Computer viruses' hijacking abilities led them to be named after biological viruses

A computer virus is a type of malware that self-replicates and spreads

Spread through emails, downloads, messaging services, and outdated software, viruses attach to programs, self-replicate, and infect other systems. They can delete files, steal data, and cause performance issues as they spread.

Some viruses evade detection by altering their own code or hiding in Microsoft Office

Computer viruses are often classified by how they spread or which files they infect, with the oldest ones—boot sector viruses—targeting systems that are active when a computer is turned on. Macros—custom codes in office productivity programs authored to automate tasks—spawned their own class of viruses.

Modern antivirus software searches for malicious behavior alongside malicious code

The first viral infections were identified by comparing the computer code of programs and files with a database of known virus codes, a method known as signature detection. The ongoing creation of new malware made databases continuously outdated, leading to the development of systems that detect patterns consistent with known viral activity.

The first computer virus was created by a USC doctoral candidate in 1983

A year after creating malware in a controlled experiment that multiplied until it took over all of a computer's memory, Fred Cohen went public with his research and its risks. He called the self-replicating software a "computer virus," a term Cohen's advisor, Leonard Adleman, coined to describe its infectious behavior. (Some readers may experience a paywall.)

Computer viruses can slow systems by allocating resources to malicious actions

Once infected software is run, instructions in the malicious code within the program or file can copy the code to various locations, exacerbating the infection and producing additional symptoms, such as slow performance, altered login credentials, changes to device settings, and system crashes.

Many early computer viruses were not created for malicious purposes

Besides those authored in research labs as proofs of concept for self-replicating software, hobbyists would create malware that played music or displayed text and animations that intentionally revealed the infection as a means of showing off, rather than hiding their spread.

The foundation for computer viruses was published after its creator's death

In the late 1940s, Hungarian American mathematician, scientist, and engineer John von Neumann gave a series of lectures where he explained the theoretical framework for a computer program that could replicate itself—the von Neumann Universal Constructor. His lectures were later compiled and published in 1966, nine years after his death from cancer.

Creating malware requires more than knowledge of programming languages

Because computer viruses, worms, and other malicious software reside within a computer's operating system, which manages computer hardware and software, cybercriminals writing effective malicious code must understand how the OS manages input and output, permissions, memory, etc. Knowledge of credentials and network access also helps create malware that easily spreads.

Different types of malware are categorized by how they spread or operate

Computer viruses require user interaction to execute a file and spread, whereas worms can self-replicate across systems without human intervention. Ransomware locks systems until a key is provided, spyware tracks and reports user activity to a third party, and trojans disguise various types of malware as legitimate software.

Every virus is classified into 7 groups based on genetic differences

Viruses infecting humans have been named based on symptoms ("chickenpox") or the location or animal in which they were first discovered ("Bolivian Haemorrhagic Fever" and "Monkeypox"). For clarity among scientists and to reduce stigma, virologists classify the 15,000 known viruses (270 of which infect humans) by their basic genetic material.

Logic bomb viruses can awaken from a dormant phase without human input

Theoretically, computer viruses can remain idle indefinitely while awaiting specific user actions, as instructed by their code. However, logic bombs—embedded code that triggers when specific conditions are met—can automatically execute viruses, such as when a certain date or time is reached.

Malware has transitioned from notoriety-driven to profit- and data-driven

Many of the first researchers and hobbyists who created viruses and worms showed a natural curiosity in experimenting with and designing such software to make a name for themselves and advance the field of computer science. In the future, AI-augmented malware may adapt in real-time or design enhanced cryptojackers, infostealers, and ransomware for cybercriminals.

The history of malware includes computer viruses, worms, trojans, and ransomware

Some of the earliest significant pieces of malware—the Creeper worm and the Elk Cloner virus—displayed silly messages to users without causing major harm. As computer science has advanced, malware has become more easily spread, incorporated social engineering to manipulate users, targeted infrastructure systems, and been used by governments for virtual espionage.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Receptors on the cell surface are key to whether a virus is successful

Viral receptors are key regulators of host range, tissue tropism, and viral pathogenesis—basically, the door locks on cells allowing viruses to invade, if they have the right key. How this process works at the microscopic level determines whether a virus is able to trigger a widespread illness in the host.

View a list of simple ways you can avoid catching a computer virus

Because this type of malware requires human intervention, such as plugging an infected flash drive into a computer or downloading and running an infected file, the chance of infection can be greatly reduced by being cautious about unfamiliar emails, attachments, and links. Keeping systems up to date with the latest security fixes is also crucial.

Computational and biological systems share fundamental principles, like randomness

Proposed by Alan Turing and John von Neumann, the concept originates from how DNA and computers run by executing encoded instructions in parallel. The advent of AI and the temperature parameter has seen neural networks mimic the randomness of protein encoding.

The ILOVEYOU virus exemplified how social engineering could help spread malware

Displaying as LOVE-LETTER-FOR-YOU.TXT on Windows computers, the file appeared to be a love letter, which many users willingly opened. However, the file contained a script that damaged and hid files, caused Internet Explorer to download software to help steal passwords, and copied itself to all Outlook contacts to continue spreading.

Explore demonstrations of hundreds of viruses and other malware in action

On their YouTube channel, Malware historian Daniel White has documented what happens when various types of malware—mostly from the 1980s and 90s—run on a computer or Nokia cell phone. The demonstrations were safely conducted within virtual machines—older operating systems run within contained windows of modern software, resembling a picture-in-picture setup.

Safely explore historic viruses and other malicious software in the Malware Museum.

The Chernobyl virus earned its name for activating on the meltdown's anniversary

Affecting Windows 95 and 98 computers, it filled gaps in the code of any program opened after infecting a computer, earning it the nickname "Spacefiller." On April 26, 1999, the virus overwrote part of the software responsible for booting up a computer, rendering it unusable.

Flu viruses use special proteins to invade and spread in the body

Influenza viruses carry two key surface proteins: hemagglutinin (H), which lets them enter cells, and neuraminidase (N), which helps them escape and spread. These proteins are the basis for the names of flu subtypes like H1N1 and H3N2

Bacteriophages—viruses that infect bacteria before multiplying within them—exist on Earth in numbers greater than all other living organisms combined.

Explore the cost of major viruses and other malware incidents through 2017

The first significant malware was the Morris worm in 1988, which caused an estimated $10,000 to $10M in damage to computers. With $38B in damage caused, Mydoom is the most costly piece of malware in history. Spread via email and, at one point, accounting for about 25% of all messages sent worldwide, the malware infected computers to create a botnet that launched cyberattacks.

The Melissa 'virus' helped associate pornographic sites with computer viruses

A worm-embedded document posted online enticed users to download and open it by alleging to contain passwords to paywalled explicit websites. Upon opening, the worm shared itself with 50 addresses in a user's Outlook contacts, masquerading as a friendly attachment. Its rapid spread overwhelmed email servers and caused $1.1B in damage worldwide.

Peter Norton, for whom Norton Antivirus is named, questioned the threat of viruses

The software author was among several computer experts in 1988 who suggested that reports on the threat of computer viruses were exaggerated, referring to testimonials of infections and their spread as "urban legends."

Before vaccines, there was 'variolation': what was it?

Before the technology behind vaccinations was discovered, some keen observers of medicine around the globe noticed how previous infections could impact future ones. Learn about the techniques early physicians used before they had vaccines.

The gut microbiome's community of viruses is collectively known as the virome, but most of its viruses remain unidentified.

The seven viruses that cause human cancers

Certain viruses have been linked to the development of human cancers. These viruses account for up to 20% of cancers worldwide, causing cancer by interacting with host proteins, proliferating within weak immune systems, and commandeering susceptible human cells. Unlike other viruses, human tumor viruses don't kill host cells, allowing them to establish persistent infections. The seven viruses include the Epstein-Barr Virus, the Human Papillomaviruses, and more.

Ebola is a filovirus, meaning it resembles a thread under a microscope.

In 2015, a custom virus program was used to destroy and transform art images

At the Art Laboratory Berlin's "bOdy pandemOnium: Immersion into Noise" exhibit, Chicago-born artist Joseph Nechvatal explored viractualism—the interface between the biological and the technological—via a custom virus program that randomly altered images representing the human eye and rectum.

Poliomyelitis is derived from Greek

Polio, formally called poliomyelitis, comes from the Greek words for gray (polios) and marrow (myelos)—a reference to the spinal cord tissue that, when infected by the virus, causes paralysis.

Henrietta Lacks' tumor cells became the first recognized 'immortal' cell line about 75 years ago, but researchers are still investigating the specific mechanisms that enabled the cells to continuously grow and divide in the laboratory.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

The virus was officially described for the first time in 1789

Michael Underwood, an English physician and surgeon, was the first to describe the disorder, noting it caused disability in the lower extremities in children. Large-scale outbreaks of the disease were not observed until the late 19th century.

Explore 3D models of some of the most dangerous viruses, allowing us to understand these and other pathogens in new ways.

HIV sidelines your immune system by destroying T cells, eventually rendering the body unable to fight off even minor illnesses.

Your device can become infected with malware by simply browsing the internet

During a drive-by download attack, security flaws in a program or operating system (e.g., Windows) used to access online content are exploited, and malicious code is downloaded—for example, when loading a hacked webpage—onto a user's device without their knowledge. Restricting internet browsing to safe sites and installing security updates helps prevent these attacks.

Bats are uniquely suited to act as reservoirs of viruses.

Some of the deadliest diseases to jump from animals to humans originate in bat species. This rich visualization explores the diversity of bats and the factors that make them efficient vectors for harboring and transmitting disease, from their long lifespans to their migration patterns.

CRISPR-Cas systems act as genetic memory banks for defending bacterial cells

When viruses called phages inject DNA into bacteria, some bacterial species store bits of this DNA in their own genomes. This allows them to recognize and destroy the same virus if it attacks again.

Snake venoms are repurposed proteins responsible for other bodily functions

Just as saliva aids digestion in humans, proteins responsible for bioactivities such as digestion and blood clotting were eventually secreted in the glands and fangs of snakes across evolutionary history. Organisms that could not withstand the effects of these molecules (e.g., excessive bloodstream clotting) became ideal prey for snakes.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola.

Up to 8% of the human genome consists of ancient viral DNA

Human endogenous retroviruses are remnants of infections that affected human primate ancestors millions of years ago and were passed on by infiltrating sperm and egg cells. Studies have shown that this DNA may play a role in immune responses and in placental formation.

Roughly 1 in 5 cancers are caused by viruses

About 20% of cancers are caused by viruses, with seven specific oncoviruses causing between 10% and 15% of cancers worldwide. These include human papillomavirus and hepatitis B and C viruses, which can lead to diseases such as cervical and liver cancer. Understanding the mechanisms of these viruses is crucial for prevention and treatment strategies.

Seven known types of coronaviruses have jumped from animals to humans

Coronaviruses, including SARS-CoV-2, belong to a large family of viruses characterized by their crown-like appearance under a microscope, due to spike proteins on their surface. While thousands are believed to exist in animals, only seven are known to have made the jump to humans.

Zoonotic diseases: Pathogens that jump from animals to humans

Such diseases may be caused by a variety of pathogens—viruses, bacteria, fungi, or parasites—and can originate in creatures ranging from ticks and mosquitoes to pigs and bats. Because they develop in animals and are often new to human immune systems, zoonotic diseases have severe consequences for public health.

Scientists now know that Henrietta Lacks, a Black woman whose 'immortal' cancer cells were nonconsensually sampled and used for research, had been infected with human papillomavirus, a group of pathogens responsible for most cervical cancers.

Gene therapy treats a disease by editing the disease's underlying DNA, replacing it with a functional variant.

Explaining how open source systems like Linux can be secure, despite their public source code

While no computer system is immune to all cyberattacks and malware, the transparency of open-source technology means many thousands of developers can review and oversee the underlying code powering the software on an ongoing basis. This increases the likelihood of catching and patching vulnerabilities more quickly than smaller groups of cybercriminals looking to exploit them.

See this diverse list of vector-borne diseases

Human illnesses caused by parasites, viruses, and bacteria, and transmitted by a living organism—often small, bloodsucking ones like mosquitoes, ticks, and sandflies—are known as vector-borne diseases. That carrier is called a vector. These diseases disproportionately affect the poorest populations in tropical and subtropical areas.