A 101 on the 'Death Cap,' the world's deadliest mushroom

Symptoms of DNA loss may mimic those seen in mushroom poisoning or chemotherapy

Although no organism has ever lost all its DNA, the destroying angel mushroom contains amatoxin, which disrupts DNA transcription and is known to cause death via liver and kidney failure in three days. Doxorubicin, which tangles DNA to disrupt cellular replication, compromises a person's immune system.

19 fungal pathogens are of key concern to world health officials

In 2022, this global health body issued its first-ever list of top fungal threats to human health. It said fungal threats are spreading and occurring more frequently. The WHO’s list included 19 fungal pathogens to watch, and said that the most dangerous ones to public health are Cryptococcus neoformans, Aspergillus fumigatus, Candida albicans, and Candida auris. There are only a handful of classes of medication currently available to combat fungal pathogens, with few others in the pipeline even though antimicrobial resistance is growing.

Mosquitoes top the ranking of the world's deadliest animals.

Natural toxins produced on plants or consumed by animals may cause food poisoning

When humans eat plants with certain natural toxins on them—including a family of toxins called aflatoxins that fungi produce on crops like peanuts and corn— they can become ill with food poisoning. Toxins can still harm humans even if animals or plants appear fine to the human eye. The World Health Organization advises that we should throw away moldy or discolored foods, refrain from eating wild plants or mushrooms that aren’t definitively nonpoisonous, and remember that just because something is “natural” it’s not always safe to eat.

The ‘humongous fungus’ may be the largest organism on Earth at more than 2,300 acres

Discovered in 1988, when it was only covering 400 acres, this massive colony of Armillaria ostoyae, based in Oregon, has taken hold among the tree roots of the Malheur National Forest. It consists of a vast network of unique long black filaments of fungal tissue called rhizomorphs that grow under the soil and infect tree roots, nourishing the fungus but killing the trees. Researchers believe this fungal growth dates back more than 8,000 years and currently weighs approximately 35,000 tons.

Mycotoxins are toxic compounds produced by fungi—some show up in food

About a quarter of the world’s agricultural products are contaminated with mycotoxins. Some of these compounds can cause serious health problems, including cancer, so the US government has set up monitoring programs to detect them in our food and in animal feed. Humans can become ill if they eat contaminated food, but also if they ingest products from animals that had previously consumed these toxic compounds, such as milk from a cow that ate contaminated corn.

The mushrooms in 'Super Mario Bros.' are modeled after a real mushroom

Almost every mushroom in "Super Mario Bros." is based on the Amanita muscaria, sometimes referred to as the fly agaric, because it is known to attract flies. It's also the basis for the original mushroom emoji and the mushrooms from the popular game "Minecraft."

Cordyceps: the fungi that turn ants into zombies

The hit show (and video game) "Last of Us" was inspired partly by real-life species of fungi that have been known to turn ants into zombies. Spores of the Cordyceps fungi are capable of penetrating the exoskeletons of arthropods, after which they break into enzymes and proliferate within the body. The fungal cells then hack the ant's nervous system and trigger compulsive climbing.

How Alzheimer's disease becomes fatal

Despite more than 100,000 people with Alzheimer's dying each year, the specific cause of death is not the disease itself. Often, secondary diseases arise from complications with the disease, including pneumonia, severe falls, malnutrition, or infection. Read more about the range of complications caused by Alzheimer's here.

Watch Cordyceps, a parasitic fungus, turn an ant into a ‘zombie’

This National Geographic TV clip shows how a parasitic Cordyceps species—sometimes colloquially called the “zombie ant fungus”—controls an ant’s behavior and kills its host. The fungus can rapidly wipe out entire insect colonies.

Fungal diseases cost the US around $19B annually.

Why bananas are in trouble

The average American eats over 25 pounds of bananas every year, but we won't for long if a deadly soil fungus continues to spread. Learn what scientists are doing to save the popular fruit.

The most severe form of malaria is caused by the Plasmodium falciparum parasite.

Fentanyl can be up to 100 times more potent than morphine

A synthetic opioid, fentanyl is highly addictive and incredibly fast-acting—a fatal dose is equal to a few grains of table salt. Once it enters the body, fentanyl floods naturally occurring opioid receptors, which can cause the body to shut down its breathing reflex, leading to a fatal overdose.

The 'definitive' history of magic mushrooms

Where did magic mushrooms come from, and how did they get their magical reputation? This article explains the history of the psychedelic fungi from pre-history to now. The earliest concrete evidence of psychedelic mushroom use is 12,000-year-old murals in Northern Australia that portray mushroom iconography. Considering how many species seek out and consume psychoactive substances, such as Siberian reindeer, it's possible human use of these psychedelic mushrooms may predate these murals.

A visualization of mycoremediation, where fungi extract toxic and radioactive pollutants from soil

As organisms such as mushrooms grow, they develop large networks of root-like structures called mycelium that spread underground and release enzymes that break down contaminants. By absorbing these chemicals, fungi limit the damage caused by these toxins and localize them within the organism for easier collection and disposal.

Candida auris spreads easily in healthcare facilities and causes high death rates

This fungus has spread rapidly in healthcare settings since the first US case was reported in 2016, and it has grown increasingly resistant to echinocandins, the antifungal medicine most commonly used to treat it. Often, it’s resistant to multiple antifungal drugs, contributing to its high death toll. It can most readily infect those with invasive medical devices like intravenous catheters and those with frequent or long-duration stays in healthcare facilities.

Chocolate can be deadly in humans, but only after consuming extraordinary quantities

Based on tests with mice, the lethal dose of chocolate is estimated to be no more than 1,000 mg/kg. This means that the lethal dose of dark chocolate for the average US adult is about 6.5 kilograms (14.33 pounds), or about 8,300 Hershey's kisses, in one sitting.

Most people breathe fungal spores daily without getting sick

Most people breathe in hundreds of Aspergillus fumigatus spores daily without getting sick—it’s a common microscopic fungus in our environment. But people who are severely ill, including those who have undergone an organ transplant, are at risk of developing infections from these spores.

Molecular evidence suggests the deadliest malaria parasite may be 100,000 years old.

In 1951, a small French town was likely overtaken by the fungus that ultimately led to LSD.

Drug-resistant staph infection is one of the deadliest superbugs, killing more than 120,000 people globally each year.

One in six Americans contracts food poisoning each year.

Oregon voters in 2020 greenlit adult use of psilocybin—the active ingredient in magic mushrooms—in state-licensed centers, and a 2026 analysis indicates the program has good safety and satisfaction data.

Mapping the spread of a dangerous fungus growing in US healthcare facilities

Explore the data showing how the fungus C. auris has spread in the US, with more than 10,000 reported cases since 2016. Recommended steps to prevent infections and limit their spread have been successful in some areas, but infection control remains complicated because the fungus is often now multidrug-resistant.

Fungi make people sick when they invade and survive in otherwise healthy human tissue

We breathe in airborne spores frequently, but they often don't make us sick. This video details how certain concerning fungal changes can occur and discusses the role of mycologists—scientists who study fungi—in helping to improve human health.

Fungi can cause disease, but they’re also our planet’s key decomposers

Fungi are their own taxonomic kingdom separate from flora and fauna, acting as the key decomposers and nutrient recyclers for our planet. Watch this video to understand the diverse types of fungi and the stages of the fungal life cycle. This video illustrates how fungi species may spread, eat nematode worms, damage nearby plants, and much more.

An interactive trek up Mount Everest

At just over 29,000 feet, Mount Everest is the highest summit on Earth and the premiere destination for serious climbers. The imposing peak has also claimed at least 322 lives over the past century, or between four and five victims per year. This...

The most critical superbug strains (as of 2024)

The World Health Organization updated its list of the highest priority pathogens known to have developed antimicrobial resistance. Topping the 2024 update is Acinetobacter baumannii, carbapenem-resistant ("CRAB"), which has a mortality rate close to 50% and has evolved defenses against last-line medications. Download the full report here.

Most fungal pathogens can't survive the heat of our bodies.

Mapping where the drug captagon is seized worldwide

In the 1960s, Captagon was patented in Germany as a stimulant similar to amphetamines. It was prescribed for a time to address narcolepsy, ADHD, and other conditions. As its addictiveness and psychosis-inducing quality became more apparent, the drug has been banned in many countries. A robust illicit manufacturing of the drug endures in the Middle East, especially in Syria and Lebanon. Track locations where the drug has been seized on this updated map.

This is the human brain on the world's strongest psychedelic

Within seconds of inhaling a high dose of vaporized synthetic 5-MeO-DMT—a lab-produced substance that otherwise is naturally derived from the glands of the Colorado River toad—it induced slow brain waves. Such waves are typically associated with unconsciousness due to a coma or anesthesia, perhaps explaining why users describe feeling like everything falls away. The compound is currently in clinical trials for treating depression.

Artificial lightning can improve the yield of shiitake mushroom growers

Researchers have found that shockwaves produced from lightning strikes homogenously break internal filaments called hyphae, transitioning the mushrooms from a vegetative growth to a fruiting phase. Repeated minor shocks near mushroom logs mimicked this effect.

What if we killed every mosquito on Earth?

Mosquitoes aren't just annoying, they're deadly. they're also responsible for an estimated 725,000 deaths worldwide, every year. Would it be so bad if we found a way to wipe them out completely? Real scientists have gamed out this hypothetical scenario, concluding it actually wouldn't be that bad. This five-minute video breaks down one way this could happen.

Cutting mold off your food does not make it safe to eat

Mold is a type of fungus, but not all fungi are molds. This video explains the value of mold, mold anatomy, health concerns around encountering and eating mold, and why mold is found all around us.

Hit show 'The Last of Us' was based on the real-life Cordyceps fungus

Though it depicted a fictional world with a collapsed society due to a fungal pandemic, this television series (based on an earlier video game) helped raise awareness about fungal threats. It even prompted the US Centers for Disease Control and Prevention to publicly comment on it—clarifying the show’s plausibility. The mind-controlling fungal species in the show is based on a real-life Cordyceps species, a fungus that modifies its host’s behavior before killing it.

Antimicrobial resistance is responsible for 1.3 million deaths each year

Antimicrobial resistance is a global health threat, driven by the misuse and overuse of antimicrobials in humans, animals, and more. Estimates suggest superbugs could lead to $1T in healthcare costs by 2050, and the world faces a shortage of new drug development to meet the challenge.

A 49-year-old American died at an ibogaine clinic in Mexico, underscoring its risks

The man had sought out the drug to help him overcome his substance abuse disorder. Though anecdotal reports indicate potential promise, there's been no large-scale clinical trials on ibogaine's safety and efficacy. The plant is derived from a root bark named iboga and has been used for centuries by indigenous communities in Gabon, but first entered scientific consciousness in 1901 after its alkaloid was isolated from Iboga.

'Blackout challenge' can cause brain damage or death in under 5 minutes

A social media trend that encourages viewers to asphyxiate themselves until they lose consciousness in the hopes of feeling "high" or euphoric has garnered the interest of teens and adolescents, with dangerous results. Variations of this deadly challenge have been adolescent trends every few years.

What can psychedelics teach us about dying?

Psychedelics have made their way into the world of licensed mental healthcare, and the drugs have been proven to help people process and lessen anxiety and depression. What does this mean for people with terminal illnesses who are afraid of death?

Why is fentanyl poisoning street drugs?

A few grains of fentanyl, a synthetic opioid far more potent than heroin or morphine, is enough to kill a typical adult human. It's made its way into other, less lethal street drugs, where it may be used to increase the highs experienced by unknowing users, increasing their likelihood of addiction and overdose. This 39-minute podcast episode is the first half of a two-part series exploring fentanyl's rise.

Poison frogs get their toxins from eating insects and mice

Other animals, including royal ground snakes, are able to survive eating poison. Scientists study the creative antitoxin defenses in these animals to discover treatments for poisoning.

What do psychedelic plants look like?

Far from the drippy aesthetic often associated with psychedelics, the plants powering naturally occurring psychoactive experiences may not stand out as anything special. This database offers a visual guide to psychoactive plants and fungi. Clicking on the title of a particular plant, such as yerba mate, will bring up a secondary screen with various hyperlinked images, such as the plant itself, related botanical drawings, and molecular structures.

In 1957, a vice president at JPMorgan became an outspoken evangelist for psychedelic mushrooms.

The world's weirdest flowers

We mostly marvel at the beauty of flowers, but some kinds of flowers are incredibly weird. This video highlights 15 of the world's strangest flowers, from the massive Titan Arum to the rare Lady Slipper Orchid.

The disease no one survives (yet)

Creutzfeldt-Jakob disease is currently incurable and can cause one's death within months of symptoms appearing. It involves misfolded proteins that, for some reason yet unknown to science, aren't cleared by the brain as typical and instead trigger similar proteins to misfold. These malformed major prion proteins—prion being a portmanteau of protein and infection—clump inside nerve cells, blocking signals crucial to processes ranging from speaking to organ function.

Black mold isn’t more worrisome than other colors of mold

Black mold typically refers to Stachybotrys chartarum, a mold that commonly appears in damp or water-damaged areas of the home. Black mold—and other molds—won’t typically make otherwise healthy people ill, and all molds should be treated the same with respect to health risks and removal. If you have mold allergies, mold can cause an allergic response, and it can trigger asthma attacks for people with asthma. If you have a compromised immune system, then black mold exposure can also cause a fungal infection in your airways or elsewhere in the body.

Cryptococcus neoformans, a growing threat, causes infections in the brain and lungs

This inhalable, microscopic pathogen is found worldwide. It rarely causes illness, but it can take root in those with compromised immune systems, including people with advanced HIV/AIDS. Symptoms of cryptococcal infection—such as a stiff neck, vomiting, and confusion—can begin weeks or months after breathing in spores, though sometimes symptoms won’t appear for years. There are no known cases of transmission between people or between people and animals.

Being struck by lightning has a mortality rate of about 10%

Near-immediate deaths are the result of electrical disruptions in the heart and nervous system, causing cardiac arrest, but severe skin burns, temporary paralysis, and blown eardrums are more common. About 74% of survivors are left with a long-term disability, which includes brain damage and changes in memory and mood.

How a deadly antarctic expedition turned poisonous

A deadly 1912 scientific expedition to the Antarctic took a turn for the worse when the expedition team's leader turned to man's best friend to fuel their journey. This 21-minute podcast episode provides a glimpse into the real-life dangers of...