See photos of ultraviolet light therapy, widely administered in the early 1900s, particularly among children with skin diseases, tuberculosis, rickets, and more.

Light therapy was widely used as a medical treatment for various maladies in the early 1900s before it was replaced by antibiotics.

A 1974 Science News article proclaimed that within a decade, light therapy would be on par with traditional drugs.

This 1440 Original video dives into what the science says about phototherapy and its various potential applications.

High-powered red light therapy—delivered directly to nerve fibers via a fiber optic needle—has been used in recent experimental research to suppress pain.

Certain visible light therapies, when applied at specific intensities, can be used to treat skin conditions, including acne.

Red light therapy—a treatment harnessing a specific form of energy that penetrates the top layers of skin—is marketed for skincare and wellness, but has its roots in NASA plant growth research.

Bright light therapy involves basking in 10,000 lux of light for 30 minutes each morning

Nothing is better than going outside and soaking up real sunlight. However, this is harder in winter, especially in very cold and cloudy regions. SAD lamps are designed to project 10,000 lux—a unit of illuminance, or how much light actually hits a surface (rather than how much is produced, like watts). This video discusses product options and practical considerations.

NASA began investigating the healing properties of red light therapy in the 1980s, when researchers studying how LED lights could aid in photosynthesis noticed that their hands seemed to heal faster than normal under the lights.

Jaundice, which can make the skin and eyes appear yellow, is a buildup of bilirubin, a waste product that forms when old red blood cells break down.

The design of a psychiatric ward in Norway aims to integrate more circadian rhythm-friendly lights as part of its treatment protocols for conditions including psychosis, severe depression, and more.

In the early 20th century, 'baby cages' were popular among parents who believed that putting their children in the cold would build their immunity to minor illnesses.

In 2026, the US FDA approved a light-activated gel combined with red light therapy as a nonsurgical treatment option for the most common type of skin cancer.

The weakest form of light that is dangerous to humans is ultraviolet

Unlike radio waves, microwave, infrared, and visible light, UV light can produce chemical changes, such as curing adhesives and resins, causing substances to fluoresce, and destroying the genetic material of microorganisms. This makes UV light useful for sterilization, forensics, and quickly drying nail polish.

Blacklights can illuminate certain biological materials, including blood, teeth, and fingernails, because they contain fluorophores—molecules that visibly glow immediately after exposure to higher-energy light.

Read Norman Rosenthal’s original 1984 paper describing SAD

The study helped formalize research and diagnosis of seasonal affective disorder, catalyzing the development of therapies (like bright light) and leading to broader adoption of effective treatments. It also helped connect the influence of light and seasons on biological mechanisms in the human body, spurring exploration of circadian rhythms.

Wood that changed the color of water was the earliest recorded example of fluorescence

Lignum nephriticum, a tea used to treat kidney and urinary illnesses, was described in the 16th century as derived from white wood that turned water a bluish hue. However, in the 17th century, accounts described the wood as reddish and creating a kaleidoscope of colors in water. In 1915, the sources were identified as two different woods, which absorb UV radiation and emit visible light.

Photographer captures glowing flowers in ultraviolet light

Debora Lombardi utilizes ultraviolet light to reveal unseen colors in flowers, re-shaping their natural beauty. Beginning during the lockdown of March 2020, Lombardi's experimentation evolved, culminating in a series recognized by the World Photography Organization. Her work highlights vibrant purples, blues, and yellows, transforming flowers into surreal, otherworldly specimens by exposing them to UV light in her Italy-based studio.

The origin of LASIK eye surgery, from a lab incident to federal funding and widespread use

After a University of Michigan engineering student suffered retinal burns from an ultrashort pulse laser, researchers realized it could be used to reshape the cornea and improve a person's vision with greater precision than a scalpel and earlier laser technologies. Agencies, including the National Science Foundation, the National Institutes of Health, and the Department of Energy, provided funding to develop and commercialize the procedure.

Diphtheria was once a leading childhood killer before antibiotics and vaccines

In 18th- and 19th-century outbreaks, some New England families lost as many as eight children to diphtheria, and fatality rates in hospitals often topped 60%. The invention of antitoxins, penicillin, and vaccines dramatically reduced deaths.

View historical records of solar observations and discoveries, from telescopes in the early 1600s revealing sunspots to NASA's Parker Solar Probe photographing the sun from within its outer corona in 2025.

Radioactivity was accidentally discovered when uranium left marks on photographic plates

In 1896, Henri Becquerel had been exploring phosphorescence—the emission of light of one color after an object is exposed to another color. He expected these emissions to come from objects exposed to sunlight, but he observed emissions after an overcast day.

In 2023, the FDA approved gene therapy for sickle cell disease, enabling one-time infusion bespoke treatments that use a patient's own stem cells to effectively cure a painful condition that disproportionately affects people of African American descent.

A history of treating frostbite

Amid Napoleon's invasion of bitterly cold Russia, soldiers succumbed to frostbite by the thousands. Nineteenth century doctors recommended walking and rubbing snow around the affected area. Fast forward to recent years, and the FDA has approved its first ever drug to treat frostbite. Listen to this podcast to learn the history of this wintry affliction.

'Magic ink' is redefining the tattoo

One University of Colorado professor has developed an ink that can be "turned on" with exposure to UV light, and "turned off" with sunlight. While the ink could help those who want to hide their body art from family members or coworkers, there are potential uses for medical procedures.

Penicillin ended scarlet fever’s deadly threat to children

Between 1840 and 1883, scarlet fever was among the leading causes of childhood death in the United States, with case fatality rates ranging from 15% to 30%. Today, thanks to antibiotics like penicillin, the mortality rate is below 1%.

With the help of one photographer who took photos of children at work, child labor in the US was eventually restricted by law in the mid-1900s.

Bioluminescent reaction enzymes are often used in biomedical research

Near-infrared luciferase systems allow researchers to image and analyze cellular activity in living animals because they penetrate tissue more deeply than visible light. This provides a means of studying gene expression and protein interactions without harming the animals.

Before vaccines, there was 'variolation': what was it?

Before the technology behind vaccinations was discovered, some keen observers of medicine around the globe noticed how previous infections could impact future ones. Learn about the techniques early physicians used before they had vaccines.

Six of history's most unethical human experiments, from deliberate flu exposure to withholding syphilis treatment

Some of the progress made in mental health treatment, vaccines, blood transfusions, and more came about before the advent of consent and ethics committees, resulting in serious physical and psychological harm that participants in studies were not even anticipating.

Photodynamic therapy is one current treatment for age-related macular degeneration.

Humans have used bioluminescence as a means of military advantage

During World War I, the British Navy sank a German U-boat after spotting the blue light forming at the sides and in the wake of the boat. Jellyfish slime was applied to a Roman walking stick for nighttime guidance, while bioluminescent fungi in Indonesia fulfilled the same purpose.

Besides allowing patients to see how much medication they had left, transparent orange pill bottles were introduced in 1968 to protect medications from degradation caused by ultraviolet radiation.

Child labor was widespread until the formation of the National Child Labor Committee in 1904.

View an animation of how certain chemicals fluoresce—that is, emit visible light after having absorbed higher-energy light, such as ultraviolet radiation.

A collective effort from multiple scientists and inventors led to the light bulb

While Thomas Edison's thin carbon filament design made light bulbs commercially viable, prior contributions, such as Joseph Swan's development of the first successful incandescent filament electric lamp, made its eventual invention possible.

Thomas Edison created the first strand of electric Christmas lights in 1880

Edison strung electric bulbs outside his laboratory in 1880, and his business partner Edward H. Johnson first wrapped a tree in lights in 1882. It wasn’t until the lights were commercialized in 1917 that they became common in household Christmas decorations.

The iron lung—a simple mechanical ventilator—was first used to treat polio

These breathing devices, developed in the late 1920s at Harvard, were used to treat polio patients with breathing difficulties. Watch this video describing how these negative pressure devices work.

Improved 19th-century sanitation meant kids encountered polio later, with worse results

Almost all children likely used to contract poliovirus, but scientists suggest that when infants encountered it very early in life—due to poorer conditions and hygiene—they still had some maternal protection from pregnancy or through breastmilk, so the symptoms were more flu-like.

Infrared light is most often associated with thermal radiation and cooking food

Although extensively used in remote controls for electronics, where LED lights send signals wirelessly, infrared cameras allow for night vision and thermography—imaging of heat patterns in the body to non-invasively reveal blood flow for supplementary diagnostics. Infrared radiation also provides heat in toasters, saunas, and other technologies.

The first newborn screen for diseases was developed in 1961.

View a gallery of plants made to shine using ultraviolet-induced visible fluorescence photography, in which organisms re-emit the ultraviolet light they are exposed to in vibrant, glowing colors.

Cathode rays are beams of electrons that emit light when hitting a fluorescent screen

When these beams are emitted into an evacuated tube containing charged plates or a nearby magnet, deflections are observed due to the electron charge. In 1897, J.J. Thomson's calculations of this deflection led to his discovery of the subatomic particle.

Scientists create contact lenses that give you infrared vision

Scientists have created lenses that use nanoparticles to convert infrared light into visible light, allowing human eyes to observe previously invisible parts of the electromagnetic spectrum. This technology may help colorblind individuals by converting colors they cannot see into wavelengths they can.

Before 1932, when particle accelerators were first used for nuclear research, scientists relied on naturally radioactive substances to advance their understanding of the atomic nucleus.

Before electric lights, Christmas trees were lit with real candles

The practice of lighting Christmas trees with electricity didn’t begin until the late 1800s. Before that, families used wax candles on branches—a dangerous tradition that originated in 16th-century Germany.

What did people do before eyeglasses were invented?

An estimated two-thirds of the world's adults use a form of prescription glasses or contacts, proof spectacles were a godsend when they were invented in 1286 CE. But what did people do before that? Different tools were used for distinct vision problems, but some would use magnifying lenses, clear emeralds, and more. Watch this video for a historical explanation.

Impressionist painter Pierre-Auguste Renoir suffered from arthritis in the 1800s when there were no treatments, and eventually had such limited hand function that he painted with brushes placed in his mouth.

See this list of FDA-approved gene therapies, including offerings for inherited conditions as well as some forms of cancer.

Light has been modeled as a wave and a stream of particles throughout history

Isaac Newton first identified white light as composed of a spectrum of colors, which he believed consisted of particles of different hues. Various light phenomena, including refraction, led Christiaan Huygens to develop an alternative wave model. Quantum mechanics validated both models through the concept of wave-particle duality.

SAD 101 from the folks at NIMH—where the condition was first identified

Norman Rosenthal led the team at the National Institute of Mental Health that first identified and described seasonal affective disorder in 1984. This 101 from NIMH explores the basics of the condition, from who develops it to how it is treated.