Health span: The number of years one is active and disease-free

Doctors shift focus from extending lifespan to lengthening health span

As scientific advances extend the average human lifespan, many are turning their attention toward extending "health span." Health span refers to the number of years one is active and disease-free. The ultimate goal is to extend one’s health span to match one’s lifespan.

Extending the worldwide lifespan by one healthy year is worth $38T

This econometric study attempts to estimate the economic value of increasing the global healthy lifespan by one year—and to answer the question of whether it is better to extend lifespans or slow the rate of healthy aging.

The quest to find natural ways to extend lifespan

Tales of searching for the Fountain of Youth persist. Our modern-day version is marked by promises of pharmaceutical miracles and a proliferation of viral "biohacking" routines. One doctor’s quest to unlock the keys to longevity stimulated much of this renewed fervor, though his ideas are often taken out of context.

The eight habits that could add up to 24 years to your life

A study presented at the American Society for Nutrition's annual meeting revealed that adopting eight healthy lifestyle habits in middle age can significantly increase life expectancy. The habits include being physically active, avoiding opioid...

Global life expectancy has more than doubled since the 1850s

The human species experienced a dramatic increase in expected lifespan over the past 150 years. Antibiotics, improved sanitation, and better worldwide food distribution are a few factors contributing to this rapid transformation. Use this interactive resource to explore longevity gains over time and compare these improvements across the globe.

Multiple new research paths may lead to slowing (or even reversing) aging

Aging has always been inevitable, but fasting, epigenetic reprogramming, and parabiosis seem to help people stay young. By studying centenarians, memory, and even the humble roundworm, scientists are looking for the genetic basis to live not just a long life, but a healthy one.

Can humans delay or reverse old age?

We're not sure yet. Researchers at the University of California San Francisco are studying why some conditions and behaviors, such as low-oxygen environments and exercise, benefit the aging process, hoping to reveal potential health applications. Some of this research focuses on klotho, a naturally occurring age-regulating hormone named after the Greek Fate Clotho. Animal studies on klotho brain injections found subjects had improved memory recall and age-related degeneration resistance.

Each part of the human body experiences aging differently

With global average life expectancy cresting at 73 years, understanding how the body ages is imperative to effective medical treatment and maintaining a desired quality of life. This 13-minute video dives into how the body and its organs age "from head to toe."

The formula behind super agers—those possessing health and cognitive skills of people decades younger

A study of about 1,400 super agers did not identify any underlying genetic mechanism for longevity. While researchers instead emphasized that sustainable habits involving positive social connections, sleep, mood, diet, exercise, and personal fulfillment help reduce long-term risks, there is no one-size-fits-all formula for everyone.

The Dog Aging Project uses information from over 50,000 dogs to explore longevity

The study gathers health, lifestyle, and genetic data to understand what helps dogs live longer, healthier lives. Findings could also provide human health insights due to our shared surroundings and biology.

Moving your body every day is key to longevity

In an era of biohacking, where millionaires subject themselves to draconian routines and tests to de-age themselves, one study suggests a super simple key predictor of mortality: more than any other trait, how much subjects moved determined how long they'd live. Movement mattered even more than age in predicting overall life longevity. Researchers suggest this means we should all simply get outside a bit more. Read more about the study here.

A Nobel laureate discuss whether stem cells can extend lifespan

Listen to Nobel laureate Shinya Yamanaka discuss the potential of induced pluripotent stem cells to extend human lifespan. By reprogramming adult cells into embryonic-like stem cells, scientists might be able to rejuvenate tissues and treat age-related diseases—though ethical and safety concerns remain.

Visit these 'blue zones,' where people live the longest

Blue zones, a term coined in 2004 by National Geographic Fellow Dan Buettner, are regions in the world where people live the longest and healthiest lives. Researchers have identified a few key aspects defining the culture of these areas—physical activity, diet, purpose-driven lives, and more. Explore the top five blue zones from across the world here.

Tech entrepreneur Bryan Johnson's mission to live forever

Johnson has invested millions of dollars into developing a biohacking program he believes will extend his life beyond typical expectations, relying on medical professionals to reduce his "biological age." Most notably, he drew significant public attention with reports of blood-swapping with his teenage son.

Super-agers: seniors 80 and above with the memory ability of people in their 50s

Studies show the number one indicator of whether someone is a "super-ager" is not diet or genetics, but the extent of their social relationships. Moreover, scans reveal noticeable physical differences in certain parts of the brain in patients with extensive social networks.

Chronological versus biological age

Science has come to understand different types of aging. What we call age is simply the number of years since birth, or chronological age. At the cellular level, biological aging happens at different rates for different people, and explains why some seem to age more quickly (or slowly).

Environment and genetics explain why animals have widely different lifespans

Both environmental conditions and genetic factors shape how long various animals live. For some creatures, colder conditions allow for less energy use and slower aging. Larger animals have fewer predators. While humans don't live the longest, we are a rare species that successfully lengthened its average lifespan over time.

Most self-reported claims of exceptional longevity are exaggerated, but read how demographers verify age claims and why some of the original blue zone demographers say blue zone regions are real and worth studying.

Perceived isolation ages you

Mounting evidence suggests that socialization is a vital component of maintaining good health. Research published in 2024 from Mayo Clinic researchers analyzed the social lives of more than 280,000 adults and concluded that individuals that weren't likely to participate in extracurricular social activities and get-togethers were more likely to have a biological age older than their actual age—meaning that you may be 60 but health indicators would suggest you're older.

Why Hawaiians live longer

Hawaii has the longest life expectancy at birth out of all 50 states, according to the US Centers for Disease Control and Prevention. Key factors include strong healthcare, lots of sunlight, and active lifestyles.

Blue zones are regions with unusually high numbers of centenarians

Factors thought to contribute to longevity in these regions include diet and social connections, but their legitimacy is often questioned due to a lack of rigorous scientific methodology and potential record inaccuracies.

Biohacking to boost personal health has become a concept that encompasses everything from vitamin regimens and cryochambers to brain implants and red light therapy.

Semaglutide treatment extended the lifespan of female mice by about 12% in research published in 2026.

Can fasting help you live longer?

Animal studies into the health benefits of calorie restrictions of 20%-40% suggest it extends life spans and reduces incidents of age-related diseases, including cancer. This article explores the research into fasting, calorie restriction, and longevity.

One biologist is leading the blue zone criticisms—both questioning the original recordkeeping for these purported longevity-prone locations and pointing to recent research showing declining numbers of healthy seniors in several official blue zone regions.

Roughly 10% of the world's population is older than 65 (2023 data)

With recent advances in medicine, sanitation, and nutrition, expected lifespans have rapidly risen around the globe—resulting in a rapidly aging global population. The worldwide distribution has seen a nearly 600% jump in the population of people aged 65 and older.

Aging is a complex biological process affecting our cells, tissues, and organs.

Helping support others in older age linked to longer life

Analysis of findings from a long-term study of older couples first interviewed in 1987 and then followed for the next five years found that individuals who lend support to friends, neighbors, and relatives live longer. Non-helpers were more than twice as likely to die as helpers during the five-year period. That's even after controlling for factors including age, gender, and physical and mental health.

Biohacking: The effort to optimize health and extend life through technology

Biohacking seeks to optimize human health and performance through everything from simple lifestyle adjustments to more radical interventions like body modifications and experimental technology. At its core, biohacking covers a wide spectrum—ranging from improving sleep and focus to implanting devices that integrate technology with the human body.

Read the main paper criticizing the concept of blue zones, which argues recordkeeping errors, pension fraud, and natural disasters likely explain the high numbers of purported healthy centenarians in certain locations.

Why do humans have such long childhoods?

Humans have over twice as long childhoods than other animals with similar lifespans like whales and elephants. A human child can grow for nearly 20 years before they become a reproducing adult. Researchers believe there's a connection between long childhoods and human's unusually large brain size, though the science is not totally clear. Dive into what scientists know here.

Inside entrepreneur Bryan Johnson's race to live forever

Created by entrepreneur Bryan Johnson in 2022, the Rejuvenation Olympics asks participants to find ways, including exercise and dietary supplements, to slow their biological aging. But some of these tactics are extreme in cost or nature—such as Johnson's regular injections of blood from his teenage son.

Visualizing cause of death over time in America

As people age, their life expectancy decreases, but the timing and speed of this decline have evolved over the years. Check out this chart which shows the shift in various causes of death of Americans over the last few decades. Data from the...

Stroke risk doubles each decade after age 55

While age is the greatest risk factor, genetics, diet, and overall health play a prominent role in determining individual stroke risk. Prevention focuses heavily on modifiable risk factors. High blood pressure is the single most important controllable risk factor, contributing to both types of stroke.

Interest in intermittent fasting outpaces the science

The public interest in fasting diets has outpaced the science behind related health claims. This article details how the science of fasting diets is mainly exploratory and focused on longevity and disease prevention. Current findings suggest fasting kick-starts regenerative processes in the body, decreases inflammation, and improves health outcomes overall. However, much of this research focuses on the short-term impact of fasting.

The exercise sweet spot is shorter than you'd think—and longer workouts aren't generally better.

Watch the trailer for journalist Dan Buettner's popular Netflix documentary series 'Live to 100: Secrets of the Blue Zones,' which focuses on longevity insights from populations around the world.

The disparity in life expectancy between wealthy and impoverished nations has notably narrowed

In 1950, people in Norway lived to age 72, on average, while those in Mali lived to just 26. By 2015, the countries with the worst conditions had made such significant progress that the global average life expectancy had surpassed the rate of any nation in 1950.

Defying the odds, Stephen Hawking outlived his ALS diagnosis by over 50 years

When diagnosed with ALS, Stephen Hawking was given two years to live. However, he survived with the progressive neurodegenerative disease for over 50 years, highlighting the disease's variability and complexity.

Inflammaging is chronic low-level inflammation as we age, and it may be a key disease driver

The term refers to the idea that largely invisible but consistent low-level inflammation as humans age fuels chronic diseases and cellular aging. Inflammaging, this article says, is due to lifestyle factors like poor sleep, low levels of activity, and poor diet, acting in concert to cause cellular damage and trigger inflammation.

One minute of exercise correlates to five extra minutes of life (on average).

Doctors use three key physical markers to determine biological aging

The length of the ends of chromosomes (known as "telomeres"), the gradual change in collections of DNA molecules called "methyl groups", and the secretion of inflammatory proteins are all used as indicators of biological age.

Optimal human functioning requires movement

There is now ample evidence to back the centuries-old hypothesis that exercise is critical to human health. This review article explores the latest discoveries in exercise science, including how exercise is intrinsic to maintaining our organ systems throughout life.

Developing adaptable brain-body systems lets athletes thrive beyond 30

Success in high-level sports after age 30 relies on physical fitness and building brain resilience through deliberate training, recovery, and stress regulation. This creates a feedback loop where body and mind reinforce each other.

At-home genetic testing results commonly led users to healthier lifestyles

Italian research that aimed to investigate what people do longer-term after receiving direct-to-consumer genetic test results indicated that whether the results were positive or negative, people tended to adopt a healthier diet after receiving the results, and they'd still maintained it a year after receiving their results. Some users also reported an overall reduction in stress over their health concerns. (Some users may encounter a paywall.)

What is biohacking? An overview

Biohacking is a broad collection of self-improvement techniques meant to enhance a human's health, lifespan, or ability. There are basic biohacks, like the use of caffeine, and more extreme ones, like under-the-skin implants. The difference between biohacking and standard medicine is that biohacking is primarily a do-it-yourself approach and is mostly unregulated.

Blue zones are geographic locations, such as Sardinia, Italy, where there have appeared to be disproportionately high numbers of healthy agers, perhaps due to factors including genetics, diet, social connections, and more.

My experience with biohacking

A general approach that employs technology to enhance the functioning of the human body, biohacking enthusiasts are continuously seeking new ways to optimize their performance. Martin Kremmer, an entrepreneur who became interested in the topic after experiencing burnout, explores his own experiences in biohacking his own diet and lifestyle in pursuit of a longer, healthier life.

Recent global health estimates suggest that inactivity is a leading risk factor for death, contributing to 6% of deaths worldwide.

Research advances suggest death takes much longer than we realized

Recent research indicates that organs, including the brain, are better at handling a lack of oxygen after the heart stops beating than previously known. Such findings may open up possibilities that include someday reversing certain death processes and expanding the availability of organs available for organ donations. (Some users may experience a paywall.)