The most common type of arthritis is osteoarthritis, which is sometimes called 'wear and tear' arthritis, referring to age-related cartilage loss.

Diagnosis and treatment of hip and knee osteoarthritis

Osteoarthritis is the most common type of arthritis, resulting from age-related degeneration of the soft cartilage lining between bones. As this layer breaks down, the normal smooth motion between bones is lost and the joint becomes painful.

Arthritis is an umbrella term for various conditions that cause joint pain, including osteoarthritis, inflammatory arthritis, posttraumatic arthritis, and septic (infectious) arthritis.

Arthritis affects almost 60 million Americans, with about 1 in 5 US adults developing this type of joint pain as they age.

Watch real knee surgery footage to see what arthritis looks like up close.

Explore the basics of arthritis in this 1440 Original video with orthopedic surgeon Dr. Nick Golinvaux.

There is no cure for arthritis, which includes more than 100 separate joint pain and stiffness conditions.

Five advancements in arthritis research

It is estimated that nearly 350 million people worldwide are currently suffering from arthritis. This resource explores five of the most promising recent advancements in arthritis research as scientists work towards improved treatments and continue the search for a cure.

Rheumatoid arthritis occurs when the immune system attacks cells within joints.

Visualizing a joint under attack from rheumatoid arthritis

A particularly difficult arthritis subtype is rheumatoid arthritis, a painful condition provoking a vicious cycle of joint inflammation, destruction, and dysfunction. It begins with a misfiring of the patient’s own immune system—for unknown reasons, it identifies joint and cartilage cells as foreign, initiating an attack to eliminate the supposed "invaders."

Rheumatoid arthritis affects about 1% of the population

Rheumatoid arthritis is an autoimmune condition leading to breakdown and inflammation of multiple joints throughout the body. This academic article provides an updated deep dive into our current cellular understanding of rheumatoid arthritis, how it is diagnosed, and the variety of medications available for treating this painful condition.

Limb regeneration research may lead to treatments for arthritis

For scientists pursuing the cure for arthritis, the holy grail of discoveries lies in how to regrow healthy cartilage inside human joints. While this feat has so far resisted our best scientific attempts, there are plenty of other human tissues—such as the liver and fingertips—that will successfully regenerate.

Impressionist painter Pierre-Auguste Renoir suffered from arthritis in the 1800s when there were no treatments, and eventually had such limited hand function that he painted with brushes placed in his mouth.

A human joint is any place in the human body where two bones connect, providing structure and stability.

Inflammaging is chronic low-level inflammation as we age, and it may be a key disease driver

The term refers to the idea that largely invisible but consistent low-level inflammation as humans age fuels chronic diseases and cellular aging. Inflammaging, this article says, is due to lifestyle factors like poor sleep, low levels of activity, and poor diet, acting in concert to cause cellular damage and trigger inflammation.

Researchers are investigating how altering the gut microbiome may influence the development of rheumatoid arthritis, which is an autoimmune disease.

Kangaroos evolved exceptionally thick knee cartilage to absorb shock, and scientists are studying the animals for potential insights about how to safeguard human knees against arthritis.

Age-related hearing loss, known as presbycusis, is a top cause of hearing loss

This video walks through the biology of why presbycusis (prez-buh-kyoo-sis) occurs and its etiology. This type of hearing loss is gradual and typically starts with reductions in the ability to hear high-pitched sounds.

Aging is a complex biological process affecting our cells, tissues, and organs.

See the anatomy of a healthy knee joint, which has smooth cartilage that cushions the joints and protects the bones from rubbing together.

Aging results from the cumulative breakdown of cellular and tissue processes

A cumulative breakdown of cellular and tissue processes combines to result in decreased organ function, disrupting the systems driving normal human physiology. This five-minute video provides a primer on the subject, complete with a discussion of risk factors, cellular changes, and potential future treatments in the fight against aging.

Alzheimer's disease is the leading cause of dementia and risks rise after age 65

Read this primer about Alzheimer's disease and learn what factors increase the risk of this form of dementia, including genetics, being a woman, and health conditions, including high blood pressure.

Explore this 1440 Original video offering a primer on Alzheimer's disease and what's known about its incidence, causes, and more.

Age-related macular degeneration is the primary cause of blindness in older Americans.

The collapse of gas bubbles in the joint synovial fluid causes 'cracking' knuckles.

Breaking down the knee's anatomy

The human knee is a remarkably complex structure carrying the full weight of the body throughout a person's life while allowing a number of complex twists, flexes, and extensions. It's also one of the body's biggest weaknesses—the location of chronic pain and replacement surgeries for millions of Americans.

Cellular aging and deterioration leads to tissue (and overall) aging

Cells are the building blocks of life, forming tissues and organs that keep our bodies working. As we age, cellular changes have progressive consequences on both the structure and function of our organs. This article examines this complex relationship as it relates to the incremental changes associated with aging.

DNA damage and chemical stress causes cellular aging

While outward signs of aging, like gray hair and wrinkles, are easy to spot, aging changes at the cellular level are less obvious. The decline within cells stems from numerous sources, including DNA damage, oxidative stress, and accumulated waste.

Stroke risk doubles each decade after age 55

While age is the greatest risk factor, genetics, diet, and overall health play a prominent role in determining individual stroke risk. Prevention focuses heavily on modifiable risk factors. High blood pressure is the single most important controllable risk factor, contributing to both types of stroke.

Why young women experience the most workplace ageism

While one might assume that older women face the most unfair treatment due to age in the workplace, some research from McKinsey & Co. suggests otherwise. The consulting firm found that while ageism impacts older women and men at similar rates, women in their 20s and 30s report much higher instances of ageism than both older women and their young, male colleagues. Learn more from the research here.

"Plaques" and "tangles" are top potential causes of Alzheimer's—but questions remain

The exact causes of Alzheimer's—and how to treat it—continue to be the subject of intense research. Two leading factors are amyloid beta plaques and tau protein tangles, which effectively pile up in the brain and interfere with neurons and cause cell death, which manifests as memory loss and other symptoms.

Resistance training can help fight osteoporosis, especially in menopausal women.

'Old people' smell is real—it's a chemical buildup when fatty acids on the skin oxidize

The chemical composition of body odor seems to change with age. Later in life, we harbor higher concentrations of a chemical compound called 2-nonenal that forms when omega-7 fatty acids on the skin oxidize, and the skin's natural antioxidant defenses weaken. Commonly called "nonenal", it's the smell widely associated with aging, and it's often described as a grassy or greasy odor.

Yoga can be beneficial for aging practitioners

Studies suggest that yoga can help alleviate several diseases associated with aging by lowering blood pressure, reducing blood fat levels, and combating obesity. It has also been shown to increase telomerase activity, which helps slow cell aging.

Each part of the human body experiences aging differently

With global average life expectancy cresting at 73 years, understanding how the body ages is imperative to effective medical treatment and maintaining a desired quality of life. This 13-minute video dives into how the body and its organs age "from head to toe."

Women experience heightened bone loss after menopause

Both women and men begin to lose some bone density after age 35, on average. But, for the first decade after menopause, women lose bone more rapidly due to the significantly decreased levels of estrogen, putting women at heightened risk of osteoporosis and related bone fractures.

Dinosaurs suffered from cancer, arthritis, and infections seen in modern animals

Using CT scans and advanced pathology techniques, paleopathologists have identified respiratory illnesses, malignant osteosarcoma, and other diseases in dinosaurs. The research has helped show how many of these ailments are not exclusively modern phenomena.

Adults may lose roughly 3% of their muscle mass each decade after 30.

Inflammaging appears to differ across global populations

Chronic, low-grade inflammation linked to aging is a byproduct of our industrialized lifestyles, according to recent research. The work compared two industrialized populations with two Indigenous, non-industrialized populations in Bolivia and Malaysia, and found that inflammation levels in the Indigenous groups—unlike the industrialized ones—did not seem to differ by age.

Why vascular dementia develops

This type of dementia, the second most common form after Alzheimer's, develops due to microscopic bleeds and blood vessel blockages in the brain. The condition isn't curable but medications to help with blood clotting and high blood pressure are part of a suite of interventions designed to minimize damage to the brain.

As deposits build up under the eye, the retina bends with macular degeneration

The retina bends due to the accumulation of proteins and other materials beneath it. That's considered the milder "dry" form of macular degeneration. Another form, called "wet" macular degeneration, is caused by abnormal blood vessels leaking fluid into the eye, which can rapidly affect central vision.

Late-stage clinical trials indicate that a common arthritis drug may be a promising treatment for a leading cause of hair loss.

Anxiety is one of the world's most common mental health disorders, causing persistent excessive fear and worry that interferes with daily activities.

Aging explained with Dr. Nick Golinvaux

Aging is more than wrinkles and gray hair—it’s a gradual decline in cellular function. Over time, DNA damage, telomere shortening, and mitochondrial inefficiency contribute to weaker bones, slower memory, and reduced vitality. While aging is inevitable, regular exercise, quality sleep, and stress management maintain health and extend one’s years.

Collagen supplements have become a multibillion-dollar industry

Beginning in our 20s, the amount of this protein in our skin, muscles, and connective tissue declines. But independent, high-quality studies—like those that are double-blind—have not yet shown a significant association between their use and evidence of it improving skin elasticity, reducing wrinkles, or combating hair loss. Some collagen supplements do seem to help with joint pain and knee function, but NPR cautions that studies on that purpose are industry-funded.

Autoimmune diseases affect between 5% and 10% of people worldwide, but their causes remain unknown

Autoantibodies—which attack the body—may be detectable in the body years before a patient develops symptoms, but some people may have detectable levels yet never go on to develop an autoimmune disease. This video discusses this and other unsolved mysteries with autoimmune disease.

How aging degrades neural functioning in the brain over time

Aging affects the brain perhaps more than any other organ in the body. Throughout life, the brain experiences radical shifts in the number of neurons, synaptic connections between neurons, and hormone levels that regulate our mood and processing.

Doctors use three key physical markers to determine biological aging

The length of the ends of chromosomes (known as "telomeres"), the gradual change in collections of DNA molecules called "methyl groups", and the secretion of inflammatory proteins are all used as indicators of biological age.

Autoimmune disorders are one of the top 10 killers of young and middle-aged women

Studies in the US and the UK, though conducted decades ago, have underscored that autoimmune diseases, when grouped together, are a top killer of women.

Skull bone marrow may be playing a key role in chronic pain.

Five to ten percent of Alzheimer's cases are early-onset

Early-onset Alzheimer’s typically emerges around 40 to 50 years of age, with devastating effects. This video follows Brian, diagnosed with the disease at age 54, as he travels the country as an advocate for research and discusses the progressive mental fog of Alzheimer’s.