A fascinating look at how our DNA is built and replicated

Watch DNA replicate itself before cell division

In the average adult human, between 50 billion and 70 billion cells die daily, requiring them to replicate their genetic instructions before dividing into new cells. This process relies on various proteins to unwind, read, build, and proofread new strands, with error rates of fewer than one per 1 billion nucleotides.

Watch how DNA is packaged to a 10,000th of its original size in a cell

In humans, the 2-meter (6.56-foot) molecule wraps around spool-like proteins called histones, forming beads—nucleosomes—that fold up into fibers. These fibers—chromatin—form loops through folding that compress into larger fibers, which tightly coil together to form a chromosome.

How do you sequence a genome?

If the genome is made up of microscopic chromosomes, how do scientists actually sequence it? Here's a 5-minute video explaining one of the most common processes.

Visualization of printing synthetic DNA

Ever wonder how synthetic DNA is made? Discover how GenScript uses innovative technology to synthesize precise, high-quality DNA at a larger scale than ever before.

DNA's four-letter blueprint makes the variety of all living things possible

The proteins responsible for cellular functions and an organism's traits are built outside of a cell's nucleus from RNA—single-stranded molecules created by reading the information in DNA. DNA's double-stranded structure makes it more stable and allows RNA to be made from either of its complementary strands.

The secret lives of cells

Cutting-edge microscopy has revealed previously unseen interactions of biological molecules within their cellular environment, enabling scientists to observe and analyze the molecules in a holistic view. This podcast explains the minute advancements made over the last few decades in observing cells, revealing how scientists have come and what the future holds for the field.

How do vaccines work? Watch this brief 101

Watch this under-3-minute video explaining how vaccines use the body's immune system to prepare our bodies against viral and bacterial threats to our health.

Watch how proteins are created from DNA

When a DNA sequence—a gene—is activated, a copy of the activated portion is created in the form of RNA, a single-stranded version of DNA, in a process known as transcription. This RNA, called messenger RNA, leaves the nucleus and travels to a ribosome, a structure within a cell, which uses it to build a chain of organic compounds that fold into a protein.

The history of the gene: an interactive timeline

Humans didn’t need modern technology to figure out that kids tend to look like their parents. But what did humans believe about genetics before we knew about DNA or cells in general? Explore this interactive timeline to see how philosophers and scientists throughout the ages tried to explain how traits are passed from generation to generation.

Watson and Crick revealed DNA's double-helix structure using others' key findings

Their 1953 model, made from cardboard cutouts, explained how DNA stores genetic information through base pairing. Rather than experimenting and collecting their own data, they incorporated patterns and data from other scientists through trial and error.

What is a cell? A great quick overview.

YourGenome.org furnishes a collection of information on cells and how they work. Every body has trillions of cells, each serving a specific function: making proteins, processing chemicals, and creating energy. Every cell contains a genome, a set of instructions for the cell's function. Brush up on your cells for a better grasp on genetics.

The oldest DNA recovered so far is 2 million years old

The oldest DNA recovered so far is about 2 million years old and has given scientists an unadulterated peek into ancient history. This nine-minute video explores the findings and implications of the DNA, which was pulled from frozen soil in...

A quick video on how your immune system works

Explore how your immune system's vast network of cells, tissues, and organs coordinate your body's defenses against bacteria, viruses and toxins with this 5-minute TED talk video.

Why don't we all have cancer?

The creation of a single cell produces 120,000 genetic mutations that can lead to cancer. This video investigates how our bodies proofread and autocorrect those mistakes.

The basics behind mRNA vaccines

In this video, Yale experts Saad Omer, MBBS, MPH, PhD; Onyema Ogbuagu, MBBCh; and Akiko Iwasaki, PhD, explain the science behind COVID-19 mRNA vaccines.

The inner life of a cell

White blood cells are responsible for protecting the human body from infection. This video uses biophysical data from Harvard researchers to accurately demonstrate what goes on inside one white blood cell as it works within the immune system.

The deceptively simple proton

Take a visual deep-dive into the proton, a near-fundamental—but deceivingly simple—building block of nature. Among other beguiling characteristics, the particle can't be described by its constituent particles (quarks), but rather exists in a...

Breaking down how and why 5G will change the world

The jump from 3G to 4G networks was pretty huge, and 4G to 5G is many times greater and is almost difficult to comprehend. This nine-minute video dives into how 5G will transform our world.

Understand the complex, biological journey of pregnancy with this science explainer.

Sex determination isn't all XX and XY

We're generally taught that chromosomes determine an animal's sex, but it is way more nuanced than that. Watch this 12-minute video to find out how.

Take a 360-degree look at biochemical activity from within a human cell

In this tour, users can observe the dynamic processes that occur within the basic units of the human body, including the production and transport of proteins and the assembly and disassembly of microtubules—thin, cylindrical structures that provide structural support and a means of moving material within the cell.

Here’s how different genetic disorders get passed on

The human genome is complex, as identified by the Human Genome Project. This article digs in to genetic disorders, the most common ones, and how they are diagnosed.

Glowing chemicals allow scientists to read DNA like a barcode

The process of determining the order of nitrogenous bases in DNA involves first cutting the DNA into fragments, which are duplicated multiple times using bacteria. Fluorescently labeled terminator bases are added to fragments, which are sorted by length and read via laser to reconstruct the sequence.

Stacking nucleotide molecules like toy blocks helps build DNA's structure

Each nucleotide is made up of a sugar—deoxyribose—a phosphate group, and one of four bases that contain nitrogen. Like building a two-tone, spiral staircase from the ground up, nucleotides are linked one on top of another so that sugars and phosphates alternate. The twisted strands are held together by hydrogen bonds between base pairs.

Storing data in DNA requires converting binary code into DNA's four-base system

Researchers have suggested that DNA's ability to form compact, dense structures justifies investigating its use for long-term, safe data archiving. This system could fit all of the world's data in a single shoebox, though processing each bit into a nucleotide base takes 2 minutes, as of 2024.

The science of dogs, from wolf origins to color-blindness

This under 10-minute podcast episode dives into the rich, fascinating science behind dogs: From their world-class sense of smell to their domestication from wolves.

Genomic sequencing is the process of determining the order of nucleotides that make up an organism's genetic information and can be done in about 24 hours or less for human DNA.

A simple visual explanation of how blockchains work

Blockchains are decentralized, distributed, and digital methods to record transactions and prevent alterations and tampering of the record. That's a simplified definition. This easy-to-understand six-minute video further and better explains what blockchains are and how they work using colorful illustrations and clear, concise clarifications on their processes and what makes them so special.

This is what happens inside your body when you're sick

This video details the biology of what happens inside the human body during illness.

How do genetics work?

Perhaps you have your mother’s hair or your grandfather’s eyes. How did you get these traits and not others? Learn how genetics work in this online video game.

How epigenetics blurs the line between nature and nurture

An exploration of the study of how behaviors and environment affect the way genes work — and how that complicates the nature-versus-nurture debate.

Aging is a complex biological process affecting our cells, tissues, and organs.

Watch how Sanger sequencing kickstarted the first generation of DNA sequencing

Sanger sequencing is a foundational DNA sequencing technology developed in 1977. The Nobel Prize-winning discovery uses fluorescent dyes at the end of DNA chains, which are sorted by length through electrophoresis, to determine the order of nucleotide bases.

Learn about the basic anatomy of mosquitoes

This short explainer video breaks down the mosquito's general body components, highlighting how mosquitoes breathe, fly, and more. It also touches on how experts can tell different mosquito species apart.

Explaining CRISPR at five levels of technical detail

CRISPR is a new area of biomedical science that enables gene editing and could be the key to eventually curing diseases like autism or cancer. WIRED challenges biologist Neville Sanjana to explain this concept to 5 different people; a 7-year-old, a 14-year-old, a college student, a grad student and a CRISPR expert.

DNA carries the unique instructions that shape how each person grows and functions

The human genome contains over six billion DNA letters, organized into 46 chromosomes inherited from both parents. Genes—sections of DNA—serve as templates for making proteins, and variations in these sequences can affect how our bodies work or respond to the environment.

A deep dive into how a body decomposes

Dead bodies are, understandably, scary and unsettling. Learn about the fascinating process of decomposition that takes place in every human, and how its teeming with life.

Synthetic biology transforms cells into custom DNA foundries

At companies like Ginkgo Bioworks, researchers are reprogramming cells to act as workshops that can create custom molecules, such as medicines and fertilizers, by stitching together DNA sequences—often in novel combinations—before inserting them into an organism's genome.

Genes are the basic units of heredity

These segments of DNA—long molecules made of nucleotides that coil into chromosomes—code instructions for making specific proteins, which correspond to different traits. Approximately 98 to 99% of human DNA is non-coding, with functions beyond protein synthesis.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The structure of DNA helices comes in three major varieties

The hereditary molecule can take the form of A-DNA, B-DNA, or Z-DNA based on environmental conditions such as ion concentration and humidity—a characteristic identified by Rosalind Franklin. A-DNA is the shortest and widest of the three, while Z-DNA is the longest and narrowest. B-DNA—the most common variety in living cells—is the intermediate.

View a collection of historical documents about molecular biology's history

The collection features materials related to those involved in the discovery of DNA and provides historical context for the discoveries of RNA, various viruses, and important bioproteins. The items include photographs, business correspondence, manuscripts, and scientific instruments.

See how computer memory really works—from binary bits to modern RAM

The video explains how computers store information as 1s and 0s, how RAM functions as fast working memory, and why systems utilize different types of storage. The video demonstrates how this process enables computers to operate.

Strands of DNA can act as biochemical Velcro and fasten two molecules together because the complementary bases that make up DNA strands bond together consistently.

A primer on 5G and how it works

You see it mentioned in countless commercials, and your phone might already use it, but do you know what it is? Watch this five-minute primer on the basics of 5G.

The average cell's DNA is damaged thousands of times daily

In the case of radiation-induced distortions in a DNA strand, specialized proteins can cut out entire segments and rebuild them using the second strand as a complementary template. If both DNA strands are completely severed, proteins interlace undamaged DNA with the severed DNA and rebuild both using complementary base pairing.

Rosalind Franklin was the long-overlooked contributor to discovering DNA's structure

Though James Watson, Francis Crick, and Maurice Wilkins are credited with discovering the DNA double helix, it incorporated Rosalind Franklin's unpublished data. Photo 51, her famous DNA image, took more than 100 hours to produce and a year’s worth of analysis to interpret.

DNA computing allows for storage and processing of massive amounts of data

Although costly and less efficient for simpler tasks, as of 2025, DNA could hold 455 exabytes of data with near limitless parallel computation potential in small data centers. Every movie ever made would fit inside the volume of a single sugar cube.

Think we decoded the genome in 2000? Nope. It was 2022.

Two decades after the draft sequence of the human genome was unveiled to great fanfare, a team of 99 scientists has finally deciphered the entire thing. They have filled in vast gaps and corrected a long list of errors in previous versions, giving us a new view of our DNA.

The 4% DNA difference between humans and chimps

On the genetic level, we're not all that different from chimps. But those small differences in DNA can have huge effects. This 11-minute video digs in to the topic.