Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

Software subscriptions, licenses, and climate control systems add to 3D printing costs

Although the sharing of designs and reduced manual labor suggested the fabrication of prosthetics would be facilitated by 3D printing, particularly in developing regions, software and hardware requirements have posed hurdles to achieving this goal. While some insurance companies have refused to cover 3D-printed limbs, they are covered by Medicare.

Every 3.5 minutes in the US, a limb is amputated due to diabetes.

An experimental bionic knee has been directly integrated into the user's muscle and bone—not an external socket—marking a significant prosthetic advancement.

Trauma-related amputations are primarily from falls, then car accidents and related traumas, followed by mechanical forces according to analysis based on global burden of disease data in 2017.

See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

Organ transplants can come with a price tag of more than $2M without insurance

According to 2025 report data that was graphically represented by Statista, average costs for organ transplants can be as steep as $2.3M for a double lung transplant and $1.9M for a heart. These figures are based on what was actually charged to insurance companies—not what individual patients paid. Following the actual transplant there are also additional costs associated with the procedure, including lifelong immunosuppressant drugs.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Nonamputees can be tricked into thinking they have phantom limbs with rubber arm experiments.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

Mind-controlled bionic arms use nerve implants to restore sensation and movement

Unlike traditional prosthetics that rely on surface electrodes or mechanical parts, this system uses implanted titanium and nerve-connected electrodes to enable a seamless brain-to-arm connection. Patients train in virtual reality with their implanted signals before using the physical prosthesis.

Black patients are losing their limbs at a rate triple that of other groups due in large part to inequities in diabetes care and management.

Brain-reading devices are helping paralyzed people to touch

In clinical trials, implanted brain-computer interfaces are allowing dozens of individuals with paralysis to control prosthetics that are restoring a range of skills, including drinking coffee and feeding oneself. One area of related prosthetic research is creating a synthetic sense of touch—coupling the brain implant with pressure sensors in prosthetic robotic fingertips to enable an approximation of a sense of touch.

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

Limb regeneration research may lead to treatments for arthritis

For scientists pursuing the cure for arthritis, the holy grail of discoveries lies in how to regrow healthy cartilage inside human joints. While this feat has so far resisted our best scientific attempts, there are plenty of other human tissues—such as the liver and fingertips—that will successfully regenerate.

Implanted neurotechnology can leave users vulnerable when manufacturers go under

Despite providing relief from neurological conditions, patients are left stranded when the companies that make these devices shut down. The lack of regulation means patients often face technical failure, insurance battles, or risky surgeries to maintain their quality of life.

Breaking down the knee's anatomy

The human knee is a remarkably complex structure carrying the full weight of the body throughout a person's life while allowing a number of complex twists, flexes, and extensions. It's also one of the body's biggest weaknesses—the location of chronic pain and replacement surgeries for millions of Americans.

Brain implants are restoring movement and communication in early human trials

Several companies developing brain-computer interfaces have begun testing on humans with promising results. These implants have helped reanimate paralyzed limbs and enable communication, though ethical concerns remain about data privacy.

Prosthetics and orthotics have been 3D printed to improve the lives of animals

Shells for hermit crabs, wheelchairs for guinea pigs and dogs, and horseshoes for improved running performance have been created using 3D printers. Other artificial body parts made using this technology include a jaw for a loggerhead turtle, a beak for a toucan, and a tail for an American alligator.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Phantom limbs aren't just limited to limbs—there are phantom breasts, teeth, and more, and these sensations are often painful.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

Hear Aristotle Domingo, a bilateral amputee athlete, discuss his amputation journey.

Artificial wombs and preterm births: an overview

Scientists are working to create artificial wombs that would help preterm babies survive their early entry into the world. But how much help could this technology provide, and how much of a problem are preterm births? This article details some of...

736,900 cochlear implants had been implanted by 2020 worldwide

In the United States, roughly 118,100 devices had been implanted in adults by that point and 65,000 in children. These estimated figures come from the US Food and Drug Administration, which first approved cochlear implants for adults experiencing hearing loss in the mid-1980s, and collected reports from cochlear implant manufacturers approved for the US market.

Hear about life as an amputee and how mirror box therapy helped.

Palliative care physician BJ Miller describes his phantom limb pain and itching after losing both legs and half an arm in an accident. Mirror box therapy eventually helped him, alongside physical therapy. This podcast also features neuroscientist VS Ramachandran who explains how he developed mirror box therapy in the 1990s.

Each day, about 60 US pregnancies end in stillbirth

This online memorial for families who experienced the unexpected death of a fetus 20 weeks or older is the result of ProPublica reporters inviting 60 families to share their baby's name and answer some questions about their unfulfilled wishes for their children. About 21,000 babies are stillborn in the US annually. About the same number of children die in the US during their first year of life.

In 2024, the US had more organ transplants than ever before—besting the 2023 record

More than 48,000 organ transplants were performed in 2024, and about 46,630 were performed in 2023. These record highs are illustrated here as part of data from 1988 to partway through 2025. Kidneys, livers, and the heart remain the most common transplanted organs. (Some users may encounter a paywall.)

Medical imaging allows 3D printers to create patient-matched devices

With imaging data on a person's anatomy, external prostheses and implants, such as cranial plates or hip joints, can be custom-printed to better match a patient's body. Fabrication of porous structures can promote bone growth, leading to longer-lasting implants.

Readers thought the fictional Civil War vet George Dedlow, a character suffering from phantom limb pain in an 1866 story in The Atlantic, was real—and sent donations and stopped by the hospital to meet him.

America's financial burden from dementia in 2025 was $781 billion

That figure, calculated by researchers at the University of Southern California, includes medical and long-term care costs, unpaid family and friend caretaking, lost productivity for patients and their families, and the economic loss in quality of life for patients and their families. In 2025, they estimate there were 5.6 million people living with dementia.

As of 2025, perfect synthetic replication of natural organs remains elusive

Advancements such as 3D printing muscles, performing vaginal reconstruction with colon tissue, and growing organs in a lab have shown promise, but artificial options and transplanting substitutions continue to exhibit functional and performance limitations compared to their natural equivalents.

Lee Spencer, a single-leg amputee, broke the world record when he rowed solo and unsupported across the Atlantic Ocean in 2019.

Some medical schools have phased out human cadavers for digital alternatives

AI-based anatomy tools and digital cadavers are increasingly used to teach students, bypassing the ethical and consent concerns around the use of real bodies. Digital cadavers have also become less expensive than real ones, though the tactile and sensory experiences of real dissection may be irreplaceable.

One estimate values concierge services at $38.9B by 2032

Data Horizons Research put the value of this global market at $18.9B in 2021, but anticipates massive growth by 2032, with North America comprising the majority of the market. Chronic health conditions, their analysis suggests, will be a contributing factor to this growth as medically complex individuals seek more personalized care.

Medical professionals have experimented with using mixed reality headsets

Devices like the Apple Vision Pro have helped doctors develop surgical plans for hip and knee replacements using software that provides 3D models and other tools. Virtual screens displayed by mixed reality devices can provide information related to surgical progress, a patient's vitals, and more.

The global xenotransplantation market may already be valued at more than $13B.

Scientific advances are unlocking a wide range of alternatives to IVF

From refined artificial insemination and microsurgical sperm extraction to experimental uterine transplants, scientific innovation is rapidly advancing potential fertilization technologies. But they come along with costly trials, some ethical dilemmas, regulatory issues, and more.

Experience a century of America's healthcare advances with this medical visualization, tracing a sampling of healthcare innovations from head to toe.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

Interface device implanted into ALS patients restored some of their abilities

Most people with amyotrophic lateral sclerosis, or Lou Gehrig's disease, require assistance with daily life due to loss of motor control. The electrode-coated, stent-like device used motor mapping data and machine learning to translate brain activity into actions.

This Texas city is having an 'amputation crisis'

Texas has some of the highest rates of diabetes-related amputations in the country. Towering over the rest of the Longhorn state is the city of San Antonio, where men are nearly three times as likely to lose a limb to diabetes than women. This article explains how men in this majority Mexican American city are genetically and culturally at risk of Type 2 diabetes, a disease involving issues with the blood sugar-regulating hormone insulin.

The first neural devices were cochlear implants, designed to treat hearing loss

Neural interfaces connect with our nervous system to restore or enhance abilities, such as hearing or movement. These neuroprostheses have enabled the restoration of mobility, communication, and activities of daily living that might otherwise require a caregiver.

The first CRISPR-approved treatment was for sickle cell anemia in 2023

Victoria Gray was the first patient to receive a CRISPR-based therapy, which eliminated her symptoms and restored her health. The therapy's initial cost of $2.2M has kept it out of reach of many patients.

About 250,000 patients accessed assisted reproductive technologies in 2022

In 2022, 251,542 patients tried assisted reproductive technologies—most commonly IVF—resulting in more than 98,000 infants. Those children represent around 2.6% of the babies born in the US.

A robot can now stand in for a phlebotomist and draw blood from adult patients after the FDA approved the device in August 2026.

In a first, eye prosthesis has restored sight to macular generation patients

In a clinical trial, 27 of 32 participants with advanced macular degeneration regained enough vision to read books, food labels, and subway signs about a year after receiving a prosthetic retina device. This is the first device to restore functional vision to patients with incurable vision loss, though in this case they can only see in black and white, with no shades in between.

Using artificial wombs to improve preterm infant health outcomes

Researchers at a hospital in the US have successfully used artificial wombs to care for preterm lambs and are now looking at the possibility of human trials. This nine-minute video includes interviews with the researchers and explains the reasoning...