Large animals like giraffes and elephants have evolved unique cancer defenses.

Cancer is a group of diseases characterized by the uncontrolled growth of abnormal, mutated cells that can spread throughout the body.

Environment and genetics explain why animals have widely different lifespans

Both environmental conditions and genetic factors shape how long various animals live. For some creatures, colder conditions allow for less energy use and slower aging. Larger animals have fewer predators. While humans don't live the longest, we are a rare species that successfully lengthened its average lifespan over time.

Dinosaurs suffered from cancer, arthritis, and infections seen in modern animals

Using CT scans and advanced pathology techniques, paleopathologists have identified respiratory illnesses, malignant osteosarcoma, and other diseases in dinosaurs. The research has helped show how many of these ailments are not exclusively modern phenomena.

The immune system is in a constant fight to detect and eliminate cellular mutations.

Low cell division rates in heart cells make heart cancer particularly rare

The heart's location in the chest also offers protection from external cancer-causing factors. The disease affects about 3 in every 10,000 people, though most cases arise from metastasis from other body parts.

The earliest evidence of cancer was found in a 1.7-million-year-old fossil—discovered in the toe of an ancestor of modern-day humans.

There are hundreds of subtypes of cancer, making a universal cure nearly impossible.

Cells cannot grow forever due to escalating inefficiency in transporting chemicals

As cells get larger, their volume grows much faster than the surface area through which nutrients and waste products pass, creating a bottleneck that eventually causes cells to die. This forces nearly all organisms visible to the naked eye to comprise enormous numbers of smaller cells, such as the approximately 30 trillion found in the average adult human.

Why don't giraffes get hypertension?

The average blood pressure of a giraffe is about double that of a human, yet they don't suffer from the symptoms of high blood pressure that humans do: stiffening of the left heart ventricle, shortness of breath, fatigue, or swollen legs and ankles. This article explains how giraffes have evolved to have the "biological equivalent of support stockings."

Some animals, including certain tropical ants, have little or no microbial populations in their gut, upending the idea that all animals rely on this ecosystem to help maintain their health and proper functioning.

Cancer is typically broken down into four stages influenced by tumor size, the presence of cancerous cells in the lymph nodes, and the extent to which the malignancy has spread to other organs in the body.

How does cancer spread through the body?

Cancer usually begins with one tumor, but it can spread to other organs if not removed. This video breaks down how cancer moves to these new areas and why some organs are more likely to get infected than others.

Lung cancer advances are making a big difference

Lung cancer deaths are declining faster than new cases due to advances in treatment. The progress illustrates what is possible, even for a cancer that has long had a poor prognosis.

Mammals gradually expanded in size and diversity after the dinosaur extinction

After an asteroid impact caused a mass extinction event 66 million years ago, small mammals were among the few surviving species. With fewer predators, mammals steadily grew larger as new habitats emerged.

An interesting perspective on whether (and how) brain size matters in cognitive ability

Some brains are bigger than others, but what is the relevance, if any, to brain size and intelligence? This Scientific American article explores the question and offers examples. It also visually compares frontal slices of several mammals' brains, showing that humans don't necessarily have the biggest cerebrums on the block.

Searching for the history of cancer in ancient human bones

Nestled under archaeology lies bioarchaeology, which involves the study of bones, human or animal. This subfield recently birthed another field of study: paleo-oncology. Paleo-oncology looks for cancer and related biomarkers in bioarchaeological remains. This TED article explains how this nascent multidisciplinary field challenges the idea that cancer is modern.

How race science influences breast cancer research

Despite researchers' and physicians' pushback, race is still used in studies and clinics to categorize human differences in health conditions and treatment responses. This article explores how race has influenced breast cancer research. Considering race as a factor in cancer research, diagnosis, and treatment can lead to racial inequalities. Sociocultural factors, including food access and air pollution, greatly influence health outcomes.

Why do humans have such long childhoods?

Humans have over twice as long childhoods than other animals with similar lifespans like whales and elephants. A human child can grow for nearly 20 years before they become a reproducing adult. Researchers believe there's a connection between long childhoods and human's unusually large brain size, though the science is not totally clear. Dive into what scientists know here.

A new type of immunotherapy focuses on healthy cells hijacked by tumors

Purdue University scientists are at work on a new cancer treatment that attacks immune system cells that feed and protect cancer cells rather than attacking them. The immunotherapy process promises to become a universal treatment for solid tumors. Thus far, the treatment has been tested and shown to work on human tumor cells in the laboratory and animal models.

The term 'cancer' is roughly 3,000 years old and derives from the Greek word for 'crab,' which may refer to how a malignant tumor can feel like a hard shell.

Relative to its size, the world's strongest animal is the dung beetle, which can lift over 1,100 times its body weight, though the African bush elephant can lift the most weight among animals.

As immobile animals, corals and the organisms that live on them have evolved a suite of chemical compounds to prevent disease and ward off predators they cannot outrun.

Combining two cancer drugs increased the life space of mice by 30%

A study shows trametinib and rapamycin, two drugs used for cancer treatment in humans, increased mouse lifespan when used together. The medications delayed the onset of cancer and reduced chronic inflammation, results that will be explored in future research.

Air sacs and lightweight bones helped some dinosaurs grow to enormous sizes

After the Triassic extinctions, new species with birdlike anatomy evolved from smaller, early dinosaurs. This anatomy allowed for more efficient breathing and lighter skeletons, favoring the evolution of larger organisms.

Immunotherapy focuses on boosting the immune system to fight cancer

The immune system detects and destroys abnormal cells, curbing the growth of many cancers. Immunotherapy works to boost the body’s immune system to target and kill cancer cells. There are many ways to accomplish this, including adaptive cell therapy, checkpoint inhibitors, vaccines, and monoclonal antibodies.

Why don't we all have cancer?

The creation of a single cell produces 120,000 genetic mutations that can lead to cancer. This video investigates how our bodies proofread and autocorrect those mistakes.

Humans are more genetically similar to cats than to dogs

While humans are not closely related to either cats or dogs from an evolutionary standpoint, scientists find that human and cat chromosomes are organized more similarly to each other than human and dog chromosomes, making cats a better model for studying human diseases.

Tigers emerged much earlier as a species than lions

Both lions and tigers are iconic big cats known for their size and power, but they remain distinct species. Beyond just looking different, they can exhibit very different behaviors. For example, tigers are significantly less social than lions, who live in social matriarchal groups. Tigers and lions are unlikely to ever interact in the wild, but humans have artificially bred them in captivity, creating a "liger."

Georges Cuvier used his knowledge of anatomy to prove extinction had occurred

Extinction had been viewed as impossible because a divine plan for the world would not rationally involve the loss of any of God’s creations. However, mammoth and mastodon bones differed from elephants’, and it seemed impossible that such creatures could be hiding elsewhere on Earth.

Six pigeons were trained to detect cancer from looking at CT scans—now that work is the basis for training new AI medical tools.

Uncovering the evolution of history's largest dinosaurs

This article details how sauropods—the dinosaurs that Little Foot would call longnecks—repeatedly evolved to attain such colossal sizes, towering over other land critters, including tyrannosaurs and mammoths. Sauropods were giant, long-necked...

Advanced drugs are closing in on cancer's deadliest mutations

The protein KRAS, mutated in many cancers, was deemed ‘undruggable’. Now scientists are hoping to save lives with a batch of new compounds that target it.

Kangaroos evolved exceptionally thick knee cartilage to absorb shock, and scientists are studying the animals for potential insights about how to safeguard human knees against arthritis.

The halting of human bone growth helps manage heat produced from metabolism

While fish, amphibians and reptiles get bigger throughout their lives until they die, their slower metabolisms allow their bodies to regulate the resulting smaller temperature increases. In humans, hormones triggered during puberty harden growth plates, ending bone lengthening.

mRNA vaccines alter immune response, not DNA, to combat diseases like cancer.

About 40% of cancer cases are linked to preventable risk factors

Maintaining a healthy weight, engaging in regular physical activity, and consuming a balanced diet can lower cancer risk. Research indicates that about 40% of US cancer cases are linked to preventable factors, including poor diet and inactivity. Understanding these mechanisms empowers individuals to adopt healthier lifestyles for cancer prevention.

Cancer rates are on the rise among GenXers and Millennials

Cancer rates are rising among Gen X and Millennials, with more cancer diagnoses being made in their 30s and 40s than previous generations. Factors such as prenatal exposures, environmental toxins, and lifestyle choices may contribute to this trend. Memorial Sloan Kettering Cancer Center's experts discuss these issues, exploring how these insights could reshape cancer risk understanding.

In the 1950s, Alan Turing developed a mathematical model to explain why animals have stripes, spots, and other patterns based on differences in how quickly two interacting chemicals spread throughout a developing organism.

Why have birds never become as large as a T. rex?

Birds are descended from dinosaurs, but none have ever reached the gigantic size of their Jurassic ancestors. Some birds in the fossil record, like the "terror birds" of South America, have reached as large as ten feet, but the energy-intensive act of flying disallows birds much larger than that. Researchers claim a lack of evolutionary pressure and predatory bird behavior likely limit bird size.

Using deep learning to analyze tumors

The explosive growth of life sciences data is driving artificial intelligence methods to gain traction in biology and medicine — including cancer research.

Cells become cancerous if checkpoints in the cell cycle are damaged

Before cells divide, a protein called p53 can halt the cell cycle if damaged DNA is identified, preventing the fault from propagating to daughter cells. If p53 and other tumor-suppressing molecules cannot function due to mutations or other instabilities, damage can accumulate over successive generations until nothing stops cells from dividing uncontrollably, creating tumors.

What is cancer bioengineering?

While new treatments for cancer are under continuous development, researchers are increasingly using engineering principles to find wholly new strategies to combat the disease. Directions include nanoparticle drug delivery, advanced imaging tools, developing new materials to interact with cells, tissue engineering, robotic surgeries, and more. Such interdisciplinary efforts are expected to unlock new tools and therapies beyond traditional drug formulation.

Metastasis: When cancer cells begin to travel through the body

Metastatic cancer starts in one part of the body and moves to another over time. This is known as metastasis. Such cancers are much more harmful since they attack multiple parts of the body, adapting new metabolic changes to suit the various environments found throughout a body.

Many cancers arise from genetic mutations inherited from your parents

These mutations may happen in response to environmental or lifestyle factors, or may be passed down through family members. Genetic testing can be important in catching certain family cancers early and ensuring patients receive the right treatment for their disease.

How snake biology allows them to eat prey larger than they are

Possessing flexible skulls with elastic ligaments and unfused jaw bones, snakes can open their mouths to engulf much larger prey, and adjustable airways enable them to continue breathing while their teeth grip onto their food. Through slow digestion and specialized cells that decompose bones, some snakes can survive on a single large meal for over a year.

Evolution doesn't want you to see these animals

Invisibility is an oft-coveted superpower that many creatures throughout the animal kingdom have evolved to mimic through transparent camouflage. This article explores the science of this seemingly magical ability. The two critical ingredients in...

Some animals seem to live well on little sleep

African bush elephants typically sleep for about 2 hours per 24-hour day, coming in well under a human's recommended seven-hour minimum. Other animals also appear to skimp on sleep, by human standards, without the consequences humans associate with being sleep deprived. This academic article details the sleeping habits of animals that appear to thrive on fewer than 40 winks and explores whether their sleep processes are just built different.

Scientists now know that Henrietta Lacks, a Black woman whose 'immortal' cancer cells were nonconsensually sampled and used for research, had been infected with human papillomavirus, a group of pathogens responsible for most cervical cancers.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Timeline of cancer research milestones

While cancer remains incurable, there's been so much progress in its treatment over the last two decades. Nature provides an abridged history of milestones and major triumphs in cancer research and treatment. Start in the year 2000, and see how much has changed in the first quarter of the new millennium