Listen to what it was like living as a medieval leper

Read excerpted accounts from some of the 8,000 residents with leprosy on Moloka'i

Accounts preserved by the Kalaupapa National Historical Park describe how residents felt about being sent to live in this remote location and knowing they would never be allowed to leave. In 2012, 20 residents with the disease continued to voluntarily live in the area.

See examples of leprosy in the Bible—a broad term for skin ailments in ancient times

People afflicted with leprosy in the Bible may have had a range of different skin diseases, rather than what's clinically diagnosed as Hansen's disease (leprosy) today. In the Bible, as in many traditional societies, those with the disease were often considered unclean or sinful.

Read an account of what life was like in America's national leprosarium—its leper colony

José Ramirez Jr. shares an account of his eight years at the 300-acre national leprosarium in Carville, Louisiana, from 1968 through the mid-1970s. Mostly staffed by nuns with nursing degrees, this facility was home to hundreds of people at a time, and it's also the site where they were required to be buried.

America had a national leprosarium—a leper colony—in Louisiana until 1999

Public health officials forcibly sent those diagnosed with leprosy to the Louisiana Leper Home in Carville, first founded in 1894. Listen to an interview about this site, its evolution, and how its residents advocated for themselves—including regaining the right to vote.

Recent research indicates leprosy was present in the Americas before European settlers

New research published in 2025 upended long-held notions that the disease was introduced to the Americas by European colonizers. Evidence of a lesser-known leprosy-causing bacterium was found in ancient human remains that date back 4,000 years.

Leprosy affects the skin, eyes, and upper respiratory tract

Untreated, the disease can lead to permanent nerve damage and the loss of sensation in arms, legs, and other extremities. The exact form of transmission remains unclear, but scientists suspect it is spread via respiratory droplets over a prolonged period. (Warning: Graphic content, including photos of deformities.)

Watch how doctors examine leprosy patients for signs of vision impairment

Clinicians must screen for symptoms of eye and vision damage in leprosy patients, including loss of sensation, reduced blink reflex, and inability to close or keep the eyes closed.

Up to 225 cases of leprosy in the US are diagnosed each year

Most cases in the US are imported, meaning someone was infected in a country where it was more common. Since symptoms can sometimes take decades to appear, tracing the origin of the disease can be hard.

About 95% of people are naturally immune to leprosy.

In 1865, Hawaii's king authorized forcible removal, quarantining of those with leprosy

King Kamehameha V authorized the removal of anyone with leprosy symptoms and for them to be placed in a medical facility later maintained by the Catholic Church on Moloka'i, Hawaii's fifth largest island. Patients weren't allowed to transfer to other medical facilities until 1969.

Nerve axons become damaged by leprosy, so patients may lose feeling in their skin

Infection of the peripheral nerves—nerves outside the brain and spinal cord—is a known complication of leprosy. That damage can cause patients to lose their sense of touch and the ability to feel pain or temperature in affected areas, leading to accidental injury.

Leprosy symptoms may appear 20 years after infection, so contact tracing isn't possible.

More than 200,000 people are diagnosed with leprosy annually

The disease still occurs in more than 120 countries. Brazil, India, and Indonesia continue to report more than 10,000 new cases annually.

Medieval hospitals existed centuries before modern medicine

Long before modern healthcare, medieval Europe established hospitals that served multiple roles, including religious, social, and medical purposes. This podcast explores how institutions like Siena's Ospedale di Santa Maria della Scala supported urban and rural communities for centuries.

Leprosy bacteria replicate extremely slowly—only once every two weeks

Mycobacterium leprae has a long incubation period and a very slow replication rate, taking roughly 12 to 14 days to make a copy of itself and divide. In contrast, bacteria like E. coli can replicate in about 20 minutes in ideal conditions. Someone can be infected for years without experiencing any symptoms. This also makes the disease difficult to treat. This video describes the knowns—and unknowns—about this infectious bacterium.

Leprosy bacteria are sometimes grown on mouse feet for research since the pathogens can't be grown in a petri dish.

See what regions report new leprosy cases

This graphic shows the burden of leprosy by region for 2023, based on data provided from the World Health Organization, which collates this information. Southeast Asia leads in the number of cases by region. (Some readers may experience a paywall.)

How did people survive the eruption in Pompeii?

In 79 CE, Mount Vesuvius erupted and buried Pompeii under roughly 20 feet of volcanic ash. This deadly eruption killed much of the city’s population, but archaeologists recently discovered evidence of survivors. In this podcast episode, classicist Steven Tuck challenges the popular belief of total annihilation and explains how people may have survived, and how they continued to live after the disaster.

People can—and have—contracted leprosy from armadillos

A 2011 study linked multiple human cases to the handling of armadillos or the consumption of their meat. The research couldn't document direct transmission, but did find that the animals and humans shared the same exact strain of the disease.

81% of Florida's leprosy cases occur in central Florida, raising concerns

Researchers noted in 2023 that about one-fifth of new US leprosy cases were reported in the central part of the Sunshine State. What's more, about a third of the new US cases overall appear to have been acquired locally, raising questions about whether the disease is now naturally occurring in parts of the southeastern US.

Explore the history of antibiotics with 'This Podcast Will Kill You'

The show blends medical history with storytelling and science. In Episode 50, the hosts trace the dramatic origins of antibiotics—from Fleming's moldy petri dish to Florey's wartime labs—and explore their lasting impact on health.

Listen to how gaps in schizophrenia care helped to lead to a murder

Michael Laudor attended Yale, succumbed to schizophrenia, and killed his pregnant fiancée. The podcast, which includes a long but moving interview with Laudor's friend Jonathan Rosen, uses the tragedy to frame how America's approach to severe mental illness has fallen short.

Hear the untold colonial backstories of the British Museum’s most famous artifacts

This podcast from VICE’s Unfiltered History Tour visits the British Museum’s prized objects through accounts from experts and communities from which they were taken.

Lupus, an autoimmune disease with varied symptoms, was named for wolf bite-like lesions

The 13th-century physician behind the name (lupus is Latin for wolf) named it after a patient he saw who had facial lesions that looked to him like a wolf's bite. Other common symptoms of the disease include extreme fatigue, painful and swollen joints, fevers, and light sensitivity.

Listen to why extensive ear rinsing can create problems

The clinician who hosts this podcast discusses how his patient developed swimmer's ear after he flooded his ears with water during his daily showers, ostensibly to clean them. The resulting itchy, painful ears were the result of removing protective earwax in the ear and also altering the typical pH of the ear.

Ghost hunting in the 19th century

This 40-minute podcast explores what it meant to hunt ghosts during the 19th century, when studying the paranormal was considered a mainstream scientific field. In 1847, a pair of sisters reportedly communicated with the spirit of a dead man...

Listen to an amputee describe what it was like in the aftermath of his partial foot amputation and how his chronic, extreme pain fueled his depression and his decision to attempt to alleviate the pain with the radical surgery.

Leprosy has been detected in British red squirrels

The animals have been infected with both strains of the bacterium that cause leprosy. Researchers have found that squirrels living in different parts of the UK were infected with different species of the disease-causing bacteria. (Some users may experience a paywall.)

What was it like to live through the Great Depression?

Hear the personal accounts of four people who lived through the Great Depression, as told by NPR's Throughline. Listen to this 47-minute podcast episode to get a bit more insight into the countrywide economic crisis and what it meant it for everyday people.

Leprosy doesn't cause fingers or toes to fall off

The nerve damage that results from infection sometimes causes loss of feeling in extremities so injuries like cuts or burns may be missed. In such cases, resulting infections can lead to digit loss. Fingers or toes can also appear to shorten with this disease because nerve damage can sometimes make muscles in fingers and toes so weak that they're reabsorbed by the body.

The story of the 1945 Minnesota Starvation Experiment

Amid the severe conditions of World War II, researchers were eager to learn the effects of starvation in a controlled study. This podcast dives into a yearlong study of 36 men at a Minneapolis college who endured a six-month period of semi-starvation, where their caloric intake was halved. Results from the experiment became a landmark study in human starvation.

Being a Byzantine emperor

The Byzantium and Friends podcast, hosted by Anthony Kaldellis, surveys current research in the history of the Byzantine Empire and its neighbors. In each episode, Professor Kaldellis interviews a scholar about their recent work. The cumulative effect is to reveal a world much more complex, and much more interesting, than the Byzantium found in traditional surveys. The linked episode considers the perks and pitfalls of being a Byzantine emperor.

'Statelessness: Citizens of Nowhere' podcast examines how statelessness erodes identity

This podcast series explores how millions live without citizenship or legal status. Through expert interviews and personal stories, it examines how history, borders, and policy can leave entire populations without citizenship and rights.

In 1951, a small French town was likely overtaken by the fungus that ultimately led to LSD.

Post-treatment Lyme disease syndrome may be caused by bacterial remnants in the liver

PTLDS, which refers to lingering symptoms of Lyme after antibiotic treatment, is an area of active research. Rodent research published in 2025 suggests that these ongoing symptoms may potentially be due to the body's inflammatory response to lingering cellular components from the bacteria that cause Lyme, Borrelia burgdorferi. In rodents, components of the bacteria's cellular wall may remain in the liver after the bacteria were eliminated with antibiotics.

Medieval European winters were colder than ours, but peasants stayed warm

Medieval winters were colder than ours today while the continent was mired in the so-called Little Ice Age. Without modern technologies, peasants survived with simple, sometimes genius, solutions, including central, chimney-less fireplaces (vented by small, draftless vents) and decorative handwarmers.

Measles evolved from an ancient cattle disease, branching off as recently as 3,000 years ago.

Lyme disease was first identified in Lyme, Connecticut in 1975

A cluster of 51 children and adults in the town all began experiencing uncommon arthritic symptoms and the cases were reported to the state health department. A quarter of the cases were preceded by a skin lesion. The patients tended to live near the woods.

True crime, explained

Tales exploring some of the most grisly and unthinkable crimes have satisfied the public's morbid curiosity for more than a century, and modern podcasting has shot the genre to new heights. Want to learn more about the history of true crime? 1440 has the breakdown here.

Explore a podcast devoted to uncovering different conspiracy theories

Hear stories of controversial events from all around the world and come to your own conclusions about why they happened—and if someone shaped the narrative around them. From art fraud to the death of a Roman emperor, this Spotify podcast covers it all.

Why might someone want to stay in psychosis?

Author Abigail Gosselin writes that her verbal auditory hallucination, often assumed by others to be harmful or threatening in nature, offered a salve to loneliness, even as it told her to kill herself. This perceived benefit and others Gosselin shares offer insight into why people in psychosis may struggle to adhere to treatment and medication plans.

Neanderthals commonly had surfer's ear, a potential sign of extensive seafood collection

Analysis from 2019 found that about half of the 23 Neanderthal skulls scientists examined seemed to have the bony growths in the inner ear, signifying they had surfer's ear. Those growths suggest our ancient relatives, dating back to between perhaps 100,000 and 40,000 years ago, were potentially hunting fish, mollusks, or other marine resources in chilly waters.

Hear how the Black Death reshaped Europe's economy

The Black Death killed tens of millions across Europe, but the labor shortages that followed shifted economic power. With fewer workers available, survivors demanded higher wages and better conditions—sparking what historians call a medieval “Golden Age of Labor.”

Explore the unexpected ways people use public libraries in this 'This American Life' episode

Libraries serve as far more than book repositories. This episode follows a family experiencing homelessness that spent months living in their local library, Iranian students reuniting with family across the US-Canada border because the library straddled both countries, and a Vermont man who built his own library to house unpublished manuscripts.

Wild chimpanzees have been spotted with leprosy lesions

In research published in 2021, scientists reported discovering cases of leprosy in wild chimpanzees from Guinea-Bissau and the Ivory Coast—marking the first time the disease has been found in any nonhuman species in Africa. They confirmed that leprosy was the cause of the deformities by testing the animals' poop for the presence of the disease-causing bacteria.

The human cost of creating medieval monsters

The concept and creation of monsters have been used since time immemorial to communicate social norms and the consequences of breaking them. Some so-called monsters were judged as such solely due to having features that would be considered birth defects in modern times. This in-depth article explores the human cost of creating medieval monsters, many of whom were defined by a physical appearance that deviates from the expected.

Land use changes in Connecticut may have helped to enable Lyme's leap into humans

Forest clearing and fragmentation, alongside suburban development, may have contributed to the emergence of Lyme disease in humans in the 1970s. Those changes brought mice, carriers of the disease, into greater contact with people. Climate change is also facilitating Lyme's spread as tick populations survive milder winters and move northward.

Read a study about racial differences in Lyme disease diagnosis

The research published in September 2025 examined differences in Lyme disease diagnosis among Medicaid and Medicare beneficiaries using data from 2016 to 2021. It notes that though US Lyme disease surveillance data indicates more than 90% of diagnosed Lyme cases are among white people, people of color—particularly those who identify as Black or African American—have higher rates of more severe disease of Lyme, with symptoms including arthritis and neurologic impacts.

Listen to a podcast about the eerie side of national parks

Although the National Park System is a relatively recent invention, the lands it includes have been around since the dawn of time and, as a result, have accumulated some interesting folklore. This podcast walks you through some of the best legends about the parks.

Learn the history and science of influenza in 'This Podcast Will Kill You'

In their flu episode, cohosts Erin Welsh and Erin Allmann Updyke unpack influenza's biology, history, and impact—explaining everything from past pandemics to modern vaccines, all with their trademark mix of science and storytelling.