Drug-resistant staph infection is one of the deadliest superbugs.

Superbugs are pathogens that have proved resistant to medications designed to combat them, rendering standard treatments ineffective.

Antimicrobial resistance is responsible for 1.3 million deaths each year

Antimicrobial resistance is a global health threat, driven by the misuse and overuse of antimicrobials in humans, animals, and more. Estimates suggest superbugs could lead to $1T in healthcare costs by 2050, and the world faces a shortage of new drug development to meet the challenge.

The most critical superbug strains (as of 2024)

The World Health Organization updated its list of the highest priority pathogens known to have developed antimicrobial resistance. Topping the 2024 update is Acinetobacter baumannii, carbapenem-resistant ("CRAB"), which has a mortality rate close to 50% and has evolved defenses against last-line medications. Download the full report here.

Drug-resistant infections worldwide have increased by about 65% since 2000

Since 1990, antibiotic resistance has claimed at least one million lives annually and is projected to account for 39 million deaths between now and 2050 if current trends continue. The expanded use of antibiotics, particularly in agriculture, combined with a slowing pipeline of new drugs has led to the crisis.

More than 39 million people are expected to die from antimicrobial resistance by 2050

In 2024, researchers published an incredibly detailed study aimed at predicting the real-world impact of antimicrobial resistance over the next 25 years. The key findings were clear: the superbug crisis is poised to get much worse and needs to be addressed. This article offers a clear, concise overview of the study, which was published in The Lancet.

Superbugs could claim 1.9 million lives per year by 2050

The increased use of antibiotics combined with an aging population, is projected to result in an almost 50% increase in global deaths from antimicrobial resistance each year. At the same time, antibiotic use for livestock is expected to increase by 30% over the same time frame.

Antibiotic resistance is a growing global health problem

Over decades, bacteria have grown increasingly resistant to antibiotics. This resistance now causes an estimated 1.27 million deaths each year and is associated with nearly 5 million deaths worldwide, according to the World Health Organization.

Candida auris spreads easily in healthcare facilities and causes high death rates

This fungus has spread rapidly in healthcare settings since the first US case was reported in 2016, and it has grown increasingly resistant to echinocandins, the antifungal medicine most commonly used to treat it. Often, it’s resistant to multiple antifungal drugs, contributing to its high death toll. It can most readily infect those with invasive medical devices like intravenous catheters and those with frequent or long-duration stays in healthcare facilities.

Tips for reducing the risk of antimicrobial resistance

Antimicrobial resistance is bad news. But there are lots of things you can do to both protect yourself from superbugs and help keep the problem of antimicrobial resistance from getting worse. This page from the CDC offers clear, straightforward guidelines that can help keep you—and your loved ones—healthy.

Sepsis is the leading cause of death in hospitals

Sepsis is the result of an overly aggressive immune system trying to combat infection, triggering inflammation throughout the body. After it begins, each passing hour increases the risk of death by 4% to 9%, and an estimated 350,000 people die from the condition in the US each year.

Mapping the spread of a dangerous fungus growing in US healthcare facilities

Explore the data showing how the fungus C. auris has spread in the US, with more than 10,000 reported cases since 2016. Recommended steps to prevent infections and limit their spread have been successful in some areas, but infection control remains complicated because the fungus is often now multidrug-resistant.

Resistant infections are no longer isolated and can spread worldwide

What does the rise of antibiotic resistance mean in practical terms? Maryn McKenna is a journalist at the forefront of covering antibiotic resistance since 2007. In this TED talk, McKenna lays out the very real consequences of antibiotic resistance—and what needs to be done to address the problem.

Overuse of antibiotics gives bacteria more opportunity to evolve their defenses

The overuse and misuse of antibiotics are significant contributors to the rise of antibiotic resistant bacteria. Experts say antibiotics should only be used for specific medical problems, and patients need to be sure to take antibiotics exactly as prescribed in order to reduce the risk of antibiotic resistance.

Superbugs evolve defenses against medication, then share them with neighbors

One reason antibiotic resistance spreads so quickly is that bacteria have multiple mechanisms allowing them to share genetic material. This short video offers a concise explanation for each of these mechanisms, and animation that helps viewers understand how antimicrobial resistance can quickly spread from one organism to another.

The international agreement to address antimicrobial resistance

Antimicrobial resistance has become an increasingly glaring problem for both health and agriculture. In 2024, the United Nations announced a new suite of clear actions and targets that—taken together with existing efforts—can help address superbugs in a meaningful way and on a global scale. This page from the UN lays out these efforts, with links to additional information on the many aspects of the initiative.

Scientists from the frontline discuss the future of antibiotics and superbugs

Superbugs are a very real problem, but researchers around the world are working to advance our understanding of these pathogens and develop new medicines. This podcast talks with several scientists on the frontier of superbug research, offering insight into what we know—and what the future of medicine may look like.

COVID accelerated antibiotic resistance

The COVID-19 pandemic was caused by a virus, and viruses can’t be treated with antibiotics. But recent research finds that COVID patients were given a tremendous amount of antibiotics, contributing to the problem of antibiotic-resistant bacteria. Why? This NPR feature sheds light on an unexpected side effect of the pandemic.

The new antibiotic killing drug-resistant bacteria

A new class of antibiotics had not been discovered in more than 50 years—until late 2023, when MIT researchers announced a new antibiotic called Zosurabalpin. In animal testing, Zosurabalpin was able to treat at least one type of superbug. While the drug still needs to go through clinical trials, it is a significant advance at a time when new antibiotics are in great demand.

19 fungal pathogens are of key concern to world health officials

In 2022, this global health body issued its first-ever list of top fungal threats to human health. It said fungal threats are spreading and occurring more frequently. The WHO’s list included 19 fungal pathogens to watch, and said that the most dangerous ones to public health are Cryptococcus neoformans, Aspergillus fumigatus, Candida albicans, and Candida auris. There are only a handful of classes of medication currently available to combat fungal pathogens, with few others in the pipeline even though antimicrobial resistance is growing.

An estimated 1% of DNA mutations in bacteria can produce more dangerous strains

Researchers have developed a technique to monitor these mutations in real time. Using this technology, scientists found that mutations occur at a steady rate, with 1% leading to potentially deadly changes.

Roughly 80% of US antibiotics sold each year go to agricultural use

Antibiotics have long been used in agriculture to treat diseases in animals and plants. However, antibiotics are also often misused, to treat non-bacterial diseases, to encourage growth in animals, and more. This expansive use of antibiotics has become one of the primary sources of the emergence of new superbugs.

Vector-borne diseases kill more than 700,000 people globally each year—and are growing

The diseases with the greatest potential to spread widely aren't the ones that quickly kill human hosts. Instead, the best hosts or reservoirs for vector-borne diseases would be chronically ill over the long term, increasing the likelihood that the pathogen could be transmitted to others.

Measles, eliminated in the US in 2000 but now making a resurgence, is one of the most contagious preventable diseases.

Corynebacterium species are particularly responsible for our funky smell

Myriad bacteria contribute to our body odor, but research suggests that Corynebacterium species are strongly associated with the bad smells emanating from adults. Staphylococcus and Cutibacterium genera may also play leading roles.

Mosquitoes top the ranking of the world's deadliest animals.

Measles attacks the body's immune system, leaving it vulnerable to secondary complications.

Pneumonia was once a leading killer before penicillin treatments

In the early 20th century, pneumonia was a top cause of death worldwide, often fatal without effective treatment. Penicillin turned a once deadly infection into one of the most treatable bacterial diseases.

Bacteria rapidly evolve (and share) new defenses against drugs they encounter

Unlike humans, bacteria rapidly make genetic changes in response to their environment, including creating defense against antibiotics. Furthermore, these defenses are passed on to their future generations and can even be shared with neighboring bacteria through horizontal gene transfer.

Cryptococcus neoformans, a growing threat, causes infections in the brain and lungs

This inhalable, microscopic pathogen is found worldwide. It rarely causes illness, but it can take root in those with compromised immune systems, including people with advanced HIV/AIDS. Symptoms of cryptococcal infection—such as a stiff neck, vomiting, and confusion—can begin weeks or months after breathing in spores, though sometimes symptoms won’t appear for years. There are no known cases of transmission between people or between people and animals.

Penicillin ended scarlet fever’s deadly threat to children

Between 1840 and 1883, scarlet fever was among the leading causes of childhood death in the United States, with case fatality rates ranging from 15% to 30%. Today, thanks to antibiotics like penicillin, the mortality rate is below 1%.

Anopheles mosquitoes are developing resistance to insecticides.

A 101 on the 'Death Cap,' the world's deadliest mushroom

The Death Cap, also known as amanita phalloides, is the most fatal mushroom on the planet, responsible for roughly 90% of the world's mushroom deaths per year. Ingestion of the mushroom wreaks havoc on the liver and kidneys, frequently leading to...

Fungal diseases cost the US around $19B annually.

Scientists have found that kitchen sponges that don't appear dirty or greasy may still harbor bacteria that can cause foodborne illness, and the cleaning items should be discarded regularly, including after wiping surfaces that have come into contact with raw meat.

'Gram-negative' bacteria: Bugs with extra defenses along their cell walls

The term 'Gram-negative' bacteria refers to bugs which react a certain way under a Gram stain test. These bacteria are harder to kill due to their double-layer cell walls with a thin peptidoglycan layer in between. This structure makes the delivery of drugs into the bacterial cell substantially more difficult.

Penicillin’s discoverer predicted antibiotic resistance

Alexander Fleming’s discovery of penicillin revolutionized modern medicine. But the same man who pioneered the development of antibiotics also recognized that bacteria could make sntibiotics obsolete if they were used irresponsibly. This story sheds light on Fleming’s discovery—and on his prophetic warning about antibiotic resistance.