The limbic system drives emotion, memory, and survival instincts in the brain.

The hippocampus, a structure in the brain, plays a crucial role in memory formation

The seahorse-shaped structure transfers short-term memories to long-term storage during sleep. It is located in the temporal lobes, above each ear, and aids in spatial navigation and remembering directions.

Various types of memory, each serving unique functions, create a complex brain system

These forms of memory, which can overlap in daily life, have been sorted into broad categories, such as short-term and long-term memory, and subtypes such as implicit memory, which uses saved information without conscious awareness that it’s being recalled.

Brain hemispheres control opposite sides of the body without either dominating

Although distinctions exist between the two halves—language processing is left-oriented, and emotions are right-oriented—signals are sent along neural pathways between the hemispheres and across different regions to collectively process information about external stimuli.

Scent is a stronger memory trigger than sight

Smell is imbued with more emotion than visual memories, and research indicates that smell triggers a significantly greater effect on amygdala activation. Scientists believe these powerful responses occur partly because smell signals bypass the thalamus and go directly to the amygdala and hippocampus, brain areas involved in emotion and memory.

Memories are formed through attention, repetition, and emotional significance

Our brains create memories by taking in sensory input, filtering it through short-term memory, and storing it in long-term memory. Emotional events are more likely to become vivid, lasting memories because they activate stronger neural connections.

Memory is a complex narrative constructed from real and imagined experiences

Memories start with perception and are processed in the hippocampus. Different types of memories use different brain regions, and episodic memory, which is involved in recalling one's life events, is more susceptible to decay than semantic memory, which is involved in general information.

The hippocampus, located deep inside the temporal lobe, appears to play a central role in dreaming and memory, according to recent research on dreaming and damage to that area of the brain.

Memory exists as multiple types stored across various brain systems

Memory isn't one uniform function—it's made up of multiple systems, like declarative (facts/events) and non-declarative (skills/habits), which involve different brain areas such as the hippocampus, amygdala, and cerebellum.

The body produces its own opioids that act on several receptor types throughout the body, triggering the release of dopamine and suppression of noradrenaline, neurotransmitters associated with reward and alertness, respectively.

These areas of the brain are hard-hit in depression—but the changes are reversible

Depressed brains can have certain characteristic changes, including an overactive amygdala, reduced hippocampus size, and changes to the thalamus and neuromodulating chemicals in the brain.

Stress activates the "fight-or-flight" response when we face threats, a reaction that can help keep us alive.

Grief rewires the human brain

The human brain handles stress and emotional traumas similarly. In response to the emotional stress of a situation like the death of a loved one, divorce, or abuse, the brain may strengthen or weaken connections between nerves to form new neural connections. Over time, chronic stress can diminish brainpower, reducing overall nerve growth and memory to shift resources to enable elevated fear responses and enable humans to survive.

Brain conditions and surgery can cause some individuals to feel no fear

Fear is a survival mechanism that originates in the brain's amygdala, triggering the body's fight-or-flight response. However, in modern society, without the same natural dangers, fear can lead to anxiety and mental health issues when unnecessarily triggered. Understanding individuals without fear may help identify new methods to treat anxiety disorders.

How brain cells carry information

At any moment, there is an electrical storm coursing through your body. Discover how chemical reactions create an electric current that drives our responses to everything from hot pans to a mother’s caress.

Retrieval cues trigger memories and emotions from long-term storage

Retrieval cues can activate specific cells in a neural network, creating a cascade of neurons that collectively make up a memory. Specific cues help regulate emotions during stress by activating positive memories.

Why does the body have a stress response?

When encountering a stressful situation, the human body typically goes into what is known as "fight-or-flight" mode. Because it evolved as a survival mechanism, the biochemical response enables people and other mammals to react quickly to life-threatening situations. The carefully orchestrated yet near-instantaneous sequence of hormonal changes and physiological responses helps someone to fight the threat off or flee to safety.

Explore an interactive 3D model of the brain

The brain contains about 86 billion neurons—nervous system cells—and controls vital bodily functions via electrochemical signals. Neurons form circuits through axons, and different brain regions use these circuits to perform specific tasks.

Several brain regions are involved in lucid dreaming, a state in which a person knows they're dreaming.

A beginner's guide to the brain

Small but powerful, the brain constitutes only about 2 percent of the human body. However, it runs jus about everything, day and night, all year round. Learn about the different parts of the human brain, as well as its unique defenses, like the blood brain barrier in this four-minute video.

Listen to how the gut microbiome influences your emotions

The gut-microbiome connection may involve the enteric nervous system, a collection of hundreds of millions of neurons throughout the gut that transmit signals up the vagus nerve to the brain.

Why the human brain loves opioids

When opioids enter the brain, they dock in receptors, blocking electrical pulses such as those that communicate pain. They also trigger the release of dopamine, a neurotransmitter tied to motivation and associated with stress relief.

Trillions of bacteria, viruses, fungi, protists, and archaea live in our guts, producing a wide range of molecules, hormones, and more—underscoring the immune system's pivotal role in the microbiota-gut-brain axis.

The hormone that spreads love and helps fish share fear

Scientists consider emotions like fear and empathy to be among the oldest evolutionary behaviors observed in mammals. Yet to date, how these reactions are processed in the brain, regardless of species, is not well understood. A new study reveals how the chemical oxytocin—known as the "love hormone" in humans—helps let fish know when their friends are in danger.

Consistency and emotional engagement can improve the formation of memories

While sleep lets the brain re-trigger neurons associated with our experiences to cement them in long-term memory, repeating actions, like storing one's keys in the same location, can mimic these benefits. Emotionally charged memories are often ruminated upon, improving their future recall.

Sensory memory is information collected from your senses

Lasting seconds before moving into short-term memory or being forgotten, sensory memory aids in environmental awareness and navigation. Key brain regions involved include auditory, somatosensory, gustatory, visual, and olfactory cortices.

Patient H.M. revealed that the hippocampus was responsible for memory formation

Henry Molaison became a landmark case in psychology after surgery removed large portions of his hippocampus, leaving him unable to form new memories. Upon his death, Molaison's brain was sliced into 2,401 sections and digitized for research.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

What is the brain up to when the mind wanders?

As you stare into the distance while washing your home's seemingly never-ending pile of dishes, the brain activates its default mode network. This collection of "task-negative" brain regions associated with memory, reward, action consideration, and prediction alight with activity when humans mentally turn inward, possibly giving rise to the brain's ability to wander and humans' ability to construct internal narratives about the world.

Take a deep dive into the neuron

Neurons are the basic unit of the brain and nervous system—electrically excitable cells that sends signals throughout the body. They can communicate with each other, fire in sequence, and conspire to do everything from drive body movement to help form memories. Check out this intro-level overview to learn more about their structure and how they work.

How neurons give rise to thoughts

Neurons in the brain are singular nerve cells that flicker on and off or connect to each other based on incoming stimuli. The more neurons communicate by firing electrical impulses through tendrils known as synapses, the stronger their connection becomes. The electrical energy zipping along these interneural connections in an attempt to classify and respond to incoming stimuli may be what gives rise to thoughts.

Visualize the difference between a healthy brain and one with Alzheimer's.

Some animals may speak because of duplicated connections in the brain

Neuroscience suggests that connections responsible for motion made during embryonic brain development—such as those connecting hearing and movement pathways that allow reactive motion when started—are duplicated and connected to the larynx in some animals. This allows some mammals and song-learning birds to speak, provided they have the necessary physiological structures.

Fearology, or the study of fear, explores the difference between stress and fear

Our brains involuntarily respond to our environment and signal alarm when that isn't always needed, triggering responses that include goose bumps. But understanding fear and how to talk our brains into calming down can improve daily life.

Psychedelics set off a flurry of brain activity that may permanently alter it

The brain seems to experience a sharp increase in communication between areas that generally don't interact. New research suggests a thin, sheet-like gray matter structure tucked deep within the brain, between the insular cortex and striatum, may be the key to this change. The area is centrally located and home to many of the receptors that psychedelics target, potentially rewiring the brain and rewriting thought patterns.

Stress and the brain

While an acute stress response is a normal bodily function, the effects of chronic stress can be extremely damaging to the human body. This is particularly true with regard to the brain. This article explores the effects of stress on the human brain, including how chronic stress may lead to psychological conditions such as depression and memory loss.

Why are humans hooked on horror?

A haunted horror attraction in Denmark is regularly stalked by researchers of the world's only laboratory dedicated to understanding fear's good side. Fear is one of many human emotions that correspond to a physiological response. As fear rises, so do adrenaline, cortisol, and heart and breath rates. As it ebbs, the body is flooded with dopamine, a hormone and neurotransmitter associated with desire, learning, and motivation.

Prolonged stress impairs the prefrontal cortex

Burnout isn't just a feeling—it physically affects the brain. Prolonged stress impairs regions of the brain responsible for decision-making, emotional control, memory, and more. It can also lead to chemical imbalances, like reduced dopamine and norepinephrine levels, that worsen these effects.

Human anatomy 101: the body's systems

Human life is made possible by the body's ten major systems, which maintain homeostasis by responding to incoming sensory and biochemical input. Each system must work independently and collaboratively for the body to maintain health and respond appropriately to its internal and external environments. The bones of the skeletal system, for example, give the body its shape and protect organs while also facilitating movement with the muscular system.

The 'sense' of direction comes from two strategies involving unique brain regions

Egocentric navigation utilizes the caudate nucleus and posterior parietal cortex, relying on a person's position in space to determine their direction of movement. Spatial navigation uses landscape features for orientation and is driven by the hippocampus.

When humans perceive touch, the information is sent to the thalamus and then to the primary somatosensory cortex, the part of the brain that receives sensory input.

A web of sensory neurons in the skin help filter out background sensations

The somatosensory system helps us organize and navigate our surroundings, enabling us to understand our bodies in relation to our environment and also filter out minor sensations that are basically background noise so they aren't overwhelming to our bodies. Meanwhile, viscerosensation—or internal sensation—refers to the internal sensory neuron system that conveys information from internal organs to the brain.

See how the gut and the brain communicate through a bundle of nerves running from the brain to the digestive tract, serving as both a physical and chemical link.

Neural rhythms shape how we move, focus, remember, and interact with the world

Millions of neurons in the brain produce rhythmic electrical signals, or brain waves, that guide physical movement and help form and store memories. Researchers also use these rhythms to create brain-computer interfaces, letting people control devices using only their thoughts.

Love and heartbreak trigger powerful, neurochemical-driven changes in the body

The feeling of falling in love floods the brain with dopamine, oxytocin and serotonin, which collectively dull pain and boost immunity. However, the loss of these chemicals during a break-up produces withdrawal-like symptoms and heart issues, such as high blood pressure.

Exercise releases chemicals that enhance cognitive function

Neurotransmitters like dopamine, serotonin, and norepinephrine, along with increased brain-derived neurotrophic factor levels, enhance a wide range of brain functions. New research demonstrates a direct link between movement and numerous cognitive benefits, including memory, learning, and stress resilience.

The evolution of the human brain

The human brain, in all its staggering complexity, is the product of millions of years of evolution. Read on to find out about brain size and intelligence, language and brain development, and more.

Age, stress, and neurological disorders can prevent memory formation and recall

Neurons transmit signals between one another at sites called synapses. Repeated interactions at these sites improve the efficiency of signal transmissions, making memories involving sensory data associated with those neurons easier to recall. Biochemical factors impacting these synaptic interactions affect memory quality.

How aging degrades neural functioning in the brain over time

Aging affects the brain perhaps more than any other organ in the body. Throughout life, the brain experiences radical shifts in the number of neurons, synaptic connections between neurons, and hormone levels that regulate our mood and processing.

ADHD impairs working memory and limits the ability to form long-term memories

While ADHD is most often recognized for producing struggles with attention and organization, these executive functions are critical for capturing the data that creates memories in the brain. Breaking data into pieces, or chunking, helps address these struggles.

Synaptic plasticity allows neurons to communicate effectively and form memories

First proposed in 1949, synaptic plasticity allows the brain to adjust communication strength between neurons. This ability to change synaptic strength—either briefly or over long periods—is essential for learning and memory, with long-term synaptic plasticity forming the basis of how memories are stored.