The earliest evidence of cancer was found in a 1.7-million-year-old fossil—discovered in the toe of an ancestor of modern-day humans.

Searching for the history of cancer in ancient human bones

Nestled under archaeology lies bioarchaeology, which involves the study of bones, human or animal. This subfield recently birthed another field of study: paleo-oncology. Paleo-oncology looks for cancer and related biomarkers in bioarchaeological remains. This TED article explains how this nascent multidisciplinary field challenges the idea that cancer is modern.

The term 'cancer' is roughly 3,000 years old and derives from the Greek word for 'crab,' which may refer to how a malignant tumor can feel like a hard shell.

Dinosaurs suffered from cancer, arthritis, and infections seen in modern animals

Using CT scans and advanced pathology techniques, paleopathologists have identified respiratory illnesses, malignant osteosarcoma, and other diseases in dinosaurs. The research has helped show how many of these ailments are not exclusively modern phenomena.

A cave painting might be the oldest illustrated story ever recorded

A nearly 44,000-year-old cave painting may be the oldest story ever recorded, offering viewers a tale of human-like creatures on a hunt. This article details the discovery of the cave and its archaeological implications.

The earliest known cardiovascular system dates to 520 million years ago.

Here's how early humans lived

Explore the evidence of early human behavior—from ancient footprints to stone tools and the earliest symbols and art – along with similarities and differences in the behavior of other primate species.

Ancient humans and other early hominins were closer than you might think

Evidence that human ancestors and other early hominins coexisted continues to accumulate, raising the question of just how close these ancient people truly were. This article details how evidence is changing the theory that early hominins like...

A timeline of human fossil discoveries

A key part of writing a coherent story about our origins is finding and identifying the remains of our ancestors and understanding their significance. Scientists will not always agree on identifications and opinions will change as new find are made and new ways of studying them are developed.

Prehistoric hunter-gatherers performed amputations and appear to have provided post-op care, according to analysis of a recent fossil discovery from almost 31,000 years ago.

The messy story of humanity's genealogical past

For decades, scientists viewed the human fossil record and concluded Neanderthals, an early hominin, came before homo sapiens, or modern humans. The story became more complicated as technology advanced and ancient DNA samples were analyzed. This video breaks down the evidence, concluding the development of humanity was a lot messier than previously believed.

Explore these collections of early human fossils

The human fossil record is filled with massive gaps, leaving archaeologists tiny samples to try and glean the history of our species. At this site, you can browse through the human fossil collection, including 3D rotatable scans of hundreds of fossils from different species of early humans.

The Paranthropus genus, our mysterious extinct cousins

In the last century, skull and jaw fragments have been discovered in East Africa suggesting an ancient hominin species lived, evolved, and died alongside humanity's ancestors. With large, broad skulls and strong jaws, the Paranthropus genus—which includes several related species—is an absorbing case of the effects of niche partitioning, where species coexist by adapting differently to the environment. Paranthropus died out and human ancestors endured. Find out why here.

The oldest DNA recovered so far is 2 million years old

The oldest DNA recovered so far is about 2 million years old and has given scientists an unadulterated peek into ancient history. This nine-minute video explores the findings and implications of the DNA, which was pulled from frozen soil in...

Large animals like giraffes and elephants have evolved unique cancer defenses.

The archaeological discovery that shifted scientists' understanding of human evolution

In 2003, archaeologists in Indonesia uncovered the remains of a 3-foot-tall skeleton that appeared to belong to a new type of human. Read this article to learn how the discovery of this 50,000-year-old skeleton upended the idea that human evolution...

Timeline of cancer research milestones

While cancer remains incurable, there's been so much progress in its treatment over the last two decades. Nature provides an abridged history of milestones and major triumphs in cancer research and treatment. Start in the year 2000, and see how much has changed in the first quarter of the new millennium

How old are stone tools?

The earliest evidence for stone tools currently dates back to 3.3 million years ago, long before modern humans started roaming about. These tools were made by stone flaking, a mode of tool creation that still is used today and is done by striking...

Why our ancestors didn't have crooked teeth

The ancient human fossil record is filled with specimens with pretty nice teeth. So why do modern humans have dental problems? Scientists can't be certain, but one hypothesis suggests the evolutionary shrinking of the human jaw crowded our mouths,...

Human anatomy provides evidence for evolution

Throughout history, scientists have used anatomy to support the Theory of Evolution in three main ways. Homologous structures, or similar physical features in organisms that serve different functions, can help scientists understand common ancestors....

Homo sapiens may have migrated into Europe earlier than previously believed

Archaeologists used to believe that Homo sapiens migrated to Europe from Africa about 42,000 years ago, at about the time that Neanderthals went extinct. This 27-minute podcast episode explores new evidence that suggests Homo sapiens migrated about...

When humans discovered fire

Fire has proven crucial for the development of human civilization, but there was a time when our hominin ancestors could not make effective use of it. This article traces the major milestones in humanity's journey with fire based on evidence from...

Ancient humans settled Australia more than 50,000 years ago

Archaeological evidence shows that modern humans reached Southeast Asia about 70,000 years ago and they spread to Australia by at least 50,000 years ago. It marks the oldest evidence of open-sea migration by humans on record.

Evidence suggests the first cells on Earth were bacteria

About 4 billion years ago, these single-celled organisms harvested carbon dioxide and sunlight to produce their own food and oxygen, setting the stage for the evolution of oxygen-breathing life forms. Archaeabacteria, which thrive on inorganic molecules in extreme habitats on Earth today, were also among the earliest organisms.

Billion-year-old Arctic fossils suggest Earth had fungi far earlier than previously thought

Named Ourasphaira giraldae, this new species of fungus, reported in 2019, was found in the Grassy Bay Formation in the Canadian Arctic. It pushed the fossil record of fungi back by about half a billion years since the oldest previously recognized fungi fossils came from the Rhynie chert, a Scottish site that dates back roughly 400 million years. This fungal discovery also suggests that fungi may have occurred on land much earlier than plants, raising questions about what ancient fungi used for nourishment.

Many cancers arise from genetic mutations inherited from your parents

These mutations may happen in response to environmental or lifestyle factors, or may be passed down through family members. Genetic testing can be important in catching certain family cancers early and ensuring patients receive the right treatment for their disease.

How do we know what prehistoric humans ate?

Without recourse to ancient menus, how can historians know what our ancient human ancestors—as far as 3 million years ago—ate on a daily basis? Researchers evaluate several factors, including the type of teeth the species had evolved, chemical analysis of the teeth, patterns of wear and tear on teeth, as well as food scraps found in the vicinity of ancient remains. Learn the approach to discovering ancient hominin diets.

Cats began cozying up to humans around 10,000 years ago

The feline family is a hugely diverse group of lions, panthers, and kitties that have spread all over the world. The ancestors of the cats we love today helped solve rodent problems when humans first invented agriculture. They've been worshipped, loved, and scorned by humans since.

Molecular evidence suggests the deadliest malaria parasite may be 100,000 years old.

Henrietta Lacks' tumor cells became the first recognized 'immortal' cell line about 75 years ago, but researchers are still investigating the specific mechanisms that enabled the cells to continuously grow and divide in the laboratory.

Dogs' disease-sniffing skills were first identified in 1989

This capability, reported in the medical journal The Lancet, was discovered when a dog reportedly detected cancer in its handler. The dog repeatedly focused on a spot on the owner's leg where a malignant melanoma lesion was later found, helping lead to an early diagnosis.

How humans evolved from single-cell organisms

Humans have had a long history. 3.8 billion years in the making, to be precise. From the primordial puddle to the modern day, here's how humans have evolved from the first life.

Human origins 101

Learn about the over 20 early human species that belong in our family tree and how the natural selection of certain physical and behavioral traits defined what it means to be human.

The lifestyles of early humans

For 2.5 million years, humans lived on Earth without leaving a written record of their lives—but they left behind other kinds of remains and artifacts.

HIV originated in Central and West Africa from a virus in chimpanzees

Researchers believe the virus crossed from chimpanzees to humans through bushmeat practices in the early 20th century, with genetic studies suggesting the most recent common ancestor of the HIV-1 M group, which is responsible for the global AIDS pandemic, emerged around 1910–1930 in Léopoldville (now Kinshasa) in the Belgian Congo.

Here's how humans migrated across the world

From our deepest origins in Africa all the way to the Americas, by looking at the fossils and archaeological materials we have been able to trace the path our ancestors took during thee short window of time when we took over the world.

Why human brains were bigger 3,000 years ago

Our modern civilisation may be the most advanced to ever exist on Earth, but around 100 generations ago, our ancestors had brains that were larger than our own.

Nail art can be traced back to 5,000 BCE

Archaeologists discovered Egyptian mummies with nail art and henna-tinted fingertips. The trend would continue informally for centuries until Revlon introduced modern nail polish in 1932.

Scientists now know that Henrietta Lacks, a Black woman whose 'immortal' cancer cells were nonconsensually sampled and used for research, had been infected with human papillomavirus, a group of pathogens responsible for most cervical cancers.

Recent research indicates leprosy was present in the Americas before European settlers

New research published in 2025 upended long-held notions that the disease was introduced to the Americas by European colonizers. Evidence of a lesser-known leprosy-causing bacterium was found in ancient human remains that date back 4,000 years.

Santa Barbara's Channel Islands revealed the oldest skeletal remains in North America

IN 1959, archaeologists found a human femur jutting out from a rock face on Santa Rosa Island. Using the then-new technology of radiocarbon dating, they measured the age of the remains at 13,000 years—the oldest in the continent.

The world’s oldest tattoos belong to 'Iceman' Ötzi

Ötzi is the corpse of "the Iceman" found in the Alps along the Italian and Austrian border in 1991. His mummified body was covered with lines and crosses along the “hard-working” areas of his body, signifying their potential application for therapeutic pain management.

The first appearance of bioluminescence was at least 540 million years ago

After analyzing fossils, genetic data, and statistical methods, scientists believe octocorals were the first organisms to evolve light-producing abilities. As a result of independent evolution across at least 94 species, this phenomenon is connected to a diverse range of behaviors.

The first Americans arrived between 14,000 and 40,000 years ago

Early peoples migrated to the Americas via the Bering Land Bridge or coastal routes, spreading across the continent as hunter-gatherers. Archaeological sites in present-day New Mexico containing stone tools and animal bones mark some of the earliest confirmed evidence of human life in North America.

The earliest mention of time travel

Time travel has fascinated humans for centuries. It appears in myths, literature, and science fiction. One of the earliest examples comes from the 400 BCE Hindu epic Mahabharata, describing time dilation long before Einstein’s Theory of Relativity. By the 19th century, stories introduced machines enabling time travel—setting the stage for modern sci-fi.

A history of belly buttons, from dinosaurs to modern dogs

Could dinosaurs have had belly buttons, just like you and me? Some researchers believe they've found evidence the ancient reptiles had the cute scar, a common feature among placental mammals (but which is also found in many more kinds of animals). Dive into their peculiar findings with this fascinating video.

Genetic analysis indicates that every organism on Earth evolved from a single cell

LUCA—the last universal common ancestor—lived about 4.2 billion years ago and likely obtained energy through the conversion of carbon dioxide and hydrogen gas consumed from atmospheric gases at the ocean's surface or hydrothermal vents—openings on the seafloor where fluid warmed and enriched with minerals by Earth's interior is expelled.

The role of fire in the evolution of humanity's big brains

Roughly 1.5 million years ago, the brain size of our hominin ancestors exploded. To understand why, Richard Wrangham posited the cooking hypothesis, arguing the adoption of fire as a means to cook food had a lasting impact on our ability to digest...

What did the earliest swords look like?

That depends on where you draw the line between daggers and swords. According to current evidence, the first swords appeared 5,000 years ago in what's now Turkey. Unfortunately, evidence of the earliest swords is colored by survivorship bias; It's...

Cell theory originated from microscopic observations of cork and dental plaque

In the mid-1600s, Robert Hooke identified compartment-like structures—which he called cells—in cork, and Anton van Leeuwenhoek discovered bacteria in samples of his dental scrapings. Almost 200 years later, Matthias Schleiden and Theodor Schwann showed that plants and animals, respectively, are composed of cells, proving that cells are the foundation of all living things.

Archaeologists decode the first known sentence in what may be the oldest written alphabet

This five-minute video details the accidental discovery and subsequent decoding of the first known sentence in what's believed to be the oldest written alphabet. The Canaanite sentence was found on a Bronze Age hair comb unearthed in Tel Lachish, a city of the ancient Biblical Kingdom of Judah, during a dig focused on excavating the kingdom's first Iron Age city. The Canaanite language developed sometime between 3,000 and 1,000 BCE.