'Cells Making Cells': 'Science Sam' discusses the potential of stem cells

The secret lives of cells

Cutting-edge microscopy has revealed previously unseen interactions of biological molecules within their cellular environment, enabling scientists to observe and analyze the molecules in a holistic view. This podcast explains the minute advancements made over the last few decades in observing cells, revealing how scientists have come and what the future holds for the field.

A Nobel laureate discuss whether stem cells can extend lifespan

Listen to Nobel laureate Shinya Yamanaka discuss the potential of induced pluripotent stem cells to extend human lifespan. By reprogramming adult cells into embryonic-like stem cells, scientists might be able to rejuvenate tissues and treat age-related diseases—though ethical and safety concerns remain.

Stem cell therapies

Stem cells' special attributes interest researchers developing new therapeutic tools for a variety of health problems. Much of this research is done with support from the National Institutes of Health (NIH). This page offers a snapshot of research programs funded by the NIH and the health problems those programs focus on.

Stem cells have the ability to self-renew

Stem cells have remarkable potential for new medical therapies. But to understand what makes stem cells so special, you must understand exactly what they are, and what they’re capable of doing. This page offers an accessible introduction to stem cell biology and their unique properties.

How do stem cells actually work?

Stem cells are unspecialized cells that can develop into various cell types while also making exact replicas of themselves. This amazing ability has made stem cells a candidate to treat a wide variety of diseases and conditions—though the vast majority of potential therapies remain in the research stage.

Stem cells can reboot the ability of cells to repair themselves

Stem cells—special cells that can self-renew and evolve into new cell types—may provide a path to address aging. Instead of repairing aging cells, stem cells can replace a cell's "repair kit," effectively rebooting the internal processes of tissues to a more youthful state.

How to turn any cell of the body into a stem cell

Scientists have developed techniques allowing them to 'reprogram' any cell in the body into an induced pluripotent stem (iPS) cell, which can be used to create either more stem cells or specialized cells for use in experimental medical treatments. This page gives readers a brief introduction to the history of iPS cells, what researchers are studying with iPS cells, and challenges associated with iPS research.

The scandal that rocked stem cell research

In 2014, a Japanese research group published a paper suggesting ordinary cells could be reverted to pluripotent stem cells by subjecting them to external stressors. The results generated interest but could never be replicated. The lead researcher was accused of fraud, and the group’s supervisor committed suicide.

Stem cells develop into a wide range of other specialized cells in the human body

Stem cells are different from other cells because they are capable of creating copies of themselves and producing other types of cells. For example, the ones found in our brains, bones, or muscles. Curious about stem cells? Here's a breakdown of how they work.

What conditions can be treated with stem cells?

Stem cell research is a global enterprise, and much of the work is being done in Europe. This page gives readers a good sense of the medical conditions stem cell researchers in Europe focus on, and the specific research challenges they address. This page also offers links to in-depth information about many of the research projects.

Scientists have created a cell from scratch—called a SpudCell—proof-of-concept work that a lab-made cell can feed, grow, and replicate like a natural cell.

In vitro gametogenesis: using induced stem cells to fertilize eggs

Using stem cells from skin and mouth cells could save hopeful parents time and money and spare egg donors from significant amounts of discomfort throughout the process. There are potential consequences, not just for infertility treatment, but for the ability to create customized cells of any type.

The spread of fraudulent stem cell treatments

All the coverage of research into promising (but often unproven) medical treatments involving stem cells has created conditions allowing some people to engage in activities regulators describe as scams. As this news article explains, attorneys general in at least seven states have taken legal action against businesses that promised (costly) stem cell treatments but allegedly engaged in fraud.

There are three types of stem cells, each with different properties

Embryonic stem cells are "blank slates" that can change into any other type of cell. Adult stem cells can become specialized cells to replenish the supply or repair injury, while induced pluripotent cells are "reset" by scientists and used in clinical and medical applications.

Stem cells become specialized cells through the activation or silencing of specific genes

After fertilization, when a sperm cell fuses with an egg, the resulting stem cell is described as totipotent—capable of transforming into any type of body cell or embryonic structures (e.g., placenta). Once differentiated into multipotent cells, they can only specialize further within specific cell type families, such as hematopoietic cells that become platelets and red and white blood cells.

In 2026, researchers at the University of Minnesota created the world's first synthetic cell—a cell made from non-living chemical components—that can eat, grow, divide, and compete with other cells for resources.

Stem cell therapy has shown promise in treating spinal injuries in an early-stage clinical trial.

‘Hope for Healing’: The first-ever use of an in utero stem cell treatment

In 2023, researchers at UC Davis performed the first-ever fetal stem cell transplant, attempting to cure a case of spinal bifida prior to childbirth using stem cells derived from the placenta. The trial, and others including an effort to treat muscular dystrophy, highlight the potential power of stem cell therapy.

Induced pluripotent stem cells are "reprogrammed" cells

Induced pluripotent stem cells are used in a great deal of stem cell research, but many people are still unfamiliar with exactly what “iPS” cells are. This video provides a clear (and short) explanation of iPS cells for non-experts, and offers insights into why scientists are interested in these cells.

Using stem cells for bone marrow transplants

Stem cells hold promise for many future medical applications, but only one type of stem cell is currently approved for use. This page offers a clear description of adult stem cells called hematopoietic stem cells, which create the full range of blood cells and are approved for use in treatments such as bone marrow transplants.

The science of dogs, from wolf origins to color-blindness

This under 10-minute podcast episode dives into the rich, fascinating science behind dogs: From their world-class sense of smell to their domestication from wolves.

Scientists from the frontline discuss the future of antibiotics and superbugs

Superbugs are a very real problem, but researchers around the world are working to advance our understanding of these pathogens and develop new medicines. This podcast talks with several scientists on the frontier of superbug research, offering insight into what we know—and what the future of medicine may look like.

Explore how cells respond to signals from their environment

In "Dropping Signals," users can drag stimuli, such as hormones and light, into various cellular environments to observe cellular responses. These include changing their shape, enabling the transport of chemicals into or out of the cell via the cell membrane, or dividing to compensate for surrounding damaged cells.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

The basics behind mRNA vaccines

In this video, Yale experts Saad Omer, MBBS, MPH, PhD; Onyema Ogbuagu, MBBCh; and Akiko Iwasaki, PhD, explain the science behind COVID-19 mRNA vaccines.

What is a cell? A great quick overview.

YourGenome.org furnishes a collection of information on cells and how they work. Every body has trillions of cells, each serving a specific function: making proteins, processing chemicals, and creating energy. Every cell contains a genome, a set of instructions for the cell's function. Brush up on your cells for a better grasp on genetics.

A first-person account of receiving an Alzheimer's diagnosis

Having Alzheimer's is a bit like having a part of your brain sliced away each day, according to author Greg O'Brien. This 34-minute podcast episode introduces O'Brien and his co-host, author David Shenk, as the two embark on a multi-season conversation on Alzheimer's disease and O'Brien's diagnosis.

Read an excerpt from 'The Immortal Life of Henrietta Lacks,' the story of the Black woman whose nonconsensually sampled cancerous cells underpin thousands of research papers and several Nobel Prize-winning works.

Synthetic biology transforms cells into custom DNA foundries

At companies like Ginkgo Bioworks, researchers are reprogramming cells to act as workshops that can create custom molecules, such as medicines and fertilizers, by stitching together DNA sequences—often in novel combinations—before inserting them into an organism's genome.

The difference between embryonic and adult stem cells

The main difference between embryonic and adult stem cells lies in their potential and origin. The former can become any cell type in the body, while the latter are limited to specific cell types. Embryonic stem cells also carry ethical concerns when used in medical or clinical applications.

How 3D printing inside cells paves the way for microscopic machines

In 2026, scientists in Slovenia developed a method to 3D print a small elephant, several microscopic geometric objects, and barcodes for cell labeling within living human cells, which continued to grow and divide thereafter. The experiment opens the door to fabricating devices within cells to study and manipulate cellular functions.

Learn the history and science of influenza in 'This Podcast Will Kill You'

In their flu episode, cohosts Erin Welsh and Erin Allmann Updyke unpack influenza's biology, history, and impact—explaining everything from past pandemics to modern vaccines, all with their trademark mix of science and storytelling.

It took scientists 277 attempts to successfully clone Dolly from an adult sheep mammalian cell, underscoring the immense undertaking and challenges—some of which still persist today.

Understanding insulin

Scientists Daniel and Kelly talk with researcher Dr. Katrine Whiteson about diabetes, the history of insulin production, and Dr. Lydia Villa-Komaroff—an essential member of the team who discovered that bacteria could be induced to produce insulin. Listen to discover interesting facts about the life-saving medicine and how it works in the human body.

The inner life of a cell

White blood cells are responsible for protecting the human body from infection. This video uses biophysical data from Harvard researchers to accurately demonstrate what goes on inside one white blood cell as it works within the immune system.

Explore the current landscape for patient consent with this 1440 Original video tied to Henrietta Lacks' legacy.

The journalist who let AI speak with his voice

Journalist Evan Ratliff became the object of his own story: He opted to clone his voice, feed it into an AI chatbot, and have it do the talking. What could seem like a fun experiment ended up revealing just how far the capacity of artificial intelligence can go in imitating our identities. Hear the ins and outs of how Ratliff achieved this in this fun and thought-provoking episode.

Organoids: 3D organs grown from stem cells in the lab

An organoid is a three-dimensional construct composed of multiple cell types that originate from stem cells that can simulate the architecture and functionality of native organs. One big benefit of these lab-grown organs is that drug candidates can be tested in model systems without needing live patients.

'Artificial embryos': The hidden steps in forming a spine

Somitogenesis is the process by which segmented body structures like vertebrae form in embryos. While the process is well understood in animals like mice or zebrafish it is difficult to study in humans. But now, researchers have created a model of somitogenesis, using pluripotent stem cells, called an axioloid.

US federal researchers are blocked from putting certain human cells in animals

In 2015, US policymakers put a halt to any government-funded work that would insert human stem cells into animals. The reasoning was that human cells might spread through the animal's body and perhaps to its brain, blurring the line between humans and nonhumans. The ban remains in place today even as gene-edited pig parts are being placed in humans.

Embryonic stem cells can develop into any other cell type in the body

Embryonic stem cells emerge around five days after fertilization, during the blastocyst stage of embryonic development. At this point, the embryo consists of about 100 to 150 cells and forms a hollow structure, and these cells are the ultimate source of all other cell types during fetal development.

The world's first commercial biological computer combines neurons with silicon

Australian start-up Cortical Labs unveiled CL1, a hybrid chip designed to help scientists study brain function in real-time. The 800,000 lab-grown neurons on the chip are kept viable for six months via a built-in life support system.

The science and ethics of artificial wombs

Artificial wombs may be able to help preterm babies survive their early entry into the world and possibly curb the long-term adverse health effects associated with such premature birth. This article dives into the current ethics and science behind artificial wombs and ectogenesis, which is when a fetus develops in artificial conditions.

View an illustrative journey of sperm cells navigating toward fertilization

In this series of comic-style panels, a "fellowship" of sperm cells travels through fictionalized versions of reproductive anatomy on their way to an egg cell. Each panel includes informative commentary on each step of the adventure, with research insights provided by a reproductive biologist, a biomedical scientist, and an andrologist.

View a gallery of images and videos of over 200 types of cells

Funded by the National Institute of General Medical Sciences of the National Institutes of Health, the Cell Image Library houses over 60,000 pieces of media, including microscopic photographs, time-lapse videos of cellular activity, and 3D reconstructions of organic processes.

The science of fear

The Hidden Brain podcast team explores the science of fear by traveling to a haunted house curated by a scientist to investigate what scares us, and why some people enjoy this sensation more than others.

Explore the history of antibiotics with 'This Podcast Will Kill You'

The show blends medical history with storytelling and science. In Episode 50, the hosts trace the dramatic origins of antibiotics—from Fleming's moldy petri dish to Florey's wartime labs—and explore their lasting impact on health.

Researchers are exploring neural links between Alzheimer's and autism

Recent DNA sequencing and molecular biology studies suggest that similarities in genes, neural circuitry and patterns of disease warrant further exploration to potentially better understand both conditions and how to treat them. (Some users may encounter a paywall.)

New eye implant clinical trial recruiting in 2026

University of Southern California researchers have launched a phase 2b clinical trial of a stem cell implant designed to restore vision in people with advanced dry macular degeneration. Patients will be randomized to receive the stem cell implant or a simulated procedure and placebo implant. This type of larger, second-stage clinical trial is designed to confirm efficacy and dosing and to look for side effects. It's one of the stages that precedes the US Food & Drug Administration approval of a device.

Is synbio really cool, really scary, or both?

There's always been a divide between technology, the inanimate stuff that we build, and biology, the living stuff that nature builds. Synthetic biologists are trying to figure out how to close the gap by building living things.