Four in 10 CPR patients report consciousness not captured by standard measures.

The body's response to cardiac arrest has been linked to near-death experiences.

Brain activity sometimes goes into overdrive around the point of death according to researchers' recent analysis of patients' brains before and after they were taken off their ventilators.

Research advances suggest death takes much longer than we realized

Recent research indicates that organs, including the brain, are better at handling a lack of oxygen after the heart stops beating than previously known. Such findings may open up possibilities that include someday reversing certain death processes and expanding the availability of organs available for organ donations. (Some users may experience a paywall.)

There's a new (contested) physiological explanation for near-death experiences based on analysis of the brains of resuscitated coma and cardiac arrest patients.

Brain death is a uniquely modern problem stemming from modern ventilators.

Meet the Dutch cardiologist who believes consciousness can exist outside the body

Dutch cardiologist Dr. Pim van Lommel conducted one of the largest studies of near-death experiences following cardiac arrest, publishing the results in the prestigous journel The Lancet. He later went on to argue (to significant criticism from peers) that his findings suggest consciousness can exist outside the body.

Pig brain cellular activity was restarted hours after death in study published in 2019

Yale University scientists restored basic cellular activity and circulatory function in pig brains about four hours after death with a synthetic cocktail of preservatives and nutrients. This work— which didn't restart electricity activity in the brain or consciousness—could help advance future human stroke and brain injury treatments.

Brain death is a top source of organ donation

Brain death is a significant source of organ donations—approximately 40% of organs in the US and the UK are recovered from people who experience brain death. Patients declared brain dead and hooked up to intensive care unit machines will still have oxygen flowing to organs like the heart, lungs, and kidneys—preserving those organs.

Brain death is a top source of organ donation

Brain death is a significant source of organ donations because patients declared brain dead and hooked up to intensive care unit machines will still have oxygen flowing to organs like the heart, lungs, and kidneys—preserving those organs.

Watch this 2021 video demonstrating a full brain death examination

This video and accompanying article in the peer-reviewed New England Journal of Medicine show the then-standard steps of a full brain death examination—demonstrating the process on a medical dummy to search for pain, blinking, eye movement, cough, gagging, or other forms of responsiveness. (May need to sign up for a free account to view.)

A radiation oncologist has studied near-death experience reports for over 25 years and compiled around 4,000 accounts in the hopes of finding more patterns that would reveal insights about consciousness and humans' final moments before or around death.

Scientists are studying dying patients' brain activity in the final moments of life

In the final moments of life there are distinctive bursts of coordinated neural activity. Researchers are interested in parsing that data to better understand the dying process and also exploring how this data relates to our understanding of consciousness.

Brain death is very rare—only 2% of hospital patients have brain death in the US

A peer-reviewed analysis examining US hospital billing code data from 2012 to 2016 concluded that the incidence of brain death is about 2% in the country. There was no available information indicating what proportion of those patients underwent organ donation.

The Lazarus Effect is when a heart begins beating on its own after declared death

Formally called autoresuscitation, this rare phenomenon occurs when someone is declared dead following a cardiac arrest but their heart beats again without help—making it seem like the person came back to life. Doctors don't know the exact cause.

'Donation after circulatory death' is on the rise

This occurs when a patient in a coma is on life support and family members agree to donate the organs. Watch this video about a 2025 New York Times investigation that identified 12 instances across nine states of bungled or premature attempts to retrieve organs from people whose families had authorized withdrawal of life support.

Some scientists argue NDEs are constructed by the brain, not actually experienced

Despite the powerful memories associated with NDEs, scientists question the idea that the experiences prove consciousness endures after death, opting instead to find physiological explanations for common reports of out-of-body experiences, euphoric and lucid thinking, and more.

A leading expert on near-death experiences, psychiatrist Dr. Bruce Greyson, says that during his decades of research on this topic, this area of research has become far more mainstream and accepted as a rigorous area of inquiry.

Brain death is a medical diagnosis without any wiggle room

Seeking to resolve long-standing variations between hospitals and state procedures, in 2023 several expert groups published comprehensive step-by-step guidance for clinicians to follow when determining brain death in kids and adults. Among other guidelines, it stated that doctors don't need to get family consent to do the tests needed to make this determination.

Observant Catholics can donate organs because the official Catholic stance is brain death is death—enabling organ donation

The Vatican states that brain death, when properly diagnosed, means that a person is dead even though machines can keep them alive. That official stance from Catholic leadership and echoed by most Catholic doctors and ethicists enables the families of observant Catholics to proceed with organ donation.

A near-death experience is a phenomenon experienced by roughly 5% to 23% of the population, and typically occurs after a traumatic physical event or a brief clinical death.

An estimated 1 in 250 people—a small subset of the population—reports they've never remembered a single dream.

Recent research found that the brain doesn't seem to massively rewire following amputation—upending earlier beliefs about the cause of phantom limb pain.

In 1968, a Harvard Medical School committee issued the first neurological definition of death

The definition set a legal and medical precedent for how we define death, important for issues including organ donation. This 2020 video podcast discusses the history of brain death controversies and the variability in how death has been determined, including discussions in the late 1960s about when patients are considered dead in the context of organ donations.

Research suggests the brain maintains connections to lost limbs

Decades-old research suggested brain reorganization after amputations, but brain scans show unchanged limb representations. Phantom limb pain may result from such unchanged brain maps, which may enhance prosthetic limb control in brain-computer interface technology.

Accounts of near-death experiences share similarities with hallucinogens, with reports of mystical-like states of consciousness across both contexts.

A 'paranormal activity' unit at the University of Virginia studies challenges to mainstream scientific ideas about human consciousness.

What happens in a dying brain?

Near-death experiences usually happen during death or on the border of life and death when a person isn't understood to be conscious. This article details the science of what's going on with the brain during NDEs.

Medical recognition of strokes stretches back to ancient Greece

Every minute, 750 milliliters of blood flows to the brain, supplying 20% of the body’s oxygen. A sudden disruption—whether from a clot (ischemic stroke) or a bleed (hemorrhagic stroke)—can be life-threatening. From ancient Greek theories to modern CT and MRI scans, here’s how stroke science has evolved over time.

Terminal lucidity is the phenomenon of sudden, heightened mental clarity when on the verge of death

The "Let's Talk Near Death" podcast explores phenomena around the end of life, inviting guests to recount their own experiences. This episode focuses on the phenomenon known as "terminal lucidity," where patients experience clarity, vivid memory recall, and more, typically following a heart attack, stroke, or other trauma.

Brain implants are restoring movement and communication in early human trials

Several companies developing brain-computer interfaces have begun testing on humans with promising results. These implants have helped reanimate paralyzed limbs and enable communication, though ethical concerns remain about data privacy.

A brain scientist's experience with a stroke

What happens when a leading brain scientist has a stroke of her own? Dr. Jill Bolte Taylor recounts moment by moment watching her brain function slow and then cease, followed by a prolonged recovery. Through this experience, she details what she learned about the phenomenon of stroke and how it has impacted her research ever since.

Sleep research published in 2021 confirmed that there is a 'creative sweet spot' when people are drifting off to sleep, and that if they wake up at that point to work, it can boost their creative problem-solving.

Who is the woman behind today's CPR doll?

According to a recent survey, about half of Americans know how to do CPR—many of whom learned on a mannequin called Rescue Annie. It turns out that this training doll may be based off a woman who became famous after drowning in the Seine, after...

An estimated 2 million brain cells die each minute a stroke goes untreated

Modern stroke treatment is a delicate balance between obtaining an accurate diagnosis and delivering treatment quickly. Each stroke has its own cause, and the appropriate treatment must be paired with the correct diagnosis to prevent further harm. Typical treatments pair emergency surgery to relieve the affected area and long-term regimens to avoid recurrence.

Brain-reading devices are helping paralyzed people to touch

In clinical trials, implanted brain-computer interfaces are allowing dozens of individuals with paralysis to control prosthetics that are restoring a range of skills, including drinking coffee and feeding oneself. One area of related prosthetic research is creating a synthetic sense of touch—coupling the brain implant with pressure sensors in prosthetic robotic fingertips to enable an approximation of a sense of touch.

Left versus right brain strokes vary significantly in long-term effects

Due to the high complexity of the brain, the aftereffects of a stroke can have widely different manifestations, ranging from minor temporary impairments to rapid death. Whether a stroke results in paralysis, speech impairments, loss of bodily function, or death will depend on whether it occurs in the left or right hemispheres or the brain stem.

The University of Virginia has the nation's most established near-death studies division, but institutions including the University of Southampton, the University of Connecticut, and the University of North Texas have also explored the field.

Using AI to restore speech 30 years after a stroke

Through a novel surgical procedure involving electrodes implanted in the brain, along with the help of artificial intelligence, a stroke patient is regaining her ability to speak. This technology converts her thoughts into speech through a digital avatar, allowing her to verbally express herself for the first time in decades.

Studies of psychedelic use may help shed light on the nature of consciousness

The nature of consciousness—what it is, where it comes from, and how it manifests as moment-to-moment experience—remains under debate by scientists. Recent studies show psychedelics were found to boost low-frequency brain signals known as delta waves, a behavior also seen during dream states.

Take a quiz to discover your brain care score

Each year, nearly 800,000 Americans have a stroke. With such a high occurrence rate, you may be asking yourself what you could do now to prevent a future stroke. Researchers at Harvard collaborated to answer this question by coming up with a "Brain Care" scoring system. Take the quiz to learn the quality of your brain health today and pick up helpful insights to lower your risk of stroke and dementia well into the future.

American medical organizations rescind recognition of diagnosis cited in police custody deaths

American medical organizations have rescinded their recognition of a syndrome whose theory stemmed from discredited research. This article explores the history and implications of "excited delirium syndrome," a medical condition that can reportedly...

How dreams affect your memory

In 1999, scientists conducted a study in which participants were asked to recall images flashed before them for milliseconds. They found that participants who slept before recalling the information performed better than those who had been asked to recall the same information that same day. This was some of the earliest convincing evidence of how crucial sleep is for learning and memory, findings that current research continues to strengthen.

The oldest medical report of a near-death experience dates to around 1740.

Sharp wave ripples in the brain tag experiences for long-term memory storage

These ripples were known to quickly replay neuronal sequences during sleep for consolidation. While awake, they help the brain prioritize memories to remember, and their disruption can impair memory formation.

The main criticism of a recent neurophysiological explanation for near-death experiences is that these events are too complex to be explained as a neurochemical response to an oxygen-deprived brain.

Dreams largely occur during REM sleep (but not entirely).

Animal brain studies show brain activity similar to what we'd expect during dreams, but parsing whether animals are truly dreaming depends on how one defines dreaming and how scientists could prove it.

Donated hearts remain viable three times longer now with new tech

Advances in organ perfusion systems have significantly lengthened the amount of time donated hearts can remain viable for transplant, expanding the possibilities for donor organs to wider geographic areas. "Heart in a box" devices, developed in recent years, enable effective oxygen flow in the donor heart during transport, which means that hearts can now travel farther to potential recipients and still be in good condition.

Heart attack risk jumps to 21 times its norm on the day of a loved one's death

Research published in 2012 suggests that the intense emotional burden of suffering a loved one's death can escalate heart rate, blood pressure, and clot risks—culminating in elevated heart attack risk. The increased heart attack risk remains after that first day, remaining eight times above normal during the first week, and then dropping down over the course of a month. (Some users may encounter a paywall.)

Humans can have brain damage after four minutes without blood flow.