Dr. William Gorgas eradicated yellow fever in Panama, crucial to canal construction

Disney World is largely mosquito-free, thanks to civil engineer Joe Potter

As a former governor of the mosquito-prone Panama Canal zone, Potter understood the danger of standing water. At Disney, Potter built ditches to reduce moisture, designed buildings to channel water away, and more. His efforts help visitors avoid bites, adding to the perceived magic of the magical kingdom.

Working conditions on the Panama Canal, built between 1904 and 1914, were abysmal, with thousands of workers dying on the job.

Roughly 25,000 workers died building the canal

For each mile of canal that was built, 500 workers lost their lives. The threats came from multiple fronts: mudslides, floods, earthquakes and disease-carrying mosquitoes. Workplace accidents became so common that artificial limb manufacturers competed for contracts with the canal builders.

Yellow fever sidelined more US troops than enemy fire during the Spanish-American War

The disease, transmitted by the Aedes aegypti mosquito, sickened more than 2,000 soldiers. Fewer than 400 American soldiers died in the 1898 war.

A French Army surgeon discovered that malaria is a parasitic disease in 1880—but scientists were initially skeptical.

The canal project required the forced removal of local inhabitants

The canal displaced Panamanian communities, with towns like Gatun and Gorgona dismantled and farmlands lost, reshaping the region forever.

The US finished what the French had started with Panama's canal

For about two decades, Suez Canal-builder and Frenchman Ferdinand de Lesseps led the project, but financial troubles forced it into the hands of the US, who completed it in 1914. This timeline, made to accompany the definitive PBS American Experience documentary about the canal, highlights major moments in its construction.

The canal carried germs as well as goods

In 1832, North America’s first cholera epidemic spread inland by way of the Erie Canal, carried by immigrants arriving on ships. Fearful towns barred passengers from disembarking, yet cholera, smallpox, and other diseases still traveled the waterway.

Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

University of Maryland Hospital researchers intentionally infected volunteers with the cholera bacterium in the late 1970s to further their understanding of the disease. They proceeded with this work following the recommendation of a US government panel. (Some users may encounter a paywall.)

Explore inside a mosquito factory where millions of mosquitoes are bred weekly

In Medellin, Colombia, scientists are infecting Aedes aegypti mosquitoes with Wolbachia, a bacterium that wouldn't otherwise infect the species, but does block its ability to transmit dengue, Zika, yellow fever, and chikungunya. In the wild, infected mosquitoes would breed with wild mosquitoes, pass down Wolbachia, and thus reduce disease transmission.

Wolbachia: the bacteria that could eliminate dengue fever

Dengue fever, transmitted by mosquitoes, kills more people annually than all types of natural disasters combined. However, mosquitoes that host Wolbachia bacterium have their ability to transmit the virus naturally suppressed, offering a route to eliminating nearly 25,000 deaths annually.

The Panama Canal boosted the US as a world power in trade, engineering, and finance

The effort proved the US could achieve grand engineering projects while granting it influence over (and benefitting economically from) a major interoceanic channel and its host country, Panama.

The century of the Panama Canal

The Panama Canal connects the Atlantic and Pacific Oceans through a 51-mile route that transformed global shipping when it opened in 1914. This breakdown covers how it was built, the workers behind its construction, and why its future may be challenged by climate and competition.

The Panama Canal was the first to use a lock-and-lake system on a massive scale.

The mosquito's role in the transmission of malaria was confirmed in 1897.

How the 1918 pandemic spurred developments in virology and vaccines

This article provides an in-depth historical account of the 1918 Spanish Flu pandemic, including its impact on the global population and how its occurrence spurred significant advancements in the study of viruses—laying the groundwork for the...

Paris and Boston were redesigned partly to combat cholera's spread

Georges-Eugène "Baron" Haussmann, who oversaw Paris's redesign in the 1800s, replaced many of the city's narrow streets with wide boulevards. This was done at least in part to bring more air and light into the city to help control cholera. Architect Arthur Gilman redeveloped Boston's Back Bay to similarly combat cholera, among other reasons.

Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

Koch was one of the first scientists to isolate the bacterium that causes cholera while investigating an outbreak in Egypt in 1883. He went on to advise about rules to control cholera outbreaks, which formed the basis of the disease control approaches and water hygiene techniques still used today.

The cholera bacteria was first isolated in 1854—but the discovery was largely ignored

The pathogen was isolated by the Italian physician Filippo Pacini in Florence, Italy, though his discovery was largely ignored in favor of the popular miasma—bad air—theory of disease at the time. The pathogen was separately isolated about three decades later by German microbiologist Robert Koch.

Wolbachia is a naturally occurring bacterium being employed to fight dengue

Scientists are fighting dengue spread in a roundabout way: injecting bacteria into Aedes aegypti mosquito eggs, which blocks the dengue virus from replicating in the tissue of mosquitoes. Researchers hope the bacterium will be passed to future generations, inoculating them against dengue. Wolbachia is also being investigated to combat other mosquito-borne diseases.

How Disney World keeps out mosquitos

Disney World may have been built on a swamp, but it's nearly free from the annoyance of mosquitos. That hasn't been an easy task; Disney has worked with engineers and pest specialists on minimizing the invasive bugs through a variety of different methods. This Reader's Digest article breaks down how they've successfully kept the park free from these unwanted guests.

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

John Snow—not the one from 'Game of Thrones'—determined that contaminated water sickened London

His pioneering epidemiology work during an 1854 cholera outbreak mapped out the commonalities between people in London who were getting sick. He discovered that ill people were getting water from the same Broad Street pump. Before Snow's work, the prevailing theory was that bad air sickened individuals instead of cholera-causing bacteria in the water.

Malaria mosquitoes in a lab were wiped out using CRISPR

Scientists at Imperial College London disabled a gene in female Anopheles gambiae mosquitoes to make them infertile and propagated the infertility mutation at unnaturally high rates using a gene drive. The entire population collapsed within a dozen generations, showing promise for subsequent with mosquitoes in mimicked tropical environments.

The US handed control of the canal back to Panama in 1999

This was the result of two treaties signed during President Jimmy Carter's presidency, one shifting control to Panama and the other declaring the canal zone neutral. In recent years, US officials have suggested the US may retake control. Experts agree that the only viable way would be through military force.

Drought conditions force fewer ships to sail the Panama Canal daily

In 2023, canal authorities reduced traffic in the canal amid severely dry conditions. These seven infographics from the Woodwell Climate Research Center explain exactly what happened that historically dry October, and how it affected global supply chains.

A malaria case in Maryland stumped doctors in 2023—leading to the wrong treatment and underscoring the challenge of physicians being mindful of tropical diseases in our interconnected world.

How we helped make Aedes aegypti mosquitoes such a problem

Mosquito genome sequencing data suggests that Aedes aegypti mosquitoes first started specializing on human blood around 5,000 years ago—when climates shifted and humans started domesticating plants in Africa and stored large amounts of water that may have attracted the bugs.

Watch the Panama Canal's lock system lift a ship 85 feet above sea level to cross between two oceans.

Jules Verne helped popularize the banana

In his 1872 book "Around the World in 80 Days," the sci-fi writer described the banana, then mostly a novelty, as "healthy as bread and as succulent as cream." That mention, along with an appearance at the 1876 World's Fair in Philadelphia, helped transform the fruit into a standard part of a healthy diet.

Cultural norms about how to handle the bodies of loved ones have hampered Ebola responses in West Africa.

Before the Panama Canal, there was the Panama railroad

The first ship to cross the isthmus of Panama went not by sea but by land: The paddlewheel steamship Explorer was taken apart and transported by rail, an effort that generated “more trouble than profit,” according to one account.

Mosquitoes are the world's deadliest animal, but gene drives could kill them.

From 1970 to 2017, invasive species have caused $1.28T in damage globally

The costliest species were the Asian tiger and yellow fever mosquitoes ($149B), which arrived in the US from Asia and sub-Saharan Africa, respectively. The bulk of their damage came from their transmission of diseases such as Zika, chikungunya, and dengue. (Some readers may experience a paywall.)

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

How a scientist discovered West Nile is spread by birds

Listen to Tracey McNamara, former chief pathologist at the Bronx Zoo, detailing her surprising late 1990s discovery that established West Nile virus is spread by birds. Financing animal disease surveillance studies, she says, saves human lives and surveillance gaps may fuel missed opportunities to identify dangerous diseases before they jump between species.

Measles reached global transmission during the 15th- and 16th-century Columbian exchange

Devastating diseases like smallpox, influenza, measles, and other viruses were largely introduced into the Western Hemisphere beginning with the 1492 arrival of Christopher Columbus and the ensuing age of exploration.

Wolbachia is also being used to slash mosquito numbers

The naturally occurring bacterium does not naturally infect Aedes aegypti mosquitoes, but communities in locations including California and Texas have released male mosquitoes infected with Wolbachia and reported a significant drop in subsequent mosquitoes: When infected males mate with uninfected wild females, the eggs don't hatch.

Using mosquitoes to vaccinate bats could curb the spread of deadly diseases.

How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

A bankrupt flour merchant in debtor's prison helped inspire the Erie Canal.

Cholera went global thanks to global trade

The first cholera pandemic grew from an outbreak in India, in 1817. Scientists suggest it spread from there throughout the continent and onward to Africa, Russia and Europe through the poop of traders.

Diphtheria was once a leading childhood killer before antibiotics and vaccines

In 18th- and 19th-century outbreaks, some New England families lost as many as eight children to diphtheria, and fatality rates in hospitals often topped 60%. The invention of antitoxins, penicillin, and vaccines dramatically reduced deaths.

Travel the 363-mile Erie Canal, the waterway that cut freight costs by 90% and opened the American frontier.

Mosquito-borne illnesses have killed two captive orcas at SeaWorld since they became water park attractions.

Europeans' arrival to America brought disease to Indigenous populations

Indigenous people lived in the Americas for centuries before the arrival of the first Europeans in the 15th century. Their arrival was disastrous for Native tribes; in addition to being enslaved and losing their land, they had no natural immunity to the diseases brought by colonists. Eventually, up to 95% of the Native American population was killed by illnesses including typhus, chickenpox, and cholera, an event now known as the Great Dying.

Jonas Salk developed the first successful polio vaccine—and tested it on himself

The American medical researcher developed the inactivated virus vaccine from 1952 to 1955 and proved that it could prevent disease. He tested the virus on himself and his family in 1954 and then carried out formal clinical trials on more than 1.3 million children.

Hear what it's like to have malaria from a patient who suffered from the mosquito-borne disease.

Thomas Jefferson dismissed the Erie Canal as 'little short of madness'

When first proposed, President Jefferson scoffed at the idea of carving a 363-mile waterway through wilderness and rock. With no precedent in American engineering, the canal seemed impossible.

Antimalarials must be taken before traveling to a malaria-endemic area

Malaria prevention involves avoiding getting bitten by mosquitoes (with bug spray and clothing choices) and taking malaria preventative drugs before, during, and after spending time in an area with malaria risk. The drug must be in the blood before the traveler is exposed to malaria parasites.