Watch patient stories describing life with macular degeneration

Hear from a couple about how they live their lives with MS—and how they met

This short narrative video describes the ups and downs of a woman's experience with progressive MS, and her husband's experience supporting her while navigating his own relapsing-remitting MS.

See the challenges of navigating Alzheimer's caregiving

This 2025 PBS documentary provides a window into the experiences of three families navigating the struggles and beauty of caregiving for a loved one with Alzheimer's.

Wet macular degeneration affects 10%-15% of those with macular degeneration

This form of molecular degeneration refers to when excess blood vessels form in the back of the eye and damage the macula. If someone with this condition looks at straight lines, they will typically appear wavy or crooked.

Watch this award-winning short film depicting what it feels like to live with dementia. (Film has English subtitles.)

In a first, eye prosthesis has restored sight to macular generation patients

In a clinical trial, 27 of 32 participants with advanced macular degeneration regained enough vision to read books, food labels, and subway signs about a year after receiving a prosthetic retina device. This is the first device to restore functional vision to patients with incurable vision loss, though in this case they can only see in black and white, with no shades in between.

There are more than 1,400 listed clinical trials for macular degeneration

The US database of clinical trials listed more than 1,400 macular degeneration trials in early 2026. That doesn't mean every trial is recruiting, but it does indicate there is significant interest in this medical condition.

How Alzheimer's disease affected one family as symptoms progressed

News program 60 Minutes interviewed a couple navigating aging and Alzheimer's over a 10-year period to illustrate the effects of the disease on their lives.

US macular degeneration burden is based on statistical modeling and Medicare claims

Prevalence estimates for age-related macular degeneration in the US are usually based on the Vision and Eye Health Surveillance System. Disease numbers are generated using Bayesian meta-regression (a type of statistical modeling), which pulls together information from multiple sources, including Medicare claims.

As deposits build up under the eye, the retina bends with macular degeneration

The retina bends due to the accumulation of proteins and other materials beneath it. That's considered the milder "dry" form of macular degeneration. Another form, called "wet" macular degeneration, is caused by abnormal blood vessels leaking fluid into the eye, which can rapidly affect central vision.

An Alzheimer's patient discusses her condition with children

Alzheimer's is a deadly disease that profoundly changes a person's abilities and personality, which makes it difficult to explain to kids. Responding to potentially uncomfortable questions with honesty (and relatable imagery) about the costs and nature of the disease goes a long way in fostering understanding.

Age-related macular degeneration is the primary cause of blindness in older Americans.

How Alzheimer's caregivers get pulled into their loved one's reality

Caregivers, most often children and spouses, do not just witness a family member's cognitive decline—they also often become drawn into it, navigating a world in which the typical rules of time, order, or logical continuity may not apply.

Drusen are bumps under the retina that distort the vision of most macular degeneration patients

These yellow deposits are made up of proteins and lipids and come in a variety of sizes. They're common in people aged 50 and older, but amassing many of them is often a symptom of age-related macular degeneration—the most prevalent type of macular degeneration.

Photodynamic therapy is one current treatment for age-related macular degeneration.

Vitamins can slow macular degeneration

Research published in 2022 affirmed that vitamin formulations containing vitamins C and E, copper, zinc, lutein, and zeaxanthin—but no beta carotene—can enhance eye health and slow the progression of macular degeneration.

Targeting cholesterol metabolism may help address macular degeneration.

World health experts expect more than 240 million global cases of AMD in 2030

The World Health Organization estimated in 2019 that by 2020 there would be roughly 195.6 million cases of age-related macular degeneration and projected that the number would continue to grow. (Some users may experience a paywall.)

New eye implant clinical trial recruiting in 2026

University of Southern California researchers have launched a phase 2b clinical trial of a stem cell implant designed to restore vision in people with advanced dry macular degeneration. Patients will be randomized to receive the stem cell implant or a simulated procedure and placebo implant. This type of larger, second-stage clinical trial is designed to confirm efficacy and dosing and to look for side effects. It's one of the stages that precedes the US Food & Drug Administration approval of a device.

Watch this 1440 Originals video on specialized residential communities designed to mimic towns or neighborhoods for dementia patients.

The macula is a small area in the center of the retina

This part of the eye—roughly the bullseye of the back of the eye—is responsible for processing the central vision of the eye. Degradation of the macula, formally called macular degeneration, leads to symptoms including blurred vision, the need for brighter lighting, and difficulty recognizing faces. The condition doesn't affect peripheral vision, but if you lose central vision, you can still be considered blind.

After a dementia diagnosis, it's important to plan ahead but also savor the moment

The next steps after a diagnosis include taking lifestyle steps to slow disease progression and completing legal paperwork about long-term medical preferences. It's also important to appreciate the moments and days ahead and find humor in them, when possible. (Some users may encounter a paywall.)

Meeting someone with common healthcare challenges can be life-changing

The understanding that comes from meeting others who have similar experiences can provide hope that life can get better, the solace of affirmation, and make navigating a new diagnosis or a rare illness, in particular, much easier.

People with blue eyes appear to be at elevated risk of developing macular degeneration, perhaps because more light can penetrate their eyes.

How family members disappeared into dementia

This narrative feature describes one family's troubling experience with frontotemporal dementia, or FTD, which emerges in the prime of adult life — as young as 40, in some cases — and degrades the brain's ability to plan, organize, express language, understand social cues, and exercise judgment.

Caucasians are at the greatest risk of developing macular degeneration

A 2016 analysis across ethnic groups found, among other things, that white participants had the highest incidence of the disease, followed by Chinese, Hispanic, and Black participants. This study did not answer why that may be the case.

A first-person account of receiving an Alzheimer's diagnosis

Having Alzheimer's is a bit like having a part of your brain sliced away each day, according to author Greg O'Brien. This 34-minute podcast episode introduces O'Brien and his co-host, author David Shenk, as the two embark on a multi-season conversation on Alzheimer's disease and O'Brien's diagnosis.

Patients are a part of the progress

Navigating a cancer diagnosis can be terrifying and overwhelming. There is a robust community of patient advocates dedicated to prevention and diagnosis, research and clinical trials, legislation, needs of individual cancer types, among others. See how patient advocacy improves cancer research leading to improved treatment options and patient care.

Females are diagnosed with MS roughly 3 to 4 times more often than males

This PBS documentary traces a filmmaker's personal journey with MS after being diagnosed at age 26. It encompasses both his efforts to stymie the disease's progression and his search for answers about the disease, when, statistically, he seemed at low risk due to his gender, lack of known family risk, and other factors.

Hear about life as an amputee and how mirror box therapy helped.

Palliative care physician BJ Miller describes his phantom limb pain and itching after losing both legs and half an arm in an accident. Mirror box therapy eventually helped him, alongside physical therapy. This podcast also features neuroscientist VS Ramachandran who explains how he developed mirror box therapy in the 1990s.

Hear firsthand stories from Americans who lived through the 1918 flu pandemic

This video shares personal accounts from survivors of the 1918 influenza epidemic, capturing memories of sickness, loss, and resilience. Their voices offer a glimpse into how ordinary people experienced one of history’s deadliest pandemics.

Learn about the more than 100 known autoimmune diseases

Explore this resource with summaries and related resources for the dozens of autoimmune diseases defined in the medical literature. Many of these disease write-ups also have interviews with a patient with the disorder—offering a personal take about challenges, advice, and lifestyle effects.

Listen to storytellers explain the legacy of memories shared between children and their mothers

In this podcast, people describe the strength of certain memories, what events stay with them, and when and why grief washes over them. One describes the challenging task of selling her mother's cemetery plots; another, keeping a promise to her son to learn to swim; and in the third, a son discusses the strength of familiar food smells.

One theory claims the retinae of SAD patients may fail to adjust to less light in winter

Most people’s eyes become more sensitive to light in the winter months, but some do not. This failure to adjust causes ripple effects on those individuals’ biological clocks. This Ted-ED video provides a clear, brief, narrative explanation of the condition in six minutes.

Explore this interactive visualization of the IVF journey as a parent or child

Watch this video letter (via Facebook) from a kidney recipient to his donor

A kidney recipient named Justin reads a letter he wrote to his deceased donor about how the person's generous kidney donation saved his parents from having to watch him suffer and his brother from having the pressure of perhaps being his only shot at a life-saving transplant.

Watch real knee surgery footage to see what arthritis looks like up close.

Alzheimer's as a family disease: When children become "parents"

Kitty Eisele's 81-year-old dad went missing while on a snowy, four-hour drive from Minneapolis to Iowa City. It was the first emergency that spelled out the danger of her dad's dementia diagnosis—and captures how Alzheimer's impacts entire families, with the influx of responsibility that comes with caregiving.

Aging is a complex biological process affecting our cells, tissues, and organs.

Usher Syndrome, a rare genetic disorder, causes progressive hearing and vision loss, and people with the condition sometimes eventually become deaf and blind.

Watch this behind-the-scenes interview about the first person ever diagnosed with autism

Two reporters from The Atlantic tell the story behind their effort to track down the first diagnosed autism patient, Donald Gray Triplett, in Forest, Mississippi, and how his life turned out decades later.

Experience a century of America's healthcare advances with this medical visualization, tracing a sampling of healthcare innovations from head to toe.

Explore this 1440 Original video offering a primer on Alzheimer's disease and what's known about its incidence, causes, and more.

Watch how doctors examine leprosy patients for signs of vision impairment

Clinicians must screen for symptoms of eye and vision damage in leprosy patients, including loss of sensation, reduced blink reflex, and inability to close or keep the eyes closed.

Black patients are losing their limbs at a rate triple that of other groups due in large part to inequities in diabetes care and management.

Explore the basics of arthritis in this 1440 Original video with orthopedic surgeon Dr. Nick Golinvaux.

See how cataracts—a leading cause of vision loss globally—form and how sound waves are often used to help remove them.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

Afterlife traditions help some humans process death

Watch this video discussing concepts of the afterlife presented through an anthropological lens about one family's experience and traditions passed down from one generation to another.

Visualizing a joint under attack from rheumatoid arthritis

A particularly difficult arthritis subtype is rheumatoid arthritis, a painful condition provoking a vicious cycle of joint inflammation, destruction, and dysfunction. It begins with a misfiring of the patient’s own immune system—for unknown reasons, it identifies joint and cartilage cells as foreign, initiating an attack to eliminate the supposed "invaders."