Edward Jenner, the father of vaccinations

Before vaccines, there was 'variolation': what was it?

Before the technology behind vaccinations was discovered, some keen observers of medicine around the globe noticed how previous infections could impact future ones. Learn about the techniques early physicians used before they had vaccines.

A 1954 outbreak at a Boston boarding school allowed scientists to isolate the measles virus and formed the basis for the first measles vaccine.

Jonas Salk developed the first successful polio vaccine—and tested it on himself

The American medical researcher developed the inactivated virus vaccine from 1952 to 1955 and proved that it could prevent disease. He tested the virus on himself and his family in 1954 and then carried out formal clinical trials on more than 1.3 million children.

Live virus vaccines predated polio—that's how we vaccinate against smallpox

Since 1796, smallpox vaccines have used a live poxvirus related to smallpox. Yellow fever vaccines have used a live weakened form of the virus responsible for yellow fever since 1937.

Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

Koch was one of the first scientists to isolate the bacterium that causes cholera while investigating an outbreak in Egypt in 1883. He went on to advise about rules to control cholera outbreaks, which formed the basis of the disease control approaches and water hygiene techniques still used today.

Diphtheria was once a leading childhood killer before antibiotics and vaccines

In 18th- and 19th-century outbreaks, some New England families lost as many as eight children to diphtheria, and fatality rates in hospitals often topped 60%. The invention of antitoxins, penicillin, and vaccines dramatically reduced deaths.

'Our greatest responsibility is to be good ancestors.'

- Polio vaccine developer Jonas Salk (1914–1995)

Leonard Thompson was the first human to receive an insulin injection for diabetes

In January 1922, the 14-year-old was the first person to receive an insulin injection to treat diabetes, just months after insulin was isolated in dogs and used to treat their induced diabetes. Thompson had an allergic response to an apparent impurity in the injection, but his second dose, 12 days later, was a success.

The virus was officially described for the first time in 1789

Michael Underwood, an English physician and surgeon, was the first to describe the disorder, noting it caused disability in the lower extremities in children. Large-scale outbreaks of the disease were not observed until the late 19th century.

Measles infection, which was nearly universal during childhood in prevaccine era, was described by the Persian physician Rhazes in the 10th century as "more to be dreaded than smallpox."

John Snow—not the one from 'Game of Thrones'—determined that contaminated water sickened London

His pioneering epidemiology work during an 1854 cholera outbreak mapped out the commonalities between people in London who were getting sick. He discovered that ill people were getting water from the same Broad Street pump. Before Snow's work, the prevailing theory was that bad air sickened individuals instead of cholera-causing bacteria in the water.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

How the 1918 pandemic spurred developments in virology and vaccines

This article provides an in-depth historical account of the 1918 Spanish Flu pandemic, including its impact on the global population and how its occurrence spurred significant advancements in the study of viruses—laying the groundwork for the...

The first successful IVF pregnancy was in the United Kingdom in 1978

Gynecologist Patrick Steptoe and his collaborator Robert Edwards, a biologist, attempted to fertilize a human egg cell in a petri dish 101 times before finally succeeding. This resulted in the birth of Louise Brown—at the time referred to as a "test tube" baby—in 1978, who was born into the spotlight.

Penicillin’s discoverer predicted antibiotic resistance

Alexander Fleming’s discovery of penicillin revolutionized modern medicine. But the same man who pioneered the development of antibiotics also recognized that bacteria could make sntibiotics obsolete if they were used irresponsibly. This story sheds light on Fleming’s discovery—and on his prophetic warning about antibiotic resistance.

When was the first blood transfusion?

In the 1600s, an English doctor transferred the blood from one dog to another via quills. The procedure ended when one of the dogs died. This article details the early days of blood transfusions, which turned toward humans shortly after the 1666 dog experiment and involved putting the blood of a sheep into a human recipient (who reportedly survived the encounter).

What is vaccination? The World Health Org explains

Read up on the basics of vaccinations with this 101 from the World Health Organization, the public health arm of the United Nations.

An overview on germ theory, the crucial framework developed by Louis Pasteur

Germ theory of disease is based on the concept that many diseases are caused by infections with microorganisms, typically only visualized under high magnification. Read this general overview to understand the basic framework which allowed for development of vaccines.

Penicillin’s pioneers were awarded the Nobel Prize in 1945

Alexander Fleming, Howard Florey, and Ernst Chain received the 1945 Nobel Prize in Physiology or Medicine for discovering and developing penicillin.

Light therapy was widely used as a medical treatment for various maladies in the early 1900s before it was replaced by antibiotics.

Improved 19th-century sanitation meant kids encountered polio later, with worse results

Almost all children likely used to contract poliovirus, but scientists suggest that when infants encountered it very early in life—due to poorer conditions and hygiene—they still had some maternal protection from pregnancy or through breastmilk, so the symptoms were more flu-like.

The cholera bacteria was first isolated in 1854—but the discovery was largely ignored

The pathogen was isolated by the Italian physician Filippo Pacini in Florence, Italy, though his discovery was largely ignored in favor of the popular miasma—bad air—theory of disease at the time. The pathogen was separately isolated about three decades later by German microbiologist Robert Koch.

Penicillin is considered one of history’s greatest medical breakthroughs

Experts widely rank penicillin’s discovery among the most important advances in medicine. It launched the antibiotic era, transformed once-deadly infections into treatable illnesses.

Measles reached global transmission during the 15th- and 16th-century Columbian exchange

Devastating diseases like smallpox, influenza, measles, and other viruses were largely introduced into the Western Hemisphere beginning with the 1492 arrival of Christopher Columbus and the ensuing age of exploration.

A scientist successfully treated her own breast cancer by injecting the tumor with lab-grown viruses.

A major US-designed polio vaccine was first tested in the Soviet Union

Albert Sabin's live attenuated virus vaccine—requiring two drops in the mouth—didn't garner political support in the US, so it was tested in the Soviet Union in the late 1950s.

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

A history of vaccine rollouts

History tells us the public will tolerate risk of harm from a vaccine if their fear of the disease exceeds their fear of the vaccine.

In 1933, the influenza virus was first identified through 'ferret flu' experiments, which proved that the disease was viral—not bacterial.

The birth of the multivitamin

In 1912, biochemist Kazimierz Funk, often anglicized as Casimir Funk, proposed that there existed an essential nutrient in food that could prevent deficiency diseases, such as scurvy or rickets. This article explores the origin of the multivitamin, an invention that has garnished...

The discovery of insulin led to a controversial Nobel Prize in 1923

For centuries, Type 1 diabetes was fatal. The 1920s "discovery" of insulin netted two of its creators—Frederick Banting and his boss, John Macleod—a Nobel prize. Separately, the German doctor Georg Zuelzer synthesized an effective version of the life-saving drug years earlier but was interrupted by World War I.

A collective effort from multiple scientists and inventors led to the light bulb

While Thomas Edison's thin carbon filament design made light bulbs commercially viable, prior contributions, such as Joseph Swan's development of the first successful incandescent filament electric lamp, made its eventual invention possible.

The history of germ theory, which explains that illnesses are caused by microorganisms

For centuries, the miasma theory, which held that illnesses were caused by clouds of "bad air" produced by decaying organic matter, was the accepted explanation for the spread of disease. The development of microscopes and the subsequent technology to isolate bacteria and test disease spread in mice greatly contributed to contagionists overturning miasmatists.

The flu vaccine has evolved alongside discoveries of new virus strains

After influenza B was identified in 1940, researchers created a two-strain vaccine by 1942. The WHO later built a global surveillance system to track mutations, enabling vaccines to be updated annually to target the strains most likely to circulate.

A New York farmer established the first cheese factory and revolutionized the industry by sourcing milk from local farms.

Variola: the second-deadliest virus on Earth

Because it was declared eradicated in 1980, many forget smallpox is one of history's deadliest diseases—in its final century, it's estimated to have claimed 500 million lives. This 11-minute video from production studio Kurzgesagt takes a look at...

Dr. William Gorgas eradicated yellow fever in Panama, crucial to canal construction

The disease was one of the factors hampering the French effort to build the canal. Gorgas' experience elsewhere in the Caribbean had taught him that good drainage and quaranting patients were essential, and he would eventually apply mosquito prevention tactics on a mass scale.

A French Army surgeon discovered that malaria is a parasitic disease in 1880—but scientists were initially skeptical.

The measles vaccine has saved an estimated 94 million lives since its introduction.

With no textbooks or antibiotics, this WWI surgeon pioneered facial reconstruction

New Zealand surgeon Dr. Harold Gillies made extraordinary advances in the field of reconstructive surgery during World War I and after. This 36-minute NPR podcast interviews historian Lindsey Fitzharris, author of Gillie's biography, The Facemaker, charting how the good doctor reconstructed the faces of numerous soldiers in an age before antibiotics and plastic surgery as we know it today.

Herd immunity works by slowing down viral transmission until a disease dies out.

The mosquito's role in the transmission of malaria was confirmed in 1897.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity.

60 years after seeing Henrietta Lacks as a patient, her doctor still remembered the unique cervical tumor that gave rise to the 'immortal' cell line now commonly used in biomedical research—it was purple, shiny, and soft—an appearance he said is very different from a typical tumor.

The first tattoo gun was based on an electric pen invented by Thomas Edison.

Penicillin was discovered by accident

In 1928, Alexander Fleming returned from vacation to find mold contaminating a petri dish of bacteria. Around the mold, the microbes had died—an accidental observation that led to the discovery of penicillin.

Thomas Edison publicly executed animals with AC to convince the public of its dangers

J.P. Morgan first backed Thomas Edison's direct current system, seeing electricity's potential to usurp John D. Rockefeller's kerosene empire. Despite the investments and smear campaign against alternating current, alternating current ultimately won public support after lighting the 1893 World's Fair, after which Morgan would fund Tesla's wireless transmission tower.

Penicillin has saved an estimated 500 million lives since its creation

Since its introduction in the 1940s, penicillin and related antibiotics are estimated to have saved around 500 million lives worldwide—making it one of the most consequential medical breakthroughs in human history.

Henrietta Lacks' tumor cells became the first recognized 'immortal' cell line about 75 years ago, but researchers are still investigating the specific mechanisms that enabled the cells to continuously grow and divide in the laboratory.

See photos of ultraviolet light therapy, widely administered in the early 1900s, particularly among children with skin diseases, tuberculosis, rickets, and more.