Biosignatures are the chemical fingerprints astrobiologists search for to find life

Astrobiology is the study of life's origins and the search for life beyond Earth

The field incorporates observational missions to find and classify exoplanets—planets orbiting stars besides the sun—the probing of Earth's most extreme environments to learn what conditions allow life to exist, and theoretical and lab work to identify and analyze potential biochemical signatures.

Questioning the results of life on K2-18b

An analysis of the atmosphere of an exoplanet called K2-18b identified the presence of biosignatures—molecules that are created by living things on Earth. This discovery may indicate life exists beyond Earth, but the lack of environmental data complicates the interpretation of results.

Exoplanet atmospheric gas patterns may indirectly provide evidence for life

When searching for life beyond the solar system, scientists first determine the range of distances from a star that liquid water—believed to be essential for life—can be found. Within this habitable zone, the presence of specific molecules in an exoplanet's atmosphere—detectable through spectral analysis—can indicate the presence of living things known to produce those compounds.

JWST might spot life faster on ocean worlds than Earth-like ones

Unlike Earth-like planets, hycean worlds with thick hydrogen atmospheres and deep oceans could allow biosignature gases like methyl halides to accumulate in detectable levels. These gases, linked to microbial life on Earth, are easier for the James Webb Space Telescope to identify than traditional markers like oxygen or methane.

Why the existence of extremophiles greatly improves the odds of life beyond Earth

The conditions for life have long been thought to include liquid water, an energy source, and the essential elements for organic molecules within environments on or near Earth's surface. However, because extremophiles thrive in far more inhospitable environments, astronomers now analyze exoplanets whose characteristics indicate environments that fall within a broader range of possibilities when searching for signs of extraterrestrial life.

Scientists determine the smells of objects in outer space

Using spectrographic techniques, scientists determine the chemical composition of planetary atmospheres, comets, and other objects in space. Combining these chemicals in labs on Earth has revealed locations in space that smell like nail polish remover, rotten fish, and urine.

A four-billion-year-old meteorite reignited the debate about life on Mars

Recovered from Antarctica in 1984, ALH84001 contained organic compounds, magnetite and iron sulfide grains of potential biological origin, and features that resembled fossilized bacteria. With technological advancements, scientists found abiotic origins for these features in the following decades.

New ways of seeing the cosmos have redrawn the map of human identity

From Galileo’s crude spyglass to the James Webb Space Telescope, each technological leap has expanded our observational reach and redefined philosophical and moral conceptions of our place in the universe. Identifying signs of life through the study of exoplanet atmospheres would represent the next great revolution.

Lining up every microbe on Earth would stretch to about 105,000 light-years

There are about 10²⁷ such organisms on the planet, many of which are adapted to produce energy through uncommon reactions in unconventional environments, such as within rocks or near volcanoes on the ocean floor. Studies of these organisms have reframed astrobiologists' search for life beyond Earth by broadening the parameters under which life can exist.

Critical organic molecules have been found on an asteroid

NASA's OSIRIS-REx mission returned samples containing amino acids and nucleobases from asteroid Bennu. Without Bennu having been destroyed—as is common for asteroids that enter Earth's atmosphere—its samples serve as a time capsule of the solar system's early chemistry.

Aliens may be closer to Earth than scientists have previously assumed

The hunt for extraterrestrial life is often associated with traveling far into the depths of space for clues. But answers could be closer than we think. Modern space missions have demonstrated our capability of sending probes beyond the solar system, making it plausible that other civilizations could do the same.

Despite privacy risks, scientists are using DNA in the air to assess ecosystem health

While DNA in soil and water samples has long been used for such analyses, airborne DNA is being incorporated into such efforts to monitor individual species abundance, detect invasive species, measure biodiversity, and determine the success of conservation actions. Future work may include detecting attacks from biological weapons.

Panspermia, the theory that cellular life came from a different planet

One of the most profound mysteries of human life on earth is the presence of living cells: organic, self-organizing, reproducing creatures with a drive to survive within given set conditions. Traditional theories posit life came from divine...

Spontaneous metabolism may give clues to origins of life

Read this article to learn more about the discovery that suggests that metabolism could have begun spontaneously on our planet—and why it means that scientists may need to rethink how we define life’s origins. A team of researchers at the...

Read the NASA overview of the results of Viking’s biological experiments on Mars

Three experiments on the Viking 1 and 2 landers searched for signs of metabolic activity in soil samples, indicating the presence of microorganisms. No definitive evidence of life was found in any experiment or lander imaging.

Where should we look for extraterrestrial life?

Not all planets are created equal. Those capable of sustaining life as we known it must meet strict criteria, the most important of which is being at the right distance from their host star to have liquid water on the surface.

Mold growth in space raises the hypothesis of life being brought to Earth

Panspermia suggests that life could be carried throughout the cosmos by asteroids, comets, and other objects, but it requires organisms that can withstand the extreme cold of space travel, stellar radiation, lack of water, and intense heat of planetary impacts. The discovery of mold on the International Space Station and experiments showing it can withstand radiation in outer space-like conditions increase the plausibility of the hypothesis.

Learn about historical uses of bioremediation, the oldest cleanup method on Earth

Biochemical reactions that decompose complex molecules into simpler ones have occurred on Earth for as long as life has existed and have gradually transformed the planet into a celestial body that is increasingly habitable to greater biodiversity. Along the way, modern, human-made bioremediation techniques began to take shape in Santa Maria, California, in the 1960s.

By separating light with tools such as prisms, scientists can reveal the presence and composition of celestial matter by identifying color fingerprints unique to specific elements and molecules.

Doctors use three key physical markers to determine biological aging

The length of the ends of chromosomes (known as "telomeres"), the gradual change in collections of DNA molecules called "methyl groups", and the secretion of inflammatory proteins are all used as indicators of biological age.

Read the academic article explaining how ancient smells can be dissected and recreated

This paper explores how biomolecular data on past scents can be teased out and then transformed into olfactory museum experiences, adding another component to our understanding of archaeology.

The key ingredients to life on Earth—and elsewhere

Life can only arise in incredibly specific conditions, an abundance of certain substances like water and phosphorus, lots of time, and the right proximity to a heat-and-light-providing star. These two experts on evolution of life say above all, life requires luck. Here's a list of eight ingredients to life.

The secret lives of cells

Cutting-edge microscopy has revealed previously unseen interactions of biological molecules within their cellular environment, enabling scientists to observe and analyze the molecules in a holistic view. This podcast explains the minute advancements made over the last few decades in observing cells, revealing how scientists have come and what the future holds for the field.

Biological terraforming studies have been conducted at Biosphere 2

The experiments involve populating barren hillslopes within the Landscape Evolution Observatory with microbes that react with air and rock to produce molecules needed by more complex organisms. Mosses and other simple plants can then grow in these spaces, gradually making them more hospitable to humans.

Abiogenesis explains how Earth's natural processes could have formed organic matter

The theory details how chemical interactions in hydrothermal vents and shallow ponds billions of years ago could have created lipids, proteins, and RNA. As these interactions involve water, life is thought to have started in oceans.

Quantum mechanics-based technology may explain the Fermi paradox

It describes the discrepancy between the high likelihood of life beyond Earth given the vastness of the universe and the lack of evidence for such life, since extraterrestrial civilizations have not communicated with us. However, quantum communication—a more information-dense and effective method than classical means—requires massive receivers and very narrow signals, which would easily miss Earth, making a lack of signals expected.

Universal limit to technological development may prevent finding alien civilizations

Given the vastness of the Universe, detecting alien life may require technological progress beyond the limits of what is sociologically viable and physically possible. Although interstellar civilizations are unlikely, messaging techniques and probes may improve the odds of successful communication with other intelligent life.

Why extremophiles may play an important role in terraforming Mars

Possessing unique biochemicals that can detoxify extreme environments and resilience against the Martian surface that is lethal to humans, scientists are exploring whether colonies of these organisms can transform small areas of the Red Planet into future habitats for humans. Extremophiles may also be best equipped to serve as microscopic factories for the fabrication of essential polymers.

Biohacking: The effort to optimize health and extend life through technology

Biohacking seeks to optimize human health and performance through everything from simple lifestyle adjustments to more radical interventions like body modifications and experimental technology. At its core, biohacking covers a wide spectrum—ranging from improving sleep and focus to implanting devices that integrate technology with the human body.

Environmental DNA monitoring can help detect the presence of invasive species

Genetic material that organisms deposit into water, soil, or air can be identified by analyzing samples from each environment, allowing land managers to more reliably detect and track organisms than visual surveys alone. eDNA has been used to develop early warning surveillance systems for various invasive marine species.

Harvard and MIT researchers are developing life-saving tattoos

Tattoos aren’t just a fashion statement. Scientists are trying to find life-saving applications for them. Harvard and MIT researchers are developing tattoo inks that react to body chemicals, alerting diabetics to blood sugar fluctuations or athletes to dehydration. Someday, patients may observe their body chemistry with tattoos that change colors.

What is biohacking? An overview

Biohacking is a broad collection of self-improvement techniques meant to enhance a human's health, lifespan, or ability. There are basic biohacks, like the use of caffeine, and more extreme ones, like under-the-skin implants. The difference between biohacking and standard medicine is that biohacking is primarily a do-it-yourself approach and is mostly unregulated.

Evidence suggests the first cells on Earth were bacteria

About 4 billion years ago, these single-celled organisms harvested carbon dioxide and sunlight to produce their own food and oxygen, setting the stage for the evolution of oxygen-breathing life forms. Archaeabacteria, which thrive on inorganic molecules in extreme habitats on Earth today, were also among the earliest organisms.

Making industrial chemicals with synthetic biology

A new report forecasts that synthetic biology will transform from creating niche, environmentally friendly products to creating new molecules within the next decade.

In 2022, NASA's OSIRIS-REx spacecraft touched down on an asteroid

Dust of asteroid Bennu, slightly wider than the Empire State Building is tall, was found to be rich in carbon, nitrogen, and organic compounds essential for life. The presence of magnesium-sodium phosphate indicated Bennu may have broken off from a primitive ocean world.

Scientists can suck animal DNA from the air

A look at how researchers filtered the air around two zoos and identified genetic material from dozens of species, a technique that could help track and conserve wildlife.

An overview of bioremediation, which can help clean up oil spills, mining waste, and some plastics

The umbrella term refers to a variety of techniques that use organisms to remove harmful substances from an environment or break them down into nontoxic compounds. Because the availability of certain resources can limit the growth of these organisms and impair bioremediation efforts, nutrients such as fertilizers can be deployed to accelerate cleanup.

Scientists used to speculate about life on the moon

In the 17th century, Galileo's observations suggested the moon could be inhabited, leading to fictional speculations about lunar life. In the 19th century, stories were published claiming the discovery of various creatures, including human bats. The Apollo missions in the 20th century explored the possibility of life there, but further exploration showed this idea to be less likely than before.

Biohacking to boost personal health has become a concept that encompasses everything from vitamin regimens and cryochambers to brain implants and red light therapy.

Extremophiles were likely to have been Earth's first, and are expected to be its last, organisms

Their ability to survive in an enormous range of environmental conditions, including some resembling what has been modeled to have existed relatively shortly after Earth's formation, makes them the leading candidates for enduring the increasing solar intensity and the subsequent effects (e.g., zero-oxygen atmosphere, evaporated oceans) expected in the coming billions of years.

The history of Earth's breathable atmosphere, made possible by photosynthetic bacteria

Between 3.2 billion and 2.8 billion years ago, threadlike microorganisms called cyanobacteria began consuming available water vapor, carbon dioxide, and sunlight to produce oxygen. However, molecules released from Earth's interior by volcanoes consumed this oxygen via chemical reactions, preventing it from accumulating until volcanism had sufficiently decreased about 2.4 billion years ago.

Biological aging tests assess the breakdown of physiological systems

Known as aging clocks, these tests compare various metrics, like DNA methylation patterns and protein profiles, to healthy baselines. However, the non-uniformity of these baselines across individuals limits testing accuracy and prevents their clinical use.

Glowing chemicals allow scientists to read DNA like a barcode

The process of determining the order of nitrogenous bases in DNA involves first cutting the DNA into fragments, which are duplicated multiple times using bacteria. Fluorescently labeled terminator bases are added to fragments, which are sorted by length and read via laser to reconstruct the sequence.

Inside the community movement behind DIY synthetic biology

Margaret Talbot spotlights the rise of DIY biology in community labs, where amateur scientists—often outside formal institutions—create everything from insulin to prosthetic prototypes. These grassroots biohackers challenge traditional science by pursuing open, accessible innovation, raising questions about credibility, ethical oversight, and acceptance by mainstream researchers.

Some 19th century astronomers thought Mars was inhabited

As telescope technology advanced, astronomers became able to observe the surfaces of objects in our solar system with greater detail. The dips, valleys, and lines crisscrossing Mars, particularly, captured onlookers' imagination, leading some to speculate that the seemingly organized features could only have been created by an intelligent civilization.

Humans can track smells on the ground quite well—our ability to crawl is a limiting factor

As part of a scientific bet, neurobiology researchers dragged a chocolate bar across the grass and sought to see if a human could track it—she could. This led to a more in-depth experiment on human olfactory capabilities and behavior when other senses were blocked.

Bioluminescent reaction enzymes are often used in biomedical research

Near-infrared luciferase systems allow researchers to image and analyze cellular activity in living animals because they penetrate tissue more deeply than visible light. This provides a means of studying gene expression and protein interactions without harming the animals.

My experience with biohacking

A general approach that employs technology to enhance the functioning of the human body, biohacking enthusiasts are continuously seeking new ways to optimize their performance. Martin Kremmer, an entrepreneur who became interested in the topic after experiencing burnout, explores his own experiences in biohacking his own diet and lifestyle in pursuit of a longer, healthier life.

In Raman spectroscopy, molecules use some of the energy from incoming light to shift into a more energetic vibration and scatter the remaining light, which scientists can use to confirm the molecule's presence.

Learn how environmental conditions are optimized to increase bioremediation efficacy

Through biostimulation, Indigenous microbes are provided with moisture, nutrients, or oxygen to prevent their death and ensure optimal progression of their biochemical reactions. Bioaugmentation can introduce new microbial cultures to target specific compounds not natively found in the environment, while landfarming can spread or aerate contaminated soil to improve access to contaminants.