Autoimmune Diseases

How autoimmune diseases, which attack your own tissues and cells, work in the body

These diseases remain some of medicine's thorniest problems because the immune system can mistakenly attack almost any tissue in the body, resulting in myriad diseases, including lupus (numerous tissues affected), Hashimoto's (thyroid), and MS (the nervous system).

Autoimmune diseases affect between 5% and 10% of people worldwide, but their causes remain unknown

Autoantibodies—which attack the body—may be detectable in the body years before a patient develops symptoms, but some people may have detectable levels yet never go on to develop an autoimmune disease. This video discusses this and other unsolved mysteries with autoimmune disease.

Autoimmune disease prevalence and incidence are on the rise—but no one knows why

Researchers theorize that environmental factors, including shifts to less healthy diets, air pollution, infections, stress, climate change, and exposures to xenobiotics—substances like pesticides, plastics, and toxins that incite immune responses—may all be fueling epigenetic changes to our bodies that make people's immune responses go awry.

More than 5 million Americans have more than one autoimmune disease

Overall, about 4.6% of the US population—15 million people—have an autoimmune condition. Some common examples include rheumatoid arthritis, psoriasis, type 1 diabetes, Grave's disease, and autoimmune thyroiditis.

Why CAR-T therapy has become one of the main focus areas for autoimmune diseases

The therapy, originally targeting cancer, involves taking a patient's own T cells, genetically reprogramming them to recognize and attack a specific target and then infusing them back into patients. For autoimmune diseases, the therapy instead programs them to target immune cells that are causing problems, restoring immune system tolerance.

Autoimmunity is when the body attacks itself, causing inflammation

Inflammation is the body's way of healing itself, and acute inflammation saves our lives when we have injuries or infections. It increases blood flow to the affected areas to bring immune cells to fight off invaders. This often results in short-term swelling, redness, and pain.

Learn about the more than 100 known autoimmune diseases

Explore this resource with summaries and related resources for the dozens of autoimmune diseases defined in the medical literature. Many of these disease write-ups also have interviews with a patient with the disorder—offering a personal take about challenges, advice, and lifestyle effects.

Almost 80% of people diagnosed with autoimmune diseases are women

Yet it's still unanswered what may account for that difference. To better understand this disparity researchers are exploring factors including hormonal changes that occur around puberty, pregnancy, and menopause, as well as gut microbe differences, and aspects of X-chromosome protein-coding genes. (Some users may encounter a paywall.)

Autoimmune disorders are one of the top 10 killers of young and middle-aged women

Studies in the US and the UK, though conducted decades ago, have underscored that autoimmune diseases, when grouped together, are a top killer of women.

Women typically have more robust immune responses than men

This difference helps women better combat infectious diseases, but this more turbo-charged response may also make women more vulnerable to autoimmune diseases by potentially priming their immune systems to overreact to their own cells and tissues and label them as invaders that must be destroyed. Roughly 80% of American women have autoimmune conditions.