Tattoos are made by injecting pigments into the skin

Tattoo inks are largely unregulated by the FDA

With hundreds of ink manufacturers, all unregulated by the FDA, it’s hard to determine the exact ingredients in tattoo inks. Some pigments may contain carcinogenic chemicals, such as heavy metals and aromatic hydrocarbons, or even bacterial contaminants. Red ink often causes allergic reactions and may even contain lead or mercury.

The immune system fights tattoos

Our skin is a fascinating organ that wants nothing more than to protect our bodies from the outside world. Tattoos penetrate that protective wall to inject ink directly into the sensitive, immunologically rich layer of skin known as the dermis.

Tattoos, explained

Tattoos last because immune cells trap ink beneath the skin—but there's more to the story. This overview looks at how ancient cultures used tattoos for status, spirituality and punishment; how technology like the electric tattoo machine transformed the art form, and where innovations like smart tattoos could take it next.

Tattoo removal breaks apart ink particles

Tattoos place ink below the skin's surface layers in packets too large for white blood cells to clear out. By breaking the ink into smaller pieces, the immune system, which is responsible for removing foreign matter, can process them.

The body can remove tattoos after they are broken down by laser

Tattoos place blobs of ink below the surface layers of the skin in packets too large for white blood cells to clear out. By breaking the ink into smaller pieces, they can be processed by the immune system, which is responsible for removing foreign matter.

Technological breakthroughs are spurring innovations in the industry

What if you could see your tattoos before they’re embedded in your skin? Or take a virtual visit into a local studio to work out your nerves over a first tattoo? The industry is anticipating some big technological changes, from 3D designs to sci-fi upgrades to more precise tattoo guns.

Harvard and MIT researchers are developing life-saving tattoos

Tattoos aren’t just a fashion statement. Scientists are trying to find life-saving applications for them. Harvard and MIT researchers are developing tattoo inks that react to body chemicals, alerting diabetics to blood sugar fluctuations or athletes to dehydration. Someday, patients may observe their body chemistry with tattoos that change colors.

The first tattoo gun was based on an electric pen invented by Thomas Edison.

'Skin stitching' is an ancient tattoo method that's made a comeback

In the slow method, artists use needles to puncture the skin. Then, pigmented thread is drawn through the punctures to create the tattoo, resembling embroidery in the flesh. The method is experiencing a cultural revival within Canada’s First Nations communities.

'Magic ink' is redefining the tattoo

One University of Colorado professor has developed an ink that can be "turned on" with exposure to UV light, and "turned off" with sunlight. While the ink could help those who want to hide their body art from family members or coworkers, there are potential uses for medical procedures.

There are stigmas attached to tattoos

Although tattoos are fairly common in the US, some taboos remain. A 2017 study in the Journal of Social Psychology found discrimination against tattoos is alive and well, and that even individuals with tattoos associate them with negative stereotypes.

Watch the engineering challenges overcome in turning a 3D printer into a tattoo machine

The DIY project required reprogramming the printer to operate on a curved, 2D surface rather than making flat layers in 3D, editing replacement firmware to bypass temperature safety checks, and developing a rapid system to stop the tattoo in case of an emergency. The final product printed "LEG" on a volunteer's leg.

Removal of different color tattoo inks may require multiple lasers

Light needs to be absorbed by ink particles to break them down into small enough pieces for the immune system to eliminate. Color ink reflects, rather than absorbs, lasers of the same color, while black ink absorbs all colored lasers.

Around 32% of American adults have at least one tattoo

Tattoos have waxed and waned in popularity over the centuries, depending upon the social standing of their wearers. Throughout US history, they were often considered taboo. However, growing acceptance of tattoos means they’re more visible in the public eye.

'Tattoo' comes from a Polynesian word that means 'to strike'

“Tatatau” roughly translates to “strike,” a reference to the ancient process, which involved tapping ink into the skin with sharpened objects, like the bronze implements used circa 1450 BCE in Egypt, below.

Laser procedures have made tattoo removal much more common

An increasing number of Americans, including high-profile celebrities, get tattoos removed because laser removal has become more advanced and cost-effective. The tattoo industry is adjusting to this mainstream trend.

Two festival-goers were hospitalized after receiving trendy peptide injections, raising safety questions that may extend beyond the event.

World Cup athletes use tattoos to convey aspects of their identity—including details of their faith, family, and accomplishments—in the otherwise tightly regulated arena of professional sports.

Tattoos were once used to identify status

Around 450 BCE, Scythians inhabiting what is now southern Siberia were recorded as wearing tattoos of swirling mythical beasts to signify nobility. At the same time, tattoos have identified lower-status and enslaved people.

How 'the Iceman' got his tattoos remains a mystery

Ötzi the Iceman, discovered in 1991, is one of the oldest human mummies ever found—and his 61 tattoos remain a mystery. This explainer looks at how researchers believe the tattoos were made, what their placement suggests about ancient medicine and culture, and why we’re still piecing together their true purpose today.

Knowing how to use an EpiPen is a life-saving skill—learn how with this video

If someone has a severe allergic response, including trouble breathing or two or more allergic symptoms, it may be necessary to administer epinephrine, usually through an injection. Epinephrine autoinjectors—often called EpiPens—should be injected into the mid-outer thigh, even through clothing, for about 10 seconds, depending on brand. Sometimes another injection with a separate EpiPen is required if the patient does not get better after a few minutes.

On average, people smell worse if they're sick

For a small 2014 research study, a panel was tasked with sniffing the smelly t-shirts of people who had been injected with a compound known to activate the immune system and those of controls without the shot. It found that those who were acting as if unwell (due to the injection) generally smelled worse. Subsequent work found that those who sniffed unpleasant odors had a mild immune response of their own—perhaps to protect them from disease. (Some users may experience a paywall.)

Fiber lasers used for metal engravings can’t burn your skin

These devices use diodes and mirrors to create pulses of light that vaporize metal in billionths of a second, though at wavelengths that cannot react with organic material. Pulse width, power, and speed adjustments can produce white, black, and even colored patterns through controlled heat reactions.

Pig-to-human transplant work has raised concerns about donor pigs' living conditions.

Needle-free polio vaccines were offered in Afghanistan for the first time in 2026

Fear of needles has been one barrier to eradicating polio in Afghanistan. Vaccinators are now using a needle-free jet injector to deliver the vaccine through the skin—an approach that's previously been used in other locations. The inoculation includes the inactivated virus vaccine (the vaccine without any live virus in it).

Sailor tattoos represent naval milestones

Sailors often come home with mermaids or turtles adorning their bodies. But what does it mean to have permanent images of propellers on your bum, British galleons with soaring tiers of sails on your chest, or a bicep portrait of the Roman god Neptune? Those tattoos represent meaningful naval milestones.

Tattoos suppressed during colonization are experiencing a revival

A few decades ago, the distinct facial tattoos worn by Maori people were on the brink of disappearing. Then, Maori artists brought the cultural practice back into the spotlight. This TVNZ story follows one reporter’s mother as, at 59 years old, she receives tā moko from a Maori artist.

Allergy tests identify antibodies, but not whether allergy symptoms may appear

Skin prick tests and blood tests, the two most common allergy tests, both detect the presence of allergen-specific antibodies. But just because the body has those antibodies doesn’t mean that a person is “allergic” to a substance or that they will develop symptoms of an allergy when encountering the substance. Allergists work with families to interpret the results and sometimes combine that data with approaches including exposure challenges—giving someone a tiny bit of the food or substance they may be allergic to—under medical supervision.

Yakuza gangsters' tattoos often portrayed moments from their lives

Although tattoos have been worn in Japan for centuries, no single group is more famous for their elaborate, full-body tattoos—featuring traditional Japanese art—than Yakuza gangsters. The criminal organization does not use tattoos to mark their association, though. Instead, the scenes are intensely personal.

Explore different pig-to-human xenotransplantation possibilities, including using pig pancreatic cells for treating diabetes.

An interactive explanation of blood transfusion

The antigens and Rh factors of blood cells (which determines your blood type) must be compatible with your immune system—which is why blood transfusions between patients must have matching types. In a mismatch, the immune system will attack and destroy donor blood cells, triggering a potentially fatal reaction.

Autoimmunity is when the body attacks itself, causing inflammation

Inflammation is the body's way of healing itself, and acute inflammation saves our lives when we have injuries or infections. It increases blood flow to the affected areas to bring immune cells to fight off invaders. This often results in short-term swelling, redness, and pain.

Alpha-gal allergy is a problem for red meat lovers, and that same alpha-gal sugar is an issue for xenotransplants, too—since it's present in pigs, human bodies reject pig-to-human transplants as foreign once they detect the substance.

Watch the safe way to remove a tick from your body

Minimizing your risk of Lyme and other tickborne diseases hinges on quickly removing ticks. To do so, place tweezers on the animal as close to the skin as possible and then pull directly upwards to try to avoid leaving bits of the tick's body behind. If possible, try to take a photo of the tick to share with your doctor to better identify potential disease risks (since certain tick species can carry specific diseases). Next, dispose of the tick without crushing it in your fingers—flushing it down the toilet, or placing it in alcohol or a sealed bag—and then thoroughly wash the bite area and your hands.

The world’s oldest tattoos belong to 'Iceman' Ötzi

Ötzi is the corpse of "the Iceman" found in the Alps along the Italian and Austrian border in 1991. His mummified body was covered with lines and crosses along the “hard-working” areas of his body, signifying their potential application for therapeutic pain management.

An interactive dive into the immune system

Our bodies are equipped with an incredible system able to fight off invasive pathogens to protect us from illness. The complicated system includes lymph nodes, the spleen, bone marrow, and even the tonsils. But this same system can turn against itself, a condition known as autoimmune disorders. Follow along with this thorough, engaging explainer on the human body's defense system.

Unlike food allergens, encountering inhaled allergens—like pollen—rarely causes life-threatening illness.

See this diverse list of vector-borne diseases

Human illnesses caused by parasites, viruses, and bacteria, and transmitted by a living organism—often small, bloodsucking ones like mosquitoes, ticks, and sandflies—are known as vector-borne diseases. That carrier is called a vector. These diseases disproportionately affect the poorest populations in tropical and subtropical areas.

We can get food poisoning from spending time in swimming pools, lakes, rivers, and ponds

Some of the same pathogens that may sicken us in food or water may also sicken us in recreational swimming environments. Bacteria can rub off of people’s (or animal’s) bodies or contaminate the water through a diarrheal episode. Washing your hands for at least 20 seconds before eating food if you are at the beach, pool, or other similar environments and being sure not to swallow the water are ways to help keep safe.

Ticks must typically be attached to a person for more than 24 hours to transmit Lyme

Infected blacklegged ticks must typically be attached to a person for more than 24 hours—and often closer to 36—to transmit Lyme. That period is enough time for the bacteria that causes Lyme to migrate from the tick's gut into the person's bloodstream while it's latched on through its bite. (There are rare documented cases of transmission under 24 hours.) Rapid removal of the tick is key to disease prevention.

A scientist successfully treated her own breast cancer by injecting the tumor with lab-grown viruses.

Home allergy tests don’t work well and experts urge caution

Doctors do not recommend at-home allergy test kits because their results may be inaccurate and confusing, and lead people to make lifestyle changes that are not warranted. Tests that require sending in a hair sample, for example, will not be helpful because hair does not have the relevant antibodies that blood testing would detect.

Pigments in paint can come from rocks, plants, insects or synthetic sources

Paint's composition is varied through the combination of pigments with binding agents. In the past, artists created their own paints by mixing pigments with water, oils or egg yolks to bind the colors together.

Mosquito necroprinting uses an insect's mouthpart as the printer nozzle

Mosquitoes are abundant, and their nozzles are 32-100 times cheaper to harvest than to create from scratch out of metal or glass. By coating the organic nozzle to increase its strength, researchers are employing necroprinting to create tiny structures at better resolutions than commercial alternatives.

Attenuated vaccines introduce a weakened version of the virus into the body

Some vaccines, like those for measles, rely on weakened versions of a virus. These weakened pathogens are introduced into the body, triggering an immune response and helping the immune system learn to protect itself against stronger versions of the virus. (This also explains why some vaccines make you feel under the weather.)

Learn how to make a print like pop artist Andy Warhol.

In 2015, a custom virus program was used to destroy and transform art images

At the Art Laboratory Berlin's "bOdy pandemOnium: Immersion into Noise" exhibit, Chicago-born artist Joseph Nechvatal explored viractualism—the interface between the biological and the technological—via a custom virus program that randomly altered images representing the human eye and rectum.

Particle beams can be used to alter the surface properties of artificial joints

Surface hardening and embedding specific elements or coatings can improve the biocompatibility and bone tissue integration of these implants. Particle accelerators are significant sources of the radioisotopes needed in medical diagnostics, and microwave linear accelerators are used in the majority of cancer irradiation treatments.

See why wearing earbuds—instead of over-the-ear headphones—can cause ear infections

Earbud headphones can heighten the risk of ear infections. They can lead to earwax buildup and create a dark, moist environment as you sweat—ideal conditions for germs to thrive. Wearing external over-the-ear headphones or ones that don't enter deep into the ear canal can help.

Less than 1% of Americans are allergic to penicillin, though about 10% of Americans believe they have this allergy.