Teddy Roosevelt was once given a daily dose of an artificial sweetener, prescribed by his doctor.

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

Saccharin was banned in Canada in the 1970s, but regulators may allow its use once again

The product, commonly known as Sweet'N Low, was banned in Canada in the late 1970s due to research indicating that the sweetener could cause cancer in lab rats. Subsequent studies have found that the rodent findings didn't hold true for humans, and so Canadian regulators state that they are considering updating their stance to allow the product to be added to certain foods (the product is currently allowed in the US).

Multiple sugar substitutes were accidental discoveries when lab workers didn't wash their hands.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

The ancient Romans invented the first known artificial sweetener—it involved lead.

See how much daily sugar substitute intake the FDA considers to be safe

The agency states in this PDF graphic that a person weighing about 132 pounds would have to consume roughly a couple dozen sweetener packets daily—or more—to reach unsafe levels of consumption. The accumulated consumption would be across all sources, including diet beverages, sugar-free candies, and actual packets added to coffee.

Aspartame was a surprise discovery from a lab working on gastric ulcers

As with saccharin and cyclamate, the aspartame discovery arose from its discoverer tasting something sweet from his workplace. In 1965, American chemist James Schlatter licked a white powder off his finger as he picked up a piece of paper and was startled to discover it tasted sweet. He applied for a patent for the substance, and received it in 1970. It is now one of the most popular artificial sweeteners. (Some users may experience a paywall.)

Artificial sweeteners are considered safe for most people, but researchers are investigating their effects on gut microbiome health.

Unlike its Mexican counterpart, American Coca-Cola contains high-fructose corn syrup rather than sugar

There are a few reasons why American Coke turned away from sugar in the 1980s, but none of them are related to consumer health. This Reader's Digest article breaks down the history behind Coke's recipe change, explaining why the company continues using high-fructose cough syrup.

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

The forgotten campaign to replace the Teddy Bear with 'Billy Possum'

After a 1909 pre-inauguration dinner for incoming President William Howard Taft featured possums and potatoes as the main course, Susie W. Allgood wanted to produce and market an alternative to the Teddy Roosevelt-inspired teddy bear: Billy Possum. Kids thought it looked too much like a rat.

Teddy Roosevelt's intervention helped save football, which previously had been a brutally violent game.

Artificial sweeteners aren't very helpful for weight loss.

The WHO labeled aspartame as 'possibly carcinogenic' but US regulators consider it safe

The International Agency for Research on Cancer, an arm of the World Health Organization, labeled aspartame—the artificial sweetener in Diet Coke—as one of several hundred possible cancer-causing substances in 2023. The determination was based on animal and human studies and "limited" evidence linking it to liver cancer. The WHO and US Food and Drug Administration both say the substance is safe at moderate levels. The FDA says a person weighing about 132 pounds would need to have 75 packets daily to reach an unsafe level.

Fake sugars may disrupt metabolic health.

How a government chemist founded the FDA—by poisoning people

The Poison Squad tells the story of government chemist Dr. Harvey Wiley who, determined to banish these dangerous substances from dinner tables, took on the powerful food manufacturers and their allies.

See how sugar stacks up against the sweetness of sugar alternatives, which can sometimes be hundreds of times sweeter than their sugar counterparts.

The dark side of modern sugar production

Humanity's ancestors evolved to wring more calories from sugary fruits by storing excess sugar as fat, an adaption that's culminated in many peoples' palettes preferring calorie-rich sweet. Now, the desire for sugar has both contributed to a widespread health crisis and been at the center of atrocities around the world.

Sugar alcohols, a type of carbohydrate used as a sweetener, may elevate risk of heart attacks and strokes.

Theodore Roosevelt is considered by many to be the "first modern president"

Roosevelt transformed the presidency by expanding executive power beyond conventional norms, arguing that the president could act in the national interest unless expressly forbidden to do so. His energetic leadership, media use, and policy activism expanded the office's role and prestige.

Roosevelt wrote a nationally syndicated newspaper column 6 days a week for 27 years

Roosevelt's My Day column was launched in late 1935 and ran nearly every day until shortly before her death in 1962. It began as an account of her daily life but grew into one of the most widely read opinion columns in the country, with 4 million readers at its peak.

George Washington had a recipe for 'small beer,' a low-alcohol beer that was once safer than drinking water.

Monsanto got its start in the early 1900s producing saccharin

The company was originally called Monsanto Chemical Works and was founded in 1901 by John Francis Queeny who was then a wholesale drug buyer. He named the company Monsanto for his wife's maiden name. At first, the company began producing saccharin with borrowed equipment and secondhand machines, aiming to produce domestically what was then being imported from Germany. (Some users may encounter a paywall.)

Over the years, the USDA has changed its definitions of healthy eating

The US Department of Agriculture began offering eating advice in 1894 and has updated its guidance as both science and politics have evolved. In the early 20th century, its guidance emphasized recommended minimum servings of important foods; in later decades, its visual guides became more nuanced, illustrating the composition of a healthy diet and encouraging exercise.

Artificial sweeteners may disrupt gut health, throwing off the balance of beneficial bacteria in the gut and shifting the composition of the microbiome.

Gummy vitamins have candy-level sugar—and that sweetness is linked to overdoses

A typical gummy vitamin contains about the same amount of sugar in a single serving as one Sour Patch candy. It's linked to the increase in pediatric overdoses for products including multivitamins and melatonin. Gummy formulations also degrade quickly, so they often include much higher levels of the product in each serving than the label advertises—boosting overdose risks due to this unchecked variability. (Some users may experience a paywall.)

The myth of sugar rushes vs. the reality of sugar crashes

It's generally accepted that sugar rushes are a myth, and that hyperactivity is a more psychological experience. However, there is real science behind the rare sugar crash that primarily impacts those with diabetes. Read this article to understand how historical and cultural factors have shaped sugar perceptions, and how low blood sugar can trigger shakiness, fatigue, weakness, and more in diabetes patients.

Hear Roosevelt's first 'Fireside Chat'

The president's casual radio addresses ditched the language of sloganeering and politiciking, intentionally framing the broadcasts as conversational explanations of current events and politics. The inaugural episode was broadcast in 1933, during the Great Depression, and outlined his plans to restore faith in the banking system.

Xylitol, a sugar alcohol, is sometimes added to foods at 1,000 times the level seen naturally in foods

This article covers the latest research in sugar alcohols and heart health. Some work indicates that after consuming sugar alcohols erythritol or xylitol people are at an elevated risk of developing blood clots, which can cause heart attacks and strokes. Both substances occur in low levels naturally in fruits and vegetables and are also produced by the human body, but as sweeteners in foods they are present at exponentially higher levels.

The 22nd Amendment was a reaction to Roosevelt's four terms

After Franklin D. Roosevelt won four elections, Congress moved to prevent future presidents from holding power indefinitely. Ratified in 1951, the 22nd Amendment set a firm two-term limit as a safeguard against extended presidencies.

Leonard Thompson was the first human to receive an insulin injection for diabetes

In January 1922, the 14-year-old was the first person to receive an insulin injection to treat diabetes, just months after insulin was isolated in dogs and used to treat their induced diabetes. Thompson had an allergic response to an apparent impurity in the injection, but his second dose, 12 days later, was a success.

Theodore Roosevelt tried for a third presidential term in 1912

In 1912, after serving nearly two full terms—one elected, the other partial after stepping in as vice president—Theodore Roosevelt sought a third. He lost the Republican nomination to William Taft, then ran as a Progressive Party candidate but was ultimately defeated by Woodrow Wilson.

Stevia has been used to treat burns and indigestion

The substance, which is roughly 300 times sweeter than sugar and scientifically known as Stevia rebaudiana, comes from a plant that grows in Paraguay and Brazil. It has long been used medicinally and as a sweetener by indigenous communities in those locations.

'The most important single ingredient in the formula of success is knowing how to get along with people.'

- Former President Theodore Roosevelt's (1858–1919)

Franklin D. Roosevelt used radio to connect directly with Americans through his 'Fireside Chats'

Beginning in 1933, FDR harnessed the new medium of radio to explain policies and reassure the public during the Great Depression and World War II. His conversational fireside chats revolutionized presidential communication.

Overmedication has put type 2 diabetics at risk of low blood sugar

Type 2 diabetics in the US risk dying from low blood sugar, an epidemic traced to a decades-old, multi-million-dollar drug industry campaign encouraging an average blood sugar level below 7%. Contemporary research correlated such levels with reduced risk of eye, nerve, and kidney damage and increased hypoglycemia risk.

After FDR was paralyzed by polio in 1921, Eleanor Roosevelt became active in politics and supported his political ambitions

FDR contracted polio at age 39 and permanently lost the use of his legs. Eleanor Roosevelt persuaded him to stay in politics, then took on the task of maintaining his public profile—attending events, building relationships, and serving as his "eyes, ears, and legs" across the country.

The CIA once tried to poison Fidel Castro's milkshake during the Cold War.

Before launching his cereal company, John Harvey Kellogg promoted a eugenics-inspired natural food regimen.

Read a history of how oral rehydration solution was created

Experiments dating back to the 1940s eventually led to the creation and standardization of a mixture of sugar, salt, and clean water that is now widely used globally.

Stevia is a plant-derived sweetener but the plant isn't approved for eating

Steviol glycosides, the sweet-tasting stuff in the plant leaves, are purified and highly processed before they end up in the food or drinks sold in stores. The US Food and Drug Administration does not allow the use of stevia leaf or crude stevia extracts in food, and the agency also bars them from being imported into the US for use as sweeteners.

The FBI surveilled Roosevelt for decades, suspicious of her civil rights and political work

J. Edgar Hoover's FBI maintained a large file on Eleanor Roosevelt, monitoring her involvement with civil rights groups, connections to progressive causes, and vocal opposition to McCarthyism. Although a formal investigation was never initiated, Hoover regarded her as a person of interest for most of her adult life.

George Washington loved to serve ice cream while hosting guests, and spent thousands of dollars on it in a single summer.

Some say baseball's drug problem goes back to the late 1800s

At age 32, pitcher James “Pud” Galvin was feeling tired and decided to take "the Brown-Séquard elixir," which contained a testicular fluid from dogs and guinea pigs, believed to invigorate tired bodies. It might've worked: Galvin pitched a two-hit shutout the next day.

The discovery of insulin led to a controversial Nobel Prize in 1923

For centuries, Type 1 diabetes was fatal. The 1920s "discovery" of insulin netted two of its creators—Frederick Banting and his boss, John Macleod—a Nobel prize. Separately, the German doctor Georg Zuelzer synthesized an effective version of the life-saving drug years earlier but was interrupted by World War I.

Food stamps were revived as a JFK pilot as one of his first actions upon taking office in 1961, but the program had its largest expansion under President Richard Nixon in the late 1960s and early 1970s.

President George Washington's adventurous eating habits included having tongue toast for breakfast and cow stomach for dinner.

See how antidepressants—used by roughly 1 in 10 Americans—were discovered.

Conversation candy hearts were originally message-free medicinal lozenges

In 1847, a Boston pharmacist invented a machine that automated the production of his pharmacy's medicinal lozenges and then formed the New England Confectionery Company, which later became part of the company now known as NECCO. By the late 1800s, they were producing cookies with Valentine-themed messages and eventually brought the romantic messages to their smaller lozenges, which they later called Sweethearts.

America's ice cream obsession began under Prohibition, with the street treat acting as a legal vice that helped ease the pain of the Great Depression.