What a railroad spike through the head taught science about the brain

Everything you know about Phineas Gage is wrong

A stray spark sent a 3.5-foot-long, 1.25-inch thick iron rod through the brain of foreman Phineas Gage in 1848, creating a scientific case that has attracted onlookers for nearly two centuries. His life reportedly soon spiraled out of control, with his behavior tending toward selfishness and chaos. Evidence of these changes is far less common, with Gage's story bloated by fabrication, scientific prejudice, and artistic license.

How a brain injury created a mathematical mind

In 2002, two men savagely attacked Jason Padgett outside a karaoke bar, leaving him with a severe concussion--and turning Padgett into a mathematical genius.

A brain scientist's experience with a stroke

What happens when a leading brain scientist has a stroke of her own? Dr. Jill Bolte Taylor recounts moment by moment watching her brain function slow and then cease, followed by a prolonged recovery. Through this experience, she details what she learned about the phenomenon of stroke and how it has impacted her research ever since.

The impact of gravitational force on our bodies surprised early coaster riders and engineers

There is only a certain amount of gravitational force that the body can handle before dealing with consequences like short-term vision loss or unconsciousness. Increased scientific understanding has largely reduced these impacts, with engineers combining periods of intense pressure with periods of relief.

Everything scientists could learn by looking at your skull

Our skulls are all unique, but they also share characteristics across groups of people. In the absence of fingerprints, forensic scientists can learn a lot about you just from your skull.

Did a Smithsonian anthropologist steal people's brains?

This comic examines "racial brain collection" of Ales Hrdlicka, the Smithsonian's head of physical anthropology during the early 1900s. Hrdlicka was a white supremacist who sought physical evidence for his theories on anatomical differences between...

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

The history of skull modification

The ancient Maya people sometimes modified their skulls to appear more conical. Body modification has been a human pastime for literal ages, from piercings to bindings and everything in between. Modifying one's skull shape may have been a way to symbolize status, beauty, belonging, or belief. The health impacts of such practices are still debated. This article explores the history and health impacts of skull modification, also known as artificial cranial deformation.

An interesting perspective on whether (and how) brain size matters in cognitive ability

Some brains are bigger than others, but what is the relevance, if any, to brain size and intelligence? This Scientific American article explores the question and offers examples. It also visually compares frontal slices of several mammals' brains, showing that humans don't necessarily have the biggest cerebrums on the block.

Medical recognition of strokes stretches back to ancient Greece

Every minute, 750 milliliters of blood flows to the brain, supplying 20% of the body’s oxygen. A sudden disruption—whether from a clot (ischemic stroke) or a bleed (hemorrhagic stroke)—can be life-threatening. From ancient Greek theories to modern CT and MRI scans, here’s how stroke science has evolved over time.

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

Searching for Albert Einstein's stolen brain

Within moments of Einstein's 1955 death, someone reportedly ferreted away the 76-year-old genius's brain. Decades later, a reporter's editor told them to solve the case. This 64-minute podcast episode follows the work of Steven Levy, the reporter who ultimately tracked down Einstein's brain, which had been sliced and stored in slides, goo, and a cardboard box in a scientist's office.

The role of fire in the evolution of humanity's big brains

Roughly 1.5 million years ago, the brain size of our hominin ancestors exploded. To understand why, Richard Wrangham posited the cooking hypothesis, arguing the adoption of fire as a means to cook food had a lasting impact on our ability to digest...

A 36-year-old Russian physicist survived a particle accelerator beam to the head

Several safety mechanisms failed during Anatoli Bugorski's inspection of malfunctioning equipment at the U-70 synchrotron, the Soviet Union's largest particle accelerator. Despite receiving as much as 600 times the lethal dose of radiation to the brain, he has shown no intellectual damage and worked until the age of 77.

The history of brainwashing in America

"Brainwashing" refers to a coerced shift in worldview, often associated with cults or oppressive totalitarian governments. Though such processes are not well understood on a neurological level, they hold an outsized role in public imagination, particularly in science fiction and dystopias. This article reviews the history of the term, first popularized by Edward Hunter in 1950, and the subsequent use of the approach in pop psychology, the CIA, and more.

How brain cells carry information

At any moment, there is an electrical storm coursing through your body. Discover how chemical reactions create an electric current that drives our responses to everything from hot pans to a mother’s caress.

Psychedelics set off a flurry of brain activity that may permanently alter it

The brain seems to experience a sharp increase in communication between areas that generally don't interact. New research suggests a thin, sheet-like gray matter structure tucked deep within the brain, between the insular cortex and striatum, may be the key to this change. The area is centrally located and home to many of the receptors that psychedelics target, potentially rewiring the brain and rewriting thought patterns.

'Susan's Brain': what happens to the brain during addiction

This engaging animation from Harvard Online breaks down the neuroscience of addiction through the story of “Susan’s brain,” demonstrating how addictive substances hijack normal reward pathways. Through clear visual metaphors and approachable narration, it explains complex brain chemistry in understandable terms.

The evolution of the human brain

The human brain, in all its staggering complexity, is the product of millions of years of evolution. Read on to find out about brain size and intelligence, language and brain development, and more.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

Patient H.M. revealed that the hippocampus was responsible for memory formation

Henry Molaison became a landmark case in psychology after surgery removed large portions of his hippocampus, leaving him unable to form new memories. Upon his death, Molaison's brain was sliced into 2,401 sections and digitized for research.

Discover how strength training may help your brain and what happens inside your cells when you work out with this original '1440 Explores' podcast.

How alcohol rewires your brain

Alcohol doesn't just make you tipsy—it rewires your brain chemistry in real time. It slows your brain with GABA, spikes dopamine to make you feel unstoppable, and blocks glutamate so you can't form memories. That mix explains everything from slurred speech to blackouts … and brutal hangovers.

Physiological changes to the brain on LSD can be captured via MRI

Psychedelics like LSD often take users on novel experiences that can result in lasting shifts in perspective and behavior. See how LSD affects brain activity in this video that details how scientists visually captured the psychedelic's effect for the first time.

How science explains déjà vu

Take a fun look at the science explaining the odd experience of déjà vu, which some theories suggest is actually a sign of a healthy brain.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.

Synaptic plasticity allows neurons to communicate effectively and form memories

First proposed in 1949, synaptic plasticity allows the brain to adjust communication strength between neurons. This ability to change synaptic strength—either briefly or over long periods—is essential for learning and memory, with long-term synaptic plasticity forming the basis of how memories are stored.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

Brain death is a uniquely modern problem stemming from modern ventilators.

In 1968, a Harvard Medical School committee issued the first neurological definition of death

The definition set a legal and medical precedent for how we define death, important for issues including organ donation. This 2020 video podcast discusses the history of brain death controversies and the variability in how death has been determined, including discussions in the late 1960s about when patients are considered dead in the context of organ donations.

Explore an interactive 3D model of the brain

The brain contains about 86 billion neurons—nervous system cells—and controls vital bodily functions via electrochemical signals. Neurons form circuits through axons, and different brain regions use these circuits to perform specific tasks.

Pig brain cellular activity was restarted hours after death in study published in 2019

Yale University scientists restored basic cellular activity and circulatory function in pig brains about four hours after death with a synthetic cocktail of preservatives and nutrients. This work— which didn't restart electricity activity in the brain or consciousness—could help advance future human stroke and brain injury treatments.

The Civil War turned the Continental Divide into an American symbol of identity

Historians argue that the boundary only became a celebrated American symbol in the 1860s, when Civil War-era leaders promoted a west-east geographic divide to replace the devastating north-south political divide, and that the term's use spiked after the transcontinental railroad crossed it in 1868.

What a tiny marine worm can tell us about our brains

Meet the amphioxus, a small eel-like animal that has a lot to teach us about brain evolution. The genetic roots of our brains can be seen in these unusual creatures. This three-minute educational video focuses on the evolutionary history of the human brain through these odd little critters with a 500-million-year-old history.

Traumatic brain injury is a leading cause of brain death—and TBIs are trending up

Traumatic brain injury-related deaths have generally increased between 2000 and 2023, growing from roughly 49,000 to more than 68,000 in 2023. Firearm-related suicide is the most common cause of TBI-related deaths in the US, according to the Centers for Disease Control and Prevention. People also experience TBIs from falls, motor vehicle crashes, or assaults.

Why the human brain loves opioids

When opioids enter the brain, they dock in receptors, blocking electrical pulses such as those that communicate pain. They also trigger the release of dopamine, a neurotransmitter tied to motivation and associated with stress relief.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

Like fingerprints, brain anatomy is unique too

Researchers have discovered that a combination of experiences and genetic factors shape the anatomy of the human brain. They found even quick experiences affect the brain’s genetic makeup, which—over time—means every person develops a completely unique brain anatomy. While brain imaging could be used to identify individuals, it remains much more expensive than fingerprinting for now. Read to found out more about this study from the University of Zurich.

Why human brains were bigger 3,000 years ago

Our modern civilisation may be the most advanced to ever exist on Earth, but around 100 generations ago, our ancestors had brains that were larger than our own.

Brain-computer interfaces create a direct link between the brain and external devices

The technology enables users to control prosthetics, computers, or even games using only their thoughts. In 2021, a monkey played table tennis using only its brain, thanks to a Neuralink device, marking a major milestone before human trials began in 2024.

Experience a century of America's healthcare advances with this medical visualization, tracing a sampling of healthcare innovations from head to toe.

NASCAR’s SAFER barriers help reduce tragedies at races

Following the death of Dale Earnhardt Sr. in 2001, NASCAR changed its culture to be safety-first. Part of its changes were to install barriers along tracks that would help absorb the majority of g-forces in a crash. This Daily Downforce article walks through the history of the SAFER barriers, why NASCAR originally chose concrete, and how much of the tracks are covered today.

Chronic drug use can cause neurological changes in the brain

Neuroscientist Judy Grisel breaks down the biology of addiction, examining how drugs hijack the brain’s natural reward system and create lasting neural changes. The physiological and neurological impacts of chronic drug use require a multifaceted treatment approach.

The body's response to cardiac arrest has been linked to near-death experiences.

Watch this 2021 video demonstrating a full brain death examination

This video and accompanying article in the peer-reviewed New England Journal of Medicine show the then-standard steps of a full brain death examination—demonstrating the process on a medical dummy to search for pain, blinking, eye movement, cough, gagging, or other forms of responsiveness. (May need to sign up for a free account to view.)

Repeated head injuries, which may occur in collision sports at the youth, amateur, and professional levels, can lead to CTE and early dementia.

A man survived being struck by lightning seven times

Roy Sullivan worked as a park ranger when he was first struck in April 1942 while fleeing a watchtower during a thunderstorm. Nicknamed the "Spark Ranger," he would be struck six more times while driving, in his garden, working in a guardhouse, sitting in his car, walking, and on a fishing trip.

Phantom limb pain may often match the pain or contortion of the injury that led to the limb loss.

Researchers are studying roller coasters to improve mental health treatments

Scary rides stimulate our fight-or-flight response while simultaneously releasing feel-good endorphins like dopamine, serotonin, and oxytocin. Once we realize we're in a safe space, we can enjoy the ride and even feel confident and relieved by the accomplishment of overcoming a fearful feat.

What's with the teen brain, anyway

In this video NIDA explores the intriguing similarities between the processes of brain development and computer programming. This analogy helps us understand why toxic environmental factors like drugs, bullying, or lack of sleep strongly affect a teenager's life The information provided by this video can empower your children or students with information they need make better decisions.