.

Retrieval cues trigger memories and emotions from long-term storage

Retrieval cues can activate specific cells in a neural network, creating a cascade of neurons that collectively make up a memory. Specific cues help regulate emotions during stress by activating positive memories.

The brain consolidates memories during sleep

During sleep, the brain appears to process memories from the day and encode them into long-term storage. At the same time, the brain prunes old memories out of the brain that are no longer useful. Understanding this process also sheds light a various neurodegenerative diseases.

What sleep loss does to the brain

Proteins in the brain perform various critical functions, such as helping neurotransmitters function or enabling electrical activity in the organ. These proteins must fold in specific ways to perform their duties, similar to paper airplanes. Sleep deprivation contributes to the gathering of misfolded proteins that aren't shaped correctly for their roles and so accumulate in undesired spaces, such as in the gaps between neurons.

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

False memories can form during recall when new information is incorporated

Often formed due to suggestion and misinformation, false memories can lead to serious consequences, such as wrongful convictions. The time between an event and recalling it affects one's susceptibility to false memories.

Researchers use the brain's ability to edit memories to explore memory deletion

Scientists have successfully implanted false memories in mice after studying how the editing process works in the brain. Beyond potentially deleting memories in those with PTSD, upcoming research may allow clinicians to forecast the onset of neurodegenerative diseases.

Long-term memory issues among West Nile survivors may be from the body's immune response, not the viral infection.

Memory is a complex narrative constructed from real and imagined experiences

Memories start with perception and are processed in the hippocampus. Different types of memories use different brain regions, and episodic memory, which is involved in recalling one's life events, is more susceptible to decay than semantic memory, which is involved in general information.

Stress and the brain

While an acute stress response is a normal bodily function, the effects of chronic stress can be extremely damaging to the human body. This is particularly true with regard to the brain. This article explores the effects of stress on the human brain, including how chronic stress may lead to psychological conditions such as depression and memory loss.

Long-term memory formation may not need short-term memory

New research shows that long-term memories can still develop even when short-term memory formation is blocked, suggesting the brain uses separate pathways for short- and long-term memory. This discovery could help scientists open new avenues for treating memory loss in diseases like Alzheimer’s.

How dreams affect your memory

In 1999, scientists conducted a study in which participants were asked to recall images flashed before them for milliseconds. They found that participants who slept before recalling the information performed better than those who had been asked to recall the same information that same day. This was some of the earliest convincing evidence of how crucial sleep is for learning and memory, findings that current research continues to strengthen.

How neurons give rise to thoughts

Neurons in the brain are singular nerve cells that flicker on and off or connect to each other based on incoming stimuli. The more neurons communicate by firing electrical impulses through tendrils known as synapses, the stronger their connection becomes. The electrical energy zipping along these interneural connections in an attempt to classify and respond to incoming stimuli may be what gives rise to thoughts.

Resistance training is linked to better memory and cognitive function in older adults.

Remylination is a huge focus for treatment—especially among older adults

Our ability to build new myelin sheaths for nerves degrades with age. There have been research advances boosting cells that support these processes and clear away debris from degraded myelin, but not yet any medications to boost myelination itself, which would aid nerve signaling and preserve nerve function.

Poor sleep increases the risk of developing Alzheimer's, and a main reason appears to be that the brain disposes of toxic protein buildup during high-quality sleep.

ADHD impairs working memory and limits the ability to form long-term memories

While ADHD is most often recognized for producing struggles with attention and organization, these executive functions are critical for capturing the data that creates memories in the brain. Breaking data into pieces, or chunking, helps address these struggles.

Neural rhythms shape how we move, focus, remember, and interact with the world

Millions of neurons in the brain produce rhythmic electrical signals, or brain waves, that guide physical movement and help form and store memories. Researchers also use these rhythms to create brain-computer interfaces, letting people control devices using only their thoughts.

Various types of memory, each serving unique functions, create a complex brain system

These forms of memory, which can overlap in daily life, have been sorted into broad categories, such as short-term and long-term memory, and subtypes such as implicit memory, which uses saved information without conscious awareness that it’s being recalled.

Chronic drug use can cause neurological changes in the brain

Neuroscientist Judy Grisel breaks down the biology of addiction, examining how drugs hijack the brain’s natural reward system and create lasting neural changes. The physiological and neurological impacts of chronic drug use require a multifaceted treatment approach.

Prolonged stress impairs the prefrontal cortex

Burnout isn't just a feeling—it physically affects the brain. Prolonged stress impairs regions of the brain responsible for decision-making, emotional control, memory, and more. It can also lead to chemical imbalances, like reduced dopamine and norepinephrine levels, that worsen these effects.

Playing music enhances the creation, storage, and retrieval of memories

Scans of the brains of individuals who play instruments have shown enhanced connectivity between multiple brain regions—visual, auditory, and motor cortices—and the corpus callosum, which connects the two brain hemispheres. These complex connections are strengthened through practice and then used in other activities that involve both logic and creativity. The brains of musicians also appear to give experiences multiple types of memory tags, such as audio, emotional, and conceptual, improving their processing.

"Plaques" and "tangles" are top potential causes of Alzheimer's—but questions remain

The exact causes of Alzheimer's—and how to treat it—continue to be the subject of intense research. Two leading factors are amyloid beta plaques and tau protein tangles, which effectively pile up in the brain and interfere with neurons and cause cell death, which manifests as memory loss and other symptoms.

Sharp wave ripples in the brain tag experiences for long-term memory storage

These ripples were known to quickly replay neuronal sequences during sleep for consolidation. While awake, they help the brain prioritize memories to remember, and their disruption can impair memory formation.

Alzheimer's brain changes may begin years before symptoms appear.

Memory exists as multiple types stored across various brain systems

Memory isn't one uniform function—it's made up of multiple systems, like declarative (facts/events) and non-declarative (skills/habits), which involve different brain areas such as the hippocampus, amygdala, and cerebellum.

The "reminiscence bump" causes memories from adolescence to last

Research shows that the "reminiscence bump" phenomenon, which applies to memories formed between the ages of 10 and 30, contributes to songs from those ages triggering the most intense nostalgia. This may be due to biological and hormonal changes enhancing memory effectiveness during adolescence.

Exercise improves brain blood flow, stimulates neural growth, and more.

Neurodegeneration is the process underlying dementia, but it may happen for myriad reasons, and its triggers are under investigation.

How burnout alters your brain

Stress is a normal part of everyday life, and it’s not necessarily all bad. But chronic stress—the kind that leads to burnout—can change the size and functioning of parts of your brain. It can alter the ability to make new brain cells and memories and even potentially modify your DNA.

Sensory memory is information collected from your senses

Lasting seconds before moving into short-term memory or being forgotten, sensory memory aids in environmental awareness and navigation. Key brain regions involved include auditory, somatosensory, gustatory, visual, and olfactory cortices.

Take a deep dive into the neuron

Neurons are the basic unit of the brain and nervous system—electrically excitable cells that sends signals throughout the body. They can communicate with each other, fire in sequence, and conspire to do everything from drive body movement to help form memories. Check out this intro-level overview to learn more about their structure and how they work.

Alzheimer's can cause significant brain shrinkage in the affected brain regions, including the hippocampus.

The hippocampus, a structure in the brain, plays a crucial role in memory formation

The seahorse-shaped structure transfers short-term memories to long-term storage during sleep. It is located in the temporal lobes, above each ear, and aids in spatial navigation and remembering directions.

When to see a doctor over memory lapses

Memory includes various, distinct functions, like working memory (storing information temporarily) and procedural memory (your body's ability to perform a task unconsciously). Forgetting a word or losing your keys can feel like red flag memory lapses, but they are, in fact, language or attention problems, not memory ones. However, a lapse on top of stress, lack of sleep, chronic dysfunction, or an injury may be a red flag to see your doctor.

Some dementia cases may be linked to treatable microorganism infections in the brain.

Why don’t you remember all your dreams?

Despite being a near-nightly occurrence, we remember very few of our dreams. Researchers believe reduced activity in regions where memories are stored, a different neurochemical environment during sleep, and rapid transition during waking contribute to this phenomenon.

Physiological muscle memory allows us to quickly regain lost musculature

The term "muscle memory" is most often associated with the neurological kind, which involves the development of strong and efficient neural pathways in the brain and spine. Physiological muscle memory also slows the loss of muscle mass, with both types affected by genetics and diet.

How depression affects the brain

Treatment for depression has historically hinged on the theory that the condition was caused by underactive or abnormal neurotransmitters, specifically serotonin and norepinephrine. This four-minute video by Yale Medicine details how these neurotransmitters didn't explain the symptoms of depression but, two other neurotransmitters involved in regulating mood and emotion did. GABA and glutamate, some of the brain's most plentiful neurotransmitters, may possibly be the source of depressive symptoms.

Learn the differences between mild cognitive impairment and age-associated memory loss

Mild cognitive impairment is a condition in which people experience more thinking and memory problems than expected for their age. It's often associated with depression and anxiety. Daily routines, writing things down, and healthy lifestyle choices can help cope with the condition, but there's no cure. The condition elevates the risk of developing dementia and Alzheimer's.

What's with the teen brain, anyway

In this video NIDA explores the intriguing similarities between the processes of brain development and computer programming. This analogy helps us understand why toxic environmental factors like drugs, bullying, or lack of sleep strongly affect a teenager's life The information provided by this video can empower your children or students with information they need make better decisions.

Paul Broca, a French brain researcher in the 19th century, hypothesized that humans evolved to trade in our "bestial sense" of smell for higher brain capacity.

Explore how excitatory cells, such as neurons and muscle cells, transmit information in the body via electrochemical signals, which can travel up to 120 meters (390 feet) per second.

How brain cells carry information

At any moment, there is an electrical storm coursing through your body. Discover how chemical reactions create an electric current that drives our responses to everything from hot pans to a mother’s caress.