Penicillin supplies were ready for every wounded soldier on D-Day

It took 14 years to deploy penicillin after its discovery

Despite its promise, US production of penicillin remained minimal in 1942—enough to treat fewer than 100 patients nationwide. Within two years, output expanded into millions of doses to supply troops for D-Day.

Penicillin production was just behind the atom bomb in wartime priorities

By 1943, the US War Department made penicillin its second-highest priority—just after the Manhattan Project. Producing enough of the antibiotic for the D-Day invasion became a central mission of Allied science and industry.

Penicillin slashed battlefield pneumonia deaths during World War II

Before antibiotics, bacterial pneumonia killed about 18% of infected soldiers in World War I. By World War II, penicillin cut that death rate to less than 1%.

Penicillin was hailed as a 'wonder drug' upon its release

When penicillin became widely available in the 1940s, newspapers and doctors alike celebrated it as a “wonder drug” that could cure infections once considered fatal.

The 'Penicillin Girls' made mass production possible

In Oxford during the early 1940s, six female technicians—later dubbed the “Penicillin Girls”—worked long hours tending mold cultures and extracting tiny amounts of penicillin.

Penicillin’s pioneers were awarded the Nobel Prize in 1945

Alexander Fleming, Howard Florey, and Ernst Chain received the 1945 Nobel Prize in Physiology or Medicine for discovering and developing penicillin.

Penicillin is considered one of history’s greatest medical breakthroughs

Experts widely rank penicillin’s discovery among the most important advances in medicine. It launched the antibiotic era, transformed once-deadly infections into treatable illnesses.

Penicillin has saved an estimated 500 million lives since its creation

Since its introduction in the 1940s, penicillin and related antibiotics are estimated to have saved around 500 million lives worldwide—making it one of the most consequential medical breakthroughs in human history.

Penicillin was discovered by accident

In 1928, Alexander Fleming returned from vacation to find mold contaminating a petri dish of bacteria. Around the mold, the microbes had died—an accidental observation that led to the discovery of penicillin.

D-Day, history's largest amphibious invasion, turned the war's tide

On D‑Day, over 156,000 American, British, and Canadian troops assaulted five heavily defended beaches along a 50‑mile stretch of northern France. Supported by nearly 3 million men, 1,200 warships, and 13,000 aircraft, the successful landings paved the way for the liberation of Western Europe and decisively shifted momentum against Nazi Germany.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

Most penicillin allergy diagnoses are wrong, leading to costlier, less effective treatments and contributing to the growing problem of antibiotic resistance.

Pneumonia was once a leading killer before penicillin treatments

In the early 20th century, pneumonia was a top cause of death worldwide, often fatal without effective treatment. Penicillin turned a once deadly infection into one of the most treatable bacterial diseases.

Penicillin’s discoverer predicted antibiotic resistance

Alexander Fleming’s discovery of penicillin revolutionized modern medicine. But the same man who pioneered the development of antibiotics also recognized that bacteria could make sntibiotics obsolete if they were used irresponsibly. This story sheds light on Fleming’s discovery—and on his prophetic warning about antibiotic resistance.

A moldy cantaloupe supercharged penicillin production

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

Less than 1% of Americans are allergic to penicillin, though about 10% of Americans believe they have this allergy.

Penicillin ended scarlet fever’s deadly threat to children

Between 1840 and 1883, scarlet fever was among the leading causes of childhood death in the United States, with case fatality rates ranging from 15% to 30%. Today, thanks to antibiotics like penicillin, the mortality rate is below 1%.

Civilian 'little ships' saved Dunkirk: over 700 civilian boats joined the evacuation

Between May  26 and June 4, 1940, Operation Dynamo evacuated roughly 338,000 Allied soldiers from Dunkirk, France. Crucially, over 700 civilian “little ships”—yachts, fishing boats, pleasure craft—ferried troops from the shallow beaches to larger vessels, embodying a national rescue effort and preserving the core of Britain’s army for the war ahead.

Penicillin works by attacking the cell walls of bacteria

Penicillin targets bacteria at their weakest point—their cell walls. By blocking wall-building, it leaves microbes unable to survive, causing them to burst and die.

Look through this WWI stretcher bearer's bag

While it was indeed the first industrialized war, medical science had yet to catch up on the battlefield. This nearly eight-minute video sorts through the contents of a World War I stretcher-bearer's satchel. A modern doctor and ex-officer assesses the bag's various medical tools for performing first aid on the battlefield.

2 months after Pearl Harbor, American libraries launched a drive to collect 10 million books for soldiers

The 1942 Victory Book Campaign—sponsored by the American Library Association, the Red Cross, and the USO—asked the public to donate books to both train and entertain troops. The national campaign exceeded its goal, collecting more than 10.2 million books.

Two-thirds of antibiotic classes were made between the 1940s and 1960s

The vast majority of bacterial treatments were developed during the "Golden Age of Antibiotics," an era of rapid innovation and drug discovery that led to the reduction of millions of deaths worldwide. Since 1970, only eight new antibiotic classes have been discovered.

The same mold behind penicillin also flavors blue cheese

There are over 300 species of Penicillium. The mold that produces the lifesaving antibiotic is a close relative to those used to make blue cheeses like Roquefort and Stilton and to flavor some types of ham.

Women's wartime suit features silk dyed with CRISPR-modified bacteria

Anna Dumitriu's bioart piece was created to commemorate the 75th anniversary of the first use of penicillin in a human patient and intends to raise awareness about the rapid development of antibiotic-resistant pathogens by using bacteria that have essentially been transformed into their pre-antibiotic era state.

10 items that could have saved your life in the trenches

Soldiers settled into trenches to defend themselves against shrapnel and bullets, but weapons such as mustard gas crawled along the ground and settled in these low-lying areas. Here are 10 items that could have helped you survive the trenches, according to this article.

Diphtheria was once a leading childhood killer before antibiotics and vaccines

In 18th- and 19th-century outbreaks, some New England families lost as many as eight children to diphtheria, and fatality rates in hospitals often topped 60%. The invention of antitoxins, penicillin, and vaccines dramatically reduced deaths.

World War II helped convince food companies to produce more processed foods

Processed foods had existed since the 19th century, but they began infiltrating the mainstream during World War II, with foods designed to last on the battlefield for days. After the war, food companies saw great potential in the relatively cheap foods aimed at busy households. (Some readers may experience a paywall.)

JD Salinger served in World War II while working on a draft of his most famous novel, 'The Catcher in the Rye.'

The food processing techniques developed for World War II, later repurposed for consumers

Research projects funded or sponsored by the military led to the development of active dry yeast to make bread easier to bake and an improved version of dehydrated cheese, which would be used in powdered cheese snacks. Freeze-drying, which had been used to ease the transport of blood plasma to battlefields, where it would be reconstituted with water, was later used on fruit for cereals.

A book series aimed at World War II soldiers helped popularize works like 'The Great Gatsby' and 'Of Mice and Men.'

The USS Nevada was refloated within three months—and later fought at Normandy

Badly damaged at Pearl Harbor, the USS Nevada was raised by February 1942 after extensive salvage work. Repaired and modernized, it returned to action and bombarded German defenses during the D-Day landings.

Two-thirds of soldier deaths during the war were due to disease

Roughly two-thirds of all Civil War deaths resulted from disease rather than battle. Poor sanitation, contaminated water, and limited medical knowledge made camps breeding grounds for dysentery, typhoid, and other deadly infections.

See what it was like to live in the United States during World War II

In America, life was transformed by total war: sixteen million service members left civilian life, while massive industrial production demanded labor. Women, minorities, and teens filled factories, fueling boomtown growth and breaking social barriers. Simultaneously, rationing, recycling drives, Victory Gardens, ration stamps, blackout drills, and war bond campaigns permeated daily routines.

Germany’s surprise offensive in December 1944 failed to break Allied lines

In a bold counterattack from December 16, 1944, to January 28, 1945, Hitler committed over 400,000 troops in a surprise “Bulge” through the Ardennes forest in France. Although initially successful in creating a 50‑mile incursion, Allied defense halted the advance. German forces suffered irrecoverable losses (~100,000), while Allied casualties totaled ~75,000, marking the offensive as the last major German gamble and a decisive step toward Nazi defeat.

World War II soldiers received specially-made vinyl records

"V-Discs" were vinyl records featuring popular folk, classical, and jazz songs. This was one of the first widespread uses of vinyl, rather than shellac, records.

What was the typical dinner like for US soldiers during WWII?

This odd little nearly 20-minute video details the very excited narrator's unpacking of a 1943 package of K rations. Such meals would have been consumed by American soldiers during World War II. A fascinating look at what soldiers had to depend on for nourishment, made slightly harder to watch by showing the narrator eating 80-year-old biscuits and more.

When German submarines lurked in US coastal waters

During World War II, German submarines (also known as U-boats) prowled the Southern coast of the US in 1942 and 1943, sinking more than 60 ships and killing 600 Allied soldiers. The campaign is less well-known, since the major battles in Stalingrad and Midway happened at the time. Several of these submarines and the ships they sank are now popular diving spots.

Champagne played a role in resisting the Nazis

When France surrendered to the Nazis in 1940, the invaders occupied the north. This was home to wine regions like Champagne and Bordeaux, which the Nazis were eager to loot. Winemakers took a stand by sheltering dissidents in their cellars, passing intelligence across borders, and even giving their lives to the cause.

Besides allowing patients to see how much medication they had left, transparent orange pill bottles were introduced in 1968 to protect medications from degradation caused by ultraviolet radiation.

Marie Curie developed and trained women to operate mobile X-ray units in World War I

The “petites Curies” allowed medical professionals to identify the severity of wounds without transporting soldiers to medical facilities, expediting treatment and saving lives. The efforts of Curie and other women led to expansions in their rights after the war.

How slugs helped soldiers during WWI

Slimy, squishy, slow-moving, and heroic? Slugs are land-dwelling mollusks known mostly for causing havoc in our gardens. But during World War I, slugs saved numerous soldier's lives as poison gas detectors. Learn how the unpleasant creatures earned their stripes in the battle to protect soldiers from chlorine, phosgene, and mustard gas as organic detectors.

How Chef Boyardee fed America

Chef Boyardee wasn’t just a grocery store staple—it was once a key supplier for US troops in WWII. Founded by Italian immigrant Hector Boiardi, the company produced thousands of canned pasta rations daily.

Exploring World War I technology on the battlefield

Industrialization brought massive changes to warfare during the Great War. Newly-invented killing machines begat novel defense mechanisms, which, in turn spurred the development of even deadlier technologies. Nearly every aspect of what we would consider modern warfare debuted on World War I battlefields. Starting with soldiers on horseback carrying lances and ending in poison gas, machine guns, and aerial battles, this gallery shows the first tools of modern warfare.

Drug-resistant infections worldwide have increased by about 65% since 2000

Since 1990, antibiotic resistance has claimed at least one million lives annually and is projected to account for 39 million deaths between now and 2050 if current trends continue. The expanded use of antibiotics, particularly in agriculture, combined with a slowing pipeline of new drugs has led to the crisis.

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

Lyme disease-causing bacteria predate any suspected biological weapons testing

Borrelia bacteria existed long before any US biological weapons program—or human presence in North America. One study comparing genomes of the bacteria behind Lyme disease collected samples of the bacteria over three decades and calculated that the bacterium has been in North America longer than humans, at least 60,000 years. Other work found related bacteria preserved in amber from millions of years ago.

Superbugs could claim 1.9 million lives per year by 2050

The increased use of antibiotics combined with an aging population, is projected to result in an almost 50% increase in global deaths from antimicrobial resistance each year. At the same time, antibiotic use for livestock is expected to increase by 30% over the same time frame.

Riveting artwork from the battlefields during World War I

During World War I, the United States government commissioned eight artists to accompany American Expeditionary Forces to Europe to sketch and document what they saw. Drawing tanks, soldiers, shattered villages, and even German prisoners of war, the artists preserved much of the war as a matter of historical record and to rally support back home.

Before Pearl Harbor, the US was a nonbelligerent ally to the Allied powers

Between September 1940 and December 7, 1941, the United States remained officially neutral—yet President Roosevelt incrementally shifted policy from “cash‑and‑carry” to Lend‑Lease, funneling critical military aid to Britain and other allies without entering the war.

Germany’s invasion of Poland in 1939 launched World War II

On September 1, 1939, Nazi Germany launched a surprise invasion of Poland using blitzkrieg—coordinated air bombardments and armored assaults—to overwhelm Polish defenses within weeks. This lightning-strike strategy shocked the world and signaled both the start of World War II and a revolutionary shift in modern military tactics.