Artificial sweeteners aren't very helpful for weight loss.

Artificial sweeteners may disrupt gut health, throwing off the balance of beneficial bacteria in the gut and shifting the composition of the microbiome.

Fake sugars may disrupt metabolic health.

Artificial sweeteners are considered safe for most people, but researchers are investigating their effects on gut microbiome health.

When people stopped using GLP-1, they regained two-thirds of the weight back.

Aspartame was a surprise discovery from a lab working on gastric ulcers

As with saccharin and cyclamate, the aspartame discovery arose from its discoverer tasting something sweet from his workplace. In 1965, American chemist James Schlatter licked a white powder off his finger as he picked up a piece of paper and was startled to discover it tasted sweet. He applied for a patent for the substance, and received it in 1970. It is now one of the most popular artificial sweeteners. (Some users may experience a paywall.)

See how much daily sugar substitute intake the FDA considers to be safe

The agency states in this PDF graphic that a person weighing about 132 pounds would have to consume roughly a couple dozen sweetener packets daily—or more—to reach unsafe levels of consumption. The accumulated consumption would be across all sources, including diet beverages, sugar-free candies, and actual packets added to coffee.

See how sugar stacks up against the sweetness of sugar alternatives, which can sometimes be hundreds of times sweeter than their sugar counterparts.

Sugar alcohols, a type of carbohydrate used as a sweetener, may elevate risk of heart attacks and strokes.

A 201-level at how GLP-1 drugs lead to appetite reduction

It's well-established that drugs which mimic the hormone GLP-1 can help people lose weight and control blood sugar levels, primarily through appetite reduction. This technical review provides an overview of how both natural and therapeutic GLP-1 interacts with the gut and brain to produce its effects.

Multiple sugar substitutes were accidental discoveries when lab workers didn't wash their hands.

The ancient Romans invented the first known artificial sweetener—it involved lead.

The WHO labeled aspartame as 'possibly carcinogenic' but US regulators consider it safe

The International Agency for Research on Cancer, an arm of the World Health Organization, labeled aspartame—the artificial sweetener in Diet Coke—as one of several hundred possible cancer-causing substances in 2023. The determination was based on animal and human studies and "limited" evidence linking it to liver cancer. The WHO and US Food and Drug Administration both say the substance is safe at moderate levels. The FDA says a person weighing about 132 pounds would need to have 75 packets daily to reach an unsafe level.

Saccharin was banned in Canada in the 1970s, but regulators may allow its use once again

The product, commonly known as Sweet'N Low, was banned in Canada in the late 1970s due to research indicating that the sweetener could cause cancer in lab rats. Subsequent studies have found that the rodent findings didn't hold true for humans, and so Canadian regulators state that they are considering updating their stance to allow the product to be added to certain foods (the product is currently allowed in the US).

Debunking myths about weight loss drugs

Business Insider delves into the research on GLP-1 to highlight the good and bad aspects other stories overlook. Few make it clear that GLP-1 drugs simply don’t work for many people. This deep dive raises a number of questions about the future of GLP-1 and how they will be used.

Xylitol, a sugar alcohol, is sometimes added to foods at 1,000 times the level seen naturally in foods

This article covers the latest research in sugar alcohols and heart health. Some work indicates that after consuming sugar alcohols erythritol or xylitol people are at an elevated risk of developing blood clots, which can cause heart attacks and strokes. Both substances occur in low levels naturally in fruits and vegetables and are also produced by the human body, but as sweeteners in foods they are present at exponentially higher levels.

Teddy Roosevelt was once given a daily dose of an artificial sweetener, prescribed by his doctor.

Stevia has been used to treat burns and indigestion

The substance, which is roughly 300 times sweeter than sugar and scientifically known as Stevia rebaudiana, comes from a plant that grows in Paraguay and Brazil. It has long been used medicinally and as a sweetener by indigenous communities in those locations.

Stevia is a plant-derived sweetener but the plant isn't approved for eating

Steviol glycosides, the sweet-tasting stuff in the plant leaves, are purified and highly processed before they end up in the food or drinks sold in stores. The US Food and Drug Administration does not allow the use of stevia leaf or crude stevia extracts in food, and the agency also bars them from being imported into the US for use as sweeteners.

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

GLP-1 helps reduce obesity through a number of mechanisms

Clinical studies show GLP-1 drugs, including semaglutide, promote weight loss through a number of effects. These include reduced appetite, slower emptying of the digestive tract, increased insulin production, and more.

History's weirdest weight loss fads, fact-checked

Nothing catches popular attention more than a claim to have found a quick weight-loss technique. History shows us such claims are often unfounded. Dr. Michael Mosley explores extreme weight-loss tips from history, from tapeworms to vinegar diets.

Risks of GLP-1s include health side effects, counterfeit drugs, and more

This episode interviews researchers and patients who have used semaglutide to explore some of the potential risks associated with using the drug to lose weight. These include insurance challenges, health scares related to counterfeit versions of these drugs, and some users lose their ability to enjoy food.

What do people do once GLP-1 medications succeed at weight loss?

The drugs have been adopted by 1 in 8 Americans, with many achieving their prescribed weight loss. They now face the question of how to keep the weight off, the key issue with any weight loss program that researchers have known about for decades. Each case is unique. Some folks continue to use GLP-1s like Ozempic in minuscule doses, while others taper them off over time.

The dark side of modern sugar production

Humanity's ancestors evolved to wring more calories from sugary fruits by storing excess sugar as fat, an adaption that's culminated in many peoples' palettes preferring calorie-rich sweet. Now, the desire for sugar has both contributed to a widespread health crisis and been at the center of atrocities around the world.

This 2022 study is one of the findings that prompted WHO to label aspartame as 'possibly carcinogenic'

This French study analyzed online periodic self-reported food journals from more than 100,000 people for a median of almost eight years and linked aspartame consumption to a roughly 15% increased cancer risk. It found that the people who consumed higher levels of aspartame had elevated cancer numbers—particularly breast and obesity-related cancers.

'Weight cycling'—when someone repeatedly loses and gains weight—can harm an individual's metabolism.

Explore the complex relationship between calories and weight

What if you found out that weight loss is actually much more complex than "calories in, calories out" and that the 2,000 calorie-a-day recommendation may not actually be accurate?

In 2023, Americans spent more than $50B on weight loss drugs, a number expected to triple or more by the end of the decade.

GLP-1s are linked to reduced worker illness and cost savings—a 2026 economic analysis finds the weight-loss drugs are tied to a 17% drop in worker sick leave days.

Semaglutides, which belong to a class of drugs called GLP-1s, are prescribed for weight loss in combination with diet and exercise because they trigger the release of the appetite-suppressing hormone incretin.

Food companies are exploring 'GLP-1 friendly' diet labels

Producers of foods like Healthy Choice frozen meals are placing "GLP-1 friendly" labels on their food, but there's no regulation about what that label means. Nutritionists say that GLP-1s can help reduce appetite, but healthy, balanced diets are a necessary complement to the medications. Data shows that about half of GLP-1 users quit these medications within a year and then rapidly regain weight, underscoring the importance of also prioritizing healthy eating.

The myth of sugar rushes vs. the reality of sugar crashes

It's generally accepted that sugar rushes are a myth, and that hyperactivity is a more psychological experience. However, there is real science behind the rare sugar crash that primarily impacts those with diabetes. Read this article to understand how historical and cultural factors have shaped sugar perceptions, and how low blood sugar can trigger shakiness, fatigue, weakness, and more in diabetes patients.

Investigation finds 'influencer' dietitians paid to promote sugar, supplements on social media

A joint investigation by The Examiner and The Washington Post found that food, beverage, and supplement corporations and groups have paid registered dietitians on social media to promote content that goes against decades of scientific evidence on...

In June 2026, EU food safety regulators approved sales of a GLP-1-inducing food additive, a change that may lead to 'supercharged' cereals and breads in Europe within a year. (free w/email)

12% of adults were taking injectable GLP-1 for weight loss according to 2025 survey

Weight loss injectable use rose sharply between 2024 and fall 2025. The percentage of adults who reported taking this class of medicine specifically for weight loss increased to 12.4%, compared with 5.8% in February 2024 when Gallup first measured it.

How weight loss drugs could reduce obesity costs

A detailed analysis from finance giant ING finds semaglutide and other weight loss drugs could significantly drive down global costs stemming from heart disease and other health problems associated with obesity. The benefits will vary, depending on each country’s demographics and drug and healthcare costs.

Miracle berries make things that normally taste acidic or sour, such as lemons, taste sweet, like sugar-coated candy, by binding a special protein called miraculin to taste buds.

Is metabolism related to weight loss?

Read this article to better understand metabolism and why doctors say it's only one piece in the puzzle to managing weight. Metabolism breaks down and converts what we consume into energy, which provides fuel for all of our body's functions—both...

Companies developing new weight loss drugs

In recent years, weight loss drugs made a tremendous amount of money for Novo Nordisk and Eli Lilly. Other companies are developing new drugs to break into the market. This piece is a concise overview of companies creating and testing new drugs, how far along they are, and what Novo Nordisk and Eli Lilly are doing to compete with these emerging rivals.

See which GLP-1 drugs are currently approved (along with their cost)

Around 75% of prescriptions for GLP-1 drugs are used to treat diabetes, while the remainder is used for weight loss. This overview from GoodRX includes a list and overview of currently available options along with prices for each.

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

Tirzepatide: A GLP-1 drug that also acts on separate receptors to promote weight loss

Tirzepatide, like semaglutide, is a GLP-1 drug used in diabetes treatment and for weight loss. Unlike semaglutide, it also acts on glucose-dependent insulinotropic polypeptide receptors, proving a second route to reducing appetite as a means to treat diabetes and promote weight loss.

How semaglutides are both better and worse than we know

The drugs were developed for use treating diabetes and, later, weight loss, but they have proven helpful with the heart, kidneys, and colon. On the flipside, it may slow digestion and lead to gastroparesis, or stomach blockages, and unexpected babies resulting from the slow effect of birth control pills.

How our sense of taste evolves as we age

Kids are hardwired to prefer sweets over greens, with sweetness a shorthand for calorie-rich and bitter flavor warning of potentially noxious plants. This holds true even in the womb, where fetuses have been seen via ultrasound scans grimacing as their hosts consume kale capsules. As they age into double digits and beyond, their taste cells and sense of smell diminish, leading to broader and less sensitive palates.

Gummy vitamins have candy-level sugar—and that sweetness is linked to overdoses

A typical gummy vitamin contains about the same amount of sugar in a single serving as one Sour Patch candy. It's linked to the increase in pediatric overdoses for products including multivitamins and melatonin. Gummy formulations also degrade quickly, so they often include much higher levels of the product in each serving than the label advertises—boosting overdose risks due to this unchecked variability. (Some users may experience a paywall.)

Can we speed up our metabolisms?

Listen to this 31-minute podcast to better understand what science knows and doesn't know about metabolism, as well as the only thing that seems capable of changing it. Scientists understand that the difference between a so-called “fast” and “slow” metabolism does not affect one’s ability to lose weight.

Weight Watchers began offering access to GLP-1 weight-loss medications in 2023 after losing more than 1.5 million members over the previous two years.

The lack of guidance on getting off GLP-1s leaves patients at risk

Dr. David Kessler, former FDA Commissioner and public health leader, explores how these drugs override the brain’s reward-driven eating habits but have notable side effects. These include developing eating disorders, muscle loss, and intestinal obstruction.

Read this analysis indicating which traditional stevia medical uses have scientific evidence

This research paper investigates the various uses of Stevia rebaudiana leaves and their extracts and concludes that the substances do hold significant potential for improving cardiovascular health and inflammatory disorders in adults, among several other potential applications. Its authors suggest that further research should examine safe dosage questions and chronic disease management approaches.

Organic food might be greener, but it’s not better for you

Weighing in on the ongoing debate surrounding organic versus “regular” foods, health experts explain whether organic foods offer significant health benefits. Studies suggest that organic foods have little additional nutritional value compared to...