Turning nuclear waste into cancer medications

Learn about the 'Goldilocks' of radioisotopes, which can help attack hard-to-treat cancers

Actinium-225 can be attached to a molecule that binds to cancer antigens, helping it target specific cancers in the body. It emits alpha particles that can damage DNA but do not penetrate deeply, confining the damage to nearby cancer cells. However, annual global production of actinium-225 is less than a grain of sand.

Methods for disposing of nuclear waste include melting it into a liquid to create glass, dumping it into graphite blocks, storing it in lead-lined rooms, and submerging it in deep pools of water.

How radioactive isotopes are created and used for medical diagnostics

In particle accelerators, protons can be accelerated into other atoms to create radioactive isotopes, which can be attached to specific molecules to create radiotracers that are taken up by specific cells. Radiotracers can emit particles that produce light once they collide with an electron, and this light can be captured by a PET scanner to diagnose specific ailments.

Over a lifetime, the average American's nuclear power usage creates a hockey puck of nuclear waste

Spent nuclear fuel remains hot and highly radioactive for long periods, requiring submersion in cooling pools before being stored in dry casks and deep underground repositories. The potential recycling of nuclear waste is impeded by security concerns and dangerous reprocessing methods, particularly when obtaining fresh uranium is often easier.

Particle beams can be used to alter the surface properties of artificial joints

Surface hardening and embedding specific elements or coatings can improve the biocompatibility and bone tissue integration of these implants. Particle accelerators are significant sources of the radioisotopes needed in medical diagnostics, and microwave linear accelerators are used in the majority of cancer irradiation treatments.

View the most expensive materials on Earth, led by antimatter and other elements forged in particle accelerators.

View the periodic table of radioactive elements, and a list of each's most stable isotopes

Technetium is the lightest artificial radioactive element, which is produced primarily as a byproduct of nuclear fission. Several unstable isotopes are commercially available to medical professionals and scientists, despite their radioactivity risks.

A new type of immunotherapy focuses on healthy cells hijacked by tumors

Purdue University scientists are at work on a new cancer treatment that attacks immune system cells that feed and protect cancer cells rather than attacking them. The immunotherapy process promises to become a universal treatment for solid tumors. Thus far, the treatment has been tested and shown to work on human tumor cells in the laboratory and animal models.

Watch a histotripsy procedure, a novel noninvasive cancer treatment approach used to destroy tumors with high-intensity sound waves.

What is immunotherapy and how does it work?

Immunotherapy is a type of treatment that harnesses the body's immune system to combat cancer. This video explainer from the American Cancer Society discusses various types of immunotherapies and their roles in targeting cancer cells. Still a new and quickly evoliving field, immunotherapy represents a significant advancement in cancer treatment and offers new options for patients.

What is cancer bioengineering?

While new treatments for cancer are under continuous development, researchers are increasingly using engineering principles to find wholly new strategies to combat the disease. Directions include nanoparticle drug delivery, advanced imaging tools, developing new materials to interact with cells, tissue engineering, robotic surgeries, and more. Such interdisciplinary efforts are expected to unlock new tools and therapies beyond traditional drug formulation.

Teaching immune cells to fight cancer

CAR T-cell therapy is a type of immunotherapy, which involves strengthening the immune system to attack cancer cells. Patient T cells, which manage immune responses and are responsible for killing pathogen-infected cells, are collected and re-engineered to produce surface-level proteins called chimeric antigen receptors. These CARs, now able to bind to specific proteins on cancer cell surfaces, are multiplied into the millions and infused back into the patient.

The difference between standard cancer treatments and emerging immunotherapies

If you've ever wondered what the difference was between immunotherapy and chemotherapy, this short video takes you through the steps. Briefly, chemotherapy attacks cancer in tumor cells directly, while immunotherapy encourages your immune system to fight it. There's more to it than that, but this delightful two-and-a-half-minute video provides a good primer.

mRNA vaccines alter immune response, not DNA, to combat diseases like cancer.

Combining two cancer drugs increased the life space of mice by 30%

A study shows trametinib and rapamycin, two drugs used for cancer treatment in humans, increased mouse lifespan when used together. The medications delayed the onset of cancer and reduced chronic inflammation, results that will be explored in future research.

A snapshot of progress in cancer treatments

The American Association for Cancer Research's "Snapshot of a Year of Progress" offers an overview of significant advancements in cancer research and treatment over the past year. Take a quick look at the rapid pace of scientific discovery and the translation of research findings into clinical practice. In 2024 alone, health regulators approved 15 new anticancer therapies alone.

Uranium's ability to split easily makes it the most common catalyst for nuclear power

Uranium is commonly found in rocks, water, and soil worldwide, but significant industrial processes are needed to process and enrich it for efficient reactor usage. After being irradiated in reactors, it must be cooled down before disposal.

How is immunotherapy used to fight cancer?

The Dana-Farber Cancer Institute provides a delightful Science Illustrated animation explaining PD-1/PD-L1 immunotherapy and how it fights cancer. Briefly, the treatment helps T-cells recognize cancerous cells that would ordinarily be "disguised" by proteins and attack. The fight is made more fair and effective by immunotherapy and similar cancer treatments.

Although they rely on radioactive elements to operate, everyday technologies such as electronic exit signs, some wristwatches, and smoke detectors are not dangerous, unless they are damaged and their radioactive material is inhaled or swallowed.

See how CAR-T cell therapy works to help fight cancer

Short for chimeric antigen receptor T-cell therapy, CAR-T Cell Therapy helps augment the body's own ability to attack cancer cells. It's a cell-based gene therapy that alters the genes in a person's T cells—which are a type of immune cell—to help them beat back cancerous growths.

Rare earth elements may be extracted from mine waste and coal ash

Rather than focusing solely on new mining operations, which can take decades to establish, some startups are developing methods to extract these metals from the toxic waste of existing operations and thereby minimize environmental impacts. (Some readers may experience a paywall.)

Before 1932, when particle accelerators were first used for nuclear research, scientists relied on naturally radioactive substances to advance their understanding of the atomic nucleus.

Nuclear batteries generate electrical currents using radioactive materials

Rather than using electrochemical reactions to produce the electrons that flow through a circuit, isotopes like nickel-63 undergo beta decay—emitting electrons—which a semiconducting material can absorb to establish a charge imbalance that generates current. Such batteries could provide low-power energy for decades.

An overview of radioactivity, which can spontaneously change one element into another

Unstable atomic nuclei can transmute into a new element—an atom with a different number of protons—by emitting an alpha particle (two protons and two neutrons) or a beta particle (an electron). The electron can emerge from the nucleus when a neutron, which has no charge, suddenly transforms into a proton and an electron, thereby maintaining zero charge before and after the transformation, but altering the original element.

Advanced drugs are closing in on cancer's deadliest mutations

The protein KRAS, mutated in many cancers, was deemed ‘undruggable’. Now scientists are hoping to save lives with a batch of new compounds that target it.

A scientist successfully treated her own breast cancer by injecting the tumor with lab-grown viruses.

In nuclear reactors, water acts as a coolant and moderator, slowing neutrons produced in nuclear reactions so they are more likely to interact with nuclear fuel and generate sustainable energy.

What is CAR T-cell therapy?

A four-minute video about CAR T-cell therapy to help answer patients' questions: What is CAR T-cell therapy? How does CAR T-cell therapy work?

Learn about the applications of radioactivity in medical, academic, and industrial settings

Besides their use for radiometric dating by archaeologists and researchers at museums and universities, radioactive materials are used in sensors that help track ocean currents and analyze pollution, soil, and petroleum products. Radioisotope-based sensors also help measure air in ice cream and prevent spillovers when soda bottles are filled in factories.

Why CAR-T therapy has become one of the main focus areas for autoimmune diseases

The therapy, originally targeting cancer, involves taking a patient's own T cells, genetically reprogramming them to recognize and attack a specific target and then infusing them back into patients. For autoimmune diseases, the therapy instead programs them to target immune cells that are causing problems, restoring immune system tolerance.

The 'Armamentarium' is a set of new gene therapy tools—including viruses that could shuttle therapies into the body—designed to fight brain diseases.

How medical robots could cure cancer

Medical robots are on the verge of being able to be injected into the body, where they will be responsible for semi-autonomous behavior, such as detecting cancer cells and distributing medication. This six-minute video dives into the science of these nanorobots, which are smaller than blood cells. Applications of these nanobots could range from disease discovery and condition monitoring to tissue repair and artificial blood delivery.

At a 2026 cancer conference, news that a novel pancreatic cancer drug doubled survival times in clinical trials led to a standing ovation.

Nuclear power relies on chain reactions involving uranium-235, but because the isotope's concentration in natural ores is too low to sustain these reactions, enrichment is needed to produce more highly concentrated fuel.

With less than 50 milligrams present in the top kilometer of Earth's crust at any given time, astatine is the rarest naturally occurring element on the planet.

AI's growing energy demands are driving tech companies to consider nuclear power

Big Tech has rebranded nuclear power as a green solution to address the strain on the grid from millions of people using power-hungry AI tools. As of mid-2025, generating one image uses as much electricity as charging the average smartphone, or leaving a household light bulb on for 87 consecutive days.

Frequently asked questions on immunotherapy

The Cancer Research Institute takes a close look at immunotherapy and its potential for treating cancer. Immunotherapy teaches the patient's own immune system to recognize and fight cancer cells. It's especially promising as an alternative for cancers that resist chemotherapy and radiation treatment. Have all your questions about the process and its promise here.

Mining of rare earth elements risks leaking radioactive wastewater

The extraction and processing of REEs requires significant amounts of water, and poorly regulated projects can contaminate groundwater with acids and heavy metals. Toxic waste spills have paused work in several US mines since the 1980s, despite growing REE demand.

Visualizing the chemistry of nuclear weapons

Nuclear weapons have devastating effects, but the science of how they work is atomically small. There are two main types of nuclear reaction: fission and fusion. The fission bomb produces immense energy by splitting an atom, the result of firing a...

Lung cancer advances are making a big difference

Lung cancer deaths are declining faster than new cases due to advances in treatment. The progress illustrates what is possible, even for a cancer that has long had a poor prognosis.

Nuclear-powered missiles replace chemical combustion with energy from nuclear fission

In these systems, energy is added to an airstream, which passes through a nozzle to generate thrust. Because the amount of energy released per unit mass of nuclear fuel is millions of times larger than that of chemical propellants, nuclear missiles can travel faster and farther with less fuel.

Isodope is the world's first nuclear energy influencer

Isabelle Boemeke, a Brazilian fashion model and social media personality, began promoting the benefits of nuclear electricity in 2015. She now debunks common objections to it through her TikTok persona Isodope—which has more than 34,000 followers.

PET scans create images of the body by detecting light emitted from the annihilation of matter and antimatter, with the latter produced by custom chemicals containing radioactive atoms.

Cyclotrons move particles in spiral paths of increasing radius

After particles are injected into the center of the device, an alternating electric field and a constant magnetic field energize the particles as they spiral outward toward a target. Cyclotrons are common in hospitals that perform molecular imaging, which relies on radioactive components that decay within hours.

A physician with a rare and deadly disease saved his own life by identifying an existing medication that he repurposed for his condition, and now he's using AI to try to do the same for other patients.

Build atomic nuclei to explore their instability and resulting radioactive decay

In this simulation, users can add protons and neutrons to create an atomic nucleus, view its half-life and decay options, and identify patterns in how specific combinations of particles create extremely stable nuclei, from which the nuclear shell model of stability emerged.

More than 97% of the world's particle accelerators are used for commercial purposes

Only a few hundred of the over 30,000 particle accelerators worldwide are used for research. Most are involved in medical imaging and treatment, food sterilization, semiconductor processing, cargo screening, and radioisotope production. They're also used to modify the properties of polymers.

Explore the National Cancer Institute's archive on cancer treatments, including complementary and alternative medicine.

A visualization of mycoremediation, where fungi extract toxic and radioactive pollutants from soil

As organisms such as mushrooms grow, they develop large networks of root-like structures called mycelium that spread underground and release enzymes that break down contaminants. By absorbing these chemicals, fungi limit the damage caused by these toxins and localize them within the organism for easier collection and disposal.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.