Anhedonia, which means 'without pleasure' in Greek, is typical in major depressive disorder

Aphantasia involves a lack of mental images—but doesn't affect behavior

The condition, generally known about for over a century, first received its name in 2015 by researcher Adam Zeman. An estimated 4% of people lack this ability to perceive mental images, and research suggests this deficiency does not have any practical impact on behavior.

The depression paradox refers to a lack of energy to take action to help alleviate it

Activities like exercise, even at low levels, have been shown to alleviate some of depression's symptoms for some people. However, depression saps energy levels, making it particularly difficult to motivate oneself to take helpful action.

'Melancholia' was the ancient Greek term for depression

"Melancholia" in Hippocrates's time was derived from the Greek word for black bile. This term made sense in its context since the Greeks believed that depression stemmed from an improper balance of the four humors.

NDEs typically change people's outlooks drastically and can prompt depression

The phenomena are regularly categorized as hallucinations, but some specialists are interested in their psychological nuances. Many survivors report feeling less anxiety about death, though some surveys show the experiences can increase physiological sensitivities.

Key tips for helping the depressed—including listening without judgment

Major depressive disorder is a clinical diagnosis and is not a lifestyle choice. Those who struggle with depression can express persistent feelings that are difficult to process and make sense of for friends and family. This guide walks through some counterintuitive perspectives, including resisting the urge to force a depressed person to do the things that would make them feel better.

Roughly 10% of the world has SSAD—SAD’s milder, nonclinical cousin

Subsyndromal affective disorder is diagnosed when someone exhibits two of the nine major criteria for depression (but not more than five) as a result of seasonal changes. While it is milder than primary SAD, SSAD is still significant and impacts millions.

Depression is much more than sadness—and isn't fleeting

The American Psychiatric Association's DSM-5—used for defining diagnoses—says a person must be experiencing five or more symptoms of depression most of the day over at least two weeks. Research indicates older people are less likely than younger people to meet that depression benchmark, though this article says they still often have at least several of the depression symptoms.

Anosmia is the total loss of the sense of smell

This type of loss—due to disease or trauma—has ripple effects, including an altered or limited sense of taste. This video details the anatomy and physiology of our sense of smell and taste and how these senses are interrelated.

Anticipatory grief describes experiencing sorrow ahead of a loss

All-consuming anticipatory grief—like if you know a loved one will soon die from a chronic illness—can be disabling. Seeking exercise, healthy food, hobbies, and trying to toggle between thinking about an upcoming loss and focusing on other matters is important for promoting health.

A famous philosophical question asks would you opt for a life with no pain—but without reality.

Having five of nine key symptoms constitutes a major depression

Before professional standards were adopted, practitioners used varying criteria to diagnose mental health disorders. By the 1970s, more objective lists were organized, culminating in this list of polythetic criteria—a list of symptoms where no single criterion is required, but a minimum number must be present.

Inflammation appears to cause specific symptoms of depression

A large analysis of existing studies published in 2021 found that systemic inflammation is associated with fatigue, appetite changes, and sleep disruption, rather than some of depression's broader symptoms including hopelessness about the future, or feeling fearful. This may suggest that inflammation influences specific symptoms of the condition, rather than the disease as a whole.

How depression affects the brain

Treatment for depression has historically hinged on the theory that the condition was caused by underactive or abnormal neurotransmitters, specifically serotonin and norepinephrine. This four-minute video by Yale Medicine details how these neurotransmitters didn't explain the symptoms of depression but, two other neurotransmitters involved in regulating mood and emotion did. GABA and glutamate, some of the brain's most plentiful neurotransmitters, may possibly be the source of depressive symptoms.

These areas of the brain are hard-hit in depression—but the changes are reversible

Depressed brains can have certain characteristic changes, including an overactive amygdala, reduced hippocampus size, and changes to the thalamus and neuromodulating chemicals in the brain.

The neurobiology of meaningfulness: the benefits of psychedelics

Psychedelics produce powerful emotions in its users, including a profound sense of meaningfulness. The philosopher William James called this sense "noetic" in the late 19th century, but for decades researchers avoided studying the effects of such drugs on the brain. However, the recent resurgence in psychedelic research has heightened interest in the relationship between this noetic sense resulting from the therapeutic use of drugs. Learn what researchers have found out here.

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

Brain conditions and surgery can cause some individuals to feel no fear

Fear is a survival mechanism that originates in the brain's amygdala, triggering the body's fight-or-flight response. However, in modern society, without the same natural dangers, fear can lead to anxiety and mental health issues when unnecessarily triggered. Understanding individuals without fear may help identify new methods to treat anxiety disorders.

A psychiatrist warns that chasing happiness can lead to misery

Rafa Euba, a retired consultant psychiatrist, argues that happiness is a vague and abstract concept that is hard to quantify. He suggests accepting that suffering and pain are a normal part of life. An attainable goal for one's life is to attempt to minimize pain, and pursue balance and contentment rather than a false ideal of permanent bliss.

Roughly 15 of every 1,000 people in the US have smell disorders

Anosmia is a lack of a sense of smell. It can be present at birth, related to diseases including Parkinson's, Alzheimer's, and COVID-19, or have unknown causes.

Grief is defined as the anguish and physiological distress experienced after significant loss

It usually occurs following the death of a loved one, and symptoms may include confusion, apprehension about the future, separation anxiety, and ruminating on the past.

Nostalgia is a psychological coping mechanism that can help combat loneliness—but it's created from bias

Researchers have observed that though nostalgia can help counteract feelings of loneliness, our memories of the past are somewhat rose colored. Negative emotions seem to fade faster than positive ones, a phenomenon that they suggest may be a psychological coping mechanism so that memories don't hurt every time they're recalled. (Some users may experience a paywall.)

When common sounds become disturbing

Misophonia causes certain sounds to feel violating, triggering a "very visceral kind of experience" filled with extremely unpleasant emotions, including annoyance, anger, and disgust. A 2017 study found that people with misophonia have elevated activity in the brain's anterior insula—a region associated with interoception, emotional processing, and behavioral responses—when exposed to trigger sounds. Ongoing research suggests trigger sound context affects the severity and manifestation of the condition.

Clinical burnout: prolonged exhaustion, mental distance, and persistent negative feelings

Burnout isn’t just stress—it’s a pervasive feeling of exhaustion that can start in the workplace and seep into everyday life. It causes feelings of dread and cynicism about work tasks. On top of emotional distress, there can be physical symptoms and a tendency towards addictive behavior.

Anxiety is one of the world's most common mental health disorders, causing persistent excessive fear and worry that interferes with daily activities.

SAD 101 from the folks at NIMH—where the condition was first identified

Norman Rosenthal led the team at the National Institute of Mental Health that first identified and described seasonal affective disorder in 1984. This 101 from NIMH explores the basics of the condition, from who develops it to how it is treated.

SAD uniquely affects people with attention-deficit hyperactivity disorder

Those with ADHD—chronic issues with attention and executive function—are primed for SAD. Many are disproportionately evening chronotypes (more awake in the evening), have a delayed sleep phase, and have low sensitivity to light in the morning. This podcast explores the overlap between these two groups.

Antidepressants alone may fail to help an estimated one-third to one-half of depressed patients.

She can't feel pain, hunger, or danger

Olivia Farnsworth, born with a rare chromosome 6p deletion, may be the only person known to lack pain, hunger, and fear responses. This overview explores her unique condition, the incredible incidents that revealed it, and how scientists hope her case could unlock new insights into human survival and sensory systems.

Mental health symptoms may manifest differently across cultures because physical and mental health are imbued with values, beliefs, and traditions.

The body produces its own opioids that act on several receptor types throughout the body, triggering the release of dopamine and suppression of noradrenaline, neurotransmitters associated with reward and alertness, respectively.

The neuroscience of heartbreak

An analysis of functional MRIs revealed a difficult fact: the active brain areas of people experiencing heartbreak were very similar to those actively in love. This is a major reason why people in the middle of rejection can't accept the reality of their loss. This article breaks down the various changes in neurotransmitters and neural pathways for those enduring that universal experience, heartbreak.

Opioids mimic naturally produced endorphins to dull pain.

Apeirophobia is the fear of everlasting life and may stem from the human brain's inability to conceptualize the concept of anything happening beyond what it can project out, such as the concept of an infinite life.

Some Ozempic users lose their desire to eat

This essay follows a writer whose Ozempic journey involves a dramatic loss of appetite, leading them to stop compulsive snacking and even lose some of the joy of eating. As a result, he becomes fixated on watching food videos and eventually tries to "beat" an all-you-can-eat steak buffet. The experience leaves him feeling disappointed and lacking in desire.

Addiction develops when the pleasure circuits in the brain get overwhelmed

Normal pleasure circuits become overwhelmed by addictive substances, triggering dopamine floods many times stronger than those induced by everyday reward experiences. The understanding of addiction as a brain disease has led to treatments pairing medication and counseling.

Is life all about pleasure? Debating the Experience Machine

If you could plug into an Experience Machine that gave you total pleasure all the time, would you do it? Philosopher Robert Nozick thinks you wouldn't, using this as evidence against hedonism, the view that life is all about pleasure. Explore the nuances of the argument and counterarguments with this accessible article.

Key symptoms of burnout can be both mental and physical

Burnout can be accompanied by several symptoms, including low energy and chronic fatigue, trouble concentrating, difficulty sleeping, and depression. It may even manifest physically as musculoskeletal pain, headaches, stomach and intestinal pain, and more. More intense cases have been linked to cardiovascular and mental health disorders.

Touch deprivation can heighten anxiety and depression

Pacinian Corpuscles are pressure receptors just under the skin that send signals to the vagus nerve in the brain—that's the cranial nerve which regulates involuntary actions like breathing, heart rate, and the general "fight or flight" response. Activating those receptors can slow the heart, decrease blood pressure, and lead to the release of oxytocin and cortisol. The absence of touch, conversely, can promote negative feelings.

People with a sleep disorder called REM Sleep without Atonia don't experience the temporary paralysis of skeletal muscles that typically occurs during REM sleep—instead, they have vivid dreams that they act out during sleep.

Stress and anxiety may lead to similar symptoms, but stress is a response to external triggers, while anxiety is persistent, and its symptoms won't disappear once an immediate stressor is gone.

Could this pseudo-psychedelic VR experience decrease symptoms of depression?

Researchers report that virtual reality and psychedelics may be leave users with similar insights and therapeutic benefits. Try out this free psychedelic virtual reality experience to see if this holds true for you. According to the program’s creators, a study into the efficacy of this 45-minute experience indicates it may help alleviate symptoms of mild to moderate depression.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

A near-death experience is a phenomenon experienced by roughly 5% to 23% of the population, and typically occurs after a traumatic physical event or a brief clinical death.

Misophonia is a neurological disorder where sounds trigger strong emotions

The phenomenon is characterized by decreased tolerance to specific sounds, such as heavy breathing, pen clicking, and water dripping, which trigger a fight-or-flight response. The resulting emotions, which can range from irritation and disgust to anxiety and fear, can be overwhelming and uncontrollable.

Researchers have investigated the benefits of extreme pain rituals, exploring how and why we engage in these events when humans generally naturally avoid pain and perceive it as a negative experience.

Menopause can exacerbate anxiety

Some research shows that menopause can fuel anxiety and also that preexisting anxiety can boost the chances of experiencing other menopause symptoms, including hot flashes, insomnia, and brain fog. But treatments—including hormone replacement therapy, breathing exercises, and other forms of exercise—can alleviate some of these symptoms.

Nostalgia is a psychological coping mechanism created from bias

Memories are naturally reconstructed during recall, and research has shown a fading effect bias that causes negative ones to fade more quickly, helping us heal. This creates a natural longing for the past, particularly when faced with loneliness, boredom, or challenging moments in the present.

Narcolepsy occurs when the brain loses its ability to control its sleep-wake cycle.

Anxiety can arise at any stage of life and make someone feel unsafe in their mind and body.

An Alzheimer's patient discusses her condition with children

Alzheimer's is a deadly disease that profoundly changes a person's abilities and personality, which makes it difficult to explain to kids. Responding to potentially uncomfortable questions with honesty (and relatable imagery) about the costs and nature of the disease goes a long way in fostering understanding.