A top Alzheimer's researcher was accused of faking results

Recent evidence raises the question of whether conventional wisdom about amyloid plaques and their connection to Alzheimer's is wrong.

The scandal that rocked stem cell research

In 2014, a Japanese research group published a paper suggesting ordinary cells could be reverted to pluripotent stem cells by subjecting them to external stressors. The results generated interest but could never be replicated. The lead researcher was accused of fraud, and the group’s supervisor committed suicide.

Scientists are reevaluating the causes of Alzheimer's beyond the amyloid hypothesis

The cause of Alzheimer's disease has been debated for decades. The amyloid cascade hypothesis—where plaques build up in the brain, triggering neurodegeneration—has long been the leading theory. But after a number of failed drug trials, researchers are beginning to reevaluate various culprits. [Untreated hearing loss is linked with dementia risk](https://www.thelancet.com/article/S0140-6736(20)30367-6/fulltext) Hearing loss does not cause dementia, but it does increase the risk of developing dementia and research suggests that people who wear hearing aids for age-related hearing loss also maintain better brain function than those who don't.

"Plaques" and "tangles" are top potential causes of Alzheimer's—but questions remain

The exact causes of Alzheimer's—and how to treat it—continue to be the subject of intense research. Two leading factors are amyloid beta plaques and tau protein tangles, which effectively pile up in the brain and interfere with neurons and cause cell death, which manifests as memory loss and other symptoms.

There are two FDA-approved blood tests that may detect early Alzheimer's disease

Yet the tests are only recommended for those who have symptoms of dementia, and are not definitive on their own. False positives are a concern with these new tests, which detect biomarkers that may indicate the presence of brain proteins linked to the disease. This podcast explores the state of research on the disease and concerns about regulators taking jobs at pharmaceutical and biotech companies, which may influence their approach to approvals. It also dives into an investigation about the data underpinning one experimental Alzheimer's drug.

Researchers are exploring neural links between Alzheimer's and autism

Recent DNA sequencing and molecular biology studies suggest that similarities in genes, neural circuitry and patterns of disease warrant further exploration to potentially better understand both conditions and how to treat them. (Some users may encounter a paywall.)

Researchers use the brain's ability to edit memories to explore memory deletion

Scientists have successfully implanted false memories in mice after studying how the editing process works in the brain. Beyond potentially deleting memories in those with PTSD, upcoming research may allow clinicians to forecast the onset of neurodegenerative diseases.

More than 200 drug trials for Alzheimer's have failed or been abandoned since 2010

The complexity of Alzheimer's disease, coupled with decades of underfunded research efforts, has left patients with little in the way of effective treatments. In recent years, scientists have synthesized several drugs that studies show can slow the progression of Alzheimer's—though the disease itself remains incurable.

Read the original 1907 paper on the first known Alzheimer's patient

Alzheimer's disease was first identified by Dr. Alois Alzheimer in 1901, following a postmortem brain examination of a patient experiencing memory loss and other symptoms. Alzheimer's original paper was largely lost until 1995, when an English translation was published in a medical journal.

Alzheimer's can cause brain shrinkage of between 10% and 30%

While the exact cause of Alzheimer's is debated, the buildup of amyloid plaques and tau protein tangles is instantly recognizable in post-mortem examinations. The atrophy of brain cells caused by this molecular pileup leads to noticeable physical changes, including significant shrinkage in affected brain regions.

One man used an AI band to conduct an elaborate social experiment

In 2025, a Canadian using the pseudonym Andrew Frelon claimed to have used generative AI to create songs, an album cover, and a profile photo for a fake band he called The Velvet Sundown. Frelon eventually revealed that he lied, and his experiment highlighted the uncertainty surrounding AI.

A pediatric journal ran 138 fictional case studies, and 61 were cited as real stories

The Canadian journal Paediatrics & Child Health issued corrections to 138 case studies published since 2000, acknowledging the cases were entirely fictional—a practice intended to protect patient privacy that was never disclosed to readers. At least 61 of the fabricated reports were cited as fact in other peer-reviewed journals a combined 218 times, including a 2006 Lancet article alleging an infant died from opioid-laced breast milk.

Some dementia cases may be linked to microorganisms in the brain

Researchers now know that, much like the gut, the brain is home to an ecosystem of microorganisms—the brain microbiome. While this area of study is still new, some scientists believe 50% of bacteria-caused dementia cases could be treated. (Some users may encounter a paywall.)

Visualize the difference between a healthy brain and one with Alzheimer's

The brain has three main parts—the cerebrum, brain stem, and cerebellum—each combining to control the entirety of the body's operations. Alzheimer's progressively deteriorates the circuitry in these structures, resulting in what we see as the symptoms of the disease.

How Alzheimer's caregivers get pulled into their loved one's reality

Caregivers, most often children and spouses, do not just witness a family member's cognitive decline—they also often become drawn into it, navigating a world in which the typical rules of time, order, or logical continuity may not apply.

Two festival-goers were hospitalized after receiving peptide injections, raising questions

Investigative journalism shop ProPublica wrote about two people who became extremely ill following antiaging peptide injections. Authorities were examining whether the individuals were sickened by an infection, contamination related to the injections, or an issue with the medication itself, according to documents obtained by the journalists at ProPublica.

Deepfakes use AI to produce manipulated media to mislead viewers

Unlike most content created from large language and diffusion models, deepfakes intentionally misrepresent real people or events with the intent to deceive. As the products of this technology become more realistic, they pose increasing risks to public trust, security, and privacy.

Poor sleep increases the risk of developing Alzheimer's

Brain imaging studies reveal poor sleep leads to production of amyloid beta proteins—molecules linked to Alzheimer’s—which are cleaned from the brain during high-quality sleep. These findings suggest conditions like sleep apnea and insomnia increase the risk of developing the disease.

Did a Smithsonian anthropologist steal people's brains?

This comic examines "racial brain collection" of Ales Hrdlicka, the Smithsonian's head of physical anthropology during the early 1900s. Hrdlicka was a white supremacist who sought physical evidence for his theories on anatomical differences between...

Investigation finds 'influencer' dietitians paid to promote sugar, supplements on social media

A joint investigation by The Examiner and The Washington Post found that food, beverage, and supplement corporations and groups have paid registered dietitians on social media to promote content that goes against decades of scientific evidence on...

Six of history's most unethical human experiments, from deliberate flu exposure to withholding syphilis treatment

Some of the progress made in mental health treatment, vaccines, blood transfusions, and more came about before the advent of consent and ethics committees, resulting in serious physical and psychological harm that participants in studies were not even anticipating.

Five to ten percent of Alzheimer's cases are early-onset

Early-onset Alzheimer’s typically emerges around 40 to 50 years of age, with devastating effects. This video follows Brian, diagnosed with the disease at age 54, as he travels the country as an advocate for research and discusses the progressive mental fog of Alzheimer’s.

American medical organizations rescind recognition of diagnosis cited in police custody deaths

American medical organizations have rescinded their recognition of a syndrome whose theory stemmed from discredited research. This article explores the history and implications of "excited delirium syndrome," a medical condition that can reportedly...

True crime fans can derail lives with misguided accusations

In the wake of four stabbing deaths at the University of Idaho in November 2023, online sleuths, without any supporting evidence, were quick to point accusatory fingers at potential perpetrators. Poring over news reports, social media pages, and internet interactions can reveal viable information that can help solve crimes. Such (sometimes monetizable) behavior can also easily give rise to rumors and threats while impeding official investigations.(Some readers may experience a paywall.)

How Alzheimer's disease affected one family as symptoms progressed

News program 60 Minutes interviewed a couple navigating aging and Alzheimer's over a 10-year period to illustrate the effects of the disease on their lives.

Watson's book was described as misleading when detailing Franklin's role in DNA

Despite working together to win the Nobel Prize for their discovery of the structure of DNA, Francis Crick and Maurice Wilkins objected to the publication of James Watson's account of DNA's discovery. Those involved describe how he villainized Rosalind Franklin and downplayed her work.

Some Nobel laureates have expressed beliefs in pseudoscience after winning

Examples of the phenomenon, known as Nobelitis or Nobel disease, include promoting psychic research, harmful practices like eugenics, and seeing talking raccoons. Increased external pressures after a win and a greater spotlight may contribute to developing or exposing these beliefs.

A man with organ failure used AI to speed discovery of his miracle drug

David Fajgenbaum had a few months to live after a diagnosis with a rare form of Castleman's disease. By studying his blood, medical records, and broader literature, he was able to identify the cause of his condition and a treatment. He's been in total relapse for ten years.

A funeral director lied and claimed he discovered a centuries-old Roman brooch

An amateur metal detectorist knowingly deceived thousands into believing he found an 1,800-year-old horse figurine. He received payment for the artifact to be featured in a museum, but he later admitted he bought the brooch online and planted it.

A 2024 cheating scandal cast doubt on the industry

In 2024, National Fantasy Football Championship, a fantasy league with big payouts, fired one of its employees for manipulating data. The episode cast doubt on the relatively unregulated industry, despite the league coming down hard on the nefarious worker.

See how faces on magazine covers have changed over time

This piece examined an archive of Time magazine containing 3,389 issues ranging from 1923 to 2014, focusing on 327,322 faces from the archive. Read what the researchers learned.

In 2008, one writer demonstrated the fickle nature of wine reviews

Robin Goldstein submitted a fake restaurant to the well-respected Wine Spectator for a competition. He created a website for the fake Milan-based business, complete with a menu of wines the magazine itself had disparaged. That didn't stop Wine Spectator from naming Goldstein's ruse among that year's winners.

How Congressional oversight can override confidentiality in the NSF's proposal review process

In 2014, to investigate claims that the NSF was funding wasteful research rather than proposals that served national interests, confidential grant files were provided and reviewed by members of the House Science Committee. The actions, led by Lamar Smith (R-TX), were denounced by the scientific research community. (Some readers may experience a paywall.)

A 1912 congressional bill attempted to prohibit fake photos in the US

In the 1800s, photographs were held up as indisputable resources of truth. But the photography industry devised ways to alter photos, resulting in the rise of fraudulent photos—from shots with celebrities to the turn-of-the-century version of fake nudes—prompting government intervention.

Government watchdog says nursing homes are inappropriately diagnosing schizophrenia

The Department of Health and Human Services Office of Inspector General said in a March 2026 report that nursing homes are incorrectly diagnosing their residents with schizophrenia to mask the facilities' misuse of antipsychotic medications. The drugs, the report states, are being widely used to make staff members' jobs easier and to keep nursing home quality measures high—since antipsychotic use for schizophrenia wouldn't be counted against the facility. (PDF)

Everything you know about Phineas Gage is wrong

A stray spark sent a 3.5-foot-long, 1.25-inch thick iron rod through the brain of foreman Phineas Gage in 1848, creating a scientific case that has attracted onlookers for nearly two centuries. His life reportedly soon spiraled out of control, with his behavior tending toward selfishness and chaos. Evidence of these changes is far less common, with Gage's story bloated by fabrication, scientific prejudice, and artistic license.

James Frey's 'A Million Little Pieces' was marketed as memoir but revealed as fiction

The addiction book became a huge success after being added to Oprah Winfrey's book club. After it was revealed to be fiction in 2005, Oprah invited Frey on her show and criticized him for deceiving her and his readers.

In the 1980s, excerpts from fake diaries of Adolf Hitler were published in a prominent German magazine

Excerpts from the diaries were published in other publications around the world, like The Sunday Times, despite uncertainty about their authenticity. After forensic analysis, the diaries were proven to be fake. The diaries were produced by Konrad Kujau, a petty criminal who frequently produced counterfeits.

The 'Facebook papers' revealed the company prioritized profit over public safety

A whistleblower came forward with internal documents showing employees warned leadership about the company's role in fueling political unrest and misinformation. Systems like XCheck shielded high-profile users like President Donald Trump from normal content rules, often to avoid PR backlash.

Court documents reveal how Anthropic destroyed millions of books to build its AI models

Anthropic cut the bindings from purchased books and discarded them after scanning to rapidly collect high-quality text at low cost for training Claude. This, despite hiring the former head of partnerships for the Google Books project, which nondestructively scanned millions of books borrowed from libraries before returning them.

Scientists used mass spectrometry to determine the materials in a 1690 painting

Previously used to map the distribution of molecules on biological tissue samples, researchers combined the technique with machine learning to uncover six layers of pigments, binders, and a thin gold leaf layer within *The Marriage of the Virgin*, from a collection in the Metropolitan Museum of Art. The technique may help identify and track artists' material use to learn about pieces of unknown provenance. (Some readers may experience a paywall.)

One pop-culture historian fooled the nation with a fake origin story of April Fools' Day

In 1983, Joseph Boskin, a professor at Boston University, was interviewed by the Associated Press to discuss the history of April Fools'. Boskin shared a made-up story about a jester who took over Rome for a day and proclaimed that April 1 would henceforth serve as 24 hours of silliness. AP published the fib about "King Kugel," creating buzz and confusion for news outlets around the country.

The plastics industry spent decades promoting recycling while privately doubting it would ever work

This FRONTLINE investigation reveals that plastic makers publicly championed recycling for years despite internal doubts about its viability, and that no more than 10% of the plastic ever produced has been recycled.

A growing number of autism researchers with the disorder are reshaping the field

People with autism are now leading research on the effects of stigma and discrimination and promoting more studies on public services for autistic people. They also serve as editors, reviewers, and board members on autism academic journals, creating a new chapter in a field littered with painful stereotypes and prejudice.

1440: Everything you need to know about Alzheimer's

What is Alzheimer's, and is it different from dementia? In short, yes—Alzheimer's is a specific brain disease that falls under the umbrella of dementia. However it is the most prevalent form of the condition, accounting for 60 to 80% of reported dementia cases.

At-home genetic testing results commonly led users to healthier lifestyles

Italian research that aimed to investigate what people do longer-term after receiving direct-to-consumer genetic test results indicated that whether the results were positive or negative, people tended to adopt a healthier diet after receiving the results, and they'd still maintained it a year after receiving their results. Some users also reported an overall reduction in stress over their health concerns. (Some users may encounter a paywall.)

Brain training game creates long-lasting changes in the brain that may help protect against dementia

Findings published in 2026 that tracked more than 2,000 older adults, examining dementia onset and completion of cognitive speed training activities, provide some of the strongest evidence yet that cognitive training games can help protect against dementia. Participants who underwent speed training and received booster sessions had a 25% reduction in the risk of dementia diagnosis compared with the control group.

Major scandals have undermined the reputation of the Olympics

With billions in public money in play and the high stakes of winning gold for one's country, the Olympics have had their fair share of scandals. This Global Investigative Journalism Network list highlights eight groundbreaking investigations by journalists about the Olympics. It includes the 2014 Russian doping scandal, venue corruption in Rio, and the decadeslong cycle of sexual abuse by an Olympic doctor.

Targeting cholesterol metabolism may help address macular degeneration

Research published in 2025, based on human plasma samples and mouse models, indicates that boosting the levels of a molecule called apolipoprotein M in the blood can improve cholesterol processing, helping prevent some cellular damage that contributes to age-related macular degeneration.

How aging degrades neural functioning in the brain over time

Aging affects the brain perhaps more than any other organ in the body. Throughout life, the brain experiences radical shifts in the number of neurons, synaptic connections between neurons, and hormone levels that regulate our mood and processing.