Coca-Cola was created during a patent medicine boom

Coca-Cola and Pepsi have a fierce rivalry

And it's been that way for a long time—both of the sodas were created in the late 1800s in the South. Pepsi was created by Caleb Bradham, and was originally called "Brad's Drink."

The drink that became Coca-Cola was originally called 'Pemberton's French Wine Coca.'

Visualize how Coca-Cola's secret formula has changed over time

Coca-Cola contained small amounts of cocaine until the early 1900s—but that's not the only time Coca-Cola has altered its recipe over the years. For instance, Coca-Cola transitioned from cane sugar to high-fructose corn syrup in the 1980s.

Coca-Cola began developing Diet Coke to compete with a diet cola called Tab

Launched in 1963, Tab was successful in part because of its diet-conscious branding, with the name "tab" referring to the idea of "keeping a tab on your weight." Diet Coke made its debut in 1982.

The Coca-Cola bottle was designed to be recognizable even when shattered

The contour bottle, which was designed and patented to prevent copycats in its distributed bottling system in 1915, would soon become one of the most identifiable shapes in commercial culture. The designers also made sure it could be easily identified even in the dark.

John Pemberton only sold roughly 25 gallons of Coca-Cola syrup in its first year

That equates to roughly 9 drinks per day. But once he brought it to pharmacies that hooked the syrup up to their soda fountains, sales increased significantly, with roughly 2,000 gallons being sold two years later. This video about Coca-Cola's early history is narrated by actress Jenny Slate for a Comedy Central series called "Drunk History," so not all of it is intended to be entirely factually accurate.

​​Andy Warhol made a Coca-Cola perfume called 'You're In'

The 100 spray-painted bottles were filled with a cheap citrusy perfume, practically begging audiences to ask if they were indeed filled with urine. The Coca-Cola Company sent a cease-and-desist letter shortly after learning of the project. IN 2017, a Japanese fashion brand remade the works without mentioning Coca-Cola.

See an original Coca-Cola coupon—one of the earliest surviving coupons used in America—that helped popularize the soda brand in its early days.

The word 'coupon' comes from a French word meaning 'to cut.'

Patents arguably grant inventors monopolies for a short period of time

As a way to reward innovation, the government grants short-term monopolies on patented products. Patents block other companies from producing or selling that product, giving inventors the rights and opportunity to establish themselves in a market before other competitors enter.

Coca-Cola claims that only two people in the world know the full Coca-Cola formula

They are supposedly two Coca-Cola executives. Over the years, a number of handwritten formulas have surfaced to the public, but Coca-Cola has ruled all of them as inauthentic.

Coca-Cola operates under an asset-light, divided structure

The "company" manages the brand itself, as well as its secret formula and syrup production. The capital-intensive "system" of independent bottlers, on the other hand, handles manufacturing and distribution.

The Coca-Cola Company also owns Sprite, Smartwater, and many more brands

The parent company owns lots of beverage brands, from sodas to water, including Dasani, Minute Maid, Topo-Chico, and more. You can see all of the roughly 200 brands it owns on its website.

'This American Life' once tried to recreate the original recipe for Coca-Cola

Given that the Coca-Cola formula is one of the company's most closely-guarded secrets, the radio show's team was surprised to come across a 1979 newspaper article with what looked like the original recipe for Coke.

The Stepan Company is the only US company with legal permission to import coca leaves

The Stepan Company works closely with Coca-Cola so that the soda giant can continue to use coca leaves for its beverages. Today, the cocaine from the coca leaves is removed before they are used to create Coca-Cola.

See how the Coca-Cola bottle's design has changed over the years, including the famous 1910's "hobbleskirt" bottle named for the once-popular tapered women's skirts that narrowed below the knee.

Trademarks protect the branding of a service or product, while patents protect the product or service itself

Trademark protections cover the branding of a service or product, like its logo, its smell, or even its shape. However, patent protections give inventors exclusive control over a new product—as long as those inventors disclose how the product works and how they made it.

Coca-Cola made up roughly 19.2% of US carbonated soft drink market share as of 2023

Separately, Diet Coke made up about 7.8% of US market share that year. Pepsi was responsible for 8.3% of market share, as was Dr. Pepper.

Unlike its Mexican counterpart, American Coca-Cola contains high-fructose corn syrup rather than sugar

There are a few reasons why American Coke turned away from sugar in the 1980s, but none of them are related to consumer health. This Reader's Digest article breaks down the history behind Coke's recipe change, explaining why the company continues using high-fructose cough syrup.

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

The pharmaceutical industry evolved, in part, from the discovery of synthetic dyes

In 1856, a chemist accidentally discovered mauveine, the world's first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

Anheuser-Busch sold half of its real estate holdings to survive Prohibition

The Budweiser parent company also created and sold out more than 25 different nonalcoholic products during this time, including but not limited to infant formula, frozen eggs, and specialized coffees and teas.

'Dirty soda' took off in Utah before exploding on TikTok

The concoction is a combination of Diet Coke, coffee creamer, and citrus. This Eater article delves into the history behind the sugary drink, pinpointing its start as a Mormon-friendly alternative to alcohol and caffeine. The explainer also explores why the drink became so popular on social media and offers helpful hints for crafting your own recipe.

How the placebo effect became mainstream

Contemporary patients and medical students take the placebo effect for granted, as its a standard element in most drug trials. But the concept was only first debated and standardized in the 1950s after a ground-breaking 1955 paper by medical...

Bottled water started as a 19th-century wellness trend

Selling drinking water in America began at resorts in New York and West Virginia, where tourists were encouraged to take the regenerative mineral water back to their homes.

Penicillin was hailed as a 'wonder drug' upon its release

When penicillin became widely available in the 1940s, newspapers and doctors alike celebrated it as a “wonder drug” that could cure infections once considered fatal.

Aspartame was a surprise discovery from a lab working on gastric ulcers

As with saccharin and cyclamate, the aspartame discovery arose from its discoverer tasting something sweet from his workplace. In 1965, American chemist James Schlatter licked a white powder off his finger as he picked up a piece of paper and was startled to discover it tasted sweet. He applied for a patent for the substance, and received it in 1970. It is now one of the most popular artificial sweeteners. (Some users may experience a paywall.)

LSD (better known as acid) was created in 1938 by Swiss chemist Dr. Albert Hofmann

Lysergic acid diethylamide, better known as LSD or acid, was first developed synthetically in 1938 by Swiss chemist Dr. Albert Hofmann. It's since become a linchpin for an entire aesthetic, fueled a counterculture movement, and is being studied for potential therapeutic uses.

Visualize the global supply chain of medicine, which may begin with basic research in the US, but outsource intermediate steps.

Supplement sales soared during the pandemic, alongside growing distrust of the health establishment, amplifying a trend that endures—even when some of the products don't even work.

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

Morphine, heroin, codeine, and more were derived from opium

Opium reached the US at about the time early colonists were itching for ways to soothe aches and pains. The active ingredient in the substance was isolated in the early 19th century, eventually leading to the manufacture and commercial sale of morphine, heroin, and other opium-based drugs.

Why Coke tastes different at McDonald's

Fans of the sugary soda Coca-Cola have noticed significant differences between its canned variety versus what pours forth from the fountain at McDonald's. Is there anything to the claim? Weird History Food takes a dive into this essential fast-food...

7/11's Slurpee was named by an advertising executive who wanted to capture the sound someone made when they sucked the drink through a straw.

How the Supreme Court established biotechnology patent law with an oil-eating microbe

While working at General Electric, microbiologist Ananda Chakrabarty engineered a strain of Pseudomonas that could break down multiple types of hydrocarbons and filed a patent on the bioremediation organism. Despite challenges over whether living things could be patented, the 5-4 decision held that genetically modified organisms could be patented because they were human-made inventions.

How a government chemist founded the FDA—by poisoning people

The Poison Squad tells the story of government chemist Dr. Harvey Wiley who, determined to banish these dangerous substances from dinner tables, took on the powerful food manufacturers and their allies.

Besides allowing patients to see how much medication they had left, transparent orange pill bottles were introduced in 1968 to protect medications from degradation caused by ultraviolet radiation.

Beer companies turned Cinco de Mayo into a mass consumer event in the 1980s

Starting in the early 1980s, breweries including Anheuser-Busch, Miller, and Coors created Hispanic marketing departments and sponsored Cinco de Mayo events. By 2003, American beer companies spent over $5M annually on Cinco de Mayo advertising. Some users may experience a paywall.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

In 2015, the FDA approved the first 3D-printed prescription tablet

Spritam, an epilepsy medication, had been too large and difficult to swallow, particularly due to its inability to dissolve easily. The new pill was designed with porous layers to enhance its dissolvability, paving the way for future 3D printing of drugs.

America's ice cream obsession began under Prohibition, with the street treat acting as a legal vice that helped ease the pain of the Great Depression.

Breaking down the main classes of intellectual property: trademark vs. copyright vs. patent

Trademarks, copyrights, and patents are all intellectual property classifications that give exclusive ownership of ideas and concepts to individuals or businesses. Patents usually refer to innovative products or processes, copyrights are centered around the right to reproduce content, and trademarks usually involve branding elements, like names, logos, and distinct product elements.

Liquor merchant Carl Conrad registered the ‘Budweiser’ trademark in 1878

He helped commercialize the beer and licensed the Budweiser name. Before working with Anheuser-Busch, Conrad was a US importer of wines, champagnes, and liquors.

The birth of the multivitamin

In 1912, biochemist Kazimierz Funk, often anglicized as Casimir Funk, proposed that there existed an essential nutrient in food that could prevent deficiency diseases, such as scurvy or rickets. This article explores the origin of the multivitamin, an invention that has garnished...

Monopoly was based on the satirical Landlord's Game, which criticized the abilities Monopoly rewarded.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

Monsanto got its start in the early 1900s producing saccharin

The company was originally called Monsanto Chemical Works and was founded in 1901 by John Francis Queeny who was then a wholesale drug buyer. He named the company Monsanto for his wife's maiden name. At first, the company began producing saccharin with borrowed equipment and secondhand machines, aiming to produce domestically what was then being imported from Germany. (Some users may encounter a paywall.)

The ancient Romans invented the first known artificial sweetener—it involved lead.

A group of daring bootleggers created NASCAR

When Prohibition made alcohol illegal in 1920, it didn’t stop Americans from making and consuming it. The law drove the practice underground. Runners risked their lives to deliver moonshine and began racing among themselves.