Read a history of how oral rehydration solution was created

Oral rehydration solution was developed in the 1960s in response to cholera deaths.

Learn the history of food science breakthroughs from the 20th century

Long after humans developed the means to produce sufficient food to feed civilizations, scientific research focused on a wide variety of objectives, such as developing methods to preserve food quality (accomplished via frozen food), speeding up cooking (leading to the microwave), and lowering the cost of sweetening food, which high fructose corn syrup provides.

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

'Dirty soda' took off in Utah before exploding on TikTok

The concoction is a combination of Diet Coke, coffee creamer, and citrus. This Eater article delves into the history behind the sugary drink, pinpointing its start as a Mormon-friendly alternative to alcohol and caffeine. The explainer also explores why the drink became so popular on social media and offers helpful hints for crafting your own recipe.

Salt is harvested from briny ocean water and underground deposits

Mostly sodium chloride, this compound is produced for human use by collecting seawater in shallow pans and allowing the Sun to evaporate the water until crystals remain. Underground rock salt is mined, crushed, and purified from deposits left behind by ancient seas that have dried-up.

Without the option of modern blood transfusions, some doctors in the mid-1800s tried to help save cholera patients by injecting them with cow's milk, hoping it would boost their nutrition and hydration.

The food processing techniques developed for World War II, later repurposed for consumers

Research projects funded or sponsored by the military led to the development of active dry yeast to make bread easier to bake and an improved version of dehydrated cheese, which would be used in powdered cheese snacks. Freeze-drying, which had been used to ease the transport of blood plasma to battlefields, where it would be reconstituted with water, was later used on fruit for cereals.

Gatorade was first designed for college football players in Florida's heat.

Bottled water started as a 19th-century wellness trend

Selling drinking water in America began at resorts in New York and West Virginia, where tourists were encouraged to take the regenerative mineral water back to their homes.

Multiple sugar substitutes were accidental discoveries when lab workers didn't wash their hands.

The ancient Romans invented the first known artificial sweetener—it involved lead.

How silica gel took over the world

Silica gel packets are those sugar packet-like bags that keep packaged foods and more dry and free of mildew. First invented in the early 20th century, they saw great commercial success starting in 1927, being deployed in traded goods across the world. This simple invention allows modern supply chains to extend across the globe by extending the preservation of shipped goods.

In the 19th century, ice-cream-related illnesses were somewhat regular in America thanks to vendors' poor hygienic practices.

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

University of Maryland Hospital researchers intentionally infected volunteers with the cholera bacterium in the late 1970s to further their understanding of the disease. They proceeded with this work following the recommendation of a US government panel. (Some users may encounter a paywall.)

Teddy Roosevelt was once given a daily dose of an artificial sweetener, prescribed by his doctor.

Why don't we synthesize blood?

We're trying. Scientists are currently working on creating viable synthetic blood, an alternative to the presently relied-upon donations that manage to fall short of demand. More than half of the world's nations struggle to meet their population's need for blood. This article details current and historical efforts to develop synthetic blood, a venture that started more than 400 years ago.

Tracing the history of refrigeration

Refrigeration has become critical to most of our lives. But not long ago, it wasn't available. How did we become so dependent on our fridges and freezers? This fun, informative podcast traces the history of keeping it cool with ice and...

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

How fecal transplants work

1,700 years ago, Chinese alchemist Ge Hong was renowned for his soup that could cure diarrhea-stricken patients. It had a surprising secret ingredient: feces. While it might seem unwise to consume feces, exciting new research suggests that taking...

Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

Koch was one of the first scientists to isolate the bacterium that causes cholera while investigating an outbreak in Egypt in 1883. He went on to advise about rules to control cholera outbreaks, which formed the basis of the disease control approaches and water hygiene techniques still used today.

Why pickles became a thing

Pickles began in Mesopotamia around 2400 BCE as a way to preserve vegetables amid heat (and spoilage). They spread through Egypt, Greece, and Rome, where Julius Caesar reportedly fed pickles to his soldiers, and brining was treated as a culinary art. The technique is broadly useful, as salt and water can extend the shelf life and deepen flavor for almost anything.

Visualize how Coca-Cola's secret formula has changed over time

Coca-Cola contained small amounts of cocaine until the early 1900s—but that's not the only time Coca-Cola has altered its recipe over the years. For instance, Coca-Cola transitioned from cane sugar to high-fructose corn syrup in the 1980s.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

Why are archaeologists brewing ancient beers?

Archaeologists have managed to brew beer from yeast found inside jugs abandoned thousands of years ago. This article explores why scientists are recreating these ancient beverages and what they hope to learn. People have been drinking beer for...

The history of blood, as told by a hematologist

Since ancient times, blood has been seen as a semi-magical substance. Alchemists theorized it was a mixture of the four elements. Others proposed it was one of four bodily fluids whose balance dictated health. This 2019 essay by a hematologist reviews blood's reputation across cultures and centuries.

'This American Life' once tried to recreate the original recipe for Coca-Cola

Given that the Coca-Cola formula is one of the company's most closely-guarded secrets, the radio show's team was surprised to come across a 1979 newspaper article with what looked like the original recipe for Coke.

Every Tootsie Roll can be traced back to a single, decades-old batch.

Jonas Salk developed the first successful polio vaccine—and tested it on himself

The American medical researcher developed the inactivated virus vaccine from 1952 to 1955 and proved that it could prevent disease. He tested the virus on himself and his family in 1954 and then carried out formal clinical trials on more than 1.3 million children.

The strange endurance of consuming blood for health

Blood's importance to humanity is best summarized this way: without it, we die. This importance naturally begets assumptions about its medicinal properties, many of which appear accessible through drinking or eating the fluid connective tissue. This article details the history of blood drinking, from ancient Roman gladiators to modern-day sanguinarians.

The unexpected origin story of the snow globe

In 1900, a Vienna tradesman named Erwin Perzy I was attempting to invent an inexpensive way to improve light amplification in hospital operating rooms. After experimenting with a glass globe filled with water, the idea for the snow globe struck. Industrious as well as inventive, Perzy eventually turned his idea into a successful business. Read the full article to learn how the invention grew to become recognized globally.

A 1954 outbreak at a Boston boarding school allowed scientists to isolate the measles virus and formed the basis for the first measles vaccine.

A major US-designed polio vaccine was first tested in the Soviet Union

Albert Sabin's live attenuated virus vaccine—requiring two drops in the mouth—didn't garner political support in the US, so it was tested in the Soviet Union in the late 1950s.

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

John Snow—not the one from 'Game of Thrones'—determined that contaminated water sickened London

His pioneering epidemiology work during an 1854 cholera outbreak mapped out the commonalities between people in London who were getting sick. He discovered that ill people were getting water from the same Broad Street pump. Before Snow's work, the prevailing theory was that bad air sickened individuals instead of cholera-causing bacteria in the water.

George Washington had a recipe for 'small beer,' a low-alcohol beer that was once safer than drinking water.

Visualize the global supply chain of medicine, which may begin with basic research in the US, but outsource intermediate steps.

Although consuming saltwater can dehydrate and kill organisms, some fish survive by using specialized gills that leach excess salt from their bodies back into the surrounding water.

Technologies developed for the ISS have brought benefits to people on Earth

About 93% of water used onboard the International Space Station is recycled through filtration and purification systems that have since been used in regions lacking access to clean water. Treatments to mitigate bone loss and muscle atrophy in astronauts can also help aging adults.

1 in 4 people around the world don't have access to clean water

Poor water sanitation puts people at risk of acquiring this diarrheal infection. Cholera infections are on the rise due to extreme weather events and conflict. In recent years there have been cholera outbreaks in locations that hadn't seen the disease in many years, including Haiti.

Aspartame was a surprise discovery from a lab working on gastric ulcers

As with saccharin and cyclamate, the aspartame discovery arose from its discoverer tasting something sweet from his workplace. In 1965, American chemist James Schlatter licked a white powder off his finger as he picked up a piece of paper and was startled to discover it tasted sweet. He applied for a patent for the substance, and received it in 1970. It is now one of the most popular artificial sweeteners. (Some users may experience a paywall.)

Unlike its Mexican counterpart, American Coca-Cola contains high-fructose corn syrup rather than sugar

There are a few reasons why American Coke turned away from sugar in the 1980s, but none of them are related to consumer health. This Reader's Digest article breaks down the history behind Coke's recipe change, explaining why the company continues using high-fructose cough syrup.

The colorful history of the world's first gummy bears

Hans Riegel Sr. founded Haribo in 1920, creating the world's first gummy bears in 1922. Initially working from his kitchen in Bonn, Germany, Riegel developed the Dancing Bear, which was larger and slimmer than modern gummy bears, inspired by dancing bears at European festivals. Haribo has continuously evolved, creating unique gummy products for different countries and addressing ethical concerns. Learn the history here.

Learn about historical uses of bioremediation, the oldest cleanup method on Earth

Biochemical reactions that decompose complex molecules into simpler ones have occurred on Earth for as long as life has existed and have gradually transformed the planet into a celestial body that is increasingly habitable to greater biodiversity. Along the way, modern, human-made bioremediation techniques began to take shape in Santa Maria, California, in the 1960s.

Understanding insulin

Scientists Daniel and Kelly talk with researcher Dr. Katrine Whiteson about diabetes, the history of insulin production, and Dr. Lydia Villa-Komaroff—an essential member of the team who discovered that bacteria could be induced to produce insulin. Listen to discover interesting facts about the life-saving medicine and how it works in the human body.

How beer became a part of medieval culture

This history of beer's evolution during the Middle Ages unpacks how the brewing process, which killed harmful bacteria, made beer a safe alternative to water. That fact, along with the Catholic church condoning (and, in some cases, producing) the beverage, helped it evolve into a major commodity.

The cholera bacteria was first isolated in 1854—but the discovery was largely ignored

The pathogen was isolated by the Italian physician Filippo Pacini in Florence, Italy, though his discovery was largely ignored in favor of the popular miasma—bad air—theory of disease at the time. The pathogen was separately isolated about three decades later by German microbiologist Robert Koch.

When was the first blood transfusion?

In the 1600s, an English doctor transferred the blood from one dog to another via quills. The procedure ended when one of the dogs died. This article details the early days of blood transfusions, which turned toward humans shortly after the 1666 dog experiment and involved putting the blood of a sheep into a human recipient (who reportedly survived the encounter).

Cholera went global thanks to global trade

The first cholera pandemic grew from an outbreak in India, in 1817. Scientists suggest it spread from there throughout the continent and onward to Africa, Russia and Europe through the poop of traders.

See how antidepressants—used by roughly 1 in 10 Americans—were discovered.