In 1939, baseball star Lou Gehrig delivered his 'Luckiest Man' speech after retiring due to a health condition

Stephen Hawking's final message

Famous cosmologist Stephen Hawking—who lived for half a century after being diagnosed with Lou Gehrig's disease—delivered a final speech just before he died in 2018. In the video, Hawking talks about the importance of science and reason in...

Defying the odds, Stephen Hawking outlived his ALS diagnosis by over 50 years

When diagnosed with ALS, Stephen Hawking was given two years to live. However, he survived with the progressive neurodegenerative disease for over 50 years, highlighting the disease's variability and complexity.

How ALS (Lou Gehrig's Disease) might work, and what scientists are learning about it

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the nerve cells (neurons) controlling muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and, eventually, death. This three-minute animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

Stephen Hawking's condition explained

Diagnosed with ALS at 21 and told he had two years to live, Stephen Hawking went on to change our understanding of black holes and the universe, living 55 more years and defying every expectation.

Stephen Hawking's early rowing days shaped the bold persona for which he became known

Before gaining fame as a physicist, Hawking was a coxswain at Oxford, where the sport helped him find his social footing and develop leadership skills, even as his motor neuron disease began to emerge.

How Stephen Hawking’s voice became iconic

Stephen Hawking relied on a voice synthesizer after losing the ability to speak due to complications with ALS. Despite technological advances, he refused to change the "Perfect Paul" voice, making it a cornerstone of his public identity.

Interface device implanted into ALS patients restored some of their abilities

Most people with amyotrophic lateral sclerosis, or Lou Gehrig's disease, require assistance with daily life due to loss of motor control. The electrode-coated, stent-like device used motor mapping data and machine learning to translate brain activity into actions.

Talese’s story on Joe DiMaggio examined the sports star’s life post-retirement

The profile, written in the aftermath of his popular “Frank Sinatra Has a Cold,” similarly offered a close look at an American icon after their prime. In DiMaggio’s story, however, the Yankees player seeks to vanish into obscurity and live a quiet life, golfing and mourning his ex-wife Marilyn Monroe.

Despite the rules, a Nobel Prize in medicine has been awarded posthumously

Ralph Steinman, whose work revealed how dendritic cells activate immune responses, passed away just days before being named a Nobel laureate. Although Nobel Prizes cannot be awarded posthumously, the committee made an exception because they believed he was alive at the time of the decision.

Some say baseball's drug problem goes back to the late 1800s

At age 32, pitcher James “Pud” Galvin was feeling tired and decided to take "the Brown-Séquard elixir," which contained a testicular fluid from dogs and guinea pigs, believed to invigorate tired bodies. It might've worked: Galvin pitched a two-hit shutout the next day.

The disease no one survives (yet)

Creutzfeldt-Jakob disease is currently incurable and can cause one's death within months of symptoms appearing. It involves misfolded proteins that, for some reason yet unknown to science, aren't cleared by the brain as typical and instead trigger similar proteins to misfold. These malformed major prion proteins—prion being a portmanteau of protein and infection—clump inside nerve cells, blocking signals crucial to processes ranging from speaking to organ function.

"Guessing what the pitcher is going to throw is 80 percent of being a successful hitter. The other 20 percent is just execution."

- Baseball star Hank Aaron (1934-2021)

Experience a century of America's healthcare advances with this medical visualization, tracing a sampling of healthcare innovations from head to toe.

How Alzheimer's disease becomes fatal

Despite more than 100,000 people with Alzheimer's dying each year, the specific cause of death is not the disease itself. Often, secondary diseases arise from complications with the disease, including pneumonia, severe falls, malnutrition, or infection. Read more about the range of complications caused by Alzheimer's here.

Read the original 1907 paper on the first known Alzheimer's patient, which was identified by Dr. Alois Alzheimer.

Baseball legend Joe DiMaggio's hitting streak, which ended at 56, cost him a sponsorship deal with Heinz.

After FDR was paralyzed by polio in 1921, Eleanor Roosevelt became active in politics and supported his political ambitions

FDR contracted polio at age 39 and permanently lost the use of his legs. Eleanor Roosevelt persuaded him to stay in politics, then took on the task of maintaining his public profile—attending events, building relationships, and serving as his "eyes, ears, and legs" across the country.

Jackie Robinson's iconic 42 is the only number that's been retired leaguewide, meaning no current players can wear it except in his honor.

Dorothea Lange contracted polio when she was 7, something she said informed her approach to photograph.

The origin story of the Paralympic movement and its founder, Dr. Ludwig Guttmann

Dr. Ludwig Guttmann, the founder of the Paralympic movement, revolutionized the treatment of spinal injuries. His belief in the power of sports for rehabilitation led to the creation of the Paralympic Games, now celebrated every Olympic year. This in-depth article from The History Press details the life and achievements of Dr. Guttmann, and includes historical photos and videos of the veterans-turned-athletes whose lives he changed.

America had a national leprosarium—a leper colony—in Louisiana until 1999

Public health officials forcibly sent those diagnosed with leprosy to the Louisiana Leper Home in Carville, first founded in 1894. Listen to an interview about this site, its evolution, and how its residents advocated for themselves—including regaining the right to vote.

Bill Nye did not have children for fear of passing on ataxia

In his 2017 documentary, Nye revealed the congenital, neurological condition on his father's side of the family, which is characterized by a lack of balance and problems with fine motor movement. He has since learned he likely does not have the disease, though both his siblings have shown symptoms.

Retired professional soccer players are showing signs of potential neurological impacts in midlife, according to a study presented at the July 2026 Alzheimer's Association International Conference in London.

Legionnaires' disease is named after a 1976 outbreak at a state convention of the American Legion in Philadelphia.

Check out a list of the top 100 players in baseball history, from Barry Larkin to Babe Ruth.

Camus was a soccer goalie as a teenager

The writer played for Algiers Racing University but had to quit after contracting tuberculosis. He remained a fan, though, once suggesting that the game taught him important lessons about morality. In the 1957 interview below, he briefly reflects on his time as a goalie and speaks about his recent Nobel Prize.

Magic Johnson's announcing he had HIV changed public perception of the disease

When Lakers superstar Magic Johnson announced he had HIV in 1991, the disease was highly misunderstood. Commissioner David Stern had behind-the-scenes conversations with Johnson about publicly handling his eventual announcement, leading to the start of the condition's destigmatization.

Camus contracted tuberculosis as a teenager

There was still little understanding of treatment for the disease at the time; for most people, a tuberculosis diagnosis was a death sentence. The 17-year-old Camus was quarantined in his uncle's house, where he grew into an avid reader. Scholars note that the experience would inform his later work, including his 1947 novel "The Plague."

In 1970, Pittsburgh Pirates' pitcher Dock Ellis threw a no-hitter—a rare feat that was just the 174th in MLB history—while high on LSD.

'I swing big, with everything I've got. I hit big or I miss big. I like to live as big as I can.'

- Baseball legend Babe Ruth (1895-1948)

In 1999, King survived a near-fatal car accident

In 1999, a distracted driver hit writer Stephen King as he walked on the side of the road near his house in Maine. He recounts the event in his famous memoir, "On Writing." This interview with Katie Couric took place five months after the accident and shows King in a fragile state, wondering about the long-term effects on his mind. When Couric asks if he'll try to work the incident into his work, he smiles. "Sooner or later," he says, "everything goes in."

A first-person account of receiving an Alzheimer's diagnosis

Having Alzheimer's is a bit like having a part of your brain sliced away each day, according to author Greg O'Brien. This 34-minute podcast episode introduces O'Brien and his co-host, author David Shenk, as the two embark on a multi-season conversation on Alzheimer's disease and O'Brien's diagnosis.

Some Nobel laureates have expressed beliefs in pseudoscience after winning

Examples of the phenomenon, known as Nobelitis or Nobel disease, include promoting psychic research, harmful practices like eugenics, and seeing talking raccoons. Increased external pressures after a win and a greater spotlight may contribute to developing or exposing these beliefs.

Five to ten percent of Alzheimer's cases are early-onset

Early-onset Alzheimer’s typically emerges around 40 to 50 years of age, with devastating effects. This video follows Brian, diagnosed with the disease at age 54, as he travels the country as an advocate for research and discusses the progressive mental fog of Alzheimer’s.

The tragic story of Jim Peters

At the 1954 Commonwealth Games, Jim Peters, then one of England's best marathoners, was just steps away from victory. He then fell to the ground and staggered about for 11 minutes until medical services took him out of the race. He'd entered the stadium 17 minutes ahead of the pack, but ultimately never finished. It was the last race of his career.

The story of Vince Lombardi, coaching legend

Born in Brooklyn in 1913, Vince Lombardi is best known for his time as the head coach of the Green Bay Packers from 1959 to 1967, when he led the team to five national championships over seven years. His all-out approach and inspiring one-liners have left an indelible mark on the game, causing the league to name the NFL's highest trophy—the one awarded to the Super Bowl winner—after him. Read up on the legend here.

Twain claimed to possess 'mental telegraphy'

In an 1891 essay, the writer claimed to possess psychic powers. It’s something that seemingly supported by his mother and his own death: Twain predicted he would die the day after Halley’s Comet returned in 1910, which did indeed happen.

Leprosy affects the skin, eyes, and upper respiratory tract

Untreated, the disease can lead to permanent nerve damage and the loss of sensation in arms, legs, and other extremities. The exact form of transmission remains unclear, but scientists suspect it is spread via respiratory droplets over a prolonged period. (Warning: Graphic content, including photos of deformities.)

Repeated head injuries, which may occur in collision sports at the youth, amateur, and professional levels, can lead to CTE and early dementia.

Watch writer John Steinbeck's Nobel Prize acceptance speech.

'A life is not important except in the impact it has on other lives.'

- Jackie Robinson, the first Black MLB player (1919-1972)

Buffett is known for being extremely generous with his fortune

So generous that in 2010 he pledged to donate 99% of his money. He said this money “can have a huge effect on the health and welfare of others.” This letter is Buffett’s philanthropic pledge, which details his commitment to giving and how luck and privilege helped him accumulate so much money.

After a dementia diagnosis, it's important to plan ahead but also savor the moment

The next steps after a diagnosis include taking lifestyle steps to slow disease progression and completing legal paperwork about long-term medical preferences. It's also important to appreciate the moments and days ahead and find humor in them, when possible. (Some users may encounter a paywall.)

Despite his disability, Stephen Hawking reshaped our understanding of black holes

His theoretical work—especially on black holes emitting radiation, now known as Hawking radiation—challenged long-held ideas. He also brought complex physics to the public through bestselling books like "A Brief History of Time."

60 years after seeing Henrietta Lacks as a patient, her doctor still remembered the unique cervical tumor that gave rise to the 'immortal' cell line now commonly used in biomedical research—it was purple, shiny, and soft—an appearance he said is very different from a typical tumor.

Explore some of the best baseball books, including Michael Lewis' influential 'Moneyball' and Bob Uecker's autobiography 'Catcher in the Wry.'

The deadly genetic disease that steals shut-eye

Few are haunted by fatal familial insomnia. This neurodegenerative disease is typically carried through bloodlines via genetic mutation of the prion protein gene, forcing the body to create abnormal and pathological protein variations that can corrupt normal versions. This article follows a musician as they attempt to come to terms with the FFI plaguing their family (and, possibly, their future).

Roger Bannister was the first person to break the 4-minute mile, a feat he accomplished while he was enrolled in medical school.

Before 1920, during the Deadball Era, a single baseball was used throughout a Major League game, leading to a notoriously dirty style of play.

CTE is a major threat to NFL players

A week before Super Bowl LVII, Boston University released findings from a study diagnosing 91.7% of former NFL players in their 376-person study with chronic traumatic encephalopathy. It was a stark comparison to the less than 1% of CTE diagnosis in non-football players.