Watch this video letter (via Facebook) from a kidney recipient to his donor

Read why one man agreed to get a pig kidney in 2025 to replace his own failing organ

The 68-year-old New Hampshire man told USA Today that a motivator for the experimental surgery was his belief that he was going to die anyway, and other people suffering from kidney disease could gain valuable insights. Yet the surgery bought him time—he lived 271 days with a pig organ and later received a human kidney transplant. Clinical trials began in 2026 to test the pig xenotransplants in more people.

One man lived with a gene-edited pig kidney for 271 days, setting a record, before he received a human kidney.

Listen to why thousands of donated human kidneys are thrown away annually, even as thousands of people are awaiting a kidney transplant.

The first successful organ transplant was performed in 1954

The successful kidney transplant procedure, at what's now-called Brigham and and Women's Hospital, ushered in a new medical era and gave hope to patients with organ failure. The recipient, 23-year-old Richard Herrick, lived eight more years after receiving the donated organ from his living twin brother, Ronald.

Living donations most commonly involve a kidney or part of a liver

In 2023, more than 6,900 transplants were made possible thanks to living donors. Living donation is when a living person donates an organ or part of an organ—usually one of their two kidneys or part of the liver, since that organ can regenerate in a healthy person. Much more rarely, living donors donate other organs. Living donations often occur when someone wants to ensure a loved one has certainty that they will quickly receive a needed organ.

'Donation after circulatory death' is on the rise

This occurs when a patient in a coma is on life support and family members agree to donate the organs. Watch this video about a 2025 New York Times investigation that identified 12 instances across nine states of bungled or premature attempts to retrieve organs from people whose families had authorized withdrawal of life support.

You can sign up to donate your organs at this website

A single person who chooses to donate their organs upon death can provide organs for as many as eight people. You can sign up to become an organ donor or update your donation status information at this website, or you can typically sign up at your state's Department of Motor Vehicles. Many states allow individuals to declare which tissues and organs you consent to donate (i.e. organs, eyes, and skin tissue). It's recommended to discuss your decision with your family so they are aware of your wishes.

How heart transplants work

Heart transplants require an old heart to be removed and a new one to be installed without killing the patient. How does that work? In this easy-to-understand five-minute video, learn each step of the intricate process, from donor matching to the preservative solution a heart is doused in while it is transported.

NSF-funded research into matching algorithms improved the success of organ transplants

Investigations in game theory, including concepts focused on creating mutually beneficial partnerships—matching theory—led to the design of computer systems that efficiently matched kidney recipients and live donors, resulting in higher-quality matches. By 2019, these matching algorithms were used for multi-organ exchanges.

A clinical trial is underway in 2026 to help kidney transplant recipients avoid a lifetime of immunosuppressing drugs

This later-stage clinical trial, in Chicago and Taiwan, evaluates the efficacy and safety of a new cellular therapy that may be swapped in for immunosuppressing drugs among kidney transplant recipients. The study randomizes people to either receive standard immunosuppressants or this cellular therapy and fewer immunosuppressants. It only includes kidney transplant recipients receiving organs from live donors so transplant surgery timing won't hinge on the unpredictable schedule of performing surgery and follow-up care when a donor dies.

Donated hearts remain viable three times longer now with new tech

Advances in organ perfusion systems have significantly lengthened the amount of time donated hearts can remain viable for transplant, expanding the possibilities for donor organs to wider geographic areas. "Heart in a box" devices, developed in recent years, enable effective oxygen flow in the donor heart during transport, which means that hearts can now travel farther to potential recipients and still be in good condition.

How personalized gene-editing saved a baby's life

KJ Muldoon had a 50% chance of surviving a genetic mutation until doctors developed a one-of-a-kind gene-editing therapy. In an interview with one of the researchers behind the treatment, learn what it will take to make personalized genetic medicine possible for everyone.

Artificial intelligence may improve organ donation systems—and even organ health

Mayo Clinic transplant experts suggest that artificial intelligence could potentially improve organ donation systems in several ways, including better identifying patients most at risk for organ rejection, enhancing donor-recipient matching, and helping to avoid organ transplant needs by identifying health issues earlier.

In 1984, a dying infant lived for three weeks with a baboon heart inside her chest.

Watch patient stories describing life with macular degeneration

This video series features patients discussing their experiences with the disorder, family members describing caregiving, and other insights about the disease.

In 2024, the US had more organ transplants than ever before—besting the 2023 record

More than 48,000 organ transplants were performed in 2024, and about 46,630 were performed in 2023. These record highs are illustrated here as part of data from 1988 to partway through 2025. Kidneys, livers, and the heart remain the most common transplanted organs. (Some users may encounter a paywall.)

Scientists may have discovered why gene-edited pig kidneys are rejected in humans

In November 2025, researchers studying how a brain-dead donor’s body responded to the transplantation of a genetically engineered pig kidney, published that they’ve identified immune system reactions that may explain why these pig organs get rejected. What’s more, they were able to reverse the rejections with an already available drug combination and the kidney functioned well. They also pinpointed a way to detect a potential rejection up to five days sooner.

Transplant organs don't always last a lifetime—that's where retransplants come in

How long a transplanted organ lasts depends on a variety of factors including the type of organ and the health of the recipient. Sometimes organs can last many decades, but other times people may need retransplants, which means another transplant following a previous one. Retransplants are most common with kidneys.

White patients waited 374 days for a kidney—Black patients waited 727 days

A 2022 congressionally mandated report highlighted racial inequities in the US organ transplant system, including disparities that made it more likely white people will be placed on organ wait lists than Black people. It spotlighted inequities such as racial differences in median kidney wait times identified in earlier research. The report, from the National Academies of Sciences, Engineering, and Medicine, recommended fixes including that the Department of Health and Human Services develop national performance goals for the system and achieve equity in the system in the next five years.

Stranger pays for a family's breakfast tab and writes heartfelt note praising the father of three kids

In Fort Worth, Texas, an Emergency Room doctor wearing scrubs was enjoying a meal with his wife and three children. While getting ready to pay, the family learned that their $85 bill had already been settled, with a kind note left behind. The message was signed by "a retired Army Medic" who thanks the man for being a good father.

3 US maps illustrate transplants, donors, and organ waitlist additions—by state.

See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

Xenotransplants are an experimental last resort for the terminally ill when they cannot or will not receive a human organ.

Organ donation isn't usually logistically possible if you die at home

Since organs need to be well-preserved for organ donation, with oxygen flowing through the body, internal organs often aren't viable for organ donation if someone dies at home. But some tissues—like eye corneas and skin tissue—may still be donated since they remain usable for a longer period without oxygen flow.

Brain death is a top source of organ donation

Brain death is a significant source of organ donations—approximately 40% of organs in the US and the UK are recovered from people who experience brain death. Patients declared brain dead and hooked up to intensive care unit machines will still have oxygen flowing to organs like the heart, lungs, and kidneys—preserving those organs.

Listen to an avowed rationalist discuss his frightening near-death experience visions from 2020 and how it changed his life outlook.

Read Mark Zuckerberg and Priscilla Chan Zuckerberg's $45B letter to their daughter

After giving birth to their daughter, the Zuckerbergs launched the Chan Zuckerberg Initiative in 2015. The pair announced the charitable organization's creation in a letter addressed to their daughter. The Zuckerbergs pledged 99% of their earnings from Facebook over the course of their lives to advance education, cure disease, and transform public policy, something the letter says is a commitment to their daughter's future. The organization has since shifted its focus to artificial intelligence and science.

Brain death is a top source of organ donation

Brain death is a significant source of organ donations because patients declared brain dead and hooked up to intensive care unit machines will still have oxygen flowing to organs like the heart, lungs, and kidneys—preserving those organs.

Transplanted organs can be rejected by the body immediately, months after transplant, or slowly over years

Organ rejection remains a huge challenge for organ transplant recipients. Rejection occurs when a recipient's immune system identifies a transplanted organ as foreign and attacks it. Recipient-donor screening processes try to match antigens to help reduce this risk.

Hear Aristotle Domingo, a bilateral amputee athlete, discuss his amputation journey.

Turning a profit with terminal illness

After Amanda Riley was diagnosed with cancer, her social media followers rallied to raise funds to ensure their favorite religious influencer could afford one miracle after another. As more than $100,000 of donations poured in, Riley shared glimpses into her health struggles, posting evidence as fake as her diagnosis. Pulling from years of journalistic investigation, this eight-episode podcast series dives into Riley's reality.

UNOS oversees the entire US organ donation system

The United Network for Organ Sharing is a private, nonprofit organization that manages much of the US organ donation and transplantation system under a federal contract. Medical urgency, blood type, organ size, and geography of the donor and recipient are all factors determining how someone who needs an organ is matched with someone who donated an organ.

Hear from a couple about how they live their lives with MS—and how they met

This short narrative video describes the ups and downs of a woman's experience with progressive MS, and her husband's experience supporting her while navigating his own relapsing-remitting MS.

Explore the current landscape for patient consent with this 1440 Original video tied to Henrietta Lacks' legacy.

In the US, you must actively sign up to donate your organs

The US has an opt-in donation system for organ donation—meaning people must provide consent to proceed with any donation. Locations including Spain, the United Kingdom, and Argentina have an opt-out donation system, which means individuals are presumed to be donors unless they actively refuse consent.

Tech entrepreneur Bryan Johnson's mission to live forever

Johnson has invested millions of dollars into developing a biohacking program he believes will extend his life beyond typical expectations, relying on medical professionals to reduce his "biological age." Most notably, he drew significant public attention with reports of blood-swapping with his teenage son.

A first-of-its-kind clinical trial taps livers from gene-edited pigs to clean blood

The experimental dialysis-like treatment from United Therapeutics, eGenesis, and OrganOx, is designed to help people with liver failure. The therapy, which involves attaching the modified pig liver externally, filters a patient’s blood so their own livers can temporarily rest and perhaps heal.

Watch this 2021 video demonstrating a full brain death examination

This video and accompanying article in the peer-reviewed New England Journal of Medicine show the then-standard steps of a full brain death examination—demonstrating the process on a medical dummy to search for pain, blinking, eye movement, cough, gagging, or other forms of responsiveness. (May need to sign up for a free account to view.)

This Indiana medical school encouraged students to get to know their cadavers' families

The school's anatomy professor instructed medical students to think of the cadavers they worked with as their "first patients"—using their names to acknowledge that this was a person and to exchange letters with the cadaver's family members if they agreed to participate. At the conclusion of the course, families were invited to a lab-based memorial service.

Afterlife traditions help some humans process death

Watch this video discussing concepts of the afterlife presented through an anthropological lens about one family's experience and traditions passed down from one generation to another.

Meeting someone with common healthcare challenges can be life-changing

The understanding that comes from meeting others who have similar experiences can provide hope that life can get better, the solace of affirmation, and make navigating a new diagnosis or a rare illness, in particular, much easier.

Inside entrepreneur Bryan Johnson's race to live forever

Created by entrepreneur Bryan Johnson in 2022, the Rejuvenation Olympics asks participants to find ways, including exercise and dietary supplements, to slow their biological aging. But some of these tactics are extreme in cost or nature—such as Johnson's regular injections of blood from his teenage son.

A letter to Ethereum’s community from an early builder

Fuel Network CEO Nick Dodson writes about his experience as an early app builder on the Ethereum blockchain. He talks about why he perceives Ethereum as being different from rival blockchains like Solana, espousing the ethos and “spirit” of the Ethereum network and community. At the same time, he lays out some hopes he has for the future of Ethereum in a telling peek into an Ethereum insider’s brain. Read the letter here.

Read an email Steve Jobs wrote himself in 2010

Steve Jobs apparently liked to email himself to save his thoughts. This archival email, written the year before he died, shows Jobs expressing gratitude and wonder for the world and its creative people.

See how pig heart valves have been placed in humans since 1965.

Organ transplants can come with a price tag of more than $2M without insurance

According to 2025 report data that was graphically represented by Statista, average costs for organ transplants can be as steep as $2.3M for a double lung transplant and $1.9M for a heart. These figures are based on what was actually charged to insurance companies—not what individual patients paid. Following the actual transplant there are also additional costs associated with the procedure, including lifelong immunosuppressant drugs.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

USA Today asked readers about their grief—and received more than 700 responses

The submissions included one moving story of two women whose sons died by drug overdose. The duo wrote that they found each other in a support group and decided to navigate their respective difficult situations by starting a podcast together called "Two Moms with Two Dead Kids," which focused on what life was like in the years following the deaths of their children.

A physician with a rare and deadly disease saved his own life by identifying an existing medication that he repurposed for his condition, and now he's using AI to try to do the same for other patients.

What is CAR T-cell therapy?

A four-minute video about CAR T-cell therapy to help answer patients' questions: What is CAR T-cell therapy? How does CAR T-cell therapy work?