European diseases killed a massive share of the Native American population

Europeans' arrival to America brought disease to Indigenous populations

Indigenous people lived in the Americas for centuries before the arrival of the first Europeans in the 15th century. Their arrival was disastrous for Native tribes; in addition to being enslaved and losing their land, they had no natural immunity to the diseases brought by colonists. Eventually, up to 95% of the Native American population was killed by illnesses including typhus, chickenpox, and cholera, an event now known as the Great Dying.

More than 300 distinct Native American languages existed at the time of European contact

Indigenous North America exhibited vast linguistic diversity, with over 300 languages spanning dozens of unrelated language families. This variety reflected centuries of distinct cultural development across the continent's many nations and regions.

In 2023, Native Americans had the lowest life expectancy at birth among all racial and ethnic groups

Native Americans and Alaska Natives face significant health disparities linked to chronic underinvestment in reservation health infrastructure, poverty, and multigenerational psychological harm—often called historical or inherited trauma.

Measles reached global transmission during the 15th- and 16th-century Columbian exchange

Devastating diseases like smallpox, influenza, measles, and other viruses were largely introduced into the Western Hemisphere beginning with the 1492 arrival of Christopher Columbus and the ensuing age of exploration.

The Wampanoag Nation inhabited the northeastern coast of North America for 12,000 years before European contact killed an estimated two-thirds of their population in a single generation.

The US government ran boarding schools designed to erase Native American identity

From the late 19th century into the 20th century, the federal government sent Native children to boarding schools under the philosophy of "kill the Indian, save the man." Children were forbidden from speaking their languages or practicing their cultures, and many endured abuse.

Native Americans were not granted US citizenship until 1924

The Indian Citizenship Act granted citizenship to all Native Americans born in the US, more than 130 years after the Constitution's ratification. Even then, some states continued to deny Native Americans the right to vote for decades.

Indigenous women are murdered at 10 times the rate of all other ethnicities in the US

Murder is the third-leading cause of death among Indigenous women, who are also 2.5 times more likely to experience violence than any other group. More than 4 in 5 Indigenous women have experienced violence in their lifetime.

The Trail of Tears killed thousands of Native Americans forced from their homelands

After the Indian Removal Act passed, the US Army marched the Cherokee and other nations hundreds of miles to the designated "Indian Territory" in present-day Oklahoma. Thousands died from starvation and disease along the way.

Recent research indicates leprosy was present in the Americas before European settlers

New research published in 2025 upended long-held notions that the disease was introduced to the Americas by European colonizers. Evidence of a lesser-known leprosy-causing bacterium was found in ancient human remains that date back 4,000 years.

Native American tribes still are waiting for museums to return the remains of their ancestors

The remains of more than 100,000 Native Americans are held by prestigious US institutions, despite a 1990 law meant to return them to tribal nations. Here’s how their ancestors were stolen—and how tribes are working to get them back.

The Dawes Act of 1887 broke up communally held tribal lands

Sometimes called the General Allotment Act, the Dawes Act divided reservation land into individual plots assigned to Native Americans, while "surplus" land was sold to white settlers. The policy led to Native tribes losing roughly 90 million acres, about two-thirds of their remaining land.

The first Americans arrived between 14,000 and 40,000 years ago

Early peoples migrated to the Americas via the Bering Land Bridge or coastal routes, spreading across the continent as hunter-gatherers. Archaeological sites in present-day New Mexico containing stone tools and animal bones mark some of the earliest confirmed evidence of human life in North America.

The share of the immigrant population in the US peaked at nearly 16% in January 2025

In January 2025, the US reached a historic high of 53.3 million immigrants—nearly 16% of the population. By June of that year, the number had fallen by more than a million, ending 50 years of continuous growth in the immigrant population.

Why the 1918 flu killed between 50 and 100 million people

The 1918–1920 flu pandemic (once called, incorrectly, the Spanish flu) killed quickly and in huge numbers, with estimates of the global death toll ranging from 50 to 100 million people. Several factors contributed to the high mortality rate: lack of antibiotics, the global disruption of World War I, and more.

US immigrants shifted from primarily originating in Ireland and Germany to Mexico and India.

The Wampanoag collaborated with the Pilgrims in order to survive

Decades of violence and disease brought by European settlers had devastated local tribes. Up to 75% of the Wampanoag people had been eliminated, leading them to sign the peace treaty to preserve those who remained.

The US Army massacred close to 300 Lakota men, women, and children at Wounded Knee in 1890

Fearing the Ghost Dance—a spiritual movement spreading across starving reservations—the Army surrounded a Lakota encampment at Wounded Knee Creek, South Dakota. When a shot was fired during an attempted disarmament, it sparked chaos, and soldiers killed nearly 300 people.

See MS prevalence by region in the United States

This map underscores that people in the northeastern United States have more cases of the disease as compared to the south, west, and midwest. On an individual level, these numbers may still differ based on genetic makeup and other factors irrespective of where people live.

The Archaic period marked Native Americans' shift from big-game hunting to foraging

Beginning around 8000 B.C.E., Indigenous peoples began relying on diverse food sources—including wild game, plants, seeds, and fish—and moved away from large-mammal hunting. Archaeological findings from this era suggest some communities began cultivating crops and establishing irrigation systems, indicating a shift toward less-nomadic lifestyles.

The trans-Atlantic slave trade brought over 10 million enslaved people to the Americas.

Early Native Americans shifted from nomadic life to permanent settlements around 8500 B.C.E.

Around 8500-7900 B.C.E., many Indigenous groups began settling near rivers and lakes to harvest fish and hunt bison, moving away from a fully nomadic lifestyle. This shift toward semipermanent communities marks one of the earliest signs of organized settlement in North America.

Native Americans developed pottery and religion, and experienced population growth during the Woodland period

Between 500 B.C.E. and 1100 C.E., Indigenous peoples produced pottery and practiced animism, a spiritual worldview in which animals, plants, and natural forces are believed to possess sacred power. They moved seasonally to make the most of available resources.

Why genetic similarities between humans suggest a past near-extinction event

Researchers have found that low genetic diversity among humans—even those on opposite sides of the planet—may result from a breeding population of as few as 1,280 adults, estimated to have existed 930,000 years ago. This genetic bottleneck may have resulted from a near-extinction or from a small population of human ancestors, from which we all descend, that broke off from a larger population.

Oral history and artifacts suggest the Wampanoag inhabited the area for 12,000 years

By 1621, Native Americans had been interacting with European explorers along the coasts for hundreds of years. European adventurers, including Giovanni da Verrazzano, mapped the coastline as early as 1524, as this timeline from the National Museum of the American Indian explains.

Yellow fever sidelined more US troops than enemy fire during the Spanish-American War

The disease, transmitted by the Aedes aegypti mosquito, sickened more than 2,000 soldiers. Fewer than 400 American soldiers died in the 1898 war.

A timeline of major pandemics from 1899–2025

Modern pandemics have been defined by the race between globalization (which increases risk) and the development of new medicines. The Great Influenza epidemic claimed some 50 million lives, and the COVID-19 pandemic killed more than 7 million. In between, diseases like Ebola, cholera, AIDS, and more have devastated communities.

Native students fought back against forced assimilation at US boarding schools

Despite harsh conditions, Native American students preserved their identities by secretly speaking their languages, maintaining cultural practices, and, in some cases, running away.

The creation of the parks often involved displacing Native tribes

Early parks like Yellowstone, Glacier, and Yosemite involved the removal of tribal communities like the Shoshone, Crow, and Nez Percé, undermining the popular narrative that parks preserved an uninhabited wilderness.

King Philip's War devastated Native resistance in colonial New England.

The Indian Removal Act of 1830 forcibly displaced tens of thousands of Native Americans

Signed by President Andrew Jackson, the act authorized the federal government to negotiate treaties relocating Native nations from their Southeastern homelands to lands west of the Mississippi, often by force.

Europe’s first recorded influenza pandemic swept the continent in 1580

The 1580 influenza pandemic, traced from Asia to Africa and into Europe, became the first flu outbreak clearly documented across the continent—killing tens of thousands and highlighting influenza’s potential for rapid global spread.

Native religious practices were suppressed for centuries before receiving federal protection in 1978

During the first two centuries of American history, the government frequently banned Native ceremonial dances, took sacred sites, and enrolled children in boarding schools where they were prevented from practicing their faith. The American Indian Religious Freedom Act of 1978 committed the federal government to safeguarding Native spiritual practices.

A 1990 law forced museums and federal agencies to return Native remains and sacred objects

The Native American Graves Protection and Repatriation Act required federally funded institutions to inventory and return Native American human remains and sacred items to descendant tribes.

Nearly 5,500 crows died during four months in 1999 from West Nile in NYC.

The Civil War was the deadliest conflict in American history

Between 1861 and 1865, an estimated 620,000 to 750,000 soldiers died from battle and disease—more than in all other US wars combined.

From 1970 to 2017, invasive species have caused $1.28T in damage globally

The costliest species were the Asian tiger and yellow fever mosquitoes ($149B), which arrived in the US from Asia and sub-Saharan Africa, respectively. The bulk of their damage came from their transmission of diseases such as Zika, chikungunya, and dengue. (Some readers may experience a paywall.)

America's demographic change in one chart

From 1901 to 2020, the US population has changed significantly. This video reveals the change in America’s demographics over more than 100 years.

Up to 225 cases of leprosy in the US are diagnosed each year

Most cases in the US are imported, meaning someone was infected in a country where it was more common. Since symptoms can sometimes take decades to appear, tracing the origin of the disease can be hard.

Humans may be the ultimate invasive species

Originating in East Africa, Homo sapiens migrated across the world beginning about 60,000 years ago and directly harmed countless species by consuming resources and modifying ecosystems to serve our needs. While meeting the definition of an invasive species, some ecologists argue the opposite, claiming that humans have helped preserve numerous species.

Visualizing cause of death over time in America

As people age, their life expectancy decreases, but the timing and speed of this decline have evolved over the years. Check out this chart which shows the shift in various causes of death of Americans over the last few decades. Data from the...

Volcanoes in the 1340s likely helped trigger the Black Death

The "bubonic plague" that wiped out roughly half of Europe and Asia originated from many factors. Recent research suggests volcanic eruptions contributed as well. The "aerosol" effects of matter released from eruptions likely prompted famine and accelerated the spread of infected fleas riding on grains avoiding spoilage.

Native, wild bees are at much greater risk of extinction than honey bees

It is estimated that there are more honey bees, which often compete with native bees for resources, on the planet than at any point in human history. Meanwhile, 40% of invertebrate pollinator species, including wild bees and butterflies, face extinction in the coming decades.

Discover the latest information on US measles cases from official outbreak tracking figures.

Most Americans are now dying at home, reversing 20th century trends

For most of the 21st and 20th centuries most Americans died in hospital settings. But in 2016, home-based deaths overtook hospitals; most Americans are now dying at home, likely fueled by individual preferences to die at home or to receive at-home palliative care.

Powassan virus, a rare tick-borne disease named after the Canadian town where it was discovered in 1958, is on the rise in the northeastern United States, and it kills roughly 10% to 15% of patients with symptomatic disease.

The bubonic plague spread in three waves over 600 years

The Black Death refers to the first wave of the plague, which swept through Europe in the 14th century and killed 25 to 50 million people. Caused by the bacterium Yersinia pestis carried by fleas (often on rats), the human toll was roughly one-third of Europe's population at the time.

Measles was declared eliminated in the US in 2000, meaning the country had been free of continuous disease transmission for 12 months or more.

Early farming created population booms—and also major busts

Europe’s ancient embrace of farming took the continent on a demographic roller-coaster ride. Regional booms and busts in human numbers occurred between 8,000 and 4,000 years ago, a new study finds.

Irish music became popular in the US during the 19th century

The influx of Irish immigrants in the mid-1800s, driven by starvation and abysmal employment opportunities, led to a significant Irish-American culture, especially in urban hubs such as New York, Boston, Philadelphia, Chicago, and San Francisco.