The term schizophrenia was coined by Swiss psychiatrist Eugen Bleuler in 1908

Schizophrenia literally means 'split mind'—a reference to patients' break with reality

Contrary to the name, patients do not have multiple personalities. Rather, the split mind refers to the sufferers' inability to distinguish reality from hallucinations when they are aware and awake. Cognitive difficulties, including challenges focusing and communicating are also common among those with schizophrenia, as well as auditory and visual hallucinations.

Schizophrenia symptoms, like psychosis, often first emerge among young adults

A combination of genetics, significant brain changes to the frontal cortex, and hormonal changes during young adulthood—late teens to early 30s—result in schizophrenic symptoms often showing up during this period. The stress of life changes at that age may also be a contributing factor.

Less than 1% of people globally have schizophrenia, a syndrome strongly linked to genetics

Schizophrenia's causes remain largely unknown, though scientists suggest it's caused by multiple factors. Its symptoms include disruption of thought processes rather than the exhibiting of multiple personalities. This brief video provides an overview of the condition.

Schizophrenia symptoms often appear suddenly

Schizophrenia is a particularly shocking mental illness because its symptoms may appear seemingly without any prior signs of illness after a person has had no symptoms for the first couple of decades of their life. Among teens, symptoms may look like typical adolescent behaviors—withdrawal, being irritable, and having trouble sleeping.

Schizophrenia is challenging to diagnose and treat

The disorder is diagnosed by a clinician who observes behaviors and medical history and may run additional tests to rule out other explanations for symptoms including physical injury or other mental health disorders. But, ultimately, it's largely a diagnosis of exclusion—since there is no definitive test for the disease. Antipsychotic medications can help control its symptoms for some patients, but there is no cure for schizophrenia.

People with schizophrenia typically die 9 years earlier than the general population

The syndrome, which affects roughly 1 in 233 adults, is often associated with other serious health issues, including cardiovascular, metabolic, and infectious diseases, which may contribute to early deaths. The side effects of long-term antipsychotic medications also may influence the mortality timing—weight gain, for example, is a common side effect of the drugs and can contribute to cardiovascular issues.

80% of schizophrenia cases may be inherited

Some research suggests that anywhere between 60% and 80% of people with schizophrenia had genes that predisposed them to the syndrome. That high rate has fueled interest in further exploration of what environmental and lifestyle factors cause some people with that genetic risk to develop the disease when others with the same genetic risks do not.

Traumatic childhood experiences heighten the risk of developing schizophrenia

Clinically termed as "adverse childhood experiences," events such as physical or mental abuse or the death of loved ones have repeatedly been linked to an increase in rates of developing schizophrenia later in life. The reasons behind this link remain under investigation.

Some data links schizophrenia to older paternal age and birth complications

Yet both associations are not yet considered firm enough to definitively be causative. Schizophrenia is a multi-causal syndrome and a mixture of factors, including genetics, are widely believed to be behind its development.

JJ Schildkraut theorized depression is linked to brain chemical imbalances—in 1965

Schildkraut was one of the first to put forward this idea, which stemmed from lab animal research. A decade later, researchers published the first landmark paper on fluoxetine—better known by trade name Prozac—which increases serotonin levels in the brain.

The term 'scientist' was coined in a 1834 book review by English polymath William Whewell, who needed an alternative to 'man of science' to describe Scottish writer Mary Somerville.

'Mental hygiene' was the 1843 term for mental health

It was coined by American psychiatrist William Sweetzer to reference the same idea as personal hygiene. Mental hygiene, in Sweetzer's view, needed to be maintained in the same way people attend to their personal cleanliness, an idea that was supplanted by better understanding of the complexities of mental health disorder causes in the decades that followed.

Schizophrenia is being studied with pea-sized 'mini-brains'

Brain organoid research is enabling researchers to study distinct electrical firing patterns associated with schizophrenia. These "mini-brains" that are constructed in the lab from patients' cells could lead to better diagnosis approaches and drug development.

Existentialism has been used as a therapeutic tool, with 2 Swiss psychiatrists pioneering the philosophy's concepts to help patients navigate their issues.

People with schizophrenia are excluded from psychedelic research

Individuals with this mental health condition are routinely eliminated from any psychedelic research due to concerns about triggering or worsening psychosis. Yet there is little high-quality research in this area, raising questions about if further research into this question is warranted as interest grows in using psychedelics for therapeutic purposes.

Deinstitutionalization in the 20th century unintentionally led to the incarceration of schizophrenia patients

Activism to shut down problematic asylums in the mid-20th century led to the community release of many patients with severe mental illnesses, including schizophrenia, but without adequate support, this deinstitutionalization in the 1960s and 1970s led to a significant increase in patients with schizophrenia ending up in prisons and homeless shelters.

'Melancholia' was the ancient Greek term for depression

"Melancholia" in Hippocrates's time was derived from the Greek word for black bile. This term made sense in its context since the Greeks believed that depression stemmed from an improper balance of the four humors.

People with schizophrenia have triple the risk of developing diabetes

It remains contentious if something inherent about the disease or antipsychotics' side effects (weight gain) are mostly to blame. Some newly diagnosed schizophrenia patients already have insulin resistance, raising questions about if patients' brains are getting enough energy from glucose, and if dietary changes—like a high-fat, low-carbohydrate, moderate-protein diet—may help alleviate symptoms.

The virus was officially described for the first time in 1789

Michael Underwood, an English physician and surgeon, was the first to describe the disorder, noting it caused disability in the lower extremities in children. Large-scale outbreaks of the disease were not observed until the late 19th century.

LSD (better known as acid) was created in 1938 by Swiss chemist Dr. Albert Hofmann

Lysergic acid diethylamide, better known as LSD or acid, was first developed synthetically in 1938 by Swiss chemist Dr. Albert Hofmann. It's since become a linchpin for an entire aesthetic, fueled a counterculture movement, and is being studied for potential therapeutic uses.

Dr. Seuss was likely the first to use the word 'nerd' in print

The word appeared in 1950's "If I Ran the Zoo," but there are theories that the word (or forms of it) were already part of popular slang before the book was published.

US FDA recently approved the first new schizophrenia drug in decades

Though other antipsychotics block dopamine receptors, a new drug, Cobenfy, influences dopamine levels via a different pathway—it stimulates a pair of specialized receptors in the brain that control the release of a substance called acetylcholine. This alternative approach may help patients avoid serious side effects like weight gain. (Some users may experience a paywall.)

Writer William Gibson invented the term 'cyberspace'

The science-fiction writer coined the term in his 1982 short story "Burning Chrome" to describe "a consensual hallucination experienced daily by billions of legitimate operators, in every nation, by children being taught mathematical concepts...A graphic representation of data abstracted from the banks of every computer in the human system. Unthinkable complexity. Lines of light ranged in the nonspace of the mind, clusters and constellations of data. Like city lights, receding."

The first identification of Alzheimer's was made in 1906.

The word 'dystopia' was first used in 1868

John Stuart Mill, an English philosopher, economist, and politician, uttered the word at the House of Commons while criticizing what he considered to be the government’s insufficient land policy for the Irish, saying, “What is commonly called Utopian is something too good to be practicable; but what they appear to favour is too bad to be practicable.”

Carl Jung proposed the controversial idea of the 'collective unconscious'—all humans share a common psychic realm.

Read the original 1907 paper on the first known Alzheimer's patient, which was identified by Dr. Alois Alzheimer.

The term 'burnout' in academia dates back to 1974

Psychologist Herbert Freudenberger introduced the term to describe the mental and emotional fatigue he witnessed among volunteers at a free clinic in New York. It was widely popularized in a 1976 article by Berkeley professor Christina Maslach.

Many writers considered 'existentialist' didn't identify with the term

“Existentialism” was first introduced in 1943 by philosopher Gabriel Marcel. Jean-Paul Sartre and Simone de Beauvoir readily adopted the term, but others, such as Albert Camus and Martin Heidegger, rejected it. Earlier philosophers, like Søren Kierkegaard and Friedrich Nietzsche, were long dead by the time the word was in vogue.

Gene expression patterns are similar between ASD, schizophrenia, and bipolar disorder

Postmortem brain tissue analysis suggests there are genetic and epigenetic similarities between individuals with autism, schizophrenia and bipolar disorder. All three conditions appeared to have activation of genes in astrocytes and suppression of specific genes that function at the junction between neurons, called synapses. (Some users may encounter a paywall.)

Listen to how gaps in schizophrenia care helped to lead to a murder

Michael Laudor attended Yale, succumbed to schizophrenia, and killed his pregnant fiancée. The podcast, which includes a long but moving interview with Laudor's friend Jonathan Rosen, uses the tragedy to frame how America's approach to severe mental illness has fallen short.

Misfired motor signals may explain why many people with schizophrenia hear voices

Up to 80% of schizophrenia patients may have auditory hallucinations. Recent research concluded that this symptom may be from misfired motor signals that feed into each other, essentially failing to suppress certain sensory neural activities and that resulting overexcitment fuels hallucinations. The finding suggests that, one day, magnetic pulses might be used to stimulate specific nerves to better regulate the errant signals and reduce or stop hallucinations. (Some users may encounter a paywall.)

In the late 1800s, over 10,000 entries of the Oxford English Dictionary were written by a patient in a psychiatric hospital.

The term 'cancer' is roughly 3,000 years old and derives from the Greek word for 'crab,' which may refer to how a malignant tumor can feel like a hard shell.

Wilhelm Wundt, the forgotten father of modern psychology

He was the first psychologist to call himself one, and he influenced a whole generation of early psychologists. Learn about the life and works of Wilhelm Wundt with this thorough entry from a philosophy encyclopedia.

Synesthesia: when sensation in one sense triggers an unrelated sense in the brain

The first reported clinical case of synesthesia dates back to the early 1800s, though the perceptual phenomenon may be much older than surviving records imply. This article by researcher Richard Cytowic details the scientific history of synesthesia, a neurological trait that causes some senses to overlap, giving color to numbers and flavors to names.

Freud and Jung were once friends. What drove them to break up?

Austrian psychologist Sigmund Freud and Swiss psychiatrist Carl Jung were fast friends, immediately hitting it off the first time they met in 1907. This four-minute video dives into the intellectual divide that drove them apart.

Churchill’s 1946 ‘Iron Curtain’ speech warned of growing Soviet domination

In a 1946 speech, Winston Churchill declared that an “Iron Curtain” had descended across Europe—dividing East from West. The address marked one of the first public acknowledgments of the emerging Cold War and coined the term that would define the conflict.

The widespread violence of World War I birthed surrealism

Following World War I, artists used unconventional forms of expression to make sense of the death and destruction they'd witnessed for years. Life as they knew it had ended, and movements like Surrealism, founded by André Breton, rebelled against tradition.

Who was Freud and what did he say?

Sigmund Freud is one of the most famous psychologists and is widely cited—but do you really know the basics of what he taught? Here's a super brief breakdown of his major insights.

Wilhelm Wundt's place in the history of psychology

While ancient philosophers considered the central problems of psychology, it was Wilhelm Wundt who first called himself one. Here's a quick video overview of his contribution.

How Scrabble got its name

Alfred Butts, a newly unemployed architect during the Great Depression, created Scrabble. But the game was named by James Brunot, who used the word to describe the most common action its players take part in: digging frantically.

Government watchdog says nursing homes are inappropriately diagnosing schizophrenia

The Department of Health and Human Services Office of Inspector General said in a March 2026 report that nursing homes are incorrectly diagnosing their residents with schizophrenia to mask the facilities' misuse of antipsychotic medications. The drugs, the report states, are being widely used to make staff members' jobs easier and to keep nursing home quality measures high—since antipsychotic use for schizophrenia wouldn't be counted against the facility. (PDF)

The word ‘fantasy’ wasn't used to describe the genre until the 20th century

The word—at least as a word used to describe fiction—didn’t appear in the Oxford English Dictionary until 1949. Scholars believe that’s due to the arrival of the Magazine of Fantasy and Science Fiction, an influential publication, and the rise in fantasy’s popularity following World War II.

Arnold Schoenberg expanded the confines of music by abandoning traditional chords and embracing dissonance.

Circadian rhythm disruption can influence various mental health disorders

This 2020 research overview surveys the relationship between disrupted circadian clocks and disorders including schizophrenia, anxiety, and bipolar disorder. It incorporates findings and therapeutic approaches drawing from human night shift studies and jet lag studies alongside animal research.

Autism spectrum disorder, defined in 2013, was previously categorized as numerous disorders.

German expressionism produced some of horror’s earliest classics

After World War I, German filmmakers turned from reality to the surreal, fusing experimental art with the nascent world of film. Some of the movement’s most notable films, like FW Murnau’s “Nosferatu: A Symphony of Horror” and Robert Wiene’s “The Cabinet of Dr. Caligari,” were intent on frightening their audiences.

The Supreme Court's first major free-speech ruling rested on a legal standard that was later overturned

In Schenck v. United States (1919), the court introduced the "clear and present danger" test—permitting the government to restrict speech that posed an immediate threat to public safety. Although the doctrine was later replaced, the ruling upheld the conviction of a man who had distributed anti-draft pamphlets.

A French Army surgeon discovered that malaria is a parasitic disease in 1880—but scientists were initially skeptical.