The 2026 Ebola outbreak in the DRC is spurring new Ebola vaccine development for the Bundibugyo species.

An Ebola vaccine was developed during the 2018 west African Ebola outbreak, but the 2026 Ebola outbreak is with a different species of the virus, not the one that the vaccine is approved to treat.

See the evolution of Ebola vaccine and treatment development.

The 2026 Ebola outbreak is hampered by a lack of vaccine against the relevant species of the virus, heightening the need for rapid tests to aid in disease control.

Ebola virus, with an average fatality rate of around 50%, has been responsible for more than 2,000 confirmed deaths during the 2026 outbreak in the Democratic Republic of the Congo and Uganda.

Three Ebola species are responsible for most large outbreaks of the disease.

Marburg virus, related to Ebola, is also extremely deadly, and has no available vaccine.

Ebola species have historically been named after the places where they were discovered, stigmatizing residents of those areas, including Bundibugyo, in Uganda.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola.

The US military, concerned about potential deployments worldwide, has long funded experimental hantavirus vaccines and therapies.

Collaborations between the military, biotech, and academic researchers led to an experimental antibody treatment for the Andes hantavirus strain—the one that more readily passes between humans. As of spring 2026, it had only been tested in animals. The US Army has also tested a potential hantavirus vaccine in people. It published early findings in 2023 that seemed promising, eliciting some immune system response. (Some users may encounter a paywall.)

There have been close to 40 Ebola outbreaks since 1976

Ebola is a rare but deadly virus that causes severe illness, organ damage, and sometimes internal bleeding. It spreads through contact with infected bodily fluids and is most common in parts of sub-Saharan Africa. This explainer covers its symptoms, transmission, and treatment options.

Scientists have struggled to pin down Ebola's natural reservoir species for decades, but the available evidence suggests that it's very likely fruit and insect-eating bats found in Africa.

Using mosquitoes to vaccinate bats could curb the spread of deadly diseases.

COVID-19 vaccine breakthroughs are driving efforts toward a universal flu shot

mRNA and other technologies used for COVID-19 vaccines are being applied to influenza research. Scientists hope these advances will lead to a universal flu vaccine that protects against multiple strains and reduces the need for yearly shots.

Two Lyme disease vaccines were in development in 2026

As of early 2026, there was no vaccine for Lyme disease available. One candidate vaccine, VLA15, was in later-stage clinical trials. Another designed to provide seasonal protection was licensed to a pharmaceutical company in 2025, and was planned for human clinical trials.

See how Ebola tore through Guinea, Sierra Leone, and Liberia in 2014-16.

A 1954 outbreak at a Boston boarding school allowed scientists to isolate the measles virus and formed the basis for the first measles vaccine.

Ebola is a filovirus, meaning it resembles a thread under a microscope.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

mRNA vaccines teach the immune system how to respond to a threat, using a molecule called messenger RNA.

What are universal vaccines?

As viruses mutate and develop, vaccines have to adapt, leading to regular recommended injections like flu shots. Researchers are working to develop universal vaccines that aim to protect against multiple virus variants if not entire virus families. These vaccines work by creating broadly neutralizing antibodies (bnAbs) that target aspects of viruses that don't typically mutate and are integral to the virus' survival.

The flu vaccine has evolved alongside discoveries of new virus strains

After influenza B was identified in 1940, researchers created a two-strain vaccine by 1942. The WHO later built a global surveillance system to track mutations, enabling vaccines to be updated annually to target the strains most likely to circulate.

A vaccine against Epstein-Barr virus, researchers hypothesize, could potentially prevent MS

As many as a quarter of MS patients have antibodies in their blood that bind to both a central protein in Epstein-Barr virus and a protein made in the brain and spinal cord that—when attacked—leads to a breakdown of protective nerve fiber insulation. This suggests the immune system's primed to attack the nervous system after mounting a defense against Epstein-Barr.

Malaria vaccines are not routine because they have limited effectiveness.

There are two recommended malaria vaccines by world health experts, but both have limited effectiveness.

Wolbachia is a naturally occurring bacterium being employed to fight dengue

Scientists are fighting dengue spread in a roundabout way: injecting bacteria into Aedes aegypti mosquito eggs, which blocks the dengue virus from replicating in the tissue of mosquitoes. Researchers hope the bacterium will be passed to future generations, inoculating them against dengue. Wolbachia is also being investigated to combat other mosquito-borne diseases.

Watch what the Ebola virus does inside the body in order to spread and survive.

Wastewater testing has detected genetic evidence of polio, triggering vaccine boosters

Sampling of wastewater in London in 2022 detected fragments of polio virus, suggesting a vaccine-derived version of polio may be circulating. No one became ill, but the finding did trigger calls for a renewed booster inoculation campaign.

The oral, live virus vaccine is the most robust but carries more risks

The live virus vaccine, delivered via oral drops, induces the best protection in the body. Because it includes a live, weakened form of the virus there's an extremely small risk it can sicken recipients and potentially cause paralysis. Recipients also shed the virus in their stool, which can rarely lead to vaccine-derived cases of the virus if the virus mutates. (Some users may experience a paywall.)

A timeline of major pandemics from 1899–2025

Modern pandemics have been defined by the race between globalization (which increases risk) and the development of new medicines. The Great Influenza epidemic claimed some 50 million lives, and the COVID-19 pandemic killed more than 7 million. In between, diseases like Ebola, cholera, AIDS, and more have devastated communities.

The business models behind vaccines

Watch experts weigh in on the prevailing business models of vaccine production, including how the Covid-19 pandemic has disrupted the industry for good in this 20-minute video from Financial Times.

Explore what it's like Inside a patient isolation unit.

How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

How the World Bank's pandemic bonds were triggered during COVID-19

In 2017, the World Bank raised a chunk of emergency funds through bonds to help developing countries cover funds in the event of a pandemic. Had no pandemic occurred, investors would have received returns of 6% to 11%. But the global pandemic meant they lost all their money.

Explore inside a mosquito factory where millions of mosquitoes are bred weekly

In Medellin, Colombia, scientists are infecting Aedes aegypti mosquitoes with Wolbachia, a bacterium that wouldn't otherwise infect the species, but does block its ability to transmit dengue, Zika, yellow fever, and chikungunya. In the wild, infected mosquitoes would breed with wild mosquitoes, pass down Wolbachia, and thus reduce disease transmission.

Wolbachia: the bacteria that could eliminate dengue fever

Dengue fever, transmitted by mosquitoes, kills more people annually than all types of natural disasters combined. However, mosquitoes that host Wolbachia bacterium have their ability to transmit the virus naturally suppressed, offering a route to eliminating nearly 25,000 deaths annually.

Horses have four licensed West Nile vaccines—but humans have none

A major hurdle for West Nile vaccine development is the lack of a market for it since so many people are symptomatic for the infections. Still, a growing number of infections, including a 40% spike in 2025, may change that calculation.

HIV originated in Central and West Africa from a virus in chimpanzees

Researchers believe the virus crossed from chimpanzees to humans through bushmeat practices in the early 20th century, with genetic studies suggesting the most recent common ancestor of the HIV-1 M group, which is responsible for the global AIDS pandemic, emerged around 1910–1930 in Léopoldville (now Kinshasa) in the Belgian Congo.

Bats have evolved to carry viruses without getting sick

Bats—the likely animal reservoir for diseases including Ebola and coronavirus—tolerate viruses without getting sick. The secret lies in evolutionary adaptations allowing bats to become the world’s only flying mammal and to thrive under immense physiological stressors.

Vector-borne diseases kill more than 700,000 people globally each year—and are growing

The diseases with the greatest potential to spread widely aren't the ones that quickly kill human hosts. Instead, the best hosts or reservoirs for vector-borne diseases would be chronically ill over the long term, increasing the likelihood that the pathogen could be transmitted to others.

mRNA vaccines alter immune response, not DNA, to combat diseases like cancer.

See how the Pfizer-BioNTech vaccine's mRNA instructions teach your own cells to trigger an immune response against the coronavirus's spike protein.

The measles vaccine has saved an estimated 94 million lives since its introduction.

Live virus vaccines predated polio—that's how we vaccinate against smallpox

Since 1796, smallpox vaccines have used a live poxvirus related to smallpox. Yellow fever vaccines have used a live weakened form of the virus responsible for yellow fever since 1937.

Cultural norms about how to handle the bodies of loved ones have hampered Ebola responses in West Africa.

Mpox, formerly known as monkeypox, does not come from monkeys but it was first identified in laboratory monkeys in 1958.

There may be 500,000 additional malaria deaths by 2050 according to peer-reviewed research published in 2026.

Increasing contact between humans and wild animals is driving zoonotic threats

Zoonotic diseases, which spread from animals to humans, present one of the most significant emerging threats worldwide. Scientists have identified around 200 viruses capable of infecting humans, and unfortunately, the number of such diseases are on the rise—at least 60% of all emerging infectious diseases are zoonotic in origin.

A scientist successfully treated her own breast cancer by injecting the tumor with lab-grown viruses.

West Nile is named after the district in Uganda where it was first isolated from a patient

In 1937, scientists isolated the virus from a woman in the West Nile District of Uganda. It's since been detected in much of Africa, Eastern Europe, West Asia, the Middle East, and was first detected in US patients during an outbreak in 1999.

A major US-designed polio vaccine was first tested in the Soviet Union

Albert Sabin's live attenuated virus vaccine—requiring two drops in the mouth—didn't garner political support in the US, so it was tested in the Soviet Union in the late 1950s.