Some animals, including certain tropical ants, have little or no microbial populations in their gut, upending the idea that all animals rely on this ecosystem to help maintain their health and proper functioning.

There are up to 100 trillion microbes in the gut, and maintaining the relative balance in this ecosystem is important for our health.

Trillions of bacteria, viruses, fungi, protists, and archaea live in our guts, producing a wide range of molecules, hormones, and more—underscoring the immune system's pivotal role in the microbiota-gut-brain axis.

The gut microbiome—a complex community of up to 100 trillion microbes—has a changing composition, influenced by our life stage, diet, medications, environment, and other factors.

What is the gut microbiome?

The gut microbiome is a microscopic ecosystem that runs off the work of microbes in the digestive tract. These workers make getting energy from food possible. What and how that energy manifests depends on what building blocks these microbes have to work with, meaning their composition and functions are strongly influenced by diet. Gut microbes have their own genes, which affect how a person's genes act.

How the microbiome affects your health

The gut microbiome is so influential to overall human health that some researchers consider it a separate organ. Its conditions, influenced by environmental and lifestyle factors such as medication and exercise, contribute to immunity, metabolism, inflammation, medical treatment efficacy, brain development and function, and the development of disorders and diseases, including asthma, depression, inflammatory bowel disease, and Alzheimer's.

In 2026, University of Cambridge researchers reported that a group of gut bacteria called CAG-170 may be a key marker of good health, occurring far more often in healthy individuals and less commonly in people with chronic diseases.

Researchers generally group gut bacteria into six different categories, with varying amounts of these microbes residing in different parts of the digestive tract.

Gut microbiome experiments involving transfers of gut microbes from depressed people to rodents indicate that the rodents may then display depression-like symptoms.

Gut bacteria are evolving and can acquire as many as 100 new genes per year, on average.

Gut microbiome rewrites may help reduce allergies

Researchers are investigating different strategies to determine if one day they could give people a combination of gut microbes to set them up for fewer allergies. In animal research, scientists have already prevented severe allergic responses in allergy-prone mice—supplying them with gut microbes from healthy, non-allergic human babies.

What happens when the gut microbiome is out of whack?

An imbalance in gut microbiome flora can lead to a condition known as dysbiosis. This condition is typically characterized by a drop in microbiota diversity and an increase in harmful unicellular and acellular organisms, such as viruses, that can negatively impact the host's immune system and overall health. Genetics, infections, dietary choices, antibiotics, food additives, artificial sweeteners, and other lifestyle and environmental factors can cause dysbiosis.

Scientists have found that the Great Barrier Reef's microbiome includes an estimated 362,802 distinct viruses and 876 distinct bacterial and archaeal species—584 of which had never been documented before 2026.

A technical review of what researchers know about the gut microbiome

This overview from the National Institutes of Health provides a deeper (but still accessible) look at the different bacteria in the gut, how the microbiome develops through life, its purpose, and more.

What is a microbiome (and why are they important)?

Jump to: What is the microbiome? How microbiota benefit the body The role of probiotics Can diet affect one’s microbiota? Future areas of research What is the microbiome? Picture a bustling city on…

What constitutes a 'healthy' diet?

A natural diet, typically high in plant-based foods and low in processed foods, appears to be the main contributor to a healthy, diverse gut microbiome.

Microbial research suggests shifts in diverse populations may help an invasive species establish itself

In 1958, English ecologist Charles Elton suggested that diverse ecosystems should be more resistant to invasive species because gaining a foothold would be more challenging when resources are more thinly spread. However, in lab-grown microbial ecosystems with greater biodiversity, population volatility opened more ecological roles that invasive species could easily fill.

Can the gut microbiome drive addiction?

New research suggests an imbalance of gut microorganisms may influence the likelihood of addiction and addictive behaviors by increasing the severity of withdrawal symptoms, triggering brain inflammation in regions of impulse control, and more.

What's next for gut microbiome science?

A Stanford microbiologist explores what we don't yet know about the gut microbiome—such as whether we can engineer the bacterial species within it—and the current scientific advances in the field.

The reason some people love exercise may be because of their microbiome

Certain gut microbes in mice trigger dopamine release and drive motivation to exercise more. Scientists are investigating whether humans carry similar microbial patterns that influence our natural inclination towards movement, exploring how unseen microbial ecosystems may shape mammalian fitness behavior and reinforce innate reward pathways. (Some users may experience a paywall.)

The gut microbiome's community of viruses is collectively known as the virome, but most of its viruses remain unidentified.

Exercise causes diet-independent changes in the gut microbiome.

Western babies often lack a gut microbe common elsewhere.

Microbes are essential to creating the many varieties of cheese, influencing texture and taste

Microbes break down proteins and fats and produce compounds with distinct tastes. These microbes can include bacteria (like the one used to give Swiss its trademark holes), molds (like the ones that give blue cheese its distinctive veining), and countless other tiny organisms.

Listen to how the gut microbiome influences your emotions

The gut-microbiome connection may involve the enteric nervous system, a collection of hundreds of millions of neurons throughout the gut that transmit signals up the vagus nerve to the brain.

Research suggests ants are the most abundant insect on the planet, with an estimated 2.5 million of them for every human on Earth.

Some mosquitoes are key pollinators—and eat disease-carrying mosquitoes.

Bacteria in our intestine influence the brain via the gut-brain axis.

The gut microbiome may play a major role in autoimmune disease and symptom flare-ups

Certain unhealthy foods can promote gut bacterial growth and inflammation in the lining of the gut, potentially disrupting its lining—leading to a leaky gut that may allow pathogens to dribble out into the bloodstream, fueling further inflammation that can both cause disease flare-ups and set the stage for future disease development.

Large animals like giraffes and elephants have evolved unique cancer defenses.

Specific gut microbiome 'fingerprints' are associated with cancer recurrence, with up to 94% accuracy.

Researchers are investigating how altering the gut microbiome may influence the development of rheumatoid arthritis, which is an autoimmune disease.

Increasing contact between humans and wild animals is driving zoonotic threats

Zoonotic diseases, which spread from animals to humans, present one of the most significant emerging threats worldwide. Scientists have identified around 200 viruses capable of infecting humans, and unfortunately, the number of such diseases are on the rise—at least 60% of all emerging infectious diseases are zoonotic in origin.

Some dementia cases may be linked to treatable microorganism infections in the brain.

Probiotics, which are living bacteria and yeasts, are not recommended for most patients.

Benign species can become invasive if introduced into predator-free habitats

Most ecosystems contain organisms that, over many generations, have evolved into a stable balance with one another and their surroundings. In a new environment, a species may no longer be restricted by the limiting factors it is used to, and the native organisms in the area may not adapt quickly enough to the invader to establish a new balance.

See how the gut and the brain communicate through a bundle of nerves running from the brain to the digestive tract, serving as both a physical and chemical link.

As immobile animals, corals and the organisms that live on them have evolved a suite of chemical compounds to prevent disease and ward off predators they cannot outrun.

Model organisms like yeast, mice, and flies help scientists decode the human body

Some species are used to quickly study the effects of human diseases and treatments because they are short-lived and have similar systems to those found in humans. Bacteria, like E. coli, have been used as human proxies given their rapid growth and ease of genetic manipulability.

Lining up every microbe on Earth would stretch to about 105,000 light-years

There are about 10²⁷ such organisms on the planet, many of which are adapted to produce energy through uncommon reactions in unconventional environments, such as within rocks or near volcanoes on the ocean floor. Studies of these organisms have reframed astrobiologists' search for life beyond Earth by broadening the parameters under which life can exist.

Environment and genetics explain why animals have widely different lifespans

Both environmental conditions and genetic factors shape how long various animals live. For some creatures, colder conditions allow for less energy use and slower aging. Larger animals have fewer predators. While humans don't live the longest, we are a rare species that successfully lengthened its average lifespan over time.

A macrophage can eat 100 bacteria, on average, before it's exhausted

These specialized immune cells are first responders during inflammation, responding to a threat or injury and then performing other inflammatory response tasks, including summoning neutrophils to help attack invaders.

Although ecologists have struggled to identify a species as a keystone—one of outsized importance to its ecosystem—an analysis of 50 years of data and 157 studies identified 230 such species.

Humans may be the ultimate invasive species

Originating in East Africa, Homo sapiens migrated across the world beginning about 60,000 years ago and directly harmed countless species by consuming resources and modifying ecosystems to serve our needs. While meeting the definition of an invasive species, some ecologists argue the opposite, claiming that humans have helped preserve numerous species.

Blood has evolved many times over hundreds of millions of years, resulting in different blood colors and compositions—and there are even some organisms that don't need blood at all.

Fungi can cause disease, but they’re also our planet’s key decomposers

Fungi are their own taxonomic kingdom separate from flora and fauna, acting as the key decomposers and nutrient recyclers for our planet. Watch this video to understand the diverse types of fungi and the stages of the fungal life cycle. This video illustrates how fungi species may spread, eat nematode worms, damage nearby plants, and much more.

Animal-to-human pathogens constitute 75% of emerging infectious diseases

Zoonotic diseases encompass more than 200 diseases transmitted from animals to humans, wherein humans are usually accidental hosts. Ranging from rabies to HIV to monkeypox, this overview lists some of the most common viral threats.

Examining the potential of the emerging field of insect-based bioremediation

Also known as entomoremediation, the novel approach uses larvae and adult insects, including their gut microbiomes and associated enzymes, to extract or degrade pollutants. As of 2025, research has shown that black soldier flies can degrade a wide range of antibiotics, highlighting their potential for bioremediating antibiotic-contaminated organic waste.

Farts are tiny status reports from our gut microbiome, with American adults typically passing gas more than 30 times daily.

Biosphere 2 revealed limitations in maintaining wildlife in unfamiliar environments

Trees appeared to become weak and more prone to breaking because a lack of wind caused them to no longer need to develop stress wood. The extinction of pollinators—potentially due to an explosion in the population of longhorn crazy ants—was also unexpected.

The history of germ theory, which explains that illnesses are caused by microorganisms

For centuries, the miasma theory, which held that illnesses were caused by clouds of "bad air" produced by decaying organic matter, was the accepted explanation for the spread of disease. The development of microscopes and the subsequent technology to isolate bacteria and test disease spread in mice greatly contributed to contagionists overturning miasmatists.