Defying the odds, Stephen Hawking outlived his ALS diagnosis by over 50 years

Stephen Hawking's condition explained

Diagnosed with ALS at 21 and told he had two years to live, Stephen Hawking went on to change our understanding of black holes and the universe, living 55 more years and defying every expectation.

Stephen Hawking's final message

Famous cosmologist Stephen Hawking—who lived for half a century after being diagnosed with Lou Gehrig's disease—delivered a final speech just before he died in 2018. In the video, Hawking talks about the importance of science and reason in...

According to his daughter, Stephen Hawking defied early doubts about his intellect

Lucy Hawking details what it was like to be the daughter of the famed cosmologist and what his life looked like from her eyes. Among the anecdotes was Stephen's enjoyment of being on "The Simpsons" because production gave him a wheelchair with helicopter blades.

How Stephen Hawking’s voice became iconic

Stephen Hawking relied on a voice synthesizer after losing the ability to speak due to complications with ALS. Despite technological advances, he refused to change the "Perfect Paul" voice, making it a cornerstone of his public identity.

In 1939, baseball star Lou Gehrig delivered his 'Luckiest Man' speech after retiring due to a health condition

Gehrig's diagnosis of amyotrophic lateral sclerosis, a disease that now bears his name, forced him to retire early. Weeks later, he spoke with gratitude and stated, "For the past two weeks, you have been reading about a bad break. Yet today I consider myself the luckiest man on the face of the earth." Gehrig died at the age of 37, about two years later.

Despite his disability, Stephen Hawking reshaped our understanding of black holes

His theoretical work—especially on black holes emitting radiation, now known as Hawking radiation—challenged long-held ideas. He also brought complex physics to the public through bestselling books like "A Brief History of Time."

Stephen Hawking's early rowing days shaped the bold persona for which he became known

Before gaining fame as a physicist, Hawking was a coxswain at Oxford, where the sport helped him find his social footing and develop leadership skills, even as his motor neuron disease began to emerge.

'The Theory of Everything' depicts Stephen Hawking through Jane Wilde’s eyes

Stephen Hawking credits Jane Wilde, his first wife, for giving him “something to live for” after his ALS diagnosis. This biographical drama of Hawking’s life, adapted from her memoir, details their relationship and the effects his illness and success in physics had on their marriage.

A blend of brilliance and humor made Stephen Hawking's cameos unforgettable

Throughout his life, he appeared in numerous pop culture moments—from "The Simpsons" to "The Big Bang Theory"—showing his talent for comedy and his love of science outreach. He was the only person to play himself on "Star Trek: The Next Generation," even writing some of his own lines.

What Stephen Hawking said about time travel

When renowned theoretical physicist Stephen Hawking did not rule out the possibility of time travel in his posthumous book Brief Answers to the Big Questions, many hopefuls got excited. But, unfortunately for them, Hawking believed that yet-to-be discovered laws of physics will prove time travel impossible. This piece outlines some practicalities about the speed of light and wormholes that lend way to Hawking’s prediction.

Using scientific bets, Hawking challenged and highlighted major physics ideas

Hawking famously placed wagers on high-stakes questions in theoretical physics—such as the Higgs boson—for fun and to draw attention to science. When Hawking lost a bet about Cygnus X-1 being a black hole, he paid up with a magazine subscription.

With his dry wit, Stephen Hawking warns of AI dangers and explains imaginary time

In this comedic interview with John Oliver, Stephen Hawking discusses his groundbreaking work in theoretical physics, his views on AI, and Oliver's chances of dating Charlize Theron in the multiverse—all with his trademark voice and humorous tone.

How ALS (Lou Gehrig's Disease) might work, and what scientists are learning about it

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the nerve cells (neurons) controlling muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and, eventually, death. This three-minute animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

Health span: The number of years one is active and disease-free

As scientific advances continue to extend the average human lifespan, many are now turning their attention toward extending "health span." The ultimate goal would be to extend one's health span to match one's lifespan, which would necessitate a shift in focus toward the pursuit of healthy aging. (Some users may experience a paywall.)

Five to ten percent of Alzheimer's cases are early-onset

Early-onset Alzheimer’s typically emerges around 40 to 50 years of age, with devastating effects. This video follows Brian, diagnosed with the disease at age 54, as he travels the country as an advocate for research and discusses the progressive mental fog of Alzheimer’s.

Doctors shift focus from extending lifespan to lengthening health span

As scientific advances extend the average human lifespan, many are turning their attention toward extending "health span." Health span refers to the number of years one is active and disease-free. The ultimate goal is to extend one’s health span to match one’s lifespan.

Why Hawaiians live longer

Hawaii has the longest life expectancy at birth out of all 50 states, according to the US Centers for Disease Control and Prevention. Key factors include strong healthcare, lots of sunlight, and active lifestyles.

Interface device implanted into ALS patients restored some of their abilities

Most people with amyotrophic lateral sclerosis, or Lou Gehrig's disease, require assistance with daily life due to loss of motor control. The electrode-coated, stent-like device used motor mapping data and machine learning to translate brain activity into actions.

The Dog Aging Project uses information from over 50,000 dogs to explore longevity

The study gathers health, lifestyle, and genetic data to understand what helps dogs live longer, healthier lives. Findings could also provide human health insights due to our shared surroundings and biology.

Hawking radiation shows black holes slowly evaporate through quantum effects.

Hawking radiation is Stephen Hawking's theoretical prediction that black holes emit radiation and eventually evaporate. Applied to known black holes, their radiation is so weak that it would take vastly longer than the current age of the universe for them to disappear.

Lung cancer advances are making a big difference

Lung cancer deaths are declining faster than new cases due to advances in treatment. The progress illustrates what is possible, even for a cancer that has long had a poor prognosis.

LIGO confirmed Stephen Hawking's theorem about black hole surface areas

Black holes are known to grow with increased mass but lose energy during mergers through the emission of gravitational waves. Amid these competing factors, the black hole area theorem—confirmed in 2021 using LIGO data—states that a merged black hole's size cannot be smaller than the combined surface area of its progenitors.

Super-agers: seniors 80 and above with the memory ability of people in their 50s

Studies show the number one indicator of whether someone is a "super-ager" is not diet or genetics, but the extent of their social relationships. Moreover, scans reveal noticeable physical differences in certain parts of the brain in patients with extensive social networks.

The speech software's origins at MIT led to Hawking's trademark voice being American

Stephen Hawking's trademark voice is called "Perfect Paul," but it mimics Dennis Klatt, an American researcher at MIT who developed the speech synthesis technology. Klatt used his voice during this development, which was immortalized through Hawking.

Listen to the audiobook version of 'A Brief History of Time'

First published in 1988, Stephen Hawking's most famous novel has sold more than 25 million copies in 40 languages. Through non-technical terminology, Hawking discusses the nature of space and time, general relativity, quantum mechanics, gravity, black holes, and cosmology.

Global life expectancy has more than doubled since the 1850s

The human species experienced a dramatic increase in expected lifespan over the past 150 years. Antibiotics, improved sanitation, and better worldwide food distribution are a few factors contributing to this rapid transformation. Use this interactive resource to explore longevity gains over time and compare these improvements across the globe.

Stephen Hawking's biggest discovery—Hawking radiation—came from a major mistake

Hawking radiation may not have been discovered without Jacob Bekenstein first convincing Stephen Hawking that black holes follow the laws of thermodynamics. The graduate student showed that black holes could shrink, setting the stage for Hawking's most significant contribution.

Stephen Hawking on the need to explore space

Should we be content with being cosmic couch potatoes? In this interview, the late Professor Stephen Hawking lays out the case for continued and increased human space exploration, despite its cost and challenges.

Hawking suggested studying black holes could reveal truths about the universe's start

After predicting black holes could evaporate and before undergoing a tracheotomy, Stephen Hawking conducted interviews in his voice, explaining phenomena like black holes and the Big Bang. In this clip, he explains how curiosity drives humans to become “masters of the universe.”

Helping support others in older age linked to longer life

Analysis of findings from a long-term study of older couples first interviewed in 1987 and then followed for the next five years found that individuals who lend support to friends, neighbors, and relatives live longer. Non-helpers were more than twice as likely to die as helpers during the five-year period. That's even after controlling for factors including age, gender, and physical and mental health.

How Alzheimer's disease becomes fatal

Despite more than 100,000 people with Alzheimer's dying each year, the specific cause of death is not the disease itself. Often, secondary diseases arise from complications with the disease, including pneumonia, severe falls, malnutrition, or infection. Read more about the range of complications caused by Alzheimer's here.

The formula behind super agers—those possessing health and cognitive skills of people decades younger

A study of about 1,400 super agers did not identify any underlying genetic mechanism for longevity. While researchers instead emphasized that sustainable habits involving positive social connections, sleep, mood, diet, exercise, and personal fulfillment help reduce long-term risks, there is no one-size-fits-all formula for everyone.

Environment and genetics explain why animals have widely different lifespans

Both environmental conditions and genetic factors shape how long various animals live. For some creatures, colder conditions allow for less energy use and slower aging. Larger animals have fewer predators. While humans don't live the longest, we are a rare species that successfully lengthened its average lifespan over time.

Stephen Hawking's children's books help make science fun and accessible for kids

Stephen Hawking co-wrote "George’s Secret Key to the Universe" with his daughter, Lucy, to introduce young readers to big questions about the cosmos. In the first book, the protagonist rides a comet and discovers that black holes aren’t black.

How Alzheimer's disease affected one family as symptoms progressed

News program 60 Minutes interviewed a couple navigating aging and Alzheimer's over a 10-year period to illustrate the effects of the disease on their lives.

Tech entrepreneur Bryan Johnson's mission to live forever

Johnson has invested millions of dollars into developing a biohacking program he believes will extend his life beyond typical expectations, relying on medical professionals to reduce his "biological age." Most notably, he drew significant public attention with reports of blood-swapping with his teenage son.

Using AI to restore speech 30 years after a stroke

Through a novel surgical procedure involving electrodes implanted in the brain, along with the help of artificial intelligence, a stroke patient is regaining her ability to speak. This technology converts her thoughts into speech through a digital avatar, allowing her to verbally express herself for the first time in decades.

A Nobel laureate discuss whether stem cells can extend lifespan

Listen to Nobel laureate Shinya Yamanaka discuss the potential of induced pluripotent stem cells to extend human lifespan. By reprogramming adult cells into embryonic-like stem cells, scientists might be able to rejuvenate tissues and treat age-related diseases—though ethical and safety concerns remain.

A 36-year-old Russian physicist survived a particle accelerator beam to the head

Several safety mechanisms failed during Anatoli Bugorski's inspection of malfunctioning equipment at the U-70 synchrotron, the Soviet Union's largest particle accelerator. Despite receiving as much as 600 times the lethal dose of radiation to the brain, he has shown no intellectual damage and worked until the age of 77.

After a dementia diagnosis, it's important to plan ahead but also savor the moment

The next steps after a diagnosis include taking lifestyle steps to slow disease progression and completing legal paperwork about long-term medical preferences. It's also important to appreciate the moments and days ahead and find humor in them, when possible. (Some users may encounter a paywall.)

Steve Jobs tried to treat his cancer with alternative medicine

After Steve Jobs was diagnosed with pancreatic cancer, he reportedly restricted his diet to just fruits or just fruits and vegetables, tried out hydrotherapy, and consulted psychics. There’s compelling evidence about the impact of alternative medicine on cancer patients.

Six-year-old boy in wheelchair surprises his family by walking at his graduation

The young boy was diagnosed with Noonan syndrome, a rare genetic disorder that impacts mobility and development, at just 2 months old. He usually needs a wheelchair or walker to get around, but he shocked and thrilled his parents by standing up to receive his kindergarten diploma.

A brain scientist's experience with a stroke

What happens when a leading brain scientist has a stroke of her own? Dr. Jill Bolte Taylor recounts moment by moment watching her brain function slow and then cease, followed by a prolonged recovery. Through this experience, she details what she learned about the phenomenon of stroke and how it has impacted her research ever since.

Extending the worldwide lifespan by one healthy year is worth $38T

This econometric study attempts to estimate the economic value of increasing the global healthy lifespan by one year—and to answer the question of whether it is better to extend lifespans or slow the rate of healthy aging.

No one showed up to the party for time travelers organized by Stephen Hawking

In 2009, Hawking hosted a reception but only sent out invitations afterward, hoping that time travelers from the future would attend and prove time travel possible. He later joked it was "experimental evidence" that time travel doesn’t exist.

A physician with a rare and deadly disease saved his own life by identifying an existing medication that he repurposed for his condition, and now he's using AI to try to do the same for other patients.

English cosmologist Stephen Hawking (1942-2018) jokes about alien sightings

"I am discounting the reports of UFOs. Why would they appear to only cranks and weirdos?"

A rare measles complication is that the virus can linger in the body for years after apparent recovery and continue to replicate—leading to a progressive and fatal breakdown of the central nervous system that can occur decades after the initial infection.

People with schizophrenia typically die 9 years earlier than the general population

The syndrome, which affects roughly 1 in 233 adults, is often associated with other serious health issues, including cardiovascular, metabolic, and infectious diseases, which may contribute to early deaths. The side effects of long-term antipsychotic medications also may influence the mortality timing—weight gain, for example, is a common side effect of the drugs and can contribute to cardiovascular issues.

One man lived with a gene-edited pig kidney for 271 days, setting a record, before he received a human kidney.