Early 20th-century ID cards protected transgender people in Germany using hormone therapy.

Gender-affirming hormone therapy cues changes similar to puberty

When HRT is part of gender affirmation care, people receive regular doses of estrogen or testosterone to alter hormone levels to more closely align with those of cis individuals of that biological sex. HRT may affect voice pitch, body hair, bone density, and more. Many of those changes are not reversible with the cessation of therapy, though the effects may diminish.

The WWII passport forgers who saved thousands of Jewish lives

Amid the chaos of Hitler's authoritarian Europe in World War II, Polish diplomats based in Switzerland used the classic toolkit of thieves to help free thousands of Jews: they perfected the art of forgery, faking passports secretly donated by sympathetic Latin American countries. Read the incredible tale of heroism here.

27% of US menopausal women used estrogen in 1999, but by 2020 that number was under 5%

The fallout of studies in the early 2000s linking hormone therapy for menopause and elevated cancer, stroke, and other health risks meant that even decades later—yet before the FDA removed its black box warning in 2025—use of HRT remained extremely uncommon. (Some users may experience a paywall.)

FDA has removed black box warnings from hormone replacement therapy for menopause.

Men are flocking to hundreds of new online testosterone clinics for low T prescriptions.

Within months of a landmark 2002 study that indicated HRT harms, sales dropped by about half

In the early 2000s, Women's Health Initiative studies indicated HRT increased risk of breast cancer, heart disease, and stroke in some women—so many physicians stopped prescribing it to help with menopause symptoms. But further research has concluded that much of the elevated risk was overblown and that it was also disproportionately seen in women in their 70s who had been taking an older HRT formulation.

US women got the right to open a credit card in their own name in 1974

Before that year, banks in the US were legally allowed to deny women credit or charge them higher interest if they failed to get a male cosigner.

It's never too late to start hormone replacement therapy for menopause symptoms because the products may help alleviate symptoms of menopause or fight bone loss.

America doesn't have enough estradiol patches for menopause and perimenopause demand

Fueled in part by the lifting of the FDA's black box warning about HRT risks, sales of estradiol patches in the US have shot upward. More than 142 million units of the patches were sold in 2025 versus 46.5 million in 2020. Suppliers are failing to keep up with demand—11 patch products were in short supply in early 2026. (Some users may experience a paywall.)

Digital passports allow identity verification to be digitized

By scanning the security chip on the back of passports and capturing images or video of a person, apps like Google Wallet and Apple Wallet create a digital version of the document. Some states have also developed their own apps for digital driver's licenses.

Common hormone therapies to treat menopausal symptoms

While there is no cure for menopause, there are ways to treat some of the intense symptoms women experience during perimenopause. There are two main hormone therapies used, one in the form of a pill, gel, or patch to treat symptoms like hot flashes, and another in the form of a cream or ring to treat symptoms like vaginal dryness. Read this article to learn more about the different hormone therapies available for menopausal women.

Six of history's most unethical human experiments, from deliberate flu exposure to withholding syphilis treatment

Some of the progress made in mental health treatment, vaccines, blood transfusions, and more came about before the advent of consent and ethics committees, resulting in serious physical and psychological harm that participants in studies were not even anticipating.

HRT patches are popular partly because they have lower blood clotting risks than oral estradiol

Women taking estradiol for menopause or perimenopause are sometimes told oral HRT is not an option for them because it increases blood clot risks. But a large analysis in 2019 concluded that other forms of the HRT, such as the patch, creams, and gel, do not.

Women in WWII used tattoos to avoid capture

During World War II, Japanese soldiers kidnapped women from Southeast Asian countries and forced them into sexual slavery. But they hesitated to capture married women, a fact that women from the island of Timor exploited, painstakingly poking tattoos onto their bodies that marked them as married women.

Cross-species transplantation has been attempted in medicine for more than 300 years.

Years before the 1969 Stonewall Uprising, patrons at another New York bar staged a protest against an antigay liquor law.

The 1935 Social Security Act drew inspiration from European social insurance models

Many of these, such as German Chancellor Otto von Bismarck's 1889 retirement system, emerged decades before America adopted them. This article dives into the modern history of economic security and the key legislation that created Social Security.

There are multiple HRT options to treat menopause and perimenopause symptoms including hot flashes, vaginal dryness, and mood swings.

After her arrest, a technicality made it harder for Holiday to perform

The Cabaret Identification Card was required for all performers in New York nightclubs that served liquor. After her arrest and yearlong imprisonment, the New York Police Department revoked Billie Holiday's card, making it extremely difficult for her to earn money. The video features contemporary jazz musician Christian McBride breaking down the history of cabaret cards and how the ban affected Holiday.

Cosmetic surgery during the Edwardian era

This 23-minute video explores cosmetic surgery in the United Kingdom during the Edwardian era, from about 1901 to 1914. Reconstructive surgery already existed by then, though it wasn't considered elective as it was used to repair damage suffered...

Ancient Romans were registered in lists of citizens to confirm their identity

Falsely claiming to be a Roman citizen was a capital offense, but taking up another identity was one way people could change their lot. Several accounts report how escaped enslaved people sought freedom by pretending to be citizens, and multiple "Neros" appeared after the real emperor died in 68 CE.

Two-spirit relationships and identities

Queer relationships and transgender people aren’t new. Even though gay marriage has been legalized fairly recently in Western countries, people all over the world have engaged in relationships beyond heterosexuality throughout the centuries. Although contemporary tribes have various views around homosexuality, there are numerous examples of queer relationships within indigenous traditions across what is now called the Americas.

German Nazi war crimes suspect, 96, who went on the run goes on trial

A 96-year-old German woman who was caught shortly after going on the run ahead of a court hearing last month on charges of committing war crimes during World War Two appeared before a judge on Tuesday in the northern town of Itzehoe.

Georgia urges residents to wear clothes in driver's license photos

A program in Georgia allows residents to create digital IDs from home for quicker passage through airports, and officials have had to warn users to be clothed in the photos they produce for the ID.

Menopause hormone therapy infuses the body with estrogen after the body's natural levels drop

The treatments can treat symptoms like hot flashes and vaginal dryness at varying doses. Progestogen, another hormone, is also typically prescribed with estrogen because estrogen alone can thicken the uterus lining, which elevates the risk of developing endometrial cancer.

A 19th-century Protestant minister in Germany encouraged 'natural eating,' creating a precursor to the natural food movement.

Privacy advocates warn menstrual cycle apps could put women at legal risk in certain states.

Almost 80% of people diagnosed with autoimmune diseases are women

Yet it's still unanswered what may account for that difference. To better understand this disparity researchers are exploring factors including hormonal changes that occur around puberty, pregnancy, and menopause, as well as gut microbe differences, and aspects of X-chromosome protein-coding genes. (Some users may encounter a paywall.)

86 commonly used drugs, including certain antidepressants, painkillers, and immunosuppressants, have different results for men and women, according to recent research.

A map of WWII refugees and their stories

Trace the paths of different people and families on this interactive map as they made their escape from the Nazi regime. Primary and secondary sources like letters, documents, memoirs and diaries, photos, interviews, and news clippings showed how many found a path to freedom, from the Kindertransport to individual stories.

Testosterone prescriptions remain very low overall

Though demand for an injectable formulation of testosterone roughly doubled between 2019 and 2025, testosterone prescriptions still remain very uncommon—adding up to less than 2 per 100,000 prescriptions in 2025.

The Berlin Wall physically separated East and West Berlin for nearly three decades, preventing East Germans from fleeing to the West and earning the nickname 'the Iron Curtain.'

Light therapy was widely used as a medical treatment for various maladies in the early 1900s before it was replaced by antibiotics.

Oktoberfest revelers wear traditional dress

Lederhosen (short leather pants) and dirndls (dresses with lace-up bodices) are found everywhere at Oktoberfest, This short documentary explores the resurgence of traditional clothing in Germany, which extends beyond Oktoberfest.

Health problems are being misdiagnosed as perimenopause symptoms

Symptoms of menopause and perimenopause (the premenopause period) can be varied enough that clinicians dismiss them in patients in their mid-30s and onward as just a symptom of hormone level change. In this story, a woman's itching was dismissed as a hormonal change, but after two years and 11 separate doctor consultations, was diagnosed as cancer. (Some users may experience a paywall.)

Australian psychiatrists already prescribe psilocybin and MDMA for depression and PTSD

The country green lighted the treatments for July 1, 2023, onward, with MDMA—ectasy—as a post-traumatic stress disorder treatment, and psilocybin—magic mushrooms—as an option for people with treatment-resistant depression.

After actress Ingrid Bergman had a child out of wedlock, a Colorado senator proposed granting the government the ability to ban performers deemed morally objectionable.

Existentialism has been used as a therapeutic tool, with 2 Swiss psychiatrists pioneering the philosophy's concepts to help patients navigate their issues.

The US FDA considered mitochondrial replacement therapy during 2014 hearings

An agency committee assessed if this approach could have undesirable ripple effects across multiple generations and whether a clinical trial involving this approach would be appropriate. As of 2026, the US has continued to prohibit this procedure though it is legal in other settings including the UK and Australia.

Marie Curie developed and trained women to operate mobile X-ray units in World War I

The “petites Curies” allowed medical professionals to identify the severity of wounds without transporting soldiers to medical facilities, expediting treatment and saving lives. The efforts of Curie and other women led to expansions in their rights after the war.

In the 1980s, excerpts from fake diaries of Adolf Hitler were published in a prominent German magazine

Excerpts from the diaries were published in other publications around the world, like The Sunday Times, despite uncertainty about their authenticity. After forensic analysis, the diaries were proven to be fake. The diaries were produced by Konrad Kujau, a petty criminal who frequently produced counterfeits.

Dreaming under the Nazi Regime

Days after Hitler seized power, a man told psychoanalyst Charlotte Beradt that he had dreamed of being forced to raise his arm in a Nazi salute ("It took me half an hour to get my arm up, inch by inch"). Beradt recorded this dream and many others so they "might one day serve as evidence." This is an English translation of her work, "The Third Reich of Dreams."

Rewrite 1930s Germany with this alternative history game of politics

You are at the head of the Social Democratic Party in Germany in 1928 and must use parliamentary politics, the media, and more to oppose the ascendant National Socialists. This text-based, narrative simulation becomes a lesson in the complexities of political history.

A Gilded Age moral crusader convinced Congress to pass a law banning 'obscene, lewd or lascivious' materials from the mail that's central to today's debate over abortion pills.

By 2030, roughly 6% of the world's population will be in menopause

An estimated 25 million women pass through menopause annually, with a projected increase in the number of women in menopause in both lower-resource and higher-income populations in the years ahead, highlighting the social and economic value of focusing on menopause care.

Paper boarding passes have become rarer in recent years

Many travelers have shared their attachment to the documents as their utility fades. This sharply illustrated timeline reviews the development of the paper boarding pass as technology evolved.

Musician Gladys Bentley defied gender norms during the Harlem Renaissance and was openly gay, even though homosexuality was still widely considered taboo.

Anticipating moon tourism by 2000, Pan Am issued 'First Moon Flights' club cards

More than 93,000 cards were issued between 1968 and 1971, creating a waitlist that began when Gerhard Pistor, an Austrian journalist, visited a Viennese travel agency to request a flight to the moon. The cards were issued at no cost and numbered in the order they were issued.

Can your identity be preserved amid dementia?

Memory loss associated with progressive dementia raises questions about whether a person's identity can be maintained during the disease's progression. One outlook suggests we define ourselves by our social relationships—offering a potentially more humane approach to caring for those with dementia.

Psychedelic therapy's ethical guidelines (or lack thereof)

With a checkered history of misconduct, how will psychedelic-assisted therapists be held accountable in the emerging legal field? This article explores the nascent field's need for ethical guidelines and clear protection of patient rights when therapeutic breakthroughs teeter "on the edge of consent."