Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

Hear about life as an amputee and how mirror box therapy helped.

Palliative care physician BJ Miller describes his phantom limb pain and itching after losing both legs and half an arm in an accident. Mirror box therapy eventually helped him, alongside physical therapy. This podcast also features neuroscientist VS Ramachandran who explains how he developed mirror box therapy in the 1990s.

Hear Aristotle Domingo, a bilateral amputee athlete, discuss his amputation journey.

Listen to how bionic limbs are reshaping what it means to live as an amputee in this award-winning 2022 podcast series covering the stories of two amputees who struggled with shortcomings in prosthetic technology.

See what analysis of one man's amputated leg, donated to The Bone Museum, tells us about his otherwise invisible pain.

Learn how a doctor successfully treated a patient's phantom limb pain with a mirror, tricking his brain into thinking his still-present arm was the missing paralyzed left one.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

Losing a brain-computer interface can trigger lasting psychological distress

A clinical trial participant with severe epilepsy described becoming “one” with her implant after it gave her unprecedented control over her seizures. When the device was removed due to the company shutting down, she experienced deep emotional trauma and a sense of personal loss.

Doctors ignored women's pain as a nurse replaced their fentanyl with saline

This five-part podcast series, produced by Serial Productions, focuses on the experiences of women undergoing fertility treatments at a Yale clinic where a nurse secretly replaced pain medication with saline solution. This led to women experiencing excruciating pain during procedures, but the clinic downplayed or ignored their complaints.

Nonamputees can be tricked into thinking they have phantom limbs with rubber arm experiments.

Listen to why extensive ear rinsing can create problems

The clinician who hosts this podcast discusses how his patient developed swimmer's ear after he flooded his ears with water during his daily showers, ostensibly to clean them. The resulting itchy, painful ears were the result of removing protective earwax in the ear and also altering the typical pH of the ear.

Listen to how gaps in schizophrenia care helped to lead to a murder

Michael Laudor attended Yale, succumbed to schizophrenia, and killed his pregnant fiancée. The podcast, which includes a long but moving interview with Laudor's friend Jonathan Rosen, uses the tragedy to frame how America's approach to severe mental illness has fallen short.

Readers thought the fictional Civil War vet George Dedlow, a character suffering from phantom limb pain in an 1866 story in The Atlantic, was real—and sent donations and stopped by the hospital to meet him.

A first-person account of receiving an Alzheimer's diagnosis

Having Alzheimer's is a bit like having a part of your brain sliced away each day, according to author Greg O'Brien. This 34-minute podcast episode introduces O'Brien and his co-host, author David Shenk, as the two embark on a multi-season conversation on Alzheimer's disease and O'Brien's diagnosis.

Using psychedelics to manage a cancer diagnosis

Dr. Roland Griffiths helped lead the revival of psychedelic research, often prescribing the use of psilocybin to address severe depression or anxiety in patients. This podcast explores how Griffiths leaned on his own career after being diagnosed with cancer and facing the prospect of death.

Learn about the point of the physical and emotional experience of pain, which has three broad categories that help determine treatment approaches.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Black patients are losing their limbs at a rate triple that of other groups due in large part to inequities in diabetes care and management.

Amputees must navigate the challenging medical and economic aspects of limb support and replacement, but advances in technology and research may reduce these costs.

Phantom limbs aren't just limited to limbs—there are phantom breasts, teeth, and more, and these sensations are often painful.

The subjectivity of pain means that one person's kidney stones may be another's childbirth, but most sources of pain do have objective, underlying causes.

Explore the biology of pain and why the experience of pain may differ widely from one person to another.

Wearing a 'schizophrenia simulator,' designed to build empathy for patients, CNN's Anderson Cooper finds he struggles to function

Donning headphones that play a track mimicking the auditory hallucinations common in schizophrenia, Cooper finds he is very distracted, disconcerted, and frustrated. The auditory track aims to help listeners build empathy with patient populations by understanding the challenges they face in daily life.

Listen to what it was like living as a medieval leper

This podcast uses paleopathological and anthropological findings to reconstruct what it was like for people diagnosed with leprosy in medieval times on the Eurasian continent. If a town lacked a leprosarium—an isolated leper asylum or colony—or the suspected leper was a foreigner or a Jew, which would make them ineligible for leprosarium admission, they'd be expelled.

Listen to an avowed rationalist discuss his frightening near-death experience visions from 2020 and how it changed his life outlook.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

Turning a profit with terminal illness

After Amanda Riley was diagnosed with cancer, her social media followers rallied to raise funds to ensure their favorite religious influencer could afford one miracle after another. As more than $100,000 of donations poured in, Riley shared glimpses into her health struggles, posting evidence as fake as her diagnosis. Pulling from years of journalistic investigation, this eight-episode podcast series dives into Riley's reality.

Surgery before the dawn of anesthesia

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

Researchers have investigated the benefits of extreme pain rituals, exploring how and why we engage in these events when humans generally naturally avoid pain and perceive it as a negative experience.

Listen to how medical error affected an emergency physician's approach

Emergency physician Dr. Sarah Gray discusses her worst medical error, what she learned from it, and how medical error and the culture around it lead to physician burnout. In addition to lawsuits, medical errors can lead to guilt, shame, anxiety, and fears of embarrassment, so this podcast discusses how sharing such errors and teaching about them can improve care.

Skull bone marrow may be playing a key role in chronic pain.

Top strategies on how to deal with other people's big feelings

This podcast offers insights on how to effectively talk to others when they're experiencing powerful emotions, and how to simultaneously protect yourself in those situations.

Why might someone want to stay in psychosis?

Author Abigail Gosselin writes that her verbal auditory hallucination, often assumed by others to be harmful or threatening in nature, offered a salve to loneliness, even as it told her to kill herself. This perceived benefit and others Gosselin shares offer insight into why people in psychosis may struggle to adhere to treatment and medication plans.

Every 3.5 minutes in the US, a limb is amputated due to diabetes.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

A workplace back injury and the opioid prescription that followed set one Texas father on the path the Washington Post's video profile calls his rise to fentanyl 'kingpin.'

Trauma-related amputations are primarily from falls, then car accidents and related traumas, followed by mechanical forces according to analysis based on global burden of disease data in 2017.

A riveting retelling of the 1846 Donner Party, the doomed western pioneers

Eighty-one people went with the Donner Party into the Sierra Nevada mountains in the winter of 1846 via what they thought would be a shortcut to the West. Only 41 came out. The infamous episode of Western travel is captured in narrative detail in this four-part podcast series. This first episode reveals the motivations that pushed the party on this specific route.

Read the 1866 story in The Atlantic that put phantom limbs on the map, a fictional story by a Civil War surgeon that was mistaken for being a true account by many readers.

Overuse of opioids can lead to hypersensitivity to pain.

The man who turned his leg into a hotspot

Biohacker Michael Laufer recently had a 512GB drive implanted in his leg, which can store data, stream music or movies, and power a hot spot and mesh network. It's called the PegLeg, and WIRED's Daniel Oberhaus spoke with Laufer about the device and the field of biohacking.

Infertility is often not discussed, forcing women and families to grieve privately

Watch this podcast discussion from Weill Cornell Medicine about the emotional journey of infertility for couples and individuals and hear advice about how to navigate the feelings of loss of control, grief, anger, and despair, including suggested tips for supporting individuals struggling with infertility.

Your favorite music can minimize physical pain, according to a 2025 study on how music can bring solace and address pain.

A teenage Springsteen struggled with his father

Springsteen's father didn't understand why his son was interested in pursuing a music career, leading to a tense relationship that was often exacerbated by his father's struggles with mental illness. Embed: Podcast

Explore a podcast devoted to uncovering different conspiracy theories

Hear stories of controversial events from all around the world and come to your own conclusions about why they happened—and if someone shaped the narrative around them. From art fraud to the death of a Roman emperor, this Spotify podcast covers it all.

Visualizing a joint under attack from rheumatoid arthritis

A particularly difficult arthritis subtype is rheumatoid arthritis, a painful condition provoking a vicious cycle of joint inflammation, destruction, and dysfunction. It begins with a misfiring of the patient’s own immune system—for unknown reasons, it identifies joint and cartilage cells as foreign, initiating an attack to eliminate the supposed "invaders."

Bipolar disorder, which is characterized by extreme mood swings, affects nearly 3% of the US population

There are two types of this disorder. Bipolar 1 features a significant manic episode—abnormally elevated mood and frantic energy—followed by repeated depression, while Bipolar 2 vacillates between depressive episodes and hypomania, a milder form of mania, but not a full mania. Listen to this podcast as experts explain the condition.

How we frame stress—as good or bad—seems to alter how it affects us

This podcast discusses research that indicates stress perception may drastically affect how we respond to it. In research exploring if our stress is presented as diminishing our health versus if we're told it enhances our performance, it will lead to differences in how successful participants are at performing tasks—with the enhancers doing better.