What is salvia divinorum?

Ibogaine, a psychedelic substance, can be used to treat mental illness

Although the substance is banned in the US, it's legal in Mexico. Americans who have traveled there for treatment, including the NFL's Braden Smith, say the drug helps deal with conditions like obsessive-compulsive disorder.

Psychedelic DMT—part of ayahuasca—shows antidepressant promise in small clinical trial

Proponents say this short-acting psychedelic, formally known as dimethyltryptamine, could be particularly promising for medicinal use because longer-acting psychedelics can sideline someone for hours after a treatment with hallucinations. DMT is the primary psychoactive ingredient in ayahuasca, a psychoactive brew used across various South American cultures for spiritual, social, and medicinal purposes.

Stevia has been used to treat burns and indigestion

The substance, which is roughly 300 times sweeter than sugar and scientifically known as Stevia rebaudiana, comes from a plant that grows in Paraguay and Brazil. It has long been used medicinally and as a sweetener by indigenous communities in those locations.

A 49-year-old American died at an ibogaine clinic in Mexico, underscoring its risks

The man had sought out the drug to help him overcome his substance abuse disorder. Though anecdotal reports indicate potential promise, there's been no large-scale clinical trials on ibogaine's safety and efficacy. The plant is derived from a root bark named iboga and has been used for centuries by indigenous communities in Gabon, but first entered scientific consciousness in 1901 after its alkaloid was isolated from Iboga.

Sinaloan sushi is a Mexican take on the Japanese classic

Sushi became popular in Mexico in the early 20th century, thanks to Japanese immigrants who settled in Sinaloa, a Mexican state that runs along the Pacific Ocean. The region’s modern-day sushi blends both cultural traditions, evident in items like the Mar y Tierra roll, which includes carne asada and shrimp.

Ibogaine is being investigated for treating mental health issues and substance abuse

This compound, which is illegal to use in the US, has had promising results for patients who have tried it in other countries for substance abuse and mental health concerns. This psychoactive substance is not without risks, however; this TED talk points out it's also caused fatal cardiac arrhythmias and shouldn't be taken without medical supervision.

Mezcal is a handcrafted spirit made by Indigenous producers in Oaxaca

Unlike tequila, mezcal can be made from dozens of agave varieties and is traditionally produced by small-scale families in Oaxaca using stone pits and clay pots. The spirit's rising popularity in US bars has brought both economic opportunity to producing communities.

Oregon voters in 2020 greenlit adult use of psilocybin—the active ingredient in magic mushrooms—in state-licensed centers, and a 2026 analysis indicates the program has good safety and satisfaction data.

Veterans reported single dose of ibogaine improved TBI, PTSD, anxiety, and depression

Research published in 2024 on the Central African plant-derived drug included 30 male combat vets who received ibogaine treatment in Mexico. It reported significant reductions in multiple mental health conditions and no serious side effects. Other work, however, has shown the substance can cause fatal cardiac arrhythmias, killing at least 19 people between 1990 and 2008. (Some users may encounter a paywall.)

This is the human brain on the world's strongest psychedelic

Within seconds of inhaling a high dose of vaporized synthetic 5-MeO-DMT—a lab-produced substance that otherwise is naturally derived from the glands of the Colorado River toad—it induced slow brain waves. Such waves are typically associated with unconsciousness due to a coma or anesthesia, perhaps explaining why users describe feeling like everything falls away. The compound is currently in clinical trials for treating depression.

Rome's herbal panacea may not be as extinct as we thought

Silphion: cure-all, aphrodisiac, birth control, tasty seasoning. Nero allegedly ate the last of this miracle plant. This article details how a researcher may have found more. Seven centuries after the yellow-flowered plant was first documented growing in what's now Libya, it vanished. Historians proposed that the loss of Silphion may have been the first recorded extinction of any species.

'Salud!' is a toast to one's health

The word is a shortened form of “para tu salud,” or “for your health.” The toast has become popular in Spanish-speaking countries as a shorthand for good health and general well-wishing. In Peru, the toast is usually made on New Year’s Eve with a sparkling wine, like Champagne or pisco sour.

Psychedelics are being fast-tracked for research after a 2026 executive order

Many such compounds (including LSD, psilocybin, and more) are classified as Schedule I drugs—illegal to possess and federally regarded as having no medical use. Researchers say such restrictions have created significant hurdles for formal clinical trials. With this executive order, the FDA will enable work particularly focused on depression, PTSD, and alcohol use disorder.

Tequila overtook whiskey as a top US spirits subcategory in 2023

Tequila sales in the US totaled $6.5B in 2023, surpassing whiskey's $5.3B. The shift was partially driven by premiumization, with the majority of supplier revenues coming from premium and super-premium tiers and brands.

Watch veterans experience psilocybin at a Mexican clinic and discuss the aftermath

This "60 Minutes" episode from 2025 follows nine veterans attending a week-long psychedelic retreat to treat their PTSD. Most of the vets say the experience at the Mexican clinic was life-changing. But results were mixed: One veteran reported he was scared and that the experience worsened his mental health overall.

Manifest destiny fueled US aggression against Mexico

The belief that the United States had a divine right to expand westward—known as manifest destiny—justified President Polk’s push for territorial conquest. It shaped public support for the Mexican-American War and framed the invasion as national destiny.

An Aztec skull whistle discovered in the 1990s was mistaken for a toy

In the late 1990s, archaeologists unearthed a sacrificed man clutching two skull-shaped clay whistles at a Mexico City temple to the wind god Ehecatl (eh-HEH-kahtl). Initially dismissed as toys, the instruments produce a scream-like sound that modern brain scans show triggers fear and urgency responses in listeners. This podcast explores the discovery.

Sugar skulls are more than a sweet snack

The colorful candy combines Indigenous traditions with European confectionery techniques. Its symbolization reminds celebrants that death can be “sweet.”

Day of the Dead has started to blend with Halloween

As American Halloween becomes more popular across the globe, Mexican Day of the Dead celebrations have begun to take on some of its traditions. While some believe this dilutes the holiday, other scholars suggest that Day of the Dead has always been rooted in Catholicism.

Watch a traditional Aztec fire-serpent dance rooted in Mexica mythology

This video captures a performance of a Xicauhuatl—or fire-serpent—dance, rooted in Mexica beliefs that these serpents carried the sun across the sky. The performance highlights the fire serpent’s central role in Aztec ritual and storytelling.

Marigolds are an iconic symbol of Day of the Dead

The native Mexican flower performs several functions in Day of the Dead celebrations. Its vibrance and unique scent help guide wandering souls home, and its cheerful color reminds celebrants that death can still be joyful.

Psychoactive drugs found in 1,000-year-old bag made of fox noses

Archaeologists in Bolivia have uncovered an ancient bag filled with "amazing goodies" that suggests the owner or owners were well-versed in the properties of psychoactive substances and sourced goods from well-established trade routes. This article details the findings, which shed light on how ancient peoples in the region consumed and obtained psychoactive substances.

Watch Mike Wallace's fascinating interview with Salvador Dalí

In 1958, Salvador Dalí spoke in a TV interview with legendary journalist Mike Wallace about genius, the subconscious, weakness, old age, luxury, religion, and dreams, among a range of other topics. During this candid conversation, Dalí challenged American audiences to consider death and mortality. Watch the discussion here.

Shrunken human heads were once a valuable commodity.

Who was Salvador Dalí?

Salvador Dalí reshaped modern art with surrealism, symbolism, and eccentricity. This snapshot covers his rise from Spanish prodigy to global icon, his Surrealist break, and his fascination with dreams and celebrity.

Kalshi is the first regulated prediction market in the US

Two migrant MIT students, Luana Lara Lopes and Tarek Mansour, shared an interest in hedging against uncertainty—from election outcomes to the Oscar awards. They fought hard for regulatory approval and their company now has a valuation in the billions. The platform has brought prediction markets into the mainstream.

The history and significance of rosemary

Rosemary is more than just an herb—it’s a powerful symbol intertwined with ancient Egypt, Christianity’s origins, Shakespeare, the culinary arts, and more. Native to the Mediterranean area, this plant has accompanied humanity for centuries, providing us with pleasant aroma, adornment, and even medicine. Explore this article for further insight into the significance of our long-standing relationship with rosemary.

Read this analysis indicating which traditional stevia medical uses have scientific evidence

This research paper investigates the various uses of Stevia rebaudiana leaves and their extracts and concludes that the substances do hold significant potential for improving cardiovascular health and inflammatory disorders in adults, among several other potential applications. Its authors suggest that further research should examine safe dosage questions and chronic disease management approaches.

The Aztecs worshipped Mictecacihuatl, goddess of the underworld

Some elements from ancient festivals honoring Mictecacihuatl and other deities, like incense, skeleton imagery and marigolds, have been incorporated into modern Day of the Dead celebrations, possibly indicating that the holiday blends indigenous and Catholic traditions.

The commercial and therapeutic potential of psychedelics

A 2006 study into the potential therapeutic benefits of psychedelics sparked a renewed interest in the field of psychedelic research, a development that has cascaded into commercialized ventures and experiences. This article details how growing research into the psychological benefits of psychedelics is matched by the rise of anecdotal reports, book deals, businesses, and corporate claims seeking to capitalize on psychedelic potential.

Psychedelic drugs are having a scientific renaissance

After decades of repression, psychedelic research is making a resurgence. Hear from a host of experts in this 20-minute video on what that could mean for the future of mental health. The current science on psychedelics believes LSD can cause a particular brain network to quiet or deactivate.

'Dirty soda' took off in Utah before exploding on TikTok

The concoction is a combination of Diet Coke, coffee creamer, and citrus. This Eater article delves into the history behind the sugary drink, pinpointing its start as a Mormon-friendly alternative to alcohol and caffeine. The explainer also explores why the drink became so popular on social media and offers helpful hints for crafting your own recipe.

How psilocybin could transform mental health treatment

How magical are magic mushrooms, at least where depression is concerned? Some 24 volunteers participated in a study to evaluate the efficacy of using psilocybin in combination with psychotherapy to treat individuals suffering from depression. While some controversies remain about its use—psilocybin is known to cause psychosis sometimes—some scientists think the benefits outweigh the risks.

How Western psychedelics research fell to the wayside

Psychedelics' modern era began when LSD was discovered in the 1930s. By the 1950s, clinical trials were underway. US user experimentation outside of medical settings (and high-profile violence, like the Manson murders) inspired negative attitudes toward psychedelics, leading to use restrictions that prohibited companies from patenting psychedelic compounds. This strangled psychedelics' profitability until the 1990s when the government loosened its grip and psychedelics research began seeing a resurgence.

GLP-1 drugs, first used to manage diabetes, were derived from Gila monster saliva.

Psychedelic side effects, including worsening mental health for some patients, give pause

This article explores whether the therapeutic potential of psychedelic drug use is really as good as current research suggests. Scientists are exploring its applications for conditions ranging from the existential crisis that can accompany terminal diagnoses to chronic mental health conditions, including anxiety and PTSD.

Mental health applications of psychedelics

Scientists are investigating psilocybin, ketamine, LSD, and MDMA (also known as ecstasy) as potential treatments for mental health issues. These drugs enable an altered state of consciousness, which can have beneficial or harmful impacts depending on the nature of the experience. Research suggests these drugs can be effective in treating substance use disorders, mental health conditions, including depression and anxiety, and psychiatric disorders, including schizophrenia.

The 'definitive' history of magic mushrooms

Where did magic mushrooms come from, and how did they get their magical reputation? This article explains the history of the psychedelic fungi from pre-history to now. The earliest concrete evidence of psychedelic mushroom use is 12,000-year-old murals in Northern Australia that portray mushroom iconography. Considering how many species seek out and consume psychoactive substances, such as Siberian reindeer, it's possible human use of these psychedelic mushrooms may predate these murals.

Studies of psychedelic use may help shed light on the nature of consciousness

The nature of consciousness—what it is, where it comes from, and how it manifests as moment-to-moment experience—remains under debate by scientists. Recent studies show psychedelics were found to boost low-frequency brain signals known as delta waves, a behavior also seen during dream states.

Oral rehydration solution was developed in the 1960s in response to cholera deaths.

LSD fueled a countercultural movement before evolving into a potential therapeutic

As the use of recreational psychedelics became common, authorities were quick to claim LSD had lasting adverse effects, criminalizing the drug and halting scientific study for decades. Over time, LSD's reputation shifted from a potential source of enlightenment to a dangerous drug that could dim a person's future, and back to a possible therapeutic compound.

In 2023, a Dalí painting was purchased from a house clearing sale for $200

"Vecchio Sultano," a 1966 work by Salvador Dalí, was sold in a house clearance sale in the UK in 2023.

A 1893 speech from a Hindu monk in Chicago set the stage for yoga in the US, which exploded in popularity in the next century.

Humans have used geothermal resources for thousands of years

In North America, Indigenous peoples viewed hot springs as sacred places and used them for medicinal purposes, cooking, and surviving cold weather. The ancient Greeks and Romans also viewed them as sacred, partaking in hot mineral baths to relieve ailments and using them for space heating.

Play a game inspired by Aztec and Mayan mythology

This free online game, Descent of the Serpent, guides players through Mesoamerican myths as they challenge the god Tezcatlipoca. Along the way, it introduces monuments and artifacts with short explanations of their meaning in Aztec and Mayan cultures.

Human sacrifice reinforced Aztec political control and religious belief

The Aztecs controlled a vast territory through military might and intimidation. One very key tactic of control was the ritual of human sacrifice. While an effective scare tactic, the ritual was also grounded in deeply held beliefs that the world was sustained by blood.

Athletes in Mexico are reviving a 3,000-year-old sacred sport

A modern team is working to revive Juego de Pelota, an ancient Mesoamerican team sport played by the Maya, Aztecs, and neighboring cultures. Once central to ritual and community life, the game was outlawed by Spanish conquistadors in the 16th century.

How America's cocaine habit fueled its migrant crisis

The United States has been facing a migration crisis along its southern border. Thousands of people have been fleeing their homes in Central America, traveling north through Mexico, and claiming asylum in the USA. Much of this crisis can be traced...

Chicano artists shaped the celebration of Day of the Dead in the US

Beginning in the 1970s, Mexican-American artists have used Day of the Dead components like ofrendas and festivals to combine cultural identity with social justice movements, highlighting indigenous traditions to address issues like gang violence.

How five of the world's most expensive salt and spices are made

Part of the charm of certain spices and salts is their exotic origin, hailing from difficult-to-access locales or hewn via special processes. That also explains why they can be so expensive. Dive into the businesses of producing and marketing five of the world's most expensive food additives with this engaging video.