Schizophrenia symptoms often appear suddenly

Schizophrenia symptoms, like psychosis, often first emerge among young adults

A combination of genetics, significant brain changes to the frontal cortex, and hormonal changes during young adulthood—late teens to early 30s—result in schizophrenic symptoms often showing up during this period. The stress of life changes at that age may also be a contributing factor.

Schizophrenia is challenging to diagnose and treat

The disorder is diagnosed by a clinician who observes behaviors and medical history and may run additional tests to rule out other explanations for symptoms including physical injury or other mental health disorders. But, ultimately, it's largely a diagnosis of exclusion—since there is no definitive test for the disease. Antipsychotic medications can help control its symptoms for some patients, but there is no cure for schizophrenia.

People with schizophrenia typically die 9 years earlier than the general population

The syndrome, which affects roughly 1 in 233 adults, is often associated with other serious health issues, including cardiovascular, metabolic, and infectious diseases, which may contribute to early deaths. The side effects of long-term antipsychotic medications also may influence the mortality timing—weight gain, for example, is a common side effect of the drugs and can contribute to cardiovascular issues.

Traumatic childhood experiences heighten the risk of developing schizophrenia

Clinically termed as "adverse childhood experiences," events such as physical or mental abuse or the death of loved ones have repeatedly been linked to an increase in rates of developing schizophrenia later in life. The reasons behind this link remain under investigation.

Less than 1% of people globally have schizophrenia, a syndrome strongly linked to genetics

Schizophrenia's causes remain largely unknown, though scientists suggest it's caused by multiple factors. Its symptoms include disruption of thought processes rather than the exhibiting of multiple personalities. This brief video provides an overview of the condition.

Schizophrenia literally means 'split mind'—a reference to patients' break with reality

Contrary to the name, patients do not have multiple personalities. Rather, the split mind refers to the sufferers' inability to distinguish reality from hallucinations when they are aware and awake. Cognitive difficulties, including challenges focusing and communicating are also common among those with schizophrenia, as well as auditory and visual hallucinations.

People with schizophrenia have triple the risk of developing diabetes

It remains contentious if something inherent about the disease or antipsychotics' side effects (weight gain) are mostly to blame. Some newly diagnosed schizophrenia patients already have insulin resistance, raising questions about if patients' brains are getting enough energy from glucose, and if dietary changes—like a high-fat, low-carbohydrate, moderate-protein diet—may help alleviate symptoms.

80% of schizophrenia cases may be inherited

Some research suggests that anywhere between 60% and 80% of people with schizophrenia had genes that predisposed them to the syndrome. That high rate has fueled interest in further exploration of what environmental and lifestyle factors cause some people with that genetic risk to develop the disease when others with the same genetic risks do not.

The term schizophrenia was coined by Swiss psychiatrist Eugen Bleuler in 1908

He launched the word during a lecture at the German Psychiatric Association in Berlin. In his talk he focused on the splitting of psychic functioning as a defining feature of the disease and noted it wasn't associated with dementia or factors like early puberty onset.

People with schizophrenia are excluded from psychedelic research

Individuals with this mental health condition are routinely eliminated from any psychedelic research due to concerns about triggering or worsening psychosis. Yet there is little high-quality research in this area, raising questions about if further research into this question is warranted as interest grows in using psychedelics for therapeutic purposes.

Postpartum psychosis is an emergency requiring immediate psychiatric intervention, with symptoms including hallucinations, paranoia, and delusions that may put a baby at risk.

Schizophrenia increases heat death risks in several complex ways

Evidence shows that people with schizophrenia have an inherently harder time regulating internal body temperatures. They may also struggle to find safe shelter during extreme heat, and their prescribed antipsychotic medications often have dehydrating effects, collectively elevating the risk of heat-related illness and death, as illustrated by this article that focuses on the final days of Stephan Goodwin's life in 2022. (Some users may encounter a paywall.)

Alzheimer's brain changes may begin years before symptoms appear.

Deinstitutionalization in the 20th century unintentionally led to the incarceration of schizophrenia patients

Activism to shut down problematic asylums in the mid-20th century led to the community release of many patients with severe mental illnesses, including schizophrenia, but without adequate support, this deinstitutionalization in the 1960s and 1970s led to a significant increase in patients with schizophrenia ending up in prisons and homeless shelters.

Schizophrenia is being studied with pea-sized 'mini-brains'

Brain organoid research is enabling researchers to study distinct electrical firing patterns associated with schizophrenia. These "mini-brains" that are constructed in the lab from patients' cells could lead to better diagnosis approaches and drug development.

Some data links schizophrenia to older paternal age and birth complications

Yet both associations are not yet considered firm enough to definitively be causative. Schizophrenia is a multi-causal syndrome and a mixture of factors, including genetics, are widely believed to be behind its development.

Why might someone want to stay in psychosis?

Author Abigail Gosselin writes that her verbal auditory hallucination, often assumed by others to be harmful or threatening in nature, offered a salve to loneliness, even as it told her to kill herself. This perceived benefit and others Gosselin shares offer insight into why people in psychosis may struggle to adhere to treatment and medication plans.

Misfired motor signals may explain why many people with schizophrenia hear voices

Up to 80% of schizophrenia patients may have auditory hallucinations. Recent research concluded that this symptom may be from misfired motor signals that feed into each other, essentially failing to suppress certain sensory neural activities and that resulting overexcitment fuels hallucinations. The finding suggests that, one day, magnetic pulses might be used to stimulate specific nerves to better regulate the errant signals and reduce or stop hallucinations. (Some users may encounter a paywall.)

Gene expression patterns are similar between ASD, schizophrenia, and bipolar disorder

Postmortem brain tissue analysis suggests there are genetic and epigenetic similarities between individuals with autism, schizophrenia and bipolar disorder. All three conditions appeared to have activation of genes in astrocytes and suppression of specific genes that function at the junction between neurons, called synapses. (Some users may encounter a paywall.)

PTSD is a long-lasting mental disorder linked to past traumatic events

Posttraumatic stress disorder is a mental health condition arising from traumatic events with four key symptoms: intrusive memories, avoidance behavior, negative moods and thoughts, and changes in emotional and physical reactions.

Depression is much more than sadness—and isn't fleeting

The American Psychiatric Association's DSM-5—used for defining diagnoses—says a person must be experiencing five or more symptoms of depression most of the day over at least two weeks. Research indicates older people are less likely than younger people to meet that depression benchmark, though this article says they still often have at least several of the depression symptoms.

Circadian rhythm disruption can influence various mental health disorders

This 2020 research overview surveys the relationship between disrupted circadian clocks and disorders including schizophrenia, anxiety, and bipolar disorder. It incorporates findings and therapeutic approaches drawing from human night shift studies and jet lag studies alongside animal research.

Stress and anxiety may lead to similar symptoms, but stress is a response to external triggers, while anxiety is persistent, and its symptoms won't disappear once an immediate stressor is gone.

MS can damage the brain up to 7 years before symptoms appear

Recent research scouring blood samples from 134 people with MS, both before and after their diagnosis, found that about seven years before these patients were diagnosed, there was a spike in a protein called myelin oligodendrocyte glycoprotein—indicating disease-associated damage to the protective myelin around nerve fibers.

An intense fear must persist for at least six months to be diagnosed as a phobia.

How seizures (potentially) alter consciousness

Seizures occur when intense electrical activity floods the brain, prompting significant loss of self-control and a variety of sensory disruptions and hallucinations. Cultures interpret the episodes differently, with many contemporary norms viewing them as negative while others characterize them as intense spiritual occasions. Author Fyodor Dostoyevsky viewed his seizures this way, as well as cultures in Mongolia, some Shamanic indigenous religions, and others.

In 2019, videos on TikTok convinced children they had Tourette syndrome

Right before the COVID-19 pandemic, an "outbreak" of Tourette syndrome was attributed to videos from a German TikToker who documented his life with the condition. The children experiencing the symptoms all had the same tics, which experts say was a case of mass sociogenic illness, also referred to as mass hysteria.

Mental health symptoms may manifest differently across cultures because physical and mental health are imbued with values, beliefs, and traditions.

In 2011, a mysterious illness spread around LeRoy, New York

A handful of girls were stricken with bizarre twitches, tics, and spasms — all apparently involuntary. Some believed the incident to be conversion disorder, an illness where emotional troubles have physical symptoms.

Anxiety can arise at any stage of life and make someone feel unsafe in their mind and body.

A rare measles complication is that the virus can linger in the body for years after apparent recovery and continue to replicate—leading to a progressive and fatal breakdown of the central nervous system that can occur decades after the initial infection.

Prolonged Grief Disorder has certain recognizable risk factors

This official diagnosis is characterized by intense, daily symptoms of grief a year after the loss of a loved one among adults and faster—around at least six months—for kids and teens. Factors that put people at increased risk of this disorder include being single, attachment anxiety, violent or unnatural death, low education, low income, and multiple losses, among others.

US FDA recently approved the first new schizophrenia drug in decades

Though other antipsychotics block dopamine receptors, a new drug, Cobenfy, influences dopamine levels via a different pathway—it stimulates a pair of specialized receptors in the brain that control the release of a substance called acetylcholine. This alternative approach may help patients avoid serious side effects like weight gain. (Some users may experience a paywall.)

Wearing a 'schizophrenia simulator,' designed to build empathy for patients, CNN's Anderson Cooper finds he struggles to function

Donning headphones that play a track mimicking the auditory hallucinations common in schizophrenia, Cooper finds he is very distracted, disconcerted, and frustrated. The auditory track aims to help listeners build empathy with patient populations by understanding the challenges they face in daily life.

People with a sleep disorder called REM Sleep without Atonia don't experience the temporary paralysis of skeletal muscles that typically occurs during REM sleep—instead, they have vivid dreams that they act out during sleep.

Symptoms of extreme radiation exposure may take hours to manifest

Large doses of ionizing radiation can damage the body within minutes, particularly in the bone marrow and inner layer of the digestive tract. Victims may briefly seem fine before rapidly deteriorating as immune failure, infection and organ collapse set in.

Narcolepsy occurs when the brain loses its ability to control its sleep-wake cycle.

Having five of nine key symptoms constitutes a major depression

Before professional standards were adopted, practitioners used varying criteria to diagnose mental health disorders. By the 1970s, more objective lists were organized, culminating in this list of polythetic criteria—a list of symptoms where no single criterion is required, but a minimum number must be present.

A new schizophrenia healthcare model is giving patients more of a role in shaping their own treatments, with good results.

Roughly 10% of the world has SSAD—SAD’s milder, nonclinical cousin

Subsyndromal affective disorder is diagnosed when someone exhibits two of the nine major criteria for depression (but not more than five) as a result of seasonal changes. While it is milder than primary SAD, SSAD is still significant and impacts millions.

Listen to how gaps in schizophrenia care helped to lead to a murder

Michael Laudor attended Yale, succumbed to schizophrenia, and killed his pregnant fiancée. The podcast, which includes a long but moving interview with Laudor's friend Jonathan Rosen, uses the tragedy to frame how America's approach to severe mental illness has fallen short.

What it's like to live with insomnia

The biological process Shakespeare referred to as the chief nourisher of life's feast is necessary for the body and mind to rest and repair from the activities of daily life. As sleep evades the exhausted, sufferers also lose emotional stability, mental clarity, social connections, and more while simultaneously gaining waves of interrupted biological processes that can lead to disease and death.

How family members disappeared into dementia

This narrative feature describes one family's troubling experience with frontotemporal dementia, or FTD, which emerges in the prime of adult life — as young as 40, in some cases — and degrades the brain's ability to plan, organize, express language, understand social cues, and exercise judgment.

Psychedelic side effects, including worsening mental health for some patients, give pause

This article explores whether the therapeutic potential of psychedelic drug use is really as good as current research suggests. Scientists are exploring its applications for conditions ranging from the existential crisis that can accompany terminal diagnoses to chronic mental health conditions, including anxiety and PTSD.

Early-onset Alzheimer's can appear as early as age 30, but estimates of its prevalence remain uncertain.

Bipolar disorder, which is characterized by extreme mood swings, affects nearly 3% of the US population

There are two types of this disorder. Bipolar 1 features a significant manic episode—abnormally elevated mood and frantic energy—followed by repeated depression, while Bipolar 2 vacillates between depressive episodes and hypomania, a milder form of mania, but not a full mania. Listen to this podcast as experts explain the condition.

Vertigo can last for minutes—or months—and may occur periodically

Vertigo can be caused by a variety of conditions, including as a side effect of medication, but if it comes on suddenly and is accompanied by other symptoms including difficulty with speech or weakness on one side of the body it's important to go to the emergency room to get checked for a stroke. For recurring vertigo, care teams can teach patients exercises to limit panic, lessen nausea and teach the brain to better tolerate head movements.

Panic attacks are intense fear episodes that often occur without a clear trigger

Unlike typical fear responses to real danger, panic attacks can mimic serious health problems, such as heart attacks. Sweating during a panic attack may seem random, but it's a leftover survival mechanism that made it easier for our ancestors to escape by slipping out of an attacker’s grasp.

What happened to thousands of teens from the 1990s?

Scientists followed thousands of teenagers from 1997 into their 30s, cataloging their adverse experiences along the way via nearly three decades of interviews. Teens who grew up dealing with poverty, uninvolved parents, and other childhood stressors and traumas racked up an ACE score. These adverse childhood experiences have lifelong impacts on one's health, relationships, financial security, and "pretty much everything else," making them more likely to suffer premature death.

There are multiple types of multiple sclerosis—they differ by attack patterns

When your immune system targets the nervous system, this can cause new or worsening symptoms and the development of scarring or damage within the central nervous system. Relapsing-remitting MS is the most common type of the disease—it includes progressive bouts of attacks that occur months or years apart.