The World Anti-Doping Agency has banned many peptides

The US FDA issued a 2025 warning about BPC-157 and other popular peptides that are marketed for various regenerative properties.

Peptides like BPC-157 are marketed based largely on animal studies, not human research

BPC-157, which purportedly helps with tissue repair and muscle growth, can cause concerning side effects, including pain and swelling. TB-500, another experimental peptide, is marketed for wound healing, but it hasn't undergone any clinical human trials, and high levels of this peptide have been linked to tumor growth. (Some users may encounter a paywall.)

BPC-157 stands for Body Protection Compound-157.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

A comprehensive review of BPC-157 studies identified no human safety data

This meta-analysis included available studies on this peptide from 1993-2024, and identified 36 studies. It found 35 preclinical (nonhuman) studies and one retrospective study in humans of musculoskeletal pain following injections of BPC-157 for unspecified chronic knee pain. In that one human study, 7 of 12 patients receiving BPC-157 reported relief after the injections (though many had injuries that often heal on their own over time).

The US FDA defines peptides as being 40 amino acids or less.

Peptide TB-500, promoted for regenerative healing, is not FDA approved

Watch a board-certified sports medicine therapist detail his thinking about this synthetic peptide; he says it's "promising but unproven." He notes that this product is designed to mimic the natural protein thymosin beta-4, found in human and animal tissues, which promotes wound healing. TB-500 is classified as a research peptide for recovery, meaning it's not approved for human use and has not yet undergone rigorous human trials on its safety and efficacy.

Two festival-goers were hospitalized after receiving trendy peptide injections, raising safety questions that may extend beyond the event.

Early peptide research focused on isolating the substances from animal tissue

In the first half of the 20th century, peptides including insulin and adrenocorticotropic hormone were isolated from animals to provide life-saving medicines. ACTH was isolated from the pituitary glands of cows and pigs and insulin was isolated from the pancreas of dogs and cows.

Peptides like GLP-1 account for 31 of 370 new drugs approved by the US FDA between 2016 and 2023.

Peptide research dates back to the late 1800s

Peptide science dates back to the late 1800s with some early peptide synthesis work, but peptides took off in the medical sphere after surgeon Frederick Banting and his colleague's isolation of insulin from dog pancreases in 1921.

China is producing many peptides or peptide components sold in the US.

Hormone and peptide compounds imported from China soared in 2025

US customs data indicates that these imports doubled to $328M in the first three quarters of 2025, from $164M in the same period of 2024. The imports include GLPs, among other products. (Some users may experience a paywall.)

Diabetes drug GLP-1 is a peptide (that's what the 'P' is for).

Contestants in an annual extreme sports competition are encouraged to use steroids and growth hormone, using athletes as guinea pigs.

The International Olympic Committee banned ibogaine decades ago

Beyond use by athletes as a stimulant before the ban, the drug has a long history. The psychoactive substance was also mass produced in the mid-20th century by a French pharmaceutical company as a product called Lambarène, which was marketed as a cure for conditions including depression and lethargy. Production halted in 1966, however, when ibogaine-containing products became illegal in France.

The gray area that makes PEDs seem like leveling up to hardcore athletes

Doping in sports is broadly condemned as unsafe and unfair. Significant controversies in major sports, including baseball and cycling, have been prompted by the widespread use of performance-enhancing drugs, which are described as clear-cut dangers and abuses of the rules. But to many competitors, the line between a PED and the next smart technique to adopt is unclear. This podcast episode explores that gray reality.

US federal researchers are blocked from putting certain human cells in animals

In 2015, US policymakers put a halt to any government-funded work that would insert human stem cells into animals. The reasoning was that human cells might spread through the animal's body and perhaps to its brain, blurring the line between humans and nonhumans. The ban remains in place today even as gene-edited pig parts are being placed in humans.

The word peptide comes from Greek

Originating from the Greek term "peptos," which means digestible, peptide as a word refers to two or more amino acids. (Some users may encounter a paywall.)

Mapping where the drug captagon is seized worldwide

In the 1960s, Captagon was patented in Germany as a stimulant similar to amphetamines. It was prescribed for a time to address narcolepsy, ADHD, and other conditions. As its addictiveness and psychosis-inducing quality became more apparent, the drug has been banned in many countries. A robust illicit manufacturing of the drug endures in the Middle East, especially in Syria and Lebanon. Track locations where the drug has been seized on this updated map.

See the first dog ever treated with insulin—a peptide

Frederick Banting and his graduate student Charles Best were the first to isolate the peptide insulin from dogs. They induced diabetes in the animals and then treated them with this peptide.

Read the FDA's statement on concerns over compound pharmacies

GLP-1 drugs popularity for weight loss and treating diabetes, led to a significant supply shortage and the rise of compound pharmacies, which produce customized drug formulations but lack formal approval from regulators. The drugs are ostensibly the same, but manufacturing methods lead to variations in concentration, filler compounds, and more.

FDA removed its cardiovascular risk warning on testosterone products in 2025

The change came a decade after the FDA added the label. Recent work, including a gold-standard randomized trial, found that men receiving the products had similar cardiovascular risk levels as men taking placebo products. Testosterone, however, may hold other health risks, including infertility.

19 fungal pathogens are of key concern to world health officials

In 2022, this global health body issued its first-ever list of top fungal threats to human health. It said fungal threats are spreading and occurring more frequently. The WHO’s list included 19 fungal pathogens to watch, and said that the most dangerous ones to public health are Cryptococcus neoformans, Aspergillus fumigatus, Candida albicans, and Candida auris. There are only a handful of classes of medication currently available to combat fungal pathogens, with few others in the pipeline even though antimicrobial resistance is growing.

Peptides may have predated ribosomes—the cell's protein factory

Some scientists have hypothesized that peptides and RNA molecules may have coevolved as a single, mixed "chimeric" molecule, fueling the beginning of protein production and predating a primitive version of the ribosome. All life today uses ribosomes to make peptides. (Some users may experience a paywall.)

A Bay Area lab was supplying MLB players with steroids

The Bay Area Laboratory Co-operative, also known as BALCO, began as a modest vitamin shop, but by the 1990s it was at the center of a doping scheme that rocked Major League Baseball and other professional sports.

Plant hormones and growth regulators guide growth stages and responses in plants

Plants naturally produce hormones like auxin and gibberellins, while humans apply synthetic or extracted growth regulators to control plant development. These substances influence processes like flowering, root growth, dormancy, and ripening—even in very small doses.

FDA has removed black box warnings from hormone replacement therapy for menopause.

Food companies are exploring 'GLP-1 friendly' diet labels

Producers of foods like Healthy Choice frozen meals are placing "GLP-1 friendly" labels on their food, but there's no regulation about what that label means. Nutritionists say that GLP-1s can help reduce appetite, but healthy, balanced diets are a necessary complement to the medications. Data shows that about half of GLP-1 users quit these medications within a year and then rapidly regain weight, underscoring the importance of also prioritizing healthy eating.

Selecting an embryo based on polygenic score is illegal in the UK, Israel, and swaths of Europe

Though their use for embryo selection is illegal in many locations, private clinics in the US may offer polygenic scores to inform embryo selection. The US Food and Drug Administration has not banned their use—instead the tests are regulated like supplements, meaning they are not regulated before they come to market but consumers can file complaints and then the agency may take action.

The WHO labeled aspartame as 'possibly carcinogenic' but US regulators consider it safe

The International Agency for Research on Cancer, an arm of the World Health Organization, labeled aspartame—the artificial sweetener in Diet Coke—as one of several hundred possible cancer-causing substances in 2023. The determination was based on animal and human studies and "limited" evidence linking it to liver cancer. The WHO and US Food and Drug Administration both say the substance is safe at moderate levels. The FDA says a person weighing about 132 pounds would need to have 75 packets daily to reach an unsafe level.

As of 2023, more than 130 nations have enacted bans or restrictions on plastic items, starting with Bangladesh's ban on plastic bags in 2002.

'Barbie' drug melanotan II purportedly offers tanning without the sun—but it's very risky

The substance is not approved by the FDA and is illegal to sell in settings including the UK and Australia. Published case reports discuss serious side effects, including melanoma, a type of skin cancer.

Opioids are a class of drugs including fentanyl, heroin, oxycodone, and more.

Ibogaine, a psychedelic substance, can be used to treat mental illness

Although the substance is banned in the US, it's legal in Mexico. Americans who have traveled there for treatment, including the NFL's Braden Smith, say the drug helps deal with conditions like obsessive-compulsive disorder.

Most of the 86,000 consumer chemicals registered with the US EPA have never received rigorous toxicity testing, though not all those are still in current use.

Psychedelics are being fast-tracked for research after a 2026 executive order

Many such compounds (including LSD, psilocybin, and more) are classified as Schedule I drugs—illegal to possess and federally regarded as having no medical use. Researchers say such restrictions have created significant hurdles for formal clinical trials. With this executive order, the FDA will enable work particularly focused on depression, PTSD, and alcohol use disorder.

Supplement sales soared during the pandemic, alongside growing distrust of the health establishment, amplifying a trend that endures—even when some of the products don't even work.

US FDA recently approved the first new schizophrenia drug in decades

Though other antipsychotics block dopamine receptors, a new drug, Cobenfy, influences dopamine levels via a different pathway—it stimulates a pair of specialized receptors in the brain that control the release of a substance called acetylcholine. This alternative approach may help patients avoid serious side effects like weight gain. (Some users may experience a paywall.)

Debunking myths about weight loss drugs

Business Insider delves into the research on GLP-1 to highlight the good and bad aspects other stories overlook. Few make it clear that GLP-1 drugs simply don’t work for many people. This deep dive raises a number of questions about the future of GLP-1 and how they will be used.

12% of adults were taking injectable GLP-1 for weight loss according to 2025 survey

Weight loss injectable use rose sharply between 2024 and fall 2025. The percentage of adults who reported taking this class of medicine specifically for weight loss increased to 12.4%, compared with 5.8% in February 2024 when Gallup first measured it.

Weight Watchers began offering access to GLP-1 weight-loss medications in 2023 after losing more than 1.5 million members over the previous two years.

GLP-1 drugs, first used to manage diabetes, were derived from Gila monster saliva.

In June 2026, EU food safety regulators approved sales of a GLP-1-inducing food additive, a change that may lead to 'supercharged' cereals and breads in Europe within a year. (free w/email)

Scientists may have discovered why gene-edited pig kidneys are rejected in humans

In November 2025, researchers studying how a brain-dead donor’s body responded to the transplantation of a genetically engineered pig kidney, published that they’ve identified immune system reactions that may explain why these pig organs get rejected. What’s more, they were able to reverse the rejections with an already available drug combination and the kidney functioned well. They also pinpointed a way to detect a potential rejection up to five days sooner.

GLP-1 drugs mimic a natural hormone that triggers appetite-suppressing effects

Ozempic, one of the brand names for the drug semaglutide, was originally developed in 2012, to help treat Type 2 diabetes. Among other effects, the drug mimics a naturally produced hormone known as GLP-1, which is released while eating to let our bodies know we are full.

Sports leagues have attempted to prevent athletes from betting

As pro and collegiate sports embrace betting (and the revenue that comes with it), each league works diligently to ensure the integrity of the games by hiring private firms to analyze irregular bets. These companies have flagged bets that led to the firing of Alabama’s baseball coach, the suspension of multiple athletes at Iowa and Iowa State, and, most recently, a lifetime ban on former Toronto Raptors forward Jontay Porter by the NBA in April 2024.

The US FDA recently tried to regulate the expanded prenatal genetic tests

The agency proposed a new rule in 2023 to make it explicit that these types of tests are devices under existing law and clarify that that the agency could move to regulate them. They finalized a regulatory change in 2024 that added the words "including when the manufacturer of these products is a laboratory" to an existing law, but a federal district court vacated that edit in March 2025—returning the law to as it was before.

A 201-level at how GLP-1 drugs lead to appetite reduction

It's well-established that drugs which mimic the hormone GLP-1 can help people lose weight and control blood sugar levels, primarily through appetite reduction. This technical review provides an overview of how both natural and therapeutic GLP-1 interacts with the gut and brain to produce its effects.

In 2023, Americans spent more than $50B on weight loss drugs, a number expected to triple or more by the end of the decade.