Can fasting help you live longer?

Interest in intermittent fasting outpaces the science

The public interest in fasting diets has outpaced the science behind related health claims. This article details how the science of fasting diets is mainly exploratory and focused on longevity and disease prevention. Current findings suggest fasting kick-starts regenerative processes in the body, decreases inflammation, and improves health outcomes overall. However, much of this research focuses on the short-term impact of fasting.

Multiple new research paths may lead to slowing (or even reversing) aging

Aging has always been inevitable, but fasting, epigenetic reprogramming, and parabiosis seem to help people stay young. By studying centenarians, memory, and even the humble roundworm, scientists are looking for the genetic basis to live not just a long life, but a healthy one.

Can humans delay or reverse old age?

We're not sure yet. Researchers at the University of California San Francisco are studying why some conditions and behaviors, such as low-oxygen environments and exercise, benefit the aging process, hoping to reveal potential health applications. Some of this research focuses on klotho, a naturally occurring age-regulating hormone named after the Greek Fate Clotho. Animal studies on klotho brain injections found subjects had improved memory recall and age-related degeneration resistance.

Semaglutide treatment extended the lifespan of female mice by about 12% in research published in 2026.

The stages of fasting

What happens to the body when it goes without caloric intake? This article overviews the immediate physical effects of fasting. Within a day of going without food, the body will have used up its glucose stores and ordered the liver and muscles to convert their glycogen (glucose storage) into usable glucose. By the second day, glycogen stores will run out, forcing the body to use fat as energy. This process is known as ketosis.

The eight habits that could add up to 24 years to your life

A study presented at the American Society for Nutrition's annual meeting revealed that adopting eight healthy lifestyle habits in middle age can significantly increase life expectancy. The habits include being physically active, avoiding opioid...

Environment and genetics explain why animals have widely different lifespans

Both environmental conditions and genetic factors shape how long various animals live. For some creatures, colder conditions allow for less energy use and slower aging. Larger animals have fewer predators. While humans don't live the longest, we are a rare species that successfully lengthened its average lifespan over time.

Doctors shift focus from extending lifespan to lengthening health span

As scientific advances extend the average human lifespan, many are turning their attention toward extending "health span." Health span refers to the number of years one is active and disease-free. The ultimate goal is to extend one’s health span to match one’s lifespan.

The quest to find natural ways to extend lifespan

Tales of searching for the Fountain of Youth persist. Our modern-day version is marked by promises of pharmaceutical miracles and a proliferation of viral "biohacking" routines. One doctor’s quest to unlock the keys to longevity stimulated much of this renewed fervor, though his ideas are often taken out of context.

Sleep deprivation may slow metabolism

This article explains that, according to research from Penn State, restricting sleep for just a few days can affect how the human body metabolizes fats and change how satisfied people feel after a meal. The study found that people who don’t get...

Health span: The number of years one is active and disease-free

As scientific advances continue to extend the average human lifespan, many are now turning their attention toward extending "health span." The ultimate goal would be to extend one's health span to match one's lifespan, which would necessitate a shift in focus toward the pursuit of healthy aging. (Some users may experience a paywall.)

The Dog Aging Project uses information from over 50,000 dogs to explore longevity

The study gathers health, lifestyle, and genetic data to understand what helps dogs live longer, healthier lives. Findings could also provide human health insights due to our shared surroundings and biology.

Sleep deprivation leads to the buildup of dangerous molecules in the gut.

Yoga can be beneficial for aging practitioners

Studies suggest that yoga can help alleviate several diseases associated with aging by lowering blood pressure, reducing blood fat levels, and combating obesity. It has also been shown to increase telomerase activity, which helps slow cell aging.

Extending the worldwide lifespan by one healthy year is worth $38T

This econometric study attempts to estimate the economic value of increasing the global healthy lifespan by one year—and to answer the question of whether it is better to extend lifespans or slow the rate of healthy aging.

Can we speed up our metabolisms?

Listen to this 31-minute podcast to better understand what science knows and doesn't know about metabolism, as well as the only thing that seems capable of changing it. Scientists understand that the difference between a so-called “fast” and “slow” metabolism does not affect one’s ability to lose weight.

Most adults don't need a daily vitamin, and it won't extend your life

A 20-year study by the National Cancer Institute involving almost 400,000 people found that daily multivitamins did not help people live longer. In some cases, these vitamins also increased the risk of death. Although some subpopulations—such as those with documented vitamin deficiencies and pregnant individuals—should take vitamins, daily multivitamins should not be taken uniformly by adults. Instead, patients should discuss vitamins with their clinicians and consider baseline vitamin testing before starting vitamin regimens.

One minute of exercise correlates to five extra minutes of life (on average).

The evolution of the human diet

Could eating like our ancestors make us healthier? One estimate suggests prehistoric hunter-gatherer communities obtained 75% of their calories from meat and fish.

Visit these 'blue zones,' where people live the longest

Blue zones, a term coined in 2004 by National Geographic Fellow Dan Buettner, are regions in the world where people live the longest and healthiest lives. Researchers have identified a few key aspects defining the culture of these areas—physical activity, diet, purpose-driven lives, and more. Explore the top five blue zones from across the world here.

The exercise sweet spot is shorter than you'd think—and longer workouts aren't generally better.

Moving your body every day is key to longevity

In an era of biohacking, where millionaires subject themselves to draconian routines and tests to de-age themselves, one study suggests a super simple key predictor of mortality: more than any other trait, how much subjects moved determined how long they'd live. Movement mattered even more than age in predicting overall life longevity. Researchers suggest this means we should all simply get outside a bit more. Read more about the study here.

A Nobel laureate discuss whether stem cells can extend lifespan

Listen to Nobel laureate Shinya Yamanaka discuss the potential of induced pluripotent stem cells to extend human lifespan. By reprogramming adult cells into embryonic-like stem cells, scientists might be able to rejuvenate tissues and treat age-related diseases—though ethical and safety concerns remain.

Most self-reported claims of exceptional longevity are exaggerated, but read how demographers verify age claims and why some of the original blue zone demographers say blue zone regions are real and worth studying.

Blue zones are regions with unusually high numbers of centenarians

Factors thought to contribute to longevity in these regions include diet and social connections, but their legitimacy is often questioned due to a lack of rigorous scientific methodology and potential record inaccuracies.

How meal timing factors into health outcomes

The world is trending toward weight gain, a development that comes with a corresponding rise in risk for health conditions, including diabetes and heart disease. This article explores how meal timing has become a factor in nutrition and weight maintenance.

Helping support others in older age linked to longer life

Analysis of findings from a long-term study of older couples first interviewed in 1987 and then followed for the next five years found that individuals who lend support to friends, neighbors, and relatives live longer. Non-helpers were more than twice as likely to die as helpers during the five-year period. That's even after controlling for factors including age, gender, and physical and mental health.

As of 2025, extensive research studies do not support fears about seed oils

Across human trials, seed oils have not been shown to increase rates of disease or inflammation, with a study of over 800 Swedish men finding that higher seed oil diets were linked to living longer. Reviews of these trials found better health outcomes when saturated fats were replaced with seed oils.

Staying on standard time permanently would slightly reduce obesity and stroke risk

A 2025 study that examined time changes found that permanently changing to standard time would slightly reduce obesity and stroke risk more than switching to permanent daylight saving time.

History's weirdest weight loss fads, fact-checked

Nothing catches popular attention more than a claim to have found a quick weight-loss technique. History shows us such claims are often unfounded. Dr. Michael Mosley explores extreme weight-loss tips from history, from tapeworms to vinegar diets.

Perceived isolation ages you

Mounting evidence suggests that socialization is a vital component of maintaining good health. Research published in 2024 from Mayo Clinic researchers analyzed the social lives of more than 280,000 adults and concluded that individuals that weren't likely to participate in extracurricular social activities and get-togethers were more likely to have a biological age older than their actual age—meaning that you may be 60 but health indicators would suggest you're older.

Research advances suggest death takes much longer than we realized

Recent research indicates that organs, including the brain, are better at handling a lack of oxygen after the heart stops beating than previously known. Such findings may open up possibilities that include someday reversing certain death processes and expanding the availability of organs available for organ donations. (Some users may experience a paywall.)

Global life expectancy has more than doubled since the 1850s

The human species experienced a dramatic increase in expected lifespan over the past 150 years. Antibiotics, improved sanitation, and better worldwide food distribution are a few factors contributing to this rapid transformation. Use this interactive resource to explore longevity gains over time and compare these improvements across the globe.

Watch the trailer for journalist Dan Buettner's popular Netflix documentary series 'Live to 100: Secrets of the Blue Zones,' which focuses on longevity insights from populations around the world.

About 40% of cancer cases are linked to preventable risk factors

Maintaining a healthy weight, engaging in regular physical activity, and consuming a balanced diet can lower cancer risk. Research indicates that about 40% of US cancer cases are linked to preventable factors, including poor diet and inactivity. Understanding these mechanisms empowers individuals to adopt healthier lifestyles for cancer prevention.

Should you eat an all-meat diet?

The carnivore diet is reportedly a way of eating inherited from human ancestors, a tale that has roots in anthropology's early days. This article explores the all-meat diet's ancestral claims and what happens if you cut vegetables and fruits from...

The formula behind super agers—those possessing health and cognitive skills of people decades younger

A study of about 1,400 super agers did not identify any underlying genetic mechanism for longevity. While researchers instead emphasized that sustainable habits involving positive social connections, sleep, mood, diet, exercise, and personal fulfillment help reduce long-term risks, there is no one-size-fits-all formula for everyone.

The halting of human bone growth helps manage heat produced from metabolism

While fish, amphibians and reptiles get bigger throughout their lives until they die, their slower metabolisms allow their bodies to regulate the resulting smaller temperature increases. In humans, hormones triggered during puberty harden growth plates, ending bone lengthening.

One biologist is leading the blue zone criticisms—both questioning the original recordkeeping for these purported longevity-prone locations and pointing to recent research showing declining numbers of healthy seniors in several official blue zone regions.

Are cats good for our health?

Being a cat lover can have a profound effect on your life. This article in The Conversation presents a fascinating collection of findings related to the benefits and consequences of cat ownership. Discover compelling research about the positive heart health and mental health outcomes cats can bring, along with potential risks.

Addressing lifestyle factors, which influence inflammation, can cure some chronic diseases

In this video, a physician claims that he reversed a patient's Type 2 diabetes in six weeks by addressing inflammation drivers such as diet. More broadly, he argues that society needs to better consider and address numerous disease factors that are modulated by inflammation, such as stress, sleep, diet, and movement.

GLP-1s may lower inflammation, possibly helping to combat cognitive decline

An analysis of existing GLP-1 research, published in April 2025, indicated that GLP-1 drugs reduce inflammation, with numerous health benefits. The work notes that GLP-1s were linked with a statistically significant reduction in dementia in randomized clinical trials.

Combining two cancer drugs increased the life space of mice by 30%

A study shows trametinib and rapamycin, two drugs used for cancer treatment in humans, increased mouse lifespan when used together. The medications delayed the onset of cancer and reduced chronic inflammation, results that will be explored in future research.

Learn the history of food science breakthroughs from the 20th century

Long after humans developed the means to produce sufficient food to feed civilizations, scientific research focused on a wide variety of objectives, such as developing methods to preserve food quality (accomplished via frozen food), speeding up cooking (leading to the microwave), and lowering the cost of sweetening food, which high fructose corn syrup provides.

Each part of the human body experiences aging differently

With global average life expectancy cresting at 73 years, understanding how the body ages is imperative to effective medical treatment and maintaining a desired quality of life. This 13-minute video dives into how the body and its organs age "from head to toe."

Why Hawaiians live longer

Hawaii has the longest life expectancy at birth out of all 50 states, according to the US Centers for Disease Control and Prevention. Key factors include strong healthcare, lots of sunlight, and active lifestyles.

What is Lent?

Lent is the 40-day period of fasting and penitence before Easter, modeled on Jesus's 40 days of fasting in the wilderness. Rooted in early Christian practice, it was formalized at the Council of Nicaea in 325 CE. Pope Gregory I established Ash Wednesday as its start in 601, creating the season's current structure of 46 days—40 fasting days plus six Sundays, which were traditionally treated as feast days.

How reading and writing can lower dementia risk by almost 40%

Research published in 2026 that tracked almost 2,000 older adults for an average of nearly eight years suggests that lifelong exposure to intellectual stimulation, such as learning a language, reading, and writing, can lower dementia risk by as much as 40%.

Learn how colorectal cancer is linked to the American diet and chronic inflammation

A University of South Carolina colon cancer researcher offers insights from his own research and notes that more exercise, social support, and eating fruits, vegetables, legumes, and foods like fish and olive oil—often called the Mediterranean diet—are associated with better health—and could improve our colons.

In the original 2004 blue zones study, which sought to verify the ages of long-lived, healthy populations in Sardinia, Italy, researchers hypothesized that inbreeding in these isolated communities may have helped promote their longevity.