The word 'influenza' comes from a 15th-century Italian belief in the stars

Human records of influenza stretch back more than two millennia

Accounts of flu-like illness appear as early as 412 BCE, when Hippocrates described a sudden wave of cough and fever. Centuries of recurring outbreaks culminated in the first clearly documented pandemic in 1580, spreading from Asia into Europe and Africa.

Human records of influenza stretch back more than two millennia

Accounts of flu-like illness appear as early as 412 BCE, when Hippocrates described a sudden wave of cough and fever. Centuries of recurring outbreaks culminated in the first clearly documented pandemic in 1580, spreading from Asia into Europe and Africa.

Europe’s first recorded influenza pandemic swept the continent in 1580

The 1580 influenza pandemic, traced from Asia to Africa and into Europe, became the first flu outbreak clearly documented across the continent—killing tens of thousands and highlighting influenza’s potential for rapid global spread.

Inflation was a word before deflation was

The word inflation has Latin roots and technically means an influx of air, first appearing in the English language in the 1890s to describe bike tires. Deflation's first known mention in an economic text was in 1919.

The flu is a contagious respiratory illness caused by influenza viruses

Unlike the common cold, influenza attacks suddenly with fever, body aches, and fatigue. Seasonal strains circulate worldwide, infecting up to a billion people each year and causing hundreds of thousands of deaths despite vaccines and treatments.

Measles reached global transmission during the 15th- and 16th-century Columbian exchange

Devastating diseases like smallpox, influenza, measles, and other viruses were largely introduced into the Western Hemisphere beginning with the 1492 arrival of Christopher Columbus and the ensuing age of exploration.

Volcanoes in the 1340s likely helped trigger the Black Death

The "bubonic plague" that wiped out roughly half of Europe and Asia originated from many factors. Recent research suggests volcanic eruptions contributed as well. The "aerosol" effects of matter released from eruptions likely prompted famine and accelerated the spread of infected fleas riding on grains avoiding spoilage.

In 1933, the influenza virus was first identified through 'ferret flu' experiments, which proved that the disease was viral—not bacterial.

Influenza infects up to a billion people worldwide each year

The World Health Organization estimates that seasonal influenza causes about 1B cases annually, including 3 to 5M severe illnesses and between 290,000 to 650,000 deaths.

Flu spreads through droplets in the air and on surfaces

Influenza passes mainly through tiny droplets released when sick people cough, sneeze or talk. The virus can also survive briefly on surfaces, allowing it to spread when others touch contaminated objects.

The political ideology of fascism originates in Italy

Fascism—first named by Benito Mussolini in 1919—derives from the Italian word fasci, linked to the Roman fasces, symbolizing authoritarian unity. Mussolini adapted this term to represent his autocratic, ultranationalist movement.

The scientific name for northern lights came from two Greco-Roman gods

Although cave paintings may have depicted them millennia earlier, one of the oldest known references to auroras is a Babylonian cuneiform tablet from about 600 BCE. In 1619, Galileo Galilei named the phenomenon in the northern hemisphere "aurora borealis" after the Roman goddess of dawn—Aurora—and the Greek god of the north wind—Boreas.

Malaria comes from the Italian term 'mal'aria,' meaning 'bad air'

The term refers to marshy areas associated with the disease. An estimated 94% of malaria cases—215 million—occur in Africa.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

How Byzantine scholars supercharged Renaissance Italy

A brief survey of how Byzantine scholars changed the course of the Renaissance by introducing Classical Greek literature to Italy. These scholars and their students were responsible for translating, interpreting, and printing many of the most fundamental texts in the Western tradition. Without their efforts, the Italian Renaissance and Western thought would have been immeasurably poorer.

How the 1918 pandemic spurred developments in virology and vaccines

This article provides an in-depth historical account of the 1918 Spanish Flu pandemic, including its impact on the global population and how its occurrence spurred significant advancements in the study of viruses—laying the groundwork for the...

Learn the history and science of influenza in 'This Podcast Will Kill You'

In their flu episode, cohosts Erin Welsh and Erin Allmann Updyke unpack influenza's biology, history, and impact—explaining everything from past pandemics to modern vaccines, all with their trademark mix of science and storytelling.

The word 'vampire' appeared in the English-speaking world in the 1730s

However, earlier mentions of creatures with similar characteristics existed throughout Medieval Europe. For example, people often spoke of revenants—restless dead creatures who tormented the living. Historians believe these stories grew in popularity in part because of influence from the Catholic Church, which was emphasizing the idea of purgatory. These older revenant stories eventually influenced modern vampire folklore.

A timeline of major pandemics from 1899–2025

Modern pandemics have been defined by the race between globalization (which increases risk) and the development of new medicines. The Great Influenza epidemic claimed some 50 million lives, and the COVID-19 pandemic killed more than 7 million. In between, diseases like Ebola, cholera, AIDS, and more have devastated communities.

The ancient Greeks and Romans viewed comets and meteors as divine omens

Both considered the appearance of a comet or its fragments as a precursor to significant events, such as the birth of a notable figure or the death of a ruler. One observed in 44 BCE was believed to be a sign of the deification of Julius Caesar after his assassination.

Florence as it was: a digital reconstruction of a medieval city

Florence, Italy, is widely considered the birthplace of the Renaissance in Europe, where artists, poets, architects, and entrepreneurs renewed interest in ancient cultural forms. Using data from primary works, researchers have created a digital reconstruction of the city where users can explore buildings, artworks, and more.

The history of germ theory, which explains that illnesses are caused by microorganisms

For centuries, the miasma theory, which held that illnesses were caused by clouds of "bad air" produced by decaying organic matter, was the accepted explanation for the spread of disease. The development of microscopes and the subsequent technology to isolate bacteria and test disease spread in mice greatly contributed to contagionists overturning miasmatists.

Hollywood's efficient response to the Spanish flu made it a filmmaking destination

In 1918, the Great Influenza epidemic killed more than 675,000 Americans. Los Angeles was one of the first cities to shut down movie theaters, most of which were independently owned and couldn’t afford the revenue loss. The results were twofold: the quick response meant that Hollywood could bounce back faster than other film hubs, and it also contributed to the rise of vertical integration as studios stepped in to purchase the flailing theaters.

A novel H1N1 influenza strain sparked a 2009 global pandemic

First detected in Mexico, the 2009 “swine flu” pandemic infected up to 1.4B people worldwide. While mortality rates were lower than earlier pandemics, the outbreak still caused more than 150,000 deaths.

Pizza is believed to have been invented in Naples

Flatbreads were eaten by ancient Egyptians, Romans, and Greeks, but historians trace pizza—flatbread with toppings, including present-day staples like tomatoes, cheese, garlic, oregano, and oil—back to 18th-century Naples, where the food was loved by its working poor, who appreciated a cheap, tasty meal. Naples formally became a part of Italy in 1861.

The word 'vertigo' derives from the Latin 'vertere,' meaning to turn

Beyond the word's origin, this article makes clear that fuzzy definitions of the disorder make it confusing for patients to describe it.

The Medicis of Italy innovated 'bills of exchange,' precursors to checks

At the time, lending money for interest (also known as usury) was banned in much of the Christian world. The enterprising Medicis developed bills of exchange to allow merchants to promise payment without cash or coin (with some discrete means of earning interest woven in). Learn more about how this family laid the foundation for modern banking.

Tarot cards weren't made for fortune telling

Tarot cards appear to be everywhere today, but their story starts not with fortune-telling, but with a card game for nobles in 15th-century Italy.

The Spanish flu had a major impact on the 1919 NHL season

Just two years after the National Hockey League was officially formed, its champion was playing the PCHA champion for the Stanley Cup. The series was tied, going into the deciding Game 5, when all but three NHL players fell ill with the Spanish flu. No champion was crowned that year.

The virus was officially described for the first time in 1789

Michael Underwood, an English physician and surgeon, was the first to describe the disorder, noting it caused disability in the lower extremities in children. Large-scale outbreaks of the disease were not observed until the late 19th century.

Flu viruses use special proteins to invade and spread in the body

Influenza viruses carry two key surface proteins: hemagglutinin (H), which lets them enter cells, and neuraminidase (N), which helps them escape and spread. These proteins are the basis for the names of flu subtypes like H1N1 and H3N2

The 1957 and 1968 influenza pandemics caused millions of deaths worldwide

The 1957 H2N2 pandemic spread from East Asia, killing more than 1M globally, while the 1968 H3N2 pandemic began in Hong Kong and caused a similar toll, with both strains rapidly moving across continents.

Ebola is a filovirus, meaning it resembles a thread under a microscope.

'Graffiti' comes from the Italian for 'a scribbling'

The word was first used in 1851 to describe the ancient inscriptions on Pompeii's walls. "Graffiti" is the plural form of "graffito," which means "a scribbling."

The Italian music contest that inspired Eurovision

Italy's Sanremo Festival began in 1951 as a way to boost tourism in the Italian Riviera during the offseason, with three acts performing original songs on a national radio broadcast. The format would be replicated five years later by Eurovision, though Sanremo is still around.

Major genetic shifts in flu viruses can spark global pandemics

Antigenic shift happens when two different influenza viruses infect the same host and swap genetic material. The result is a brand-new subtype of influenza which, if easily spread among people, can trigger a worldwide pandemic.

Europeans' arrival to America brought disease to Indigenous populations

Indigenous people lived in the Americas for centuries before the arrival of the first Europeans in the 15th century. Their arrival was disastrous for Native tribes; in addition to being enslaved and losing their land, they had no natural immunity to the diseases brought by colonists. Eventually, up to 95% of the Native American population was killed by illnesses including typhus, chickenpox, and cholera, an event now known as the Great Dying.

Galileo Galilei—considered the father of modern science—was once president of the Academy of Lynxes and used the name Galileo Galilei Linceo on the title pages of his works in its honor.

Humans have speculated about alien life since ancient times

Around 50 B.C.E., Roman poet and philosopher Lucretius shared the idea that alien life was possible, which was put forth by Greek philosopher Epicurus. The writing is believed to be the first straightforward assertion in Western literature that aliens must exist.

Hear firsthand stories from Americans who lived through the 1918 flu pandemic

This video shares personal accounts from survivors of the 1918 influenza epidemic, capturing memories of sickness, loss, and resilience. Their voices offer a glimpse into how ordinary people experienced one of history’s deadliest pandemics.

Lupus, an autoimmune disease with varied symptoms, was named for wolf bite-like lesions

The 13th-century physician behind the name (lupus is Latin for wolf) named it after a patient he saw who had facial lesions that looked to him like a wolf's bite. Other common symptoms of the disease include extreme fatigue, painful and swollen joints, fevers, and light sensitivity.

The flu vaccine has evolved alongside discoveries of new virus strains

After influenza B was identified in 1940, researchers created a two-strain vaccine by 1942. The WHO later built a global surveillance system to track mutations, enabling vaccines to be updated annually to target the strains most likely to circulate.

The bubonic plague spread in three waves over 600 years

The Black Death refers to the first wave of the plague, which swept through Europe in the 14th century and killed 25 to 50 million people. Caused by the bacterium Yersinia pestis carried by fleas (often on rats), the human toll was roughly one-third of Europe's population at the time.

The list of historic volcanic eruptions includes the 1883 blast from Krakatau, which killed more than 36,000 and was the first such event to be documented in real time, thanks to the telegraph.

Pizza became more popular in Italy after it took off in the US

Pizza was invented in Naples, though it wasn't particularly popular outside the region. As it grew more popular elsewhere—and as more American and European tourists visiting Italy began asking for it—restaurants across Italy adopted the cuisine. It's something anthropologist Agehananda Bharati calls "the pizza effect."

Small genetic changes that accumulate over time force flu vaccines to be updated regularly.

Before vaccines, there was 'variolation': what was it?

Before the technology behind vaccinations was discovered, some keen observers of medicine around the globe noticed how previous infections could impact future ones. Learn about the techniques early physicians used before they had vaccines.

Galileo’s discovery of Jupiter’s moons led to multiple scientific advancements

Beyond challenging Earth-centric views upon their discovery in 1610, the Galilean moons were also later analyzed to contribute to early astrometry and astronomical interferometry. Measurements of eclipses were also used to estimate the speed of light.

What the stars once meant to ordinary people

The stars were a crucial aid for ordinary human beings in premodern societies, acting as regular timekeeping phenomena and celestial navigators. Today, light pollution and modern technology have rendered the stars a mere aesthetic delight for most of us, but their significance in history remains. Watch this brief video to learn how premodern humans used the stars for navigation, mathematics, and more.

Tinnitus is derived from the Latin verb tinnire, meaning to ring

Read the entry in The Physical Dictionary by Stephen Blankaart, from 1693, where the word first appeared in English.