1 in 10 US adults are taking medication for depression

US depression rates at historic high among adults

More than 18% of US adults reported that they currently have or are being treated for depression in both 2024 and 2025. In the 2025 survey, more than 11,000 adults were surveyed. The numbers have ticked upward since 2015—by about 8 percentage points—with most of the increase occurring from the 2020 pandemic onward.

Teen depression levels jumped during the pandemic

US government data published in 2025 but gathered from August 2021 through August 2023 indicated that depression prevalence among teens aged 12 to 19 was at 19.2%. It was even higher among females of that age group—26.5%

See how anxiety disorder rates vary across 200+ countries, with Portugal, Malta, Brazil, and Iran reporting the highest burdens.

Women are four times as likely to be diagnosed with seasonal depression

This prevalence trend mirrors the broader incidence of depression among women and is well-documented. Researchers suggest the disparity stems from differences in hormones, social role expectations, coping mechanisms, and more. Men may also present with depression differently, and seek help less.

35% of polled Americans said they'd view people differently if they knew they had a mental illness.

1 in 5 American adults report daily loneliness

Twenty percent of US adults said they felt lonely "a lot of the day yesterday" in Gallup polling conducted in 2024. The survey was conducted with more than 6,000 adults who took part in a web survey.

86 commonly used drugs, including certain antidepressants, painkillers, and immunosuppressants, have different results for men and women, according to recent research.

See how antidepressants—used by roughly 1 in 10 Americans—were discovered.

Antidepressants alone may fail to help an estimated one-third to one-half of depressed patients.

More than a third of America's incarcerated population has a mental illness.

Depression is much more than sadness—and isn't fleeting

The American Psychiatric Association's DSM-5—used for defining diagnoses—says a person must be experiencing five or more symptoms of depression most of the day over at least two weeks. Research indicates older people are less likely than younger people to meet that depression benchmark, though this article says they still often have at least several of the depression symptoms.

How did the pandemic affect mental health?

Read this research brief to learn more about why heightened mental health and substance use concerns persist three years after the outbreak of COVID-19. According to a recent survey, the vast majority of American adults view the nation as facing a...

Over 28% of US adults use yoga for pain management.

12% of adults were taking injectable GLP-1 for weight loss according to 2025 survey

Weight loss injectable use rose sharply between 2024 and fall 2025. The percentage of adults who reported taking this class of medicine specifically for weight loss increased to 12.4%, compared with 5.8% in February 2024 when Gallup first measured it.

Alcohol use disorder is the most common addiction in the US

This comprehensive overview from the Addiction Center uses recent data from SAMHSA’s National Survey to examine the 10 most common substance dependencies in the United States. It ranks addictions from alcohol (affecting 28.3 million Americans) to barbiturates, while highlighting key trends, risks, and societal impacts.

Bupropion is the only antidepressant approved for the preventive treatment of SAD

Clinical trials showed a 44% reduction in risk for recurrence of SAD for those who took the drug compared to a placebo group. Bupropion is a norepinephrine–dopamine reuptake inhibitor, which increases dopamine (other common antidepressants, known as selective serotonin reuptake inhibitors, sometimes can suppress dopamine, but not always).

27% of US menopausal women used estrogen in 1999, but by 2020 that number was under 5%

The fallout of studies in the early 2000s linking hormone therapy for menopause and elevated cancer, stroke, and other health risks meant that even decades later—yet before the FDA removed its black box warning in 2025—use of HRT remained extremely uncommon. (Some users may experience a paywall.)

Roughly 10% of the world has SSAD—SAD’s milder, nonclinical cousin

Subsyndromal affective disorder is diagnosed when someone exhibits two of the nine major criteria for depression (but not more than five) as a result of seasonal changes. While it is milder than primary SAD, SSAD is still significant and impacts millions.

Winter-risk SAD is more likely in regions above 40 degrees latitude north

Using latitude, depression prevalence, and populations of women and those aged 18-30, this map shows the risk of experiencing seasonal affective disorder during the winter. Researchers weighted latitude most (50%) and demographics least (5% each for women and young adults). Overall risk is not a useful predictor of prognosis for an individual.

Mental illness in the US costs roughly $282B annually nationwide.

Bipolar disorder, which is characterized by extreme mood swings, affects nearly 3% of the US population

There are two types of this disorder. Bipolar 1 features a significant manic episode—abnormally elevated mood and frantic energy—followed by repeated depression, while Bipolar 2 vacillates between depressive episodes and hypomania, a milder form of mania, but not a full mania. Listen to this podcast as experts explain the condition.

Testosterone prescriptions remain very low overall

Though demand for an injectable formulation of testosterone roughly doubled between 2019 and 2025, testosterone prescriptions still remain very uncommon—adding up to less than 2 per 100,000 prescriptions in 2025.

America doesn't have enough estradiol patches for menopause and perimenopause demand

Fueled in part by the lifting of the FDA's black box warning about HRT risks, sales of estradiol patches in the US have shot upward. More than 142 million units of the patches were sold in 2025 versus 46.5 million in 2020. Suppliers are failing to keep up with demand—11 patch products were in short supply in early 2026. (Some users may experience a paywall.)

JJ Schildkraut theorized depression is linked to brain chemical imbalances—in 1965

Schildkraut was one of the first to put forward this idea, which stemmed from lab animal research. A decade later, researchers published the first landmark paper on fluoxetine—better known by trade name Prozac—which increases serotonin levels in the brain.

Having five of nine key symptoms constitutes a major depression

Before professional standards were adopted, practitioners used varying criteria to diagnose mental health disorders. By the 1970s, more objective lists were organized, culminating in this list of polythetic criteria—a list of symptoms where no single criterion is required, but a minimum number must be present.

An estimated 91% of all Americans had used a coupon at least once as of 2022

Coupon use accelerated during the Great Depression, when the US unemployment rate reached nearly 25 percent. While coupons were invented in the late 1800s, they became more popular during the Depression as a way to stretch household budgets during the era’s economic hardships. Companies soon began distributing coupons via newspapers and women’s magazines.

Visualizing obesity rates across the US

Nearly 70% of adults in the US are either overweight or obese, rates that have tripled over the last 60 years. Severe cases have risen tenfold during this period. Factors like location, income level, and demographics contribute to various obesity levels across the US. Visualize the statistics with this article and chart series.

Opioid prescription rates by states and counties

The origins of the US' ongoing opioid crisis are typically traced to the more than 1 billion prescription pain pills that flooded medicine cabinets between 2005 and 2019. This prescription opioid epidemic resulted in more than 210,000 fatal overdoses and set the stage for the ongoing crisis fueled by heroin and fentanyl.

One in 10 adults worldwide has diabetes.

Oregon voters in 2020 greenlit adult use of psilocybin—the active ingredient in magic mushrooms—in state-licensed centers, and a 2026 analysis indicates the program has good safety and satisfaction data.

Australian psychiatrists already prescribe psilocybin and MDMA for depression and PTSD

The country green lighted the treatments for July 1, 2023, onward, with MDMA—ectasy—as a post-traumatic stress disorder treatment, and psilocybin—magic mushrooms—as an option for people with treatment-resistant depression.

Mental health is much more than the absence of mental illness, according to its official definition from the World Health Organization.

How many Americans receive government assistance?

In 2022, nearly half of all American children—and roughly one in three Americans overall—were enrolled in at least one government assistance program. Those programs provide support for people who cannot afford healthcare, food, housing, or other needs. Find out more about the number of Americans receiving government assistance here.

Roughly 75% of Americans report feeling okay financially

Since 2022, fewer Americans report feeling worse off financially, moving from 35% in 2022 to 28% in 2025. Likewise, the number of Americans who reported feeling better about the economy is up 4% from 2022. More than 90% of Americans cite price increases as their biggest financial concern.

More than 5 million Americans have more than one autoimmune disease

Overall, about 4.6% of the US population—15 million people—have an autoimmune condition. Some common examples include rheumatoid arthritis, psoriasis, type 1 diabetes, Grave's disease, and autoimmune thyroiditis.

How depression affects the brain

Treatment for depression has historically hinged on the theory that the condition was caused by underactive or abnormal neurotransmitters, specifically serotonin and norepinephrine. This four-minute video by Yale Medicine details how these neurotransmitters didn't explain the symptoms of depression but, two other neurotransmitters involved in regulating mood and emotion did. GABA and glutamate, some of the brain's most plentiful neurotransmitters, may possibly be the source of depressive symptoms.

Despite the popularity of podcasts, most US adults still listen to radio

A 2026 survey found that 84% of adults aged 25-64 report listening to the radio weekly. That's more than double the number of those who listen to podcasts.

Anxiety is one of the world's most common mental health disorders, causing persistent excessive fear and worry that interferes with daily activities.

By 2030, roughly 6% of the world's population will be in menopause

An estimated 25 million women pass through menopause annually, with a projected increase in the number of women in menopause in both lower-resource and higher-income populations in the years ahead, highlighting the social and economic value of focusing on menopause care.

Millions of aging Americans are facing dementia or cognitive impairment—alone

An estimated 4.3 million people aged 55 or older who have cognitive impairment or dementia live alone in the US. The individuals facing these challenges are more likely to be women, people of color, and to generally be poorer and less educated than other older adults who are also living alone.

Nearly 70% of the US government’s debt is domestic

This includes intragovernmental holdings like the Social Security Trust Fund and investments from US citizens, banks, and mutual funds. About 30% is foreign-held, with countries like Japan and China as major creditors, investing in US Treasury securities due to their perceived safety.

Obesity rates have more than doubled worldwide since 1990

In the US alone, the percentage of the population meeting the clinical standard of obesity rose from less than 20% to more than 40% over the past three decades. This rise has been matched by many countries across the globe, from industrialized to developing nations.

The US had about 155.4 million emergency room visits in 2022, and more than a third involved injuries, including poisonings.

As of 2025, about 16% of US adults are 'smartphone-only' internet users

Demographically, smartphone dependency is greatest among those below 30, Hispanics, Blacks, economically disadvantaged individuals, and those with less formal education. Home broadband adoption is at 78%, with rates highest among suburban residents.

As of 2025, about 16% of US adults are 'smartphone-only' internet users

Demographically, smartphone dependency is greatest among those below 30, Hispanics, Blacks, economically disadvantaged individuals, and those with less formal education. Home broadband adoption is at 78%, with rates highest among suburban residents.

40% of Americans didn't read a book in 2025, with 19% of adults responsible for 82% of the country's book reading.

One-third of early- and mid-career workers have considered quitting due to stress

In 2024, around half of all full-time employees polled by the National Alliance on Mental Illness reported experiencing burnout at their jobs. Around a third of all employees ages 18 to 49 had considered quitting their jobs due to workplace stress.

See the religious breakdown of the US from 2007 to 2024.

Men are flocking to hundreds of new online testosterone clinics for low T prescriptions.

1 in 31 kids in the US has autism

That figure comes from an analysis published by the US Centers for Disease Control and Prevention based on data gathered on eight-year-olds in 2022. Its figures mark a significant increase from 2000, when the estimated autism figure was one in 150, but improvements in diagnosis and changes to the disease criteria that broadened the diagnostic criteria are widely believed to be driving that increase.