Widespread use of LSD sparked a counter-cultural artistic movement in the 1960s

LSD fueled a countercultural movement before evolving into a potential therapeutic

As the use of recreational psychedelics became common, authorities were quick to claim LSD had lasting adverse effects, criminalizing the drug and halting scientific study for decades. Over time, LSD's reputation shifted from a potential source of enlightenment to a dangerous drug that could dim a person's future, and back to a possible therapeutic compound.

Psychedelic drugs are having a scientific renaissance

After decades of repression, psychedelic research is making a resurgence. Hear from a host of experts in this 20-minute video on what that could mean for the future of mental health. The current science on psychedelics believes LSD can cause a particular brain network to quiet or deactivate.

How Western psychedelics research fell to the wayside

Psychedelics' modern era began when LSD was discovered in the 1930s. By the 1950s, clinical trials were underway. US user experimentation outside of medical settings (and high-profile violence, like the Manson murders) inspired negative attitudes toward psychedelics, leading to use restrictions that prohibited companies from patenting psychedelic compounds. This strangled psychedelics' profitability until the 1990s when the government loosened its grip and psychedelics research began seeing a resurgence.

LSD (better known as acid) was created in 1938 by Swiss chemist Dr. Albert Hofmann

Lysergic acid diethylamide, better known as LSD or acid, was first developed synthetically in 1938 by Swiss chemist Dr. Albert Hofmann. It's since become a linchpin for an entire aesthetic, fueled a counterculture movement, and is being studied for potential therapeutic uses.

The Beat Generation inspired significant parts of 1960s counterculture

The Beat Generation championed the transformative power of psychedelics, rebelled against the post-war social order, and called for more radical politics. With a strong foothold in San Francisco, it's no surprise these themes were carried over to the city's 1960s counterculture, informing the larger national hippie movement.

Physiological changes to the brain on LSD can be captured via MRI

Psychedelics like LSD often take users on novel experiences that can result in lasting shifts in perspective and behavior. See how LSD affects brain activity in this video that details how scientists visually captured the psychedelic's effect for the first time.

The commercial and therapeutic potential of psychedelics

A 2006 study into the potential therapeutic benefits of psychedelics sparked a renewed interest in the field of psychedelic research, a development that has cascaded into commercialized ventures and experiences. This article details how growing research into the psychological benefits of psychedelics is matched by the rise of anecdotal reports, book deals, businesses, and corporate claims seeking to capitalize on psychedelic potential.

The Beats also influenced the imagery of the 1960s

First editions of Burroughs’s "The Naked Lunch," Kerouac’s "The Dharma Bums," and Ferlinghetti’s "A Coney Island of the Mind" were just as notable for their text as they were for their design, which anticipated the psychedelic imagery of 1960s countercultural touchstones like Ken Kesey, Andy Warhol, and R. Crumb.

Psychedelic compounds: a visual library

However psychedelic experiences manifest, they all begin with the presence of psychoactive compounds. Learn about their various chemical compositions in this structural library of psychedelic compounds. Clicking on an entry will take readers to a new page where they can learn about the chemistry and pharmacology of each compound, as well as the drug's possible applications.

Psychedelic side effects, including worsening mental health for some patients, give pause

This article explores whether the therapeutic potential of psychedelic drug use is really as good as current research suggests. Scientists are exploring its applications for conditions ranging from the existential crisis that can accompany terminal diagnoses to chronic mental health conditions, including anxiety and PTSD.

Retracing the 1960s history of dropping out

A core element of the 1960s counterculture was the idea of dropping out of school and the broader technocratic institutions at the time. This push coincided with paranoia over mind control during the Cold War, and as some rogue psychologists advocated for the liberating use of psychedelics.

Studies of psychedelic use may help shed light on the nature of consciousness

The nature of consciousness—what it is, where it comes from, and how it manifests as moment-to-moment experience—remains under debate by scientists. Recent studies show psychedelics were found to boost low-frequency brain signals known as delta waves, a behavior also seen during dream states.

What do psychedelic plants look like?

Far from the drippy aesthetic often associated with psychedelics, the plants powering naturally occurring psychoactive experiences may not stand out as anything special. This database offers a visual guide to psychoactive plants and fungi. Clicking on the title of a particular plant, such as yerba mate, will bring up a secondary screen with various hyperlinked images, such as the plant itself, related botanical drawings, and molecular structures.

How to make LSD

Lysergic acid diethylamide, often shortened to LSD, comes from ergot, a parasitic fungus that can be found in grains. Chemists rearrange the fungus' chemical structure or the structure of an ergot derivative through complex chemical reactions, transforming it into the hallucinogenic bicycle-shaped LSD crystal. Due to the partially synthetic drug's criminalization, many of the details of modern LSD crafting honed by "underground chemists" are kept secret.

How psychedelics can potentially reinvent learning

Critical periods, discovered in the early 20th century, describe a period when someone is incredibly sensitive to their environment, and any information learned can stick with them for life. Some researchers argue these states can be "reopened" via psychedelics, which put the mind into a malleable state that can potentially be used to treat conditions ranging from lazy eyes to PTSD.

Mental health applications of psychedelics

Scientists are investigating psilocybin, ketamine, LSD, and MDMA (also known as ecstasy) as potential treatments for mental health issues. These drugs enable an altered state of consciousness, which can have beneficial or harmful impacts depending on the nature of the experience. Research suggests these drugs can be effective in treating substance use disorders, mental health conditions, including depression and anxiety, and psychiatric disorders, including schizophrenia.

Psychedelics are being fast-tracked for research after a 2026 executive order

Many such compounds (including LSD, psilocybin, and more) are classified as Schedule I drugs—illegal to possess and federally regarded as having no medical use. Researchers say such restrictions have created significant hurdles for formal clinical trials. With this executive order, the FDA will enable work particularly focused on depression, PTSD, and alcohol use disorder.

Psychedelics set off a flurry of brain activity that may permanently alter it

The brain seems to experience a sharp increase in communication between areas that generally don't interact. New research suggests a thin, sheet-like gray matter structure tucked deep within the brain, between the insular cortex and striatum, may be the key to this change. The area is centrally located and home to many of the receptors that psychedelics target, potentially rewiring the brain and rewriting thought patterns.

Psychedelics interact with neurotransmitter systems to alter one's perception

LSD, psilocybin, and MDMA can suppress the brain's default mode network and enhance connectivity. Research shows that, when paired with therapy, psychedelics may help treat mental health conditions, including depression, addiction, and PTSD.

In 1957, a vice president at JPMorgan became an outspoken evangelist for psychedelic mushrooms.

An overview of modern clinical research on LSD

Researchers have determined that LSD, taken in a medical setting, decreases anxiety related to "life-threatening disease," reduces brain reactivity to fearful faces, increases the meaning and emotional response derived from music, and more. No complications of LSD administration have been observed in medical settings, though acute adverse effects, including exhaustion, nausea, and difficulty concentrating.

In 1951, a small French town was likely overtaken by the fungus that ultimately led to LSD.

What does LSD have to do with Bicycle Day?

Bicycle Day, generally celebrated on April 19, doesn't have much to do with the two-wheeled, human-powered vehicle as the name would imply. Instead, it's a celebration of the world's first acid trip. On April 19, 1943, Albert Hofmann took an experimental dose of LSD at his lab before trying to return home via bike. This article includes comics from a graphic novel detailing Hofmann's trip.

LSD was derived from natural compounds produced by the ergot fungus

Ergot is a fungus that slowly infects and replaces individual grains on grasses, including rye and wheat. Ingesting ergot can cause ergotism, a form of poisoning with symptoms—including headaches, hallucinations, gangrene, and convulsions—varying by season and geography. This grain was used for medicinal purposes as early as the 1500s.

The neurobiology of meaningfulness: the benefits of psychedelics

Psychedelics produce powerful emotions in its users, including a profound sense of meaningfulness. The philosopher William James called this sense "noetic" in the late 19th century, but for decades researchers avoided studying the effects of such drugs on the brain. However, the recent resurgence in psychedelic research has heightened interest in the relationship between this noetic sense resulting from the therapeutic use of drugs. Learn what researchers have found out here.

An LSD scientist's role in a US mind control project

Within a decade of LSD's discovery, the US government had launched a secret initiative involving hypnosis and hallucinogens. LSD researcher Louis Jolyon West conducted experiments for the CIA's MKUltra project, which focused on the potential of mind control. He later took part in a criminal trial that hinged on testimony whose sourcing was seemingly inspired by MKUltra experiments. This article explores light shed by West's personal archive.

The de stijl movement embraced bright colors and abstract images

The 20th-century movement sought to develop a universal language for the modern era by fusing form and function. Modern day viewers will recognize its bright colors and clean aesthetic, popular with retro-styled book and album covers.

MoMA hosted 1962's 'Symposium on Pop Art,' which made the term 'pop art' official

MoMA's history with pop art and its conceptual roots extends to its early origins, and its collection of works includes iconic works like Warhol's "Campbell's Soup Cans" and Lichtenstein's "Drowning Girl."

LSD was discovered accidentally after its inventor touched his face and hallucinated.

Pop art brought 'low culture' to the fine art world

Pop art’s embrace of kitsch American pop culture furthered a centuries-long tradition of the visual arts during the second half of the 20th century. Its most famous exemplars, including Andy Warhol, were heirs to a vast tradition they sought to transcend and upend.

Only a fraction of LSD reaches the brain, but it concentrates in key regions

When taken, LSD is absorbed quickly (often within an hour of ingestion) and exerts its effects primarily by binding to serotonin receptors. While only a small amount enters the brain, it's active in regions controlling the visual and auditory senses, potentially driving its psychedelic effects. The drug doesn't linger in the body, and is typically undetectable within a day.

Pop art explored the concepts of mass production and consumerism

Consumerism emerged from industrial capitalism, promoting the idea that consuming goods was linked to personal success and happiness. Artists, especially pop artists, approached this cultural phenomenon through various perspectives, some supportive of consumerism and others against. Figures like Andy Warhol embraced mass media imagery and mimicked its style, while many artists rejected the “commodification” of things by creating art that couldn’t be sold or focusing on experiences rather than objects.

Haight-Ashbury's hippie character was shaped by a store selling psychedelic texts and wares.

LSD-like drugs may inspire new antidepressants

LSD and psilocybin have shown promise as antidepressants. Using a virtual library of similar chemical compounds, researchers determined via animal studies that two molecules inspired by LSD have antidepressant effects without any associated hallucinogenic experience. These molecules were found to be 40 times more potent than the common antidepressant fluoxetine, also known as Prozac, with antidepressant effects lasting up to 21 days.

Psychedelic therapy's ethical guidelines (or lack thereof)

With a checkered history of misconduct, how will psychedelic-assisted therapists be held accountable in the emerging legal field? This article explores the nascent field's need for ethical guidelines and clear protection of patient rights when therapeutic breakthroughs teeter "on the edge of consent."

The 1980s neo-pop movement put pop art back in the zeitgeist

Pop art’s legacy is perhaps best exemplified in its longevity. Long after the end of pop art’s classical phase, a neo-pop revival ushered in a new cohort of artists like Murakami, Hirst, and Koons who brought pop once again to the top. To this day, contemporary pop artists—young and seasoned—command high prices on the open market.

The psychedelic playlist inspired by a Johns Hopkins experiment

Dating back to 1967, the playlist is over seven hours long and organized in such a manner as to echo users’ experiences as their trips rise, crest, and fall. According to the initial creator of the playlist, the music is a “nonverbal support system” that keeps users from prematurely returning to normal consciousness.

LSD's molecular structure closely resembles the neurotransmitter serotonin

Lysergic acid diethylamide (C20H25N3O) is a colorless, odorless, and flavorless chemical compound that can induce altered perception, mood, and cognition. One of its roles in the brain is as a serotonin agonist, meaning it enters serotonin receptors and triggers a fraction of the response the neurotransmitter would typically warrant.

Hippies explored the possibilities of organic food

The 1960s counterculture sought to buck traditions, including culinary ones. Hippies believed that healthier food was integral to dismantling the status quo and, in turn, started health food stores, espoused vegetarian diets, and cultivated organic food, which they found to be a welcome alternative to the over-commercialized farming industry. In the decades since the movement’s decline, many of its practices have been absorbed by the mainstream.

Gary Panter's punk art defined the '70s and '80s counterculture

The artist got his start providing fliers and logos for early Los Angeles punk bands, but later took his psychedelic, Pop Art-vision to designing on "Pee-Wee's Playhouse," for which he won three Emmy Awards.

Both British and American pop art took inspiration from US culture

Pop art emerged in the mid-1950s in Britain and the late 1950s in America. American pop art focused on representational art and was directly inspired by living within American popular culture, using hard edges and distinct forms. Its British sibling, on the other hand, took a more academic approach, viewing American culture from a distance and employing irony and parody.

Surrealism toyed with ideas from psychoanalysis

The movement's artists were interested in the ideas being explored in the burgeoning fields of psychology and psychoanalysis. Dalí, in particular, often created works that toyed with Freudian theories.

Defining Dalí's surreal aesthetic

Salvador Dalí is known for his modernist paintings, but his surreal aesthetic has lived on long after his passing, with elements of his art making their way into fashion, film, and interior decorating. This incisive Artnet explainer unpacks the elements that make up Dalí's larger artistic vision and highlights the ways they still appear throughout popular culture.

The 'definitive' history of magic mushrooms

Where did magic mushrooms come from, and how did they get their magical reputation? This article explains the history of the psychedelic fungi from pre-history to now. The earliest concrete evidence of psychedelic mushroom use is 12,000-year-old murals in Northern Australia that portray mushroom iconography. Considering how many species seek out and consume psychoactive substances, such as Siberian reindeer, it's possible human use of these psychedelic mushrooms may predate these murals.

Coachella fashion repurposes looks from Woodstock

Coachella attendees' flower-forward fashion sense has been widely replicated (and lampooned) since the festival became a mainstay of the cultural calendar. This podcast, featuring a panel of style writers and music reporters, traces the aesthetic back to the 1969 Woodstock festival. In the process, they also look to untangle why festivalgoers fall into certain styles—and what that means for Coachella and its attendees.

The widespread violence of World War I birthed surrealism

Following World War I, artists used unconventional forms of expression to make sense of the death and destruction they'd witnessed for years. Life as they knew it had ended, and movements like Surrealism, founded by André Breton, rebelled against tradition.

‘The Kandy-Kolored Tangerine-Flake Streamline Baby’ mapped a major transition

The hilarious 1963 story offered insight into how Americans were shifting away from elite interests to “low culture” by focusing on customized cars and their teen enthusiasts in Southern California. Wolfe pokes fun at the trend while also recognizing young people’s post-war desire for freedom, individualism and creativity.

How four types of psychedelics affect the brain

Brain imaging shows that ayahuasca, MDMA, DMT, and psilocybin profoundly affect neural activity, giving rise to higher states of introspection and consciousness. This article details exactly how each of these drugs physically affects the brain and what that means for mental health treatment. Some of these drugs quiet the brain or trigger the release of neurochemicals associated with mood regulation and learning.

Oregon voters in 2020 greenlit adult use of psilocybin—the active ingredient in magic mushrooms—in state-licensed centers, and a 2026 analysis indicates the program has good safety and satisfaction data.

Drugs 101: An interactive guide

What's the difference between opioids and psychedelics? This guide details specific drugs and their various associated effects. Drugs in this wheel fall into seven categories: stimulants, depressants, empathogens, psychedelics, dissociatives, cannabinoids, and opioids.