How to prevent a worst-case scenario with synbio

Is synbio really cool, really scary, or both?

There's always been a divide between technology, the inanimate stuff that we build, and biology, the living stuff that nature builds. Synthetic biologists are trying to figure out how to close the gap by building living things.

Challenges for synthetic biology

Can engineering approaches tame the complexity and unpredictability of living systems? An exploration of five challenges for the field and how they might be resolved.

Will AI kill us all? A debate

As AI becomes a bigger part of our lives, what does that mean for the future of humanity? The podcast Entanglements hosts a pessimistic former OpenAI employee and an optimistic Princeton professor to discuss whether AI brings dystopia or a brighter future.

AI experts argue that artificial intelligence could annihilate humanity in two primary ways: Humans weaponizing extremely powerful AI, or humans losing control of it.

Synthetic biology can prevent extinction by creating create disease-resilient plants and animals

Through gene editing and the deployment of artificial cells, scientists can leverage learnings from the genetic sequencing of animals with known resistances to protect endangered species. Gene editing of certain species, such as mosquitoes, can also reduce their ability to spread diseases like malaria between humans.

Meet six commercially available synbio products

An article exploring the science behind synbio products currently on the market, and projecting the products that can be expected over the next 10 years.

Inside the community movement behind DIY synthetic biology

Margaret Talbot spotlights the rise of DIY biology in community labs, where amateur scientists—often outside formal institutions—create everything from insulin to prosthetic prototypes. These grassroots biohackers challenge traditional science by pursuing open, accessible innovation, raising questions about credibility, ethical oversight, and acceptance by mainstream researchers.

Some experts suggest there is an approximately 10% chance that AI agents will cause human extinction if they become superintelligent, go rogue, and hijack critical computer systems.

Anthropic's Frontier Red Team assesses the dangers of its AI tools through 'evals'—safety tests that probe models to disclose sensitive information.

Genetic engineering will change everything forever

Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. As scientists increasingly understand how specific genes cause disease, the possibility of engineering our genes to not only "fix" problems but enhance our natural ability grows.

More than 39 million people are expected to die from antimicrobial resistance by 2050

In 2024, researchers published an incredibly detailed study aimed at predicting the real-world impact of antimicrobial resistance over the next 25 years. The key findings were clear: the superbug crisis is poised to get much worse and needs to be addressed. This article offers a clear, concise overview of the study, which was published in The Lancet.

Through prompt injection attacks, bad actors provide deceptive prompts to generative AI systems in order to manipulate their outputs and acquire sensitive data.

Scientists from the frontline discuss the future of antibiotics and superbugs

Superbugs are a very real problem, but researchers around the world are working to advance our understanding of these pathogens and develop new medicines. This podcast talks with several scientists on the frontier of superbug research, offering insight into what we know—and what the future of medicine may look like.

In 2025, researchers in the UK began working on developing artificial DNA

The Synthetic Human Genome Project aims to one day construct human DNA, molecule by molecule, in the hopes of creating disease-resistant cells and synthetic chromosomes for study. However, critics warn it may be misused to create enhanced or modified humans.

Researchers report that Anthropic's Claude Mythos AI model has identified thousands of high-severity vulnerabilities across various software, including major operating systems and web browsers, and has suggested ways to exploit them.

See how distant aliens could preemptively strike humanity

Could aliens destroy us from light-years away? The team at Kurzgesagt imagines the impact of a highly sophisticated alien civilization setting out to crush humanity and considers the real-world logistics for warfare conducted across the Universe.

Hacking the body for a future that didn't happen

Journalist Adi Robertson experimented with one of the most accessible biohacks: magnets. Having a tiny magnet in their right ring finger meant they could sense magnetic fields, attract small metal objects, and more. But magnets weaken over time, eroding this new sense. Such implants do more than offer a new way of interacting with the world, they also pose new complications, such as the inability to get an MRI.

Tech entrepreneur Bryan Johnson's mission to live forever

Johnson has invested millions of dollars into developing a biohacking program he believes will extend his life beyond typical expectations, relying on medical professionals to reduce his "biological age." Most notably, he drew significant public attention with reports of blood-swapping with his teenage son.

In 2018, it took about 2.3 years to develop a way to exploit a software bug for malicious purposes, but as of 2026, AI tools have reduced this time to about 20 hours.

Sam Altman acknowledges the fears around creativity, copyright, and misuse of AI

In 2022, OpenAI's CEO, Sam Altman, popularized the use of large language models with the release of ChatGPT. He has emphasized the importance of involving society in shaping AI’s safety frameworks before models begin to act independently online.

Synthetic biology transforms cells into custom DNA foundries

At companies like Ginkgo Bioworks, researchers are reprogramming cells to act as workshops that can create custom molecules, such as medicines and fertilizers, by stitching together DNA sequences—often in novel combinations—before inserting them into an organism's genome.

The risks of bioremediation, from intermediate products to ecological disruption

A step in the series of complex biochemical reactions involved in the implemented bioremediation process may produce dangerous molecules—sometimes more toxic than the initial pollutants—that require ongoing monitoring to ensure optimal conditions for processing these intermediates toward the eventual, safe outputs. Introducing non-native nutrients or species, including GMOs, may alter existing food webs and gene pools.

My experience with biohacking

A general approach that employs technology to enhance the functioning of the human body, biohacking enthusiasts are continuously seeking new ways to optimize their performance. Martin Kremmer, an entrepreneur who became interested in the topic after experiencing burnout, explores his own experiences in biohacking his own diet and lifestyle in pursuit of a longer, healthier life.

Warren Buffett has worried that AI might end up being as consequential as the development of the nuclear bomb

Berkshire Hathaway chairman Warren Buffett is one of the many people who’ve come face-to-face with the downside effects of AI, and in particular, deepfakes. He was recently shown a deepfake of himself in a video, which caused him to worry about how bad actors will take advantage of the technology.

Scientists increasingly can't predict what AI will do

Most AI systems are so-called "black box" models, where we only see inputs and outputs while the inner workings remain obscure. This piece, written prior to the launch of ChatGPT, cautions developers to know why and how a system produces its results, and not to sacrifice explainability for accuracy.

The crypto city home to biohacking experiments

The DIY nature of biohacking gives the work an entrepreneurial feel, as seen by the emergence of community labs, at-home testing kits, and corporation-backed cities that don't necessarily require government-approved testing standards. Próspera, Honduras, created by a business of the same (first) name, was born from legislation that allowed international businesses to shave off a slice of the country to establish their own micronations.

Superbugs could claim 1.9 million lives per year by 2050

The increased use of antibiotics combined with an aging population, is projected to result in an almost 50% increase in global deaths from antimicrobial resistance each year. At the same time, antibiotic use for livestock is expected to increase by 30% over the same time frame.

Biohacking: The effort to optimize health and extend life through technology

Biohacking seeks to optimize human health and performance through everything from simple lifestyle adjustments to more radical interventions like body modifications and experimental technology. At its core, biohacking covers a wide spectrum—ranging from improving sleep and focus to implanting devices that integrate technology with the human body.

Explaining CRISPR at five levels of technical detail

CRISPR is a new area of biomedical science that enables gene editing and could be the key to eventually curing diseases like autism or cancer. WIRED challenges biologist Neville Sanjana to explain this concept to 5 different people; a 7-year-old, a 14-year-old, a college student, a grad student and a CRISPR expert.

As occurred during the 2026 hack of an AI platform by OpenAI, agentic AI may exploit a system vulnerability to access sensitive data if that information enables it to complete its assigned task.

Tracing the history of the philosophy of human extinction

Global catastrophe is at the center of much contemporary debate over climate, war, science, technology, and more, and our period is marked by a lurking sense everything we know—including the human species—could end overnight. It wasn't always...

Unpacking the famous argument in the 'Are We Living in a Computer Simulation?' paper

In 2003, philosopher Nick Bostrom published a paper in a journal arguing the technological possibility that humanity is living in a simulation. The argument, while popularly mocked (or cheered), is presented seriously in the paper. This podcast episode explores the contours of the arguments in an accessible way.

In 2026, researchers at the University of Minnesota created the world's first synthetic cell—a cell made from non-living chemical components—that can eat, grow, divide, and compete with other cells for resources.

Implanted neurotechnology can leave users vulnerable when manufacturers go under

Despite providing relief from neurological conditions, patients are left stranded when the companies that make these devices shut down. The lack of regulation means patients often face technical failure, insurance battles, or risky surgeries to maintain their quality of life.

Making industrial chemicals with synthetic biology

A new report forecasts that synthetic biology will transform from creating niche, environmentally friendly products to creating new molecules within the next decade.

Biohacking to boost personal health has become a concept that encompasses everything from vitamin regimens and cryochambers to brain implants and red light therapy.

Minor technology failures can spiral into massive internet outages

A mix of centralized cloud infrastructure and legacy protocols leaves the internet susceptible to downtime from minor cyberattacks or software bugs, infrastructure damage caused by extreme weather, and human error if a DNS service provider—the internet's phone book—or a backend system, such as Amazon Web Services, were compromised.

Are smart cities a dumb idea?

Smart cities require vast troves of data to run, making their systems attractive to hackers. Listen to this one hour podcast to learn about the risks and what is being done to mitigate them.

Scientists have created a cell from scratch—called a SpudCell—proof-of-concept work that a lab-made cell can feed, grow, and replicate like a natural cell.

Superbugs evolve defenses against medication, then share them with neighbors

One reason antibiotic resistance spreads so quickly is that bacteria have multiple mechanisms allowing them to share genetic material. This short video offers a concise explanation for each of these mechanisms, and animation that helps viewers understand how antimicrobial resistance can quickly spread from one organism to another.

A physician with a rare and deadly disease saved his own life by identifying an existing medication that he repurposed for his condition, and now he's using AI to try to do the same for other patients.

The promises and perils of using at-home genetic tests for your health

A primer on genetic testing, personalized medicine, and the promise of pharmacogenomics–the use of genetics to predict an individual's response to a drug.

How to prepare for cyberattacks

An easy-to-digest checklist on the many ways you want protect yourself from a cyberattack before it happens, if it happens, and after it happens.

Listen to tech company Palantir's CEO Alex Karp discuss the threat of a surveillance state.

Experiments involving AI agents operating in virtual societies for 15 days produced diverse outcomes, ranging from every agent dying to the creation of a functioning democracy, depending on the AI model used.

Critic Neil Postman argued modern technology is dystopian

Cultural critic Neil Postman argued in 1985's "Amusing Ourselves to Death" that mass media had made the dystopia of Huxley's "Brave New World" a reality. In 1992, he published "Technopoly," a wider critique of the utopian visions of technology or, as Postman calls it, "all of the machinery that takes people out of public arenas and keeps them fixed in their homes."

A comic book-style review of attending a biohacking conference

When Andrew Greenstone attended a biohacking conference in Austin, Texas, he didn't expect to walk away a newly implanted member of the techy cadre. Partway through the event, he paid $150 to have an NFC chip inserted into his right hand.

The origin of cyborgs

The term "cyborg" was coined in a 1960 academic paper discussing what alterations humans would need to undergo to survive in extraterrestrial environments, a venture far "more logical than providing an earthly environment" in space. According to authors Manfred E. Clynes and Nathan S. Kline, Cyborgs with a capital C have incorporated exogenous components that extend their ability to adapt to new environments. Read the paper here.

The rise of generative AI could exacerbate anxiety because people may turn to chatbots for constant reassurance.

A deeper (nontechnical) dive into how CRISPR works

Extra crispy? No, it's CRISPR, but this gene-editing technology is "extra" in the sense of being momentous and destined to change everything. Through CRISPR, scientist exploit a quirk in bacteria immune systems, allowing them to potentially, and quickly, control genes, remove undesirable traits, and add preferred ones. The possibilities and applications are endless.